메뉴 건너뛰기




Volumn 5, Issue 9, 2010, Pages 1-5

Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; B RAF KINASE; EPHRIN RECEPTOR A3; EPHRIN RECEPTOR B2; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE;

EID: 77958603990     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012653     Document Type: Article
Times cited : (14)

References (51)
  • 1
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P, Hunter T (2001) Oncogenic kinase signalling. Natre 411: 355-365.
    • (2001) Natre , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 2
    • 0035235736 scopus 로고    scopus 로고
    • Mitotic kinases as regulators of cell division and its checkpoints
    • Nigg EA (2001) Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2: 21-32.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 21-32
    • Nigg, E.A.1
  • 3
    • 0034614490 scopus 로고    scopus 로고
    • Signaling-2000 and beyond
    • Hunter T (2000) Signaling-2000 and beyond. Cell 100: 113-127.
    • (2000) Cell , vol.100 , pp. 113-127
    • Hunter, T.1
  • 4
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103: 211-225.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 6
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 7
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW (2004) Cancer genes and the pathways they control. Nat Med 10: 789-799.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 8
    • 0035990893 scopus 로고    scopus 로고
    • Protein kinases as targets for anticancer agents: From inhibitors to useful drugs
    • Fabbro D, Ruetz S, Buchdunger E, Cowan-Jacob SW, Fendrich G, et al. (2002) Protein kinases as targets for anticancer agents: from inhibitors to useful drugs. Pharmacol Ther 93: 79-98.
    • (2002) Pharmacol Ther , vol.93 , pp. 79-98
    • Fabbro, D.1    Ruetz, S.2    Buchdunger, E.3    Cowan-Jacob, S.W.4    Fendrich, G.5
  • 9
    • 34547523463 scopus 로고    scopus 로고
    • Small molecule signal transduction inhibitors for the treatment of solid tumors
    • Leary A, Johnston SR (2007) Small molecule signal transduction inhibitors for the treatment of solid tumors. Cancer Invest 25: 347-365.
    • (2007) Cancer Invest , vol.25 , pp. 347-365
    • Leary, A.1    Johnston, S.R.2
  • 10
    • 33846621955 scopus 로고    scopus 로고
    • Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: An update of recent developments
    • Steeghs N, Nortier JW, Gelderblom H (2007) Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: an update of recent developments. Ann Surg Oncol 14: 942-953.
    • (2007) Ann Surg Oncol , vol.14 , pp. 942-953
    • Steeghs, N.1    Nortier, J.W.2    Gelderblom, H.3
  • 11
    • 0034946243 scopus 로고    scopus 로고
    • Ataxia telangiectasia gene mutations in leukaemia and lymphoma
    • Boultwood J (2001) Ataxia telangiectasia gene mutations in leukaemia and lymphoma. J Clin Pathol 54: 512-516.
    • (2001) J Clin Pathol , vol.54 , pp. 512-516
    • Boultwood, J.1
  • 12
    • 0035503171 scopus 로고    scopus 로고
    • Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability
    • Menoyo A, Alazzouzi H, Espin E, Armengol M, Yamamoto H, et al. (2001) Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability. Cancer Res 61: 7727-7730.
    • (2001) Cancer Res , vol.61 , pp. 7727-7730
    • Menoyo, A.1    Alazzouzi, H.2    Espin, E.3    Armengol, M.4    Yamamoto, H.5
  • 13
    • 41549139097 scopus 로고    scopus 로고
    • Eph-ephrin signalling in adult tissues and cancer
    • Merlos-Suarez A, Batlle E (2008) Eph-ephrin signalling in adult tissues and cancer. Curr Opin Cell Biol 20: 194-200.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 194-200
    • Merlos-Suarez, A.1    Batlle, E.2
  • 14
    • 34248547564 scopus 로고    scopus 로고
    • Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma
    • Balakrishnan A, Bleeker FE, Lamba S, Rodolfo M, Daniotti M, et al. (2007) Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma. Cancer Res 67: 3545-3550.
    • (2007) Cancer Res , vol.67 , pp. 3545-3550
    • Balakrishnan, A.1    Bleeker, F.E.2    Lamba, S.3    Rodolfo, M.4    Daniotti, M.5
