메뉴 건너뛰기




Volumn 15, Issue 8, 2009, Pages 866-870

Neutralizing antibodies generated during natural hiv-1 infection: Good news for an hiv-1 vaccine?

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS VACCINE; VIRUS ANTIBODY;

EID: 69149083668     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.1949     Document Type: Article
Times cited : (366)

References (46)
  • 1
    • 47549116006 scopus 로고    scopus 로고
    • Vaccines: Correlates of vaccine-induced immunity
    • Plotkin, S.A. Vaccines: Correlates of vaccine-induced immunity. Clin. Infect. Dis. 47, 401-409 (2008).
    • (2008) Clin. Infect. Dis , vol.47 , pp. 401-409
    • Plotkin, S.A.1
  • 2
    • 50849112772 scopus 로고    scopus 로고
    • Protective immunity following vaccination: How is it defined?
    • Amanna, I.J., Messaoudi, I. & Slifka, M.K. Protective immunity following vaccination: How is it defined? Hum. Vaccin. 4, 316-319 (2008).
    • (2008) Hum. Vaccin , vol.4 , pp. 316-319
    • Amanna, I.J.1    Messaoudi, I.2    Slifka, M.K.3
  • 3
    • 0029310641 scopus 로고
    • Perspective: Hypothesis: Serum IgG antibody is sufficient to confer protection against infectious diseases by inactivating the inoculum
    • Robbins, J.B., Schneerson, R. & Szu, S.C. Perspective: Hypothesis: serum IgG antibody is sufficient to confer protection against infectious diseases by inactivating the inoculum. J. Infect. Dis. 171, 1387-1398 (1995).
    • (1995) J. Infect. Dis , vol.171 , pp. 1387-1398
    • Robbins, J.B.1    Schneerson, R.2    Szu, S.C.3
  • 4
    • 1542317452 scopus 로고    scopus 로고
    • HIV vaccine design and the neutralizing antibody problem
    • Burton, D.R. et al. HIV vaccine design and the neutralizing antibody problem. Nat. Immunol. 5, 233-236 (2004).
    • (2004) Nat. Immunol , vol.5 , pp. 233-236
    • Burton, D.R.1
  • 5
    • 33746763724 scopus 로고    scopus 로고
    • Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates
    • Haynes, B.F. & Montefiori, D.C. Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates. Expert Rev. Vaccines 5, 579-595 (2006).
    • (2006) Expert Rev. Vaccines , vol.5 , pp. 579-595
    • Haynes, B.F.1    Montefiori, D.C.2
  • 6
    • 19144365910 scopus 로고    scopus 로고
    • Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1
    • Mascola, J.R. et al. Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1. J. Infect. Dis. 173, 340-348 (1996).
    • (1996) J. Infect. Dis , vol.173 , pp. 340-348
    • Mascola, J.R.1
  • 7
    • 13944254982 scopus 로고    scopus 로고
    • Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection
    • Flynn, N.M. et al. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J. Infect. Dis. 191, 654-665 (2005).
    • (2005) J. Infect. Dis , vol.191 , pp. 654-665
    • Flynn, N.M.1
  • 8
    • 33845207660 scopus 로고    scopus 로고
    • Progress and obstacles in the development of an AIDS vaccine
    • Letvin, N.L. Progress and obstacles in the development of an AIDS vaccine. Nat. Rev. Immunol. 6, 930-939 (2006).
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 930-939
    • Letvin, N.L.1
  • 9
    • 53349160053 scopus 로고    scopus 로고
    • Challenges in the development of an HIV-1 vaccine
    • Barouch, D.H. Challenges in the development of an HIV-1 vaccine. Nature 455, 613-619 (2008).
    • (2008) Nature , vol.455 , pp. 613-619
    • Barouch, D.H.1
  • 10
    • 0028337166 scopus 로고
    • Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
    • Koup, R.A. et al. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68, 4650-4655 (1994).
    • (1994) J. Virol , vol.68 , pp. 4650-4655
    • Koup, R.A.1
  • 11
    • 56649105122 scopus 로고    scopus 로고
    • Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (The Step Study): A double-blind, randomised, placebo-controlled, test-of-concept trial
    • Buchbinder, S.P. et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): A double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet 372, 1881-1893 (2008).
