Increased neutralization sensitivity of CD4-independent human immunodeficiency virus variants

Journal of Virology

Volumn 75, Issue 5, 2001, Pages 2041-2050

  Kolchinsky, P ^a   Kiprilov, E ^a   Sodroski, J ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; GLYCOPROTEIN GP 120; NEUTRALIZING ANTIBODY;

ANTIBODY AFFINITY; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; VIRUS CELL INTERACTION; VIRUS INHIBITION; VIRUS MUTANT; VIRUS NEUTRALIZATION;

AMINO ACID SEQUENCE; ANTIGENS, CD4; CELL LINE; GIANT CELLS; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; RECEPTORS, CCR5; RECOMBINANT PROTEINS; TRANSFECTION; VIRUS SHEDDING;

EID: 0035131175     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.5.2041-2050.2001     Document Type: Article

References (96)

1. CC-CKR5: A RANTES, MIP-1a, MIP-1b receptor as a fusion cofactor for macrophage-tropic HIV-1
2. Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III
3. Receptor-mediated activation of immunodeficiency viruses in viral fusion
4. Enhancement of SIV infection with soluble receptor molecules
5. The level of CD4 expression limits the infection of primary rhesus monkey macrophages by a T-tropic simian immunodeficiency virus and macrophagetropic human immunodeficiency viruses
6. Isolation of a T-lymphocyte retrovirus from a patient at risk for acquired immunodeficiency syndrome (AIDS)
7. HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR5 co-receptor
8. Soluble CD4 and dextran sulfate mediate release of gp120 from HIV-1: Implications for clinical trials
9. Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody
10. Replication and neutralization of human immunodeficiency virus type 1 lacking the V1/V2 variable loops of the gp120 envelope glycoprotein
11. Core structure of gp41 from HIV envelope glycoprotein
12. Genetically divergent strains of simian immunodeficiency virus use CCR5 as cofactor for entry
13. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
14. Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: Induction and enhancement by soluble CD4
15. HIV-2, the West African AIDS virus
16. The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
17. High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates
18. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
19. Conformational transitions in CD4 due to complexation with HIV-envelope glycoprotein gp120
20. A soluble form of CD4 (T4) protein inhibits AIDS virus infection
21. Identification of a major co-receptor for primary isolates of HIV-1
22. The simian immunodeficiency viruses
23. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
24. + cells is mediated by the chemokine receptor CC-CKR-5
25. Spontaneous mutations in the env gene of the human immunodeficiency virus type 1 NDK isolate are associated with a CD4-independent phenotype
26. Structure-function relationships of the HIV-1 envelope V3 loop tropism determinant: Evidence for two distinct conformations
27. CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain
28. CD4-independent infection by HIV-2 is mediated by fusin/ CXCR4
29. Tyrosine sulfation of the amino-terminus of CCR5 facilitates HIV-1 entry
30. Acquired immunodeficiency syndrome: Epidemiologic, clinical, immunologic, and therapeutic considerations
31. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
32. HIV infection is blocked in vitro by recombinant soluble CD4
33. Physicochemical dissociation of CD4-mediated syncytium formation and shedding of human immunodeficiency virus type 1 gp120
34. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS
35. Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope giycoprotein gp120
36. Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants
37. Stable exposure of the coreceptor-binding site in a CD4-independent human immunodeficiency virus type 1 envelope protein
38. A soluble CD4 protein selectively inhibits HIV replication and syncytium formation
39. Differences in CD4 dependence for infectivity of laboratory-adapted and primary isolates of human immunodeficiency virus type 1
40. Serological identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III
41. Morphometric analysis of recombinant soluble CD4-mediated release of the envelope glycoprotein gp120 from HIV-1
42. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
43. Adaptation of a CCR5-using, primary human immunodeficiency virus type 1 isolate for CD4-independent replication
44. Loss of a single N-linked glycan allows CD4-independent human immunodeficiency virus type 1 infection by altering the position of the gp120 V1/V2 variable loops
45. Structure of an HIV-1 gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing antibody
46. Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions for coreceptor specificity
47. Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells
48. Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III
49. Induction of CD4-independent cell fusion by the HTLV-III/LAV envelope glycoprotein
50. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
51. Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus (SIVmac239)
52. CD4-independent binding of SIV gp120 to rhesus CCR5
53. Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1
54. Dilemma of neutralization resistance of HIV-1 field isolates and vaccine development
55. Neutralization sensitivity of cell culture-passaged simian immunodeficiency virus
56. Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor
57. Dissociation of gp120 from HIV-1 virions induced by soluble CD4
58. Thermodynamic and kinetic analysis of sCD4 binding to HIV-1 virions and of gp120 dissociation
59. Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4
60. Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive ones
61. Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120
62. A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1
63. Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity
64. Critical role of enhanced CD4 affinity in laboratory adaptation of human immunodeficiency virus type 1
65. A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding
66. Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1
67. Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients
68. + T cell responses associated with the control of viremia
69. Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding
70. Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding
71. An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface
72. Neutralization sensitivity of human immunodeficiency virus type 1 is determined in part by the cell in which the virus is propagated
73. Effects of soluble CD4 on simian immunodeficiency virus infection of CD4-positive and CD4-negative cells
74. Blocking of HIV-1 infectivity by a soluble secreted form of the CD4 antigen
75. Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity
76. Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop
77. An envelope modification that renders a primary, neutralization-resistant clade B human immunodeficiency virus type 1 isolate highly susceptible to neutralization by sera from other clades
78. pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane
79. Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates
80. CD4-induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: Consequences for virus entry and neutralization
81. Lack of correlation between soluble CD4-induced shedding of the human immunodeficiency virus type 1 exterior envelope glycoprotein and subsequent membrane fusion events
82. Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding
83. Soluble CD4 molecules neutralize human immunodeficiency virus type 1
84. CD4-dependent, antibody-sensitive interactions between HIV-1 and its coreceptor CCR5
85. Atomic structure of the ectodomain from gp41
86. Human immunodeficiency virus type 1 envelope gp120 is cleaved after incubation with recombinant soluble CD4
87. Common mechanism of infection by lentiviruses
88. Increase in soluble CD4 binding to and CD4-induced dissociation of gp120 from virions correlates with infectivity of human immunodeficiency virus type 1
89. Adaptation to persistent growth in the H9 cell line renders a primary isolate of human immunodeficiency virus type 1 sensitive to neutralization by vaccine sera
90. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5
91. Functional and immunological characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regions
92. Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding
93. The antigenic structure of the human immunodeficiency virus gp120 envelope glycoprotein
94. Passage of HIV-1 molecular clones into different cell lines confers differential sensitivity to neutralization