-
1
-
-
36249025723
-
Autophagy: process and function
-
Mizushima N. Autophagy: process and function. Genes Dev. 2007, 21:2861-2873.
-
(2007)
Genes Dev.
, vol.21
, pp. 2861-2873
-
-
Mizushima, N.1
-
2
-
-
8344242220
-
Autophagy in health and disease: a double-edged sword
-
Shintani T., Klionsky D.J. Autophagy in health and disease: a double-edged sword. Science 2004, 306:990-995.
-
(2004)
Science
, vol.306
, pp. 990-995
-
-
Shintani, T.1
Klionsky, D.J.2
-
3
-
-
39849109338
-
Autophagy fights disease through cellular self-digestion
-
Mizushima N., et al. Autophagy fights disease through cellular self-digestion. Nature 2008, 451:1069-1075.
-
(2008)
Nature
, vol.451
, pp. 1069-1075
-
-
Mizushima, N.1
-
4
-
-
34250753161
-
Cell death modalities: classification and pathophysiological implications
-
Galluzzi L., et al. Cell death modalities: classification and pathophysiological implications. Cell Death Differ. 2007, 14:1237-1243.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 1237-1243
-
-
Galluzzi, L.1
-
5
-
-
22344444616
-
Does autophagy contribute to cell death?
-
Debnath J., et al. Does autophagy contribute to cell death?. Autophagy 2005, 1:66-74.
-
(2005)
Autophagy
, vol.1
, pp. 66-74
-
-
Debnath, J.1
-
6
-
-
77954116814
-
Autophagy gone awry in neurodegenerative diseases
-
Wong E., Cuervo A.M. Autophagy gone awry in neurodegenerative diseases. Nat. Neurosci. 2010, 13:805-811.
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 805-811
-
-
Wong, E.1
Cuervo, A.M.2
-
7
-
-
0002549377
-
The lysosome
-
De Duve C. The lysosome. Sci. Am. 1963, 208:64-72.
-
(1963)
Sci. Am.
, vol.208
, pp. 64-72
-
-
De Duve, C.1
-
8
-
-
35448981935
-
Autophagy: from phenomenology to molecular understanding in less than a decade
-
Klionsky D.J. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat. Rev. Mol. Cell Biol. 2007, 8:931-937.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 931-937
-
-
Klionsky, D.J.1
-
9
-
-
50249084987
-
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
-
Axe E.L., et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J. Cell Biol. 2008, 182:685-701.
-
(2008)
J. Cell Biol.
, vol.182
, pp. 685-701
-
-
Axe, E.L.1
-
10
-
-
70349919804
-
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
-
Simonsen A., Tooze S.A. Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J. Cell Biol. 2009, 186:773-782.
-
(2009)
J. Cell Biol.
, vol.186
, pp. 773-782
-
-
Simonsen, A.1
Tooze, S.A.2
-
11
-
-
77952495224
-
Mitochondria supply membranes for autophagosome biogenesis during starvation
-
Hailey D.W., et al. Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell 2010, 141:656-667.
-
(2010)
Cell
, vol.141
, pp. 656-667
-
-
Hailey, D.W.1
-
12
-
-
77955131007
-
Plasma membrane contributes to the formation of pre-autophagosomal structures
-
Ravikumar B., et al. Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat. Cell Biol. 2010, 12:747-757.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 747-757
-
-
Ravikumar, B.1
-
13
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y., et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000, 19:5720-5728.
-
(2000)
EMBO J.
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
-
14
-
-
57849136841
-
Autophagy: principles and significance in health and disease
-
Todde V., et al. Autophagy: principles and significance in health and disease. Biochim. Biophys. Acta 2009, 1792:3-13.
-
(2009)
Biochim. Biophys. Acta
, vol.1792
, pp. 3-13
-
-
Todde, V.1
-
15
-
-
33745023775
-
Chaperone-mediated autophagy in aging and disease
-
Massey A.C., et al. Chaperone-mediated autophagy in aging and disease. Curr. Top. Dev. Biol. 2006, 73:205-235.
