Enhancement of α-helicity in the HIV-1 inhibitory peptide DP178 leads to an increased affinity for human monoclonal antibody 2F5 but does not elicit neutralizing responses in vitro: Implications for vaccine design

Journal of Biological Chemistry

Volumn 277, Issue 48, 2002, Pages 45811-45820

  Joyce, Joseph G ^a   Hurni, William M ^a   Bogusky, Michael J ^a   Garsky, Victor M ^a   Liang, Xiaoping ^a   Citron, Michael P ^a   Danzeisen, Renee C ^a   Miller, Michael D ^a   Shiver, John W ^a   Keller, Paul M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ASSAYS; CONFORMATIONS; DIMERIZATION; IMMUNIZATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; VIRUSES;

CIRCULAR DICHROISM;

BIOCHEMISTRY;

ANTIGEN; ASPARAGINE; EPITOPE; GLUTAMIC ACID; GLYCOPROTEIN GP 41; INHIBITOR PROTEIN; LEUCINE ZIPPER PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2F5; PEPTIDE DERIVATIVE; PROTEIN DP178; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ADOLESCENT; ALPHA HELIX; AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY TITER; ARTICLE; CIRCULAR DICHROISM; DIMERIZATION; FEMALE; GUINEA PIG; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNIZATION; IMMUNOGENICITY; MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN CONFORMATION; VIRUS INHIBITION; VIRUS NEUTRALIZATION;

AIDS VACCINES; AMINO ACID SEQUENCE; ANTI-HIV AGENTS; ANTIBODIES, MONOCLONAL; CIRCULAR DICHROISM; HIV ENVELOPE PROTEIN GP41; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PEPTIDE FRAGMENTS;

CAVIA PORCELLUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; SUS SCROFA;

EID: 0037195784     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205862200     Document Type: Article

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