Withanolide induces apoptosis in HL-60 leukemia cells via mitochondria mediated cytochrome c release and caspase activation

Chemico-Biological Interactions

Volumn 167, Issue 1, 2007, Pages 19-30

  Senthil, V ^a   Ramadevi, S ^a   Venkatakrishnan, V ^a   Giridharan, P ^b   Lakshmi, B S ^a   Vishwakarma, R A ^b   Balakrishnan, A ^b  

^a ANNA UNIVERSITY   (India)

^b Piramal Enterprises Limited   (India)

Author keywords

Apoptosis; Bcl 2; Caspase 3; Cytochrome c; DNA fragmentation; Flow cytometry; HL 60 cells; Mitochondria; Withania somnifera

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DNA FRAGMENT; PROTEIN BAX; PROTEIN BCL 2; WITHANOLIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL STRAIN HL 60; CELL SURVIVAL; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA; MITOCHONDRION; PLANT LEAF; PROTEIN EXPRESSION; SURVIVAL RATE; TIME; UPREGULATION; WITHANIA SOMNIFERA;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL PROLIFERATION; CYTOCHROMES C; DNA FRAGMENTATION; ERGOSTEROL; HL-60 CELLS; HUMANS; METHANOL; MITOCHONDRIA; PLANT EXTRACTS; PLANT LEAVES; PROTO-ONCOGENE PROTEINS C-BCL-2; RHODAMINE 123; WITHANIA;

WITHANIA SOMNIFERA;

EID: 33947192027     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2007.01.004     Document Type: Article

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