-
(2006)
Curr. Top. Dev. Biol.
, vol.73
, pp. 205-235
-
-
Massey, A.C.1
-
16
-
-
77950506157
-
Chaperone-mediated autophagy in health and disease
-
Kon M., Cuervo A.M. Chaperone-mediated autophagy in health and disease. FEBS Lett. 2010, 584:1399-1404.
-
(2010)
FEBS Lett.
, vol.584
, pp. 1399-1404
-
-
Kon, M.1
Cuervo, A.M.2
-
17
-
-
38349046973
-
Autophagy, amyloidogenesis and Alzheimer disease
-
Nixon R.A. Autophagy, amyloidogenesis and Alzheimer disease. J. Cell Sci. 2007, 120:4081-4091.
-
(2007)
J. Cell Sci.
, vol.120
, pp. 4081-4091
-
-
Nixon, R.A.1
-
18
-
-
26444587508
-
Macroautophagy - a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
-
Yu W.H., et al. Macroautophagy - a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease. J. Cell Biol. 2005, 171:87-98.
-
(2005)
J. Cell Biol.
, vol.171
, pp. 87-98
-
-
Yu, W.H.1
-
19
-
-
14844303381
-
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
-
Nixon R.A., et al. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J. Neuropathol. Exp. Neurol. 2005, 64:113-122.
-
(2005)
J. Neuropathol. Exp. Neurol.
, vol.64
, pp. 113-122
-
-
Nixon, R.A.1
-
20
-
-
3843114301
-
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology
-
Cataldo A.M., et al. Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. J. Neuropathol. Exp. Neurol. 2004, 63:821-830.
-
(2004)
J. Neuropathol. Exp. Neurol.
, vol.63
, pp. 821-830
-
-
Cataldo, A.M.1
-
21
-
-
77953913051
-
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
-
Lee J.H., et al. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 2010, 141:1146-1158.
-
(2010)
Cell
, vol.141
, pp. 1146-1158
-
-
Lee, J.H.1
-
22
-
-
45749114895
-
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
-
Pickford F., et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J. Clin. Invest. 2008, 118:2190-2199.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2190-2199
-
-
Pickford, F.1
-
23
-
-
0035950225
-
Clearing the brain's amyloid cobwebs
-
Selkoe D.J. Clearing the brain's amyloid cobwebs. Neuron 2001, 32:177-180.
-
(2001)
Neuron
, vol.32
, pp. 177-180
-
-
Selkoe, D.J.1
-
24
-
-
77956215864
-
Regulation of amyloid precursor protein processing by the beclin 1 complex
-
Jaeger P.A., et al. Regulation of amyloid precursor protein processing by the beclin 1 complex. PLoS One 2010, 5:e11102.
-
(2010)
PLoS One
, vol.5
-
-
Jaeger, P.A.1
-
25
-
-
0035341254
-
Mitochondrial abnormalities in Alzheimer's disease
-
Hirai K., et al. Mitochondrial abnormalities in Alzheimer's disease. J. Neurosci. 2001, 21:3017-3023.
-
(2001)
J. Neurosci.
, vol.21
, pp. 3017-3023
-
-
Hirai, K.1
-
26
-
-
77956199031
-
A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease
-
Santos R.X., et al. A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease. J. Alzheimers Dis. 2010, 20(Suppl. 2):S401-412.
-
(2010)
J. Alzheimers Dis.
, vol.20
, Issue.SUPPL. 2
-
-
Santos, R.X.1
-
27
-
-
48749085779
-
Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients
-
Wang X., et al. Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients. Am. J. Pathol. 2008, 173:470-482.
-
(2008)
Am. J. Pathol.
, vol.173
, pp. 470-482
-
-
Wang, X.1
-
28
-
-
58049218922
-
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
-
Wang X., et al. Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:19318-19323.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 19318-19323
-
-
Wang, X.1
-
29
-
-
64249133725
-
S-Nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury
-
Cho D.H., et al. S-Nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 2009, 324:102-105.
