Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor

Blood

Volumn 96, Issue 5, 2000, Pages 1772-1781

  Liu, Lixin ^a   Tsai, Jo C ^a   Aird, William C ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EGR 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; EPIDERMIS CELL; FEMALE; GENE INDUCTION; GROWTH STIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

EID: 0034284310     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.5.1772     Document Type: Article

References (37)

1. A zinc finger-encoding gene co-regulated with c-fos during growth and differentiation, and after cellular depolarization
2. Early growth response protein 1 (Egr-1): Prototype of a zinc-finger family of transcription factors
3. Identification and characterisation of the egr-1 gene product as an inducible, short-lived, nuclear phosphoprotein
4. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor
5. Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells
6. A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with 'zinc finger' sequences
7. Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant
8. PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements
9. V-Fps-responsiveness in the Egr-1 promoter is mediated by serum response elements
10. V-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements
11. Characterization of cis-acting sequences and trans-acting signals regulating early growth response 1 and c-fos promoters through the granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells
12. Urea inducibility of egr-1 in murine inner medullary collecting duct cells is mediated by the serum response element and adjacent Ets motifs
13. Functional serum response elements upstream of the growth factor-inducible gene zif268
14. Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts
15. Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2
16. Reverse transcriptase-polymerase chain reaction (RTPCR): A sensitive method to examine basic fibroblast growth factor-induced expression of the early growth response gene-1 (egr-1) in human umbilical arterial endothelial cells
17. FGF-1-induced platelet-derived growth factor-A chain gene expression in endothelial cells involves transcriptional activation by early growth response factor-1
18. Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2
19. Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway
20. Vascular endothelial cell growth factor-induced tissue factor expression in endothelial cells is mediated by EGR-1
21. Pathways of Egr-1-mediated gene transcription in vascular biology
22. Inducible expression of Egr-1-dependent genes: A paradigm of transcriptional activation in vascular endothelium
23. Functional heterogeneity of vascular endothelial cells
24. Antigenic heterogeneity of vascular endothelium
25. Endothelial cells in physiology and in the pathophysiology of vascular disorders
26. Human von Willebrand factor gene sequences target expression to a subpopulation of endothelial cells in transgenic mice
27. Vascular-bed-specific hemostasis and hypercoagulable states
28. Modulation of Ras/Raf/extracellular signal-regulated kinase pathway by reactive oxygen species is involved in cyclic strain-induced early growth response-1 gene expression in endothelial cells
29. Epithelial injury induces egr-1 and fos expression by a pathway involving protein kinase C and ERK
30. Hypotonicity activates transcription through ERK-dependent and -independent pathways in renal cells
31. Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo
32. Uncoupling of hepatic, epidermal growth factor-mediated mitogen-activated protein kinase activation in the fetal rat
33. Epidermal growth factor and tyrosine phosphorylation of SHC in the mouse
34. Epidermal growth factor and lipopolysaccharide activate stat3 transcription factor in mouse liver
35. Stimulation of p85/RING3 kinase in multiple organs after systemic administration of mitogens into mice
36. Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors
37. 125l-PDGF-AB to the blood after extravascular administration in mice