Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria

Molecular Cancer Therapeutics

Volumn 4, Issue 8, 2005, Pages 1277-1285

  Wu, Chin Chung ^a   Chan, Mei Ling ^a   Chen, Wen Ying ^a   Tsai, Ching Yi ^a   Chang, Fang Rong ^a   Wu, Yang Chang ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE INHIBITOR; CYCLOSPORIN A; CYTOCHROME C; DNA FRAGMENT; PRISTIMERIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL FREE SYSTEM; CELL ISOLATION; CELL MEMBRANE PERMEABILITY; CELL STRUCTURE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME RELEASE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN TRANSPORT; STRUCTURE ANALYSIS; TUMOR CELL;

AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CASPASES; CYTOCHROMES C; FEMALE; HUMANS; INTRACELLULAR MEMBRANES; MEMBRANE POTENTIALS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TRITERPENES; TUMOR CELLS, CULTURED;

EID: 23844549870     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-05-0027     Document Type: Article

References (45)

1. Debatin KM. Activation of apoptosis pathways by anticancer drugs. Adv Exp Med Biol 1999;457:237-44.
2. Kaufmann SH, Earnshaw WC. Induction of apoptosis by cancer chemotherapy. Exp Cell Res 2000;256:42-9.
3. Hengartner MO. The biochemistry of apoptosis. Nature 2000;407: 770-6.
4. Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med 2000;6:513-9.
5. Gulbins E, Dreschers S, Bock J. Role of mitochondria in apoptosis. Exp Physiol 2003;88:85-90.
6. Friesen C, Fulda S, Debatin KM. Cytotoxic drugs and the CD95 pathway. Leukemia 1999;13:1854-8.
7. Sharma K, Wang RX, Zhang LY, et al. Death the Fas way: regulation and pathophysiology of CD95 and its ligand. Pharmacol Ther 2000; 88:333-47.
8. Chang FR, Hayashi K, Chen IH, et al. Antitumor agents. 228. Five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii. J Nat Prod 2003;66:1416-20.
9. Gonzalez GJ, Monache DG, Monache DF, Marini-Bettolo BG. Chuchuhuasha - a drug used in folk medicine in the Amazonian and Andean areas. A chemical study of Maytenus laevis. J Ethnopharmacol 1982;5:73-7.
10. Shirota O, Morita H, Takeya K, Itokawa H. Cytotoxic aromatic triterpenes from Maytenus ilicifolia and Maytenus chuchuhuasca. J Nat Prod 1994;57:1675-81.
11. Dirsch V, Wiemann W, Wagner H. Antiinflammatory activity of triterpene quinone-methides and proanthocyanidines from the stem bark of Heisteria pallida. Engl Pharm Pharmacol Lett 1992;2:184-6.
12. Chen CR, Li WG, Wu YJ, Gao MT. The anti-tumor and antioxidation action of pristimerin. Zhongguo Zhong Yao Za Zhi 2002;18:20-1.
13. Hui B, Wu YJ, Wang H, Tian X. Effect of pristimerin on experimental inflammation in mice and rats. Chin Pharm Bull 2003;19:656-9.
14. Dirsch VM, Kiemer AK, Wagner H, Vollmer AM. The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages. Eur J Pharmacol 1997;336:211-7.
15. Sureda FX, Escubedo E, Gabriel C, Comas J, Camarasa J, Camins A. Mitochondrial membrane potential measurement in rat cerebellar neurons by flow cytometry. Cytometry 1997;28:74-80.
16. LeBel CP, Ischiropoulos H, Bondy SC. Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 1992;5:227-31.
17. Davis W Jr, Ronai Z, Tew KD. Cellular thiols and reactive oxygen species in drug-induced apoptosis. J Pharmacol Exp Ther 2001;296:1-6.
18. Muller M, Strand S, Hug H, et al. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J Clin Invest 1997;99: 403-13.
19. 1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells. Oncogene 1995;11:493-504.
20. Hockenbery DM, Giedt CD, O'Neill JW, Manion MK, Banker DE. Mitochondria and apoptosis: new therapeutic targets. Adv Cancer Res 2002;85:203-42.
