Molecular determinants for PP2A substrate specificity: Charged residues mediate dephosphorylation of tyrosine hydroxylase by the PP2A/B′ regulatory subunit

Biochemistry

Volumn 49, Issue 5, 2010, Pages 986-995

  Saraf, Amit ^a   Oberg, Elizabeth A ^a   Strack, Stefan ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC SITES; CELL TYPES; CHARGED RESIDUES; DEPHOSPHORYLATIONS; DOCKING SITES; HETEROTRIMERS; IN-VITRO; MODEL SUBSTRATES; MOLECULAR DETERMINANTS; MULTI-SITE; N-TERMINALS; NERVE GROWTH FACTOR; PC12 CELLS; PHOSPHATASE ACTIVITY; PHOSPHORYLATION SITES; POSITIVE CHARGES; PROTEIN PHOSPHATASE 2A; PROTEIN PHOSPHATASE-1; RATE-LIMITING ENZYMES; REGULATORY SUBUNITS; SIDE CHAINS; SITE-SPECIFIC; SUBSTRATE SPECIFICITY; TYROSINE HYDROXYLASE;

AMINO ACIDS; CRYSTAL STRUCTURE; PHOSPHATASES; PHOSPHORYLATION; POLYPEPTIDES; PROTEINS;

SUBSTRATES;

AMINO ACID; CALCINEURIN; HOLOENZYME; NERVE GROWTH FACTOR; PHOSPHOPROTEIN PHOSPHATASE 2A; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ARTICLE; BETA CHAIN; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME INACTIVATION; ENZYME SPECIFICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; RAT;

ANIMALS; ARGININE; CONSERVED SEQUENCE; ENZYME ACTIVATION; GLUTAMIC ACID; ISOENZYMES; MODELS, MOLECULAR; NERVE GROWTH FACTOR; NEURONS; PC12 CELLS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; PROTEOME; RATS; SEQUENCE DELETION; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY; TYROSINE 3-MONOOXYGENASE;

EID: 75749140882     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi902160t     Document Type: Article

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