Genetic signatures in the envelope glycoproteins of HIV-1 that associate with broadly neutralizing antibodies

PLoS Computational Biology

Volumn 6, Issue 10, 2010, Pages

  Gnanakaran, S ^a   Daniels, Marcus G ^a   Bhattacharya, Tanmoy ^a,b   Lapedes, Alan S ^a   Sethi, Anurag ^a,c   Li, Ming ^d   Tang, Haili ^d   Greene, Kelli ^d   Gao, Hongmei ^d   Haynes, Barton F ^d   Cohen, Myron S ^e   Shaw, George M ^f,g   Seaman, Michael S ^h   Kumar, Amit ^d   Gao, Feng ^d   Montefiori, David C ^d   Korber, Bette ^a,b  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

^b SANTA FE INSTITUTE   (United States)

^c CENTER FOR NONLINEAR STUDIES   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f and Clinical Center   (United States)

^g University of Alabama at Birmingham   (United States)

^h BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTONOMOUS AGENTS; BINDING SITES; COMPUTATIONAL METHODS; GLYCOPROTEINS; MONOCLONAL ANTIBODIES; VIRUSES;

AMINO-ACIDS; ANTIGENICS; BINDING SURFACE; COMMON FEATURES; ENVELOPE GLYCOPROTEINS; IMMUNOGENS; NEUTRALISATION; NEUTRALIZING ANTIBODIES; SIMPLE ALGORITHM; SIMPLER ALGORITHMS;

VACCINES;

CD4 ANTIGEN; GLYCOPROTEIN GP 120; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; VIRUS ENVELOPE PROTEIN; EPITOPE; GLYCOPROTEIN GP 41;

AMINO ACID SEQUENCE; ANTIBODY RESPONSE; ARTICLE; BINDING SITE; HUMAN IMMUNODEFICIENCY VIRUS 1; MATHEMATICAL ANALYSIS; PHENOTYPE; PHYLOGENY; SEQUENCE ANALYSIS; STATISTICAL ANALYSIS; VIRAL GENETICS; VIRUS NEUTRALIZATION; ALGORITHM; ARTIFICIAL INTELLIGENCE; BIOLOGY; BLOOD; CHEMICAL STRUCTURE; CLUSTER ANALYSIS; EPITOPE MAPPING; GENETICS; HUMAN; METABOLISM; METHODOLOGY; MUTATION; NUCLEOTIDE SEQUENCE; SEQUENCE ALIGNMENT; SERODIAGNOSIS; STATISTICAL MODEL;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ALGORITHMS; AMINO ACID SEQUENCE; ANTIBODIES, NEUTRALIZING; ARTIFICIAL INTELLIGENCE; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; DNA MUTATIONAL ANALYSIS; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMANS; LOGISTIC MODELS; MODELS, MOLECULAR; MUTATION; NEUTRALIZATION TESTS; PHYLOGENY; SEQUENCE ALIGNMENT;

EID: 78349299783     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000955     Document Type: Article

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