Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis

British Journal of Cancer

Volumn 87, Issue 1, 2002, Pages 98-105

  Giridharan, P ^a   Somasundaram, S T ^a   Perumal, K ^a   Vishwakarma, R A ^b   Karthikeyan, N P ^c   Velmurugan, R ^c   Balakrishnan, A ^a  

^a ANNA UNIVERSITY   (India)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^c Maruthi Biotech   (India)

Author keywords

Apoptosis; In vitro bioscreen; P urinaria; Telomerase; Tubulin

Indexed keywords

7' HYDROXY 3',4',5,9,9' PENTAMETHOXY 3,4 METHYLENEDIOXYLIGNAN; ACETIC ACID ETHYL ESTER; ANTINEOPLASTIC AGENT; CASPASE; CASPASE 3; CASPASE 8; MYC PROTEIN; PHYLLANTUS URINARIA EXTRACT; PROTEIN BCL 2; TELOMERASE; THYMIDINE; TRITIUM; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; GENE ACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PURIFICATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; CELL DIVISION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INDUCTION; EUPHORBIACEAE; GENES, MYC; HUMANS; LIGNANS; PLANT COMPONENTS; PLANT EXTRACTS; PLANT PREPARATIONS; SOLVENTS; TELOMERASE; TUMOR CELLS, CULTURED;

EID: 0036648449     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600422     Document Type: Article

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