HIV gp41 C-terminal heptad repeat contains multifunctional domains: Relation to mechanisms of action of anti-HIV peptides

Journal of Biological Chemistry

Volumn 282, Issue 13, 2007, Pages 9612-9620

  Liu, Shuwen ^a   Jing, Weiguo ^b   Cheung, Byron ^b   Lu, Hong ^b   Sun, Jane ^b   Yan, Xuxia ^b,c   Niu, Jinkui ^b,d   Farmar, James ^b   Wu, Shuguang ^a   Jiang, Shibo ^a,b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b NEW YORK BLOOD CENTER   (United States)

^c Division of Molecular Biology   (China)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MULTIFUNCTIONAL DOMAINS; PEPSCAN STRATEGY; POCKET-BINDING DOMAIN;

ADDITION REACTIONS; AMINO ACIDS; CELL MEMBRANES; DISEASES; PEPTIDES; VIRUSES;

DRUG PRODUCTS;

ANTIVIRUS AGENT; ENFUVIRTIDE; PEPTIDE; PEPTIDE C34; PEPTIDE C36; PEPTIDE CHR 1; PEPTIDE CHR 3; PEPTIDE CHR 5; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; GLYCOPROTEIN GP 41; HYBRID PROTEIN; PEPTIDE FRAGMENT;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG BINDING; DRUG MECHANISM; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; DRUG EFFECT; GENETICS; HUMAN; MEMBRANE FUSION; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMANS; MEMBRANE FUSION; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; REPETITIVE SEQUENCES, AMINO ACID;

EID: 34248155890     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609148200     Document Type: Article

References (43)