-
(2009)
Science
, vol.324
, pp. 102-105
-
-
Cho, D.H.1
-
30
-
-
77951227122
-
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and tau: effects on cognitive impairments
-
Caccamo A., et al. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and tau: effects on cognitive impairments. J. Biol. Chem. 2010, 285:13107-13120.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 13107-13120
-
-
Caccamo, A.1
-
31
-
-
77956305343
-
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
-
Spilman P., et al. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One 2010, 5:e9979.
-
(2010)
PLoS One
, vol.5
-
-
Spilman, P.1
-
32
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison D.E., et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009, 460:392-395.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
-
33
-
-
77952083662
-
Rapamycin extends maximal lifespan in cancer-prone mice
-
Anisimov V.N., et al. Rapamycin extends maximal lifespan in cancer-prone mice. Am. J. Pathol. 2010, 176:2092-2097.
-
(2010)
Am. J. Pathol.
, vol.176
, pp. 2092-2097
-
-
Anisimov, V.N.1
-
34
-
-
68949197599
-
Parkinson's disease: from molecular pathways in disease to therapeutic approaches
-
Thomas B. Parkinson's disease: from molecular pathways in disease to therapeutic approaches. Antioxid. Redox Signal. 2009, 11:2077-2082.
-
(2009)
Antioxid. Redox Signal.
, vol.11
, pp. 2077-2082
-
-
Thomas, B.1
-
35
-
-
62449129138
-
Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps
-
Levy O.A., et al. Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps. Apoptosis 2009, 14:478-500.
-
(2009)
Apoptosis
, vol.14
, pp. 478-500
-
-
Levy, O.A.1
-
36
-
-
78149469728
-
Chaperone-mediated autophagy markers in Parkinson disease brains
-
Alvarez-Erviti L., et al. Chaperone-mediated autophagy markers in Parkinson disease brains. Arch. Neurol. 2010, 10.1001/archneurol.2010.198.
-
(2010)
Arch. Neurol.
-
-
Alvarez-Erviti, L.1
-
37
-
-
0041589248
-
α-Synuclein is degraded by both autophagy and the proteasome
-
Webb J.L., et al. α-Synuclein is degraded by both autophagy and the proteasome. J. Biol. Chem. 2003, 278:25009-25013.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25009-25013
-
-
Webb, J.L.1
-
38
-
-
4344659685
-
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
-
Cuervo A.M., et al. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 2004, 305:1292-1295.
-
(2004)
Science
, vol.305
, pp. 1292-1295
-
-
Cuervo, A.M.1
-
39
-
-
53049098471
-
Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
-
Vogiatzi T., et al. Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J. Biol. Chem. 2008, 283:23542-23556.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 23542-23556
-
-
Vogiatzi, T.1
-
40
-
-
41449113168
-
Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease
-
Engelender S. Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease. Autophagy 2008, 4:372-374.
-
(2008)
Autophagy
, vol.4
, pp. 372-374
-
-
Engelender, S.1
-
41
-
-
38849174979
-
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
-
Martinez-Vicente M., et al. Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J. Clin. Invest. 2008, 118:777-788.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 777-788
-
-
Martinez-Vicente, M.1
-
42
-
-
58149215720
-
Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy
-
Yang Q., et al. Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science 2009, 323:124-127.
-
(2009)
Science
, vol.323
, pp. 124-127
-
-
Yang, Q.1
-
43
-
-
68649108355
-
Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis
-
Banerjee R., et al. Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis. Biochim. Biophys. Acta 2009, 1792:651-663.
-
(2009)
Biochim. Biophys. Acta
, vol.1792
, pp. 651-663
-
-
Banerjee, R.1
-
44
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
Narendra D., et al. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 2008, 183:795-803.
-
(2008)
J. Cell Biol.
, vol.183
, pp. 795-803
-
-
Narendra, D.1
-
45
-
-
77952326081
-
Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy
-
Lee J.Y., et al. Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J. Cell Biol. 2010, 189:671-679.