21. Henry-Mowatt J, Dive C, Martinou JC, James D. Role of mitochondrial membrane permeabilization in apoptosis and cancer. Oncogene 2004;23:2850-60.
22. Kuwana T, Smith JJ, Muzio M, Dixit V, Newmeyer DD, Kornbluth S. Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c. J Biol Chem 1998;273:16589-94.
23. Jacotot E, Costantini P, Laboureau E, Zamzami N, Susin SA, Kroemer G. Mitochondrial membrane permeabilization during the apoptotic process. Ann N Y Acad Sci 1999;887:18-30.
24. Ly JD, Grubb DR, Lawen A. The mitochondrial membrane potential (δ psi(m)) in apoptosis; an update. Apoptosis 2003; 8:115-28.
25. Bossy-Wetzel E, Newmeyer DD, Green DR. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J 1998;17:37-49.
26. Madesh M, Hajnoczky G. VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release. J Cell Biol 2001;155:1003-15.
27. Shimizu S, Tsujimoto Y. Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity. Proc Natl Acad Sci U S A 2000;97:577-82.
28. von Ahsen O, Renken C, Perkins G, Kluck RM, Bossy-Wetzel E, Newmeyer DD. Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release. J Cell Biol 2000;150: 1027-36.
29. Deshmukh M, Kuida K, Johnson EM Jr. Caspase inhibition extends the commitment to neuronal death beyond cytochrome c release to the point of mitochondrial depolarization. J Cell Biol 2000;150:131-43.
30. Kuwana T, Newmeyer DD. Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr Opin Cell Biol 2003;15:691-9.
31. Scorrano L, Korsmeyer SJ. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun 2003;304:437-44.
32. Vieira HL, Boys P, Cohen I, et al. Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-XL. Oncogene 2002; 21:1963-77.
33. Chan SL, Lee MC, Tan KO, et al. Identification of chelerythrine as an inhibitor of BclXL function. J Biol Chem 2003;278:20453-6.
34. Machida K, Hayashi Y, Osada H. A novel adenine nucleotide translocase inhibitor, MT-21, induces cytochrome c release by a mitochondrial permeability transition-independent mechanism. J Biol Chem 2002;277:31243-8.
35. Hirsch T, Decaudin D, Susin SA, et al. PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection. Exp Cell Res 1998;241:426-34.
36. Decaudin D, Castedo M, Nemati F, et al. Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo. Cancer Res 2002;62:1388-93.
37. Nagahara Y, Ikekita M, Shinomiya T. Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria. J Immunol 2000;165:3250-9.
38. Fulda S, Susin SA, Kroemer G, Debatin KM. Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells. Cancer Res 1998;58:4453-60.
39. Haridas V, Higuchi M, Jayatilake GS, et al. Avicins: triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation. Proc Natl Acad Sci U S A 2001;98:5821-6.
40. Debatin KM, Poncet D, Kroemer G. Chemotherapy: targeting the mitochondrial cell death pathway. Oncogene 2002;21:8786-803.
41. Costantini P, Jacotot E, Decaudin D, Kroemer G. Mitochondrion as a novel target of anticancer chemotherapy. J Natl Cancer Inst 2000;92: 1042-53.
42. Schnaitman C, Erwin VG, Greenawalt JW. The submitochondrial localization of monoamine oxidase. An enzymatic marker for the outer membrane of rat liver mitochondria. J Cell Biol 1967;32:719-35.
43. Nicholls DG. Calcium transport and proton electrochemical potential gradient in mitochondria from guinea-pig cerebral cortex and rat heart. Biochem J 1978;170:511-22.
44. Brustovetsky N, Jemmerson R, Dubinsky JM. Calcium-induced cytochrome c release from rat brain mitochondria is altered by digitonin. Neurosci Lett 2002;332:91-4.
45. Konopleva M, Tsao T, Estrov Z, et al. The synthetic triterpenoid 2-cyano-3, 12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia. Cancer Res 2004;64:7927-35.