3β-Hydroxylup-20(29)-ene-27,28-dioic acid dimethyl ester, a novel natural product from Plumbago zeylanica inhibits the proliferation and migration of MDA-MB-231 cells

Chemico-Biological Interactions

Volumn 188, Issue 3, 2010, Pages 412-420

  Sathya, Shanmugaraj ^a   Sudhagar, Selvaraj ^a   Vidhya Priya, Murugan ^a   Bharathi Raja, Rajaganapathy ^a   Muthusamy, Velusamy Shanmuganathan ^a   Niranjali Devaraj, S ^b   Lakshmi, Baddireddi Subhadra ^a  

^a ANNA UNIVERSITY   (India)

^b UNIVERSITY OF MADRAS   (India)

Author keywords

Apoptosis; Breast cancer; Metastasis; PI3K Akt; Triterpene

Indexed keywords

3 BETA HYDROXYLUP 20 (29)ENE 27,28 DIOIC ACID DIMETHYL ESTER; ANTIMETASTATIC AGENT; ANTIMITOTIC AGENT; CASPASE 3; CYTOCHROME C; FIBRONECTIN; GELATINASE A; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; METHANOL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLUMBAGO ZEYLANICA EXTRACT; PROTEIN BAD; PROTEIN BCL 2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CARCINOMA CELL; CELL ADHESION; CELL INVASION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME RELEASE; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; METASTASIS INHIBITION; MIGRATION INHIBITION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOSIS INHIBITION; MOLECULAR DYNAMICS; PLUMBAGINACEAE; PLUMBAGO ZEYLANICA; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; ZYMOGRAPHY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL PRODUCTS; CASPASE 3; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; DNA FRAGMENTATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LEUKOCYTES, MONONUCLEAR; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASES; METHANOL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; PLANT EXTRACTS; PLUMBAGINACEAE; POLY(ADP-RIBOSE) POLYMERASES; TRITERPENES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

PLUMBAGO ZEYLANICA;

EID: 78149468744     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.07.019     Document Type: Article

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