-
(2010)
J. Cell Biol.
, vol.189
, pp. 671-679
-
-
Lee, J.Y.1
-
46
-
-
77953877676
-
A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease
-
Chu C.T. A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease. Hum. Mol. Genet. 2010, 19:R28-37.
-
(2010)
Hum. Mol. Genet.
, vol.19
-
-
Chu, C.T.1
-
47
-
-
67649399288
-
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission
-
Dagda R.K., et al. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J. Biol. Chem. 2009, 284:13843-13855.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 13843-13855
-
-
Dagda, R.K.1
-
48
-
-
75949098487
-
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
-
Vives-Bauza C., et al. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:378-383.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 378-383
-
-
Vives-Bauza, C.1
-
49
-
-
77949478474
-
Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
-
Sha D., et al. Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum. Mol. Genet. 2010, 19:352-363.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 352-363
-
-
Sha, D.1
-
51
-
-
33750361540
-
A century-old debate on protein aggregation and neurodegeneration enters the clinic
-
Lansbury P.T., Lashuel H.A. A century-old debate on protein aggregation and neurodegeneration enters the clinic. Nature 2006, 443:774-779.
-
(2006)
Nature
, vol.443
, pp. 774-779
-
-
Lansbury, P.T.1
Lashuel, H.A.2
-
52
-
-
33947719279
-
Potential therapeutic applications of autophagy
-
Rubinsztein D.C., et al. Potential therapeutic applications of autophagy. Nat. Rev. Drug Discov. 2007, 6:304-312.
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 304-312
-
-
Rubinsztein, D.C.1
-
53
-
-
0016148336
-
Studies on brain biopsies of patients with Huntington's chorea
-
Tellez-Nagel I., et al. Studies on brain biopsies of patients with Huntington's chorea. J. Neuropathol. Exp. Neurol. 1974, 33:308-332.
-
(1974)
J. Neuropathol. Exp. Neurol.
, vol.33
, pp. 308-332
-
-
Tellez-Nagel, I.1
-
54
-
-
26944478180
-
Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts
-
Sawa A., et al. Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts. Neurobiol. Dis. 2005, 20:267-274.
-
(2005)
Neurobiol. Dis.
, vol.20
, pp. 267-274
-
-
Sawa, A.1
-
55
-
-
0034307476
-
Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy
-
Kegel K.B., et al. Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. J. Neurosci. 2000, 20:7268-7278.
-
(2000)
J. Neurosci.
, vol.20
, pp. 7268-7278
-
-
Kegel, K.B.1
-
56
-
-
0033081766
-
Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition
-
Kim M., et al. Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition. J. Neurosci. 1999, 19:964-973.
-
(1999)
J. Neurosci.
, vol.19
, pp. 964-973
-
-
Kim, M.1
-
57
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell 2000, 103:253-262.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
58
-
-
2642586352
-
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
-
Ravikumar B., et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 2004, 36:585-595.
-
(2004)
Nat. Genet.
, vol.36
, pp. 585-595
-
-
Ravikumar, B.1
-
59
-
-
38049053467
-
A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for huntingtin in the regulation of autophagy
-
Atwal R.S., Truant R. A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for huntingtin in the regulation of autophagy. Autophagy 2008, 4:91-93.
-
(2008)
Autophagy
, vol.4
, pp. 91-93
-
-
Atwal, R.S.1
Truant, R.2
-
60
-
-
77649219699
-
Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice
-
Zheng S., et al. Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. PLoS Genet. 2010, 6:e1000838.
-
(2010)
PLoS Genet.
, vol.6
-
-
Zheng, S.1
-
61
-
-
77951665859
-
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
-
Martinez-Vicente M., et al. Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat. Neurosci. 2010, 13:567-576.
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 567-576
-
-
Martinez-Vicente, M.1
-
62
-
-
33744916798
-
Regulation of intracellular accumulation of mutant huntingtin by beclin 1
-
Shibata M., et al. Regulation of intracellular accumulation of mutant huntingtin by beclin 1. J. Biol. Chem. 2006, 281:14474-14485.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 14474-14485
-
-
Shibata, M.1
-
63
-
-
77957565855
-
Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7
-
Metzger S., et al. Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. Hum. Genet. 2010, 128:453-459.