    • (2008) Lancet , vol.372 , pp. 1881-1893
    • Buchbinder, S.P.1
  • 12
    • 0037456827 scopus 로고    scopus 로고
    • Antibody neutralization and escape by HIV-1
    • Wei, X. et al. Antibody neutralization and escape by HIV-1. Nature 422, 307-312 (2003).
    • (2003) Nature , vol.422 , pp. 307-312
    • Wei, X.1
  • 13
    • 0023990347 scopus 로고
    • Identification of human immunodeficiency virus subtypes with distinct patterns of sensitivity to serum neutralization
    • Cheng-Mayer, C., Homsy, J., Evans, L.A. & Levy, J.A. Identification of human immunodeficiency virus subtypes with distinct patterns of sensitivity to serum neutralization. Proc. Natl. Acad. Sci. USA 85, 2815-2819 (1988).
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 2815-2819
    • Cheng-Mayer, C.1    Homsy, J.2    Evans, L.A.3    Levy, J.A.4
  • 14
    • 0029655566 scopus 로고    scopus 로고
    • Quantitative analysis of serum neutralization of human immunodeficciency virus type 1 from subtypes A, B, C, D, E, F and I: Lack of direct correlation between neutralization serotypes and genetic subtypes and evidence for prevalent serum-dependent infectivity enhancement
    • Kostrikis, L.G., Cao, Y., Ngai, H., Moore, J.P. & Ho, D.D. Quantitative analysis of serum neutralization of human immunodeficciency virus type 1 from subtypes A, B, C, D, E, F and I: Lack of direct correlation between neutralization serotypes and genetic subtypes and evidence for prevalent serum-dependent infectivity enhancement. J. Virol. 70, 445-458 (1996).
    • (1996) J. Virol , vol.70 , pp. 445-458
    • Kostrikis, L.G.1    Cao, Y.2    Ngai, H.3    Moore, J.P.4    Ho, D.D.5
  • 15
    • 0029656045 scopus 로고    scopus 로고
    • Inter-and intraclade neutralization of human immunodeficiency virus type 1: Genetic clades do not correspond to neutralization serotypes but partially correspond to gp120 serotypes
    • Moore, J.P. et al. Inter-and intraclade neutralization of human immunodeficiency virus type 1: Genetic clades do not correspond to neutralization serotypes but partially correspond to gp120 serotypes. J. Virol. 70, 427-444 (1996).
    • (1996) J. Virol , vol.70 , pp. 427-444
    • Moore, J.P.1
  • 16
    • 43249120051 scopus 로고    scopus 로고
    • Cross-clade neutralization patterns among HIV-1 strains from the six major clades of the pandemic evaluated and compared in two different models
    • Brown, B.K. et al. Cross-clade neutralization patterns among HIV-1 strains from the six major clades of the pandemic evaluated and compared in two different models. Virology 375, 529-538 (2008).
    • (2008) Virology , vol.375 , pp. 529-538
    • Brown, B.K.1
  • 17
    • 35348937119 scopus 로고    scopus 로고
    • Genetic characteristics of HIV-1 subtype C envelopes inducing cross-neutralizing antibodies
    • Rademeyer, C. et al. Genetic characteristics of HIV-1 subtype C envelopes inducing cross-neutralizing antibodies. Virology 368, 172-181 (2007).
    • (2007) Virology , vol.368 , pp. 172-181
    • Rademeyer, C.1
  • 18
    • 33751224478 scopus 로고    scopus 로고
    • Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular Env clones from acute and early hetero-sexually acquired infections in Southern Africa
    • Li, M. et al. Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular Env clones from acute and early hetero-sexually acquired infections in Southern Africa. J. Virol. 80, 11776-11790 (2006).
    • (2006) J. Virol , vol.80 , pp. 11776-11790
    • Li, M.1
  • 19
    • 34249950588 scopus 로고    scopus 로고
    • Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors
    • Dhillon, A.K. et al. Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors. J. Virol. 81, 6548-6562 (2007).
    • (2007) J. Virol , vol.81 , pp. 6548-6562
    • Dhillon, A.K.1
  • 20
    • 34948854718 scopus 로고    scopus 로고
    • Broad HIV-1 neutralization mediated by CD4-binding site antibodies
    • Li, Y. et al. Broad HIV-1 neutralization mediated by CD4-binding site antibodies. Nat. Med. 13, 1032-1034 (2007).
