Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor κB in human dermal microvascular endothelial cells

Journal of Investigative Dermatology

Volumn 118, Issue 2, 2002, Pages 380-385

  Shpacovitch, Victoria M ^a   Brzoska, Thomas ^a   Buddenkotte, Jörg ^a   Stroh, Christoph ^a   Sommerhoff, Christian P ^b   Ansel, John C ^c   Schulze Osthoff, Klaus ^b   Bunnett, Nigel W ^d   Luger, Thomas A ^a   Steinhoff, Martin ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

G protein coupled receptor; Inflammation; PAR; Proteases; Skin

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; PROTEINASE ACTIVATED RECEPTOR 2; TRYPSIN; TRYPTASE;

ARTICLE; CALCIUM MOBILIZATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; MICROVASCULATURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BLOOD FLOW;

EID: 0036174696     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202x.2001.01658.x     Document Type: Article

References (32)

1. Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle
2. Ligand cross-reactivity within the protease-activated receptor family
3. Mechanisms of desensitization and resensitization of proteinase-activated receptor-2
4. Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-alpha
5. Protease-activated receptors: Sentires for inflammation?
6. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2
7. Thrombin signalling and protease-activated receptors
8. Proteinase-activated receptor-2 inhibits cell growth and differentiation of human epidermal keratinocytes
9. Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases
10. Protease-activated receptors. PAR-4 and counting: How long is the course?
11. Immunolocalization of protease-activated receptor-2 in skin: Receptor activation stimulates interleukin-8 secretion by keratinocytes in vitro
12. NF-kappa B subunit-specific regulation of the interleukin-8 promoter
13. Proteinase-activated receptors
14. The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells
15. Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell alpha- or beta-tryptases
16. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor
17. Use of the polymerase chain reaction in quantification of interleukin 8 mRNA in minute epidermal samples
18. Evidence for the presence and biological activity of protease-activated receptor-2 in guinea pig airway inflammation
19. Reaction of mast cell proteases tryptase and chymase with protease-activated receptors on keratinocytes and fibroblasts
20. The protease-activated receptor 2 regulates pigmentation via keratinocyte-melanocyte interactions
21. Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines
22. Mechanism of trypsin-induced contraction in the rat myometrium: The possible involvement of a novel member of protease-activated receptor
23. Evidence for selective effects of chronic hypertension on cerebral artery vasodilatation to protease-activated receptor-2 activation
24. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-kappa B
25. Proteinase-activated receptor-2 in human skin: Tissue distribution and activation of keratinocytes by mast cell tryptase
26. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
27. Induction of the gene encoding mucosal vascular addressin cell adhesion molecule 1 by tumor necrosis factor alpha is mediated by NF-kappa B proteins
28. Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo
29. Protease-activated receptors in inflammation, neuronal signaling and pain
30. Thrombin and trypsin stimulate granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes
31. Expression of recombinant human mast cell tryptases