-
(2010)
Hum. Genet.
, vol.128
, pp. 453-459
-
-
Metzger, S.1
-
64
-
-
77749319356
-
Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein
-
Bauer P.O., et al. Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein. Nat. Biotechnol. 2010, 28:256-263.
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 256-263
-
-
Bauer, P.O.1
-
65
-
-
41449113885
-
Altered macroautophagy in the spinal cord of SOD1 mutant mice
-
Li L., et al. Altered macroautophagy in the spinal cord of SOD1 mutant mice. Autophagy 2008, 4:290-293.
-
(2008)
Autophagy
, vol.4
, pp. 290-293
-
-
Li, L.1
-
66
-
-
70349627027
-
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
-
Hetz C., et al. XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev. 2009, 23:2294-2306.
-
(2009)
Genes Dev.
, vol.23
, pp. 2294-2306
-
-
Hetz, C.1
-
67
-
-
34548125010
-
Increased autophagy in transgenic mice with a G93A mutant SOD1 gene
-
Morimoto N., et al. Increased autophagy in transgenic mice with a G93A mutant SOD1 gene. Brain Res. 2007, 1167:112-117.
-
(2007)
Brain Res.
, vol.1167
, pp. 112-117
-
-
Morimoto, N.1
-
68
-
-
77949881714
-
Pathology of protein synthesis and degradation systems in ALS
-
Okamoto K., et al. Pathology of protein synthesis and degradation systems in ALS. Neuropathology 2010, 30:189-193.
-
(2010)
Neuropathology
, vol.30
, pp. 189-193
-
-
Okamoto, K.1
-
69
-
-
70350454798
-
Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability
-
Caccamo A., et al. Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability. J. Biol. Chem. 2009, 284:27416-27424.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 27416-27424
-
-
Caccamo, A.1
-
70
-
-
33749006845
-
ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)
-
Parkinson N., et al. ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B). Neurology 2006, 67:1074-1077.
-
(2006)
Neurology
, vol.67
, pp. 1074-1077
-
-
Parkinson, N.1
-
71
-
-
67749106389
-
Autophagy, lithium, and amyotrophic lateral sclerosis
-
Pasquali L., et al. Autophagy, lithium, and amyotrophic lateral sclerosis. Muscle Nerve 2009, 40:173-194.
-
(2009)
Muscle Nerve
, vol.40
, pp. 173-194
-
-
Pasquali, L.1
-
72
-
-
77955365630
-
The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)
-
Crippa V., et al. The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). Hum. Mol. Genet. 2010, 19:3440-3456.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 3440-3456
-
-
Crippa, V.1
-
73
-
-
77954344953
-
Clinical trials for neuroprotection in ALS
-
Siciliano G., et al. Clinical trials for neuroprotection in ALS. CNS Neurol. Disord. Drug Targets 2010, 9:305-313.
-
(2010)
CNS Neurol. Disord. Drug Targets
, vol.9
, pp. 305-313
-
-
Siciliano, G.1
-
74
-
-
70350550208
-
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases
-
Spencer B., et al. Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J. Neurosci. 2009, 29:13578-13588.
-
(2009)
J. Neurosci.
, vol.29
, pp. 13578-13588
-
-
Spencer, B.1
-
75
-
-
77949504405
-
Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy
-
Crews L., et al. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PLoS One 2010, 5:e9313.
-
(2010)
PLoS One
, vol.5
-
-
Crews, L.1
-
76
-
-
33947269323
-
Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer's disease
-
Terni B., et al. Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer's disease. Acta Neuropathol. 2007, 113:403-416.
-
(2007)
Acta Neuropathol.
, vol.113
, pp. 403-416
-
-
Terni, B.1
-
77
-
-
75949130828
-
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
-
Geisler S., et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat. Cell Biol. 2010, 12:119-131.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 119-131
-
-
Geisler, S.1
-
78
-
-
70350131893
-
Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism
-
Gal J., et al. Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism. J. Neurochem. 2009, 111:1062-1073.