1. Moore, J. P., Jameson, B. A., Weiss, R. A., and Sattentau, Q. J. (1993) in Viral Fusion Mechanisms (Bentz, J., ed) pp. 233-289, CRC Press, Boca Raton, FL
2. Berger, E. A., Murphy, P. M., and Farber, J. M. (1999) Annu. Rev. Immunol. 17, 657-700
3. Chan, D. C., and Kim, P. S. (1998) Cell 93, 681-684
4. Jiang, S., Lin, K., Strick, N., and Neurath, A. R. (1993) Nature 365, 113
5. Wild, C. T., Shugars, D. C., Greenwell, T. K., McDanal, C. B., and Matthews, T. J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 9770-9774
6. Kilby, J. M., Hopkins, S., Venetta, T. M., DiMassimo, B., Cloud, G. A., Lee, J. Y., Alldredge, L., Hunter, E., Lambert, D., Bolognesi, D., Matthews, T., Johnson, M. R., Nowak, M. A., Shaw, G. M., and Saag, M. S. (1998) Nat. Med. 4, 1302-1307
7. Kilby, J. M., and Eron, J. J. (2003) N. Engl. J. Med. 348, 2228-2238
8. Lalezari, J. P., Henry, K., O'Hearn, M., Montaner, J. S., Piliero, P. J., Trottier, B., Walmsley, S., Cohen, C., Kuritzkes, D. R., Eron, J. J., Jr., Chung, J., DeMasi, R., Donatacci, L., Drobnes, C., Delehanty, J., and Salgo, M. (2003) N. Engl. J. Med. 348, 2175-2185
9. Lu, M., and Kim, P. S. (1997) J. Biomol. Struct. Dyn. 15, 465-471
10. Chan, D. C., Fass, D., Berger, J. M., and Kim, P. S. (1997) Cell 89, 263-273
11. Liu, S., Zhao, Q., and Jiang, S. (2003) Peptide 24, 1303-1313
12. Liu, S., Boyer-Chatenet, L., Lu, H., and Jiang, S. (2003) J. Biomol. Screening 8, 685-693
13. Liu, S., Lu, H., Xu, Y., Wu, S., and Jiang, S. (2005) J. Biol. Chem. 280, 11259-11273
14. Jiang, S., Radigan, L., and Zhang, L. (2000) Proc. SPIE 3926, 212-219
15. Lu, H., Zhao, Q., Xu, Z., and Jiang, S. (2003) J. Virol. Methods 107, 155-161
16. Chou, T. C., and Hayball, M. P. (1991) CalcuSyn, Windows software for dose effect analysis, BIOSOFT, Ferguson, MO
17. Jiang, S., Lin, K., and Lu, M. (1998) J. Virol. 72, 10213-10217
18. Gallo, S. A., Wang, W., Rawat, S. S., Jung, G., Waring, A. J., Cole, A. M., Lu, H., Yan, X., Daly, N. L., Craik, D. J., Jiang, S., Lehrer, R. I., and Blumenthal, R. (2006) J. Biol. Chem. 281, 18787-18792
19. Jiang, S., Lu, H., Liu, S., Zhao, Q., He, Y., and Debnath, A. K. (2004) Antimicrob. Agents Chemother. 48, 4349-4359
20. Wei, X., Decker, J. M., Liu, H., Zhang, Z., Arani, R. B., Kilby, J. M., Saag, M. S., Wu, X., Shaw, G. M., and Kappes, J. C. (2002) Antimicrob. Agents Chemother. 46, 1896-1905
21. Wild, C., Greenwell, T., Shugars, D., Rimsky-Clarke, L., and Matthews, T. (1995) AIDS Res. Hum. Retroviruses 11, 323-325
22. Lawless, M. K., Barney, S., Guthrie, K. I., Bucy, T. B., Petteway, S. R., Jr., and Merutka, G. (1996) Biochemistry 35, 13697-13708
23. Shu, W., Ji, H., and Lu, M. (2000) J. Biol. Chem. 275, 1839-1845
24. Wild, C., Dubay, J. W., Greenwell, T., Baird, T., Jr., Oas, T. G., McDanal, C., Hunter, E., and Matthews, T. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 12676-12680
25. Baldwin, C. E., Sanders, R. W., Deng, Y., Jurriaans, S., Lange, J. M., Lu, M., and Berkhout, B. (2004) J. Virol. 78, 12428-12437
26. Rimsky, L. T., Shugars, D. C., and Matthews, T. J. (1998) J. Virol. 72, 986-993
27. Weissenhorn, W., Dessen, A., Harrison, S. C., Skehel, J. J., and Wiley, D. C. (1997) Nature 387, 426-428
28. Moore, J. P., and Doms, R. W. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 10598-10602
29. Furuta, R., Wild, C. T., Weng, Y., and Weiss, C. D. (1998) Nat. Struct. Biol. 5, 276-279
30. Armand-Ugon, M., Gutierrez, A., Clotet, B., and Este, J. A. (2003) Antiviral Res. 59, 137-142
31. Chan, D. C., Chutkowski, C. T., and Kim, P. S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 15613-15617
32. Dwyer, J. J., Hasan, A., Wilson, K. L., White, J. M., Matthews, T. J., and Delmedico, M. K. (2003) Biochemistry 42, 4945-4953
33. Trivedi, V. D., Cheng, S. F., Wu, C. W., Karthikeyan, R., Chen, C. J., and Chang, D. K. (2003) Protein Eng. 16, 311-317
34. Wexler-Cohen, Y., Johnson, B. T., Puri, A., Blumenthal, R., and Shai, Y. (2006) J. Biol. Chem. 281, 9005-9010
35. Kliger, Y., Gallo, S. A., Peisajovich, S. G., Munoz-Barroso, I., Avkin, S., Blumenthal, R., and Shai, Y. (2001) J. Biol. Chem. 276, 1391-1397
36. Peisajovich, S. G., Gallo, S. A., Blumenthal, R., and Shai, Y. (2003) J. Biol. Chem. 278, 21012-21017
37. Hildinger, M., Dittmar, M. T., Schult-Dietrich, P., Fehse, B., Schnierle, B. S., Thaler, S., Stiegler, G., Welker, R., and von Laer, D. (2001) J. Virol. 75, 3038-3042
38. Veiga, A. S., Santos, N. C., Loura, L. M., Fedorov, A., and Castanho, M. A. (2004) J. Am. Chem. Soc. 126, 14758-14763
39. Salzwedel, K., West, J. T., and Hunter, E. (1999) J. Virol. 73, 2469-2480
40. Schibli, D. J., Montelaro, R. C., and Vogel, H. J. (2001) Biochemistry 40, 9570-9578
41. Munoz-Barroso, I., Durell, S., Sakaguchi, K., Appella, E., and Blumenthal, R. (1998) J. Cell Biol. 140, 315-323
42. Cohen, F. S., and Melikyan, G. B. (2004) J. Membr. Biol. 199, 1-14
43. Shnaper, S., Sackett, K., Gallo, S. A., Blumenthal, R., and Shai, Y. (2004) J. Biol. Chem. 279, 18526-18534