    • (2007) Nat. Med , vol.13 , pp. 1032-1034
    • Li, Y.1
  • 21
    • 0033952103 scopus 로고    scopus 로고
    • Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection
    • Baba, T.W. et al. Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection. Nat. Med. 6, 200-206 (2000).
    • (2000) Nat. Med , vol.6 , pp. 200-206
    • Baba, T.W.1
  • 22
    • 0032947286 scopus 로고    scopus 로고
    • Protection of macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies
    • Mascola, J.R. et al. Protection of macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies. J. Virol. 73, 4009-4018 (1999).
    • (1999) J. Virol , vol.73 , pp. 4009-4018
    • Mascola, J.R.1
  • 23
    • 0033951746 scopus 로고    scopus 로고
    • Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies
    • Mascola, J.R. et al. Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies. Nat. Med. 6, 207-210 (2000).
    • (2000) Nat. Med , vol.6 , pp. 207-210
    • Mascola, J.R.1
  • 24
    • 0034864776 scopus 로고    scopus 로고
    • Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro
    • Parren, P.W. et al. Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro. J. Virol. 75, 8340-8347 (2001).
    • (2001) J. Virol , vol.75 , pp. 8340-8347
    • Parren, P.W.1
  • 25
    • 0032907674 scopus 로고    scopus 로고
    • Neutralizing antibody directed against the HIV-1 envelope glyco-protein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys
    • Shibata, R. et al. Neutralizing antibody directed against the HIV-1 envelope glyco-protein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys. Nat. Med. 5, 204-210 (1999).
    • (1999) Nat. Med , vol.5 , pp. 204-210
    • Shibata, R.1
  • 26
    • 56449131391 scopus 로고    scopus 로고
    • Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C
    • Binley, J.M. et al. Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C. J. Virol. 82, 11651-11668 (2008).
    • (2008) J. Virol , vol.82 , pp. 11651-11668
    • Binley, J.M.1
  • 27
    • 58149399396 scopus 로고    scopus 로고
    • Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies
    • Doria-Rose, N.A. et al. Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies. J. Virol. 83, 188-199 (2009).
    • (2009) J. Virol , vol.83 , pp. 188-199
    • Doria-Rose, N.A.1
  • 28
    • 58149517700 scopus 로고    scopus 로고
    • Analysis of the neutralization specificities in polyclonal sera derived from human immunodeficiency virus type-1 infected individuals
    • Li, Y. et al. Analysis of the neutralization specificities in polyclonal sera derived from human immunodeficiency virus type-1 infected individuals. J. Virol 83, 1045-1059 (2009).
    • (2009) J. Virol , vol.83 , pp. 1045-1059
    • Li, Y.1
  • 29
    • 58149487645 scopus 로고    scopus 로고
    • Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection
    • Sather, D.N. et al. Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection. J. Virol. 83, 757-769 (2009).
    • (2009) J. Virol , vol.83 , pp. 757-769
    • Sather, D.N.1
  • 30
    • 23244434512 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies
    • Li, M. et al. Human immunodeficiency virus type 1 Env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies. J. Virol. 79, 10108-10125 (2005).
    • (2005) J. Virol , vol.79 , pp. 10108-10125
    • Li, M.1
  • 31
    • 67650453747 scopus 로고    scopus 로고
    • HIV-1 elite neutralizers: Individuals with broad and potent neutralizing activity identified using a high throughput neutralization assay together with an analytical selection algorithm
    • published online, doi, 13 May
    • Simek, D.M. et al. HIV-1 elite neutralizers: Individuals with broad and potent neutralizing activity identified using a high throughput neutralization assay together with an analytical selection algorithm. J. Virol. published online, doi: 10.1128/JVI. 00110-09 (13 May 2009).
    • (2009) J. Virol
    • Simek, D.M.1
  • 32
    • 0026655937 scopus 로고
    • Recombinant human Fab fragments neutralize human type 1 immunodeficiency virus in vitro
    • Barbas, C.F., III et al. Recombinant human Fab fragments neutralize human type 1 immunodeficiency virus in vitro. Proc. Natl. Acad. Sci. USA 89, 9339-9343 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9339-9343
    • Barbas, C.F.1
  • 33
    • 0027985431 scopus 로고
    • Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody
    • Burton, D.R. et al. Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody. Science 266, 1024-1027 (1994).