-
(2009)
J. Neurochem.
, vol.111
, pp. 1062-1073
-
-
Gal, J.1
-
79
-
-
4143084861
-
Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS
-
Munch C., et al. Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS. Neurology 2004, 63:724-726.
-
(2004)
Neurology
, vol.63
, pp. 724-726
-
-
Munch, C.1
-
80
-
-
22844436451
-
Dynein mutations impair autophagic clearance of aggregate-prone proteins
-
Ravikumar B., et al. Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat. Genet. 2005, 37:771-776.
-
(2005)
Nat. Genet.
, vol.37
, pp. 771-776
-
-
Ravikumar, B.1
-
81
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
Kitada T., et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998, 392:605-608.
-
(1998)
Nature
, vol.392
, pp. 605-608
-
-
Kitada, T.1
-
82
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
Valente E.M., et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004, 304:1158-1160.
-
(2004)
Science
, vol.304
, pp. 1158-1160
-
-
Valente, E.M.1
-
83
-
-
77951181836
-
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
-
Matsuda N., et al. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J. Cell Biol. 2010, 189:211-221.
-
(2010)
J. Cell Biol.
, vol.189
, pp. 211-221
-
-
Matsuda, N.1
-
84
-
-
77950371695
-
PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy
-
Kawajiri S., et al. PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy. FEBS Lett. 2010, 584:1073-1079.
-
(2010)
FEBS Lett.
, vol.584
, pp. 1073-1079
-
-
Kawajiri, S.1
-
85
-
-
31544454404
-
Rapamycin alleviates toxicity of different aggregate-prone proteins
-
Berger Z., et al. Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum. Mol. Genet. 2006, 15:433-442.
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 433-442
-
-
Berger, Z.1
-
86
-
-
34248994604
-
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
-
Sarkar S., et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat. Chem. Biol. 2007, 3:331-338.
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 331-338
-
-
Sarkar, S.1
-
87
-
-
0038364056
-
Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy
-
Ravikumar B., et al. Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum. Mol. Genet. 2003, 12:985-994.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 985-994
-
-
Ravikumar, B.1
-
88
-
-
43949102061
-
Autophagy and amyotrophic lateral sclerosis: the multiple roles of lithium
-
Fornai F., et al. Autophagy and amyotrophic lateral sclerosis: the multiple roles of lithium. Autophagy 2008, 4:527-530.
-
(2008)
Autophagy
, vol.4
, pp. 527-530
-
-
Fornai, F.1
-
89
-
-
25444483066
-
Lithium induces autophagy by inhibiting inositol monophosphatase
-
Sarkar S., et al. Lithium induces autophagy by inhibiting inositol monophosphatase. J. Cell Biol. 2005, 170:1101-1111.
-
(2005)
J. Cell Biol.
, vol.170
, pp. 1101-1111
-
-
Sarkar, S.1
-
90
-
-
33645916698
-
Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations
-
Sarkar S., Rubinsztein D.C. Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. Autophagy 2006, 2:132-134.
-
(2006)
Autophagy
, vol.2
, pp. 132-134
-
-
Sarkar, S.1
Rubinsztein, D.C.2
-
91
-
-
34247161367
-
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
-
Sarkar S., et al. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J. Biol. Chem. 2007, 282:5641-5652.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 5641-5652
-
-
Sarkar, S.1
-
92
-
-
42249106042
-
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
-
Williams A., et al. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat. Chem. Biol. 2008, 4:295-305.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 295-305
-
-
Williams, A.1
-
93
-
-
77954955573
-
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
-
Rodriguez-Navarro J.A., et al. Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation. Neurobiol. Dis. 2010, 39:423-438.
-
(2010)
Neurobiol. Dis.
, vol.39
, pp. 423-438
-
-
Rodriguez-Navarro, J.A.1
-
94
-
-
78049231804
-
A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
-
Tsvetkov A.S., et al. A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:16982-16987.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 16982-16987
-
-
Tsvetkov, A.S.1
|