The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV β-lactamase: A study of Ambler position Asn276

Biochemistry

Volumn 48, Issue 21, 2009, Pages 4557-4566

  Drawz, Sarah M ^a   Bethel, Christopher R ^b   Hujer, Kristine M ^b   Hurless, Kelly N ^c   Distler, Anne M ^a   Caselli, Emilia ^d   Prati, Fabio ^d   Bonomo, Robert A ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^c ST EDWARD'S UNIVERSITY   (United States)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; CARBAPENEM; CLASS A; CONFORMATIONAL FLEXIBILITY; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; ELECTROSTATIC INTERACTIONS; ENERGY COST; INHIBITOR COMBINATION; LACTAMASE; LACTAMASES; MEROPENEM; SPATIAL POSITIONS; STEADY-STATE KINETICS; TEM;

AMINES; AMINO ACIDS; CARBOXYLATION; ELECTROSPRAY IONIZATION; ESCHERICHIA COLI; MASS SPECTROMETRY; ORGANIC ACIDS;

SUBSTRATES;

AMPICILLIN; ASPARAGINE; BETA LACTAMASE SHV; CEFALOTIN; CEFOTAXIME; CLAVULANIC ACID; ENZYME VARIANT; MEROPENEM; PIPERACILLIN; SULBACTAM; TAZOBACTAM;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME KINETICS; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTI-INFECTIVE AGENTS; ASPARAGINE; BETA-LACTAMASES; CATALYTIC DOMAIN; CLAVULANIC ACID; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; IMMUNOBLOTTING; KINETICS; MUTAGENESIS; PROTEIN BINDING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ESCHERICHIA COLI;

EID: 66349089235     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9003292     Document Type: Article

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