    • (1994) Science , vol.266 , pp. 1024-1027
    • Burton, D.R.1
  • 34
    • 20844448731 scopus 로고    scopus 로고
    • Antigenic conservation and immunogenicity of the HIV coreceptor binding site
    • Decker, J.M. et al. Antigenic conservation and immunogenicity of the HIV coreceptor binding site. J. Exp. Med. 201, 1407-1419 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 1407-1419
    • Decker, J.M.1
  • 35
    • 34249940652 scopus 로고    scopus 로고
    • Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection
    • Gray, E.S. et al. Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection. J. Virol. 81, 6187-6196 (2007).
    • (2007) J. Virol , vol.81 , pp. 6187-6196
    • Gray, E.S.1
  • 36
    • 0141521564 scopus 로고    scopus 로고
    • Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1
    • Labrijn, A.F. et al. Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1. J. Virol. 77, 10557-10565 (2003).
    • (2003) J. Virol , vol.77 , pp. 10557-10565
    • Labrijn, A.F.1
  • 37
    • 0034759882 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41
    • Zwick, M.B. et al. Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41. J. Virol. 75, 10892-10905 (2001).
    • (2001) J. Virol , vol.75 , pp. 10892-10905
    • Zwick, M.B.1
  • 38
    • 64049092486 scopus 로고    scopus 로고
    • Vivo gp41 Antibodies targeting the 2F5 mAb epitope mediate HIV-1 neutralization breadth
    • Shen, X. et al. In Vivo gp41 Antibodies targeting the 2F5 mAb epitope mediate HIV-1 neutralization breadth. J. Virol. 83, 3617-3625 (2009).
    • (2009) J. Virol , vol.83 , pp. 3617-3625
    • Shen, X.1
  • 39
    • 21344434534 scopus 로고    scopus 로고
    • Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies
    • Haynes, B.F. et al. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science 308, 1906-1908 (2005).
    • (2005) Science , vol.308 , pp. 1906-1908
    • Haynes, B.F.1
  • 40
    • 0036637385 scopus 로고    scopus 로고
    • The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120
    • Sanders, R.W. et al. The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120. J. Virol. 76, 7293-7305 (2002).
    • (2002) J. Virol , vol.76 , pp. 7293-7305
    • Sanders, R.W.1
  • 41
    • 18244422922 scopus 로고    scopus 로고
    • The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of α1 → 2 mannose residues on the outer face of gp120
    • Scanlan, C.N. et al. The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of α1 → 2 mannose residues on the outer face of gp120. J. Virol. 76, 7306-7321 (2002).
    • (2002) J. Virol , vol.76 , pp. 7306-7321
    • Scanlan, C.N.1
  • 42
    • 12444291017 scopus 로고    scopus 로고
    • Antibody domain exchange is an immunological solution to carbohydrate cluster recognition
    • Calarese, D.A. et al. Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. Science 300, 2065-2071 (2003).
    • (2003) Science , vol.300 , pp. 2065-2071
    • Calarese, D.A.1
  • 43
    • 67249131966 scopus 로고    scopus 로고
    • Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
    • published online, doi, 15 May
    • Hessell, A.J. et al. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathog. published online, doi:10.1371/journal.ppat.1000433 (15 May 2009).
    • (2009) Plos Pathog
    • Hessell, A.J.1
  • 44
    • 68349160853 scopus 로고    scopus 로고
    • Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
    • advance online publication, doi, 7 June
    • Hessell, A.J. et al. Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques. Nat. Med. advance online publication, doi:10.1038/nm.1974 (7 June 2009).
    • (2009) Nat. Med
    • Hessell, A.J.1
  • 45
    • 36849031722 scopus 로고    scopus 로고
    • Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning
    • Tiller, T. et al. Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning. J. Immunol. Methods 329, 112-124 (2008).
    • (2008) J. Immunol. Methods , vol.329 , pp. 112-124
    • Tiller, T.1
  • 46
    • 44449118948 scopus 로고    scopus 로고
    • Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
    • Wrammert, J. et al. Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature 453, 667-671 (2008).
    • (2008) Nature , vol.453 , pp. 667-671
    • Wrammert, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.