  • 15
    • 0038670241 scopus 로고    scopus 로고
    • Mutational analysis of the tyrosine kinome in colorectal cancers
    • Bardelli A, Parsons DW, Silliman N, Ptak J, Szabo S, et al. (2003) Mutational analysis of the tyrosine kinome in colorectal cancers. Science 300: 949.
    • (2003) Science , vol.300 , pp. 949
    • Bardelli, A.1    Parsons, D.W.2    Silliman, N.3    Ptak, J.4    Szabo, S.5
  • 16
    • 24744453982 scopus 로고    scopus 로고
    • Somatic mutations of the protein kinase gene family in human lung cancer
    • Davies H, Hunter C, Smith R, Stephens P, Greenman C, et al. (2005) Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res 65: 7591-7595.
    • (2005) Cancer Res , vol.65 , pp. 7591-7595
    • Davies, H.1    Hunter, C.2    Smith, R.3    Stephens, P.4    Greenman, C.5
  • 19
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314: 268-274.
    • (2006) Science , vol.314 , pp. 268-274
    • Sjoblom, T.1    Jones, S.2    Wood, L.D.3    Parsons, D.W.4    Lin, J.5
  • 20
    • 20044381123 scopus 로고    scopus 로고
    • A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
    • Stephens P, Edkins S, Davies H, Greenman C, Cox C, et al. (2005) A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet 37: 590-592.
    • (2005) Nat Genet , vol.37 , pp. 590-592
    • Stephens, P.1    Edkins, S.2    Davies, H.3    Greenman, C.4    Cox, C.5
  • 22
    • 36248962105 scopus 로고    scopus 로고
    • The genomic landscapes of human breast and colorectal cancers
    • Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318: 1108-1113.
    • (2007) Science , vol.318 , pp. 1108-1113
    • Wood, L.D.1    Parsons, D.W.2    Jones, S.3    Lin, J.4    Sjoblom, T.5
  • 25
    • 17744382174 scopus 로고    scopus 로고
    • Successful xenografting of cryopreserved primary pancreatic cancers
    • Sorio C, Bonora A, Orlandini S, Moore PS, Capelli P, et al. (2001) Successful xenografting of cryopreserved primary pancreatic cancers. Virchows Arch 438: 154-158.
    • (2001) Virchows Arch , vol.438 , pp. 154-158
    • Sorio, C.1    Bonora, A.2    Orlandini, S.3    Moore, P.S.4    Capelli, P.5
  • 26
    • 0035207991 scopus 로고    scopus 로고
    • Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4
    • Moore PS, Sipos B, Orlandini S, Sorio C, Real FX, et al. (2001) Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch 439: 798-802.
    • (2001) Virchows Arch , vol.439 , pp. 798-802
    • Moore, P.S.1    Sipos, B.2    Orlandini, S.3    Sorio, C.4    Real, F.X.5
  • 27
    • 31944444234 scopus 로고    scopus 로고
    • Cancer-specific mutations in PIK3CA are oncogenic in vivo
    • Bader AG, Kang S, Vogt PK (2006) Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proc Natl Acad Sci U S A 103: 1475-1479.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1475-1479
    • Bader, A.G.1    Kang, S.2    Vogt, P.K.3
  • 28
    • 21144457217 scopus 로고    scopus 로고
    • Functional analysis of PIK3CA gene mutations in human colorectal cancer
    • Ikenoue T, Kanai F, Hikiba Y, Obata T, Tanaka Y, et al. (2005) Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Res 65: 4562-4567.
    • (2005) Cancer Res , vol.65 , pp. 4562-4567
    • Ikenoue, T.1    Kanai, F.2    Hikiba, Y.3    Obata, T.4    Tanaka, Y.5
  • 30
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, et al. (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3    Silliman, N.4    Ptak, J.5
  • 31
    • 0035328856 scopus 로고    scopus 로고
    • Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers
    • Jang JH, Shin KH, Park JG (2001) Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. Cancer Res 61: 3541-3543.
    • (2001) Cancer Res , vol.61 , pp. 3541-3543
    • Jang, J.H.1    Shin, K.H.2    Park, J.G.3
  • 32
    • 34250829395 scopus 로고    scopus 로고
    • Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
    • Pollock PM, Gartside MG, Dejeza LC, Powell MA, Mallon MA, et al. (2007) Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes. Oncogene 26: 7158-7162.
    • (2007) Oncogene , vol.26 , pp. 7158-7162
    • Pollock, P.M.1    Gartside, M.G.2    Dejeza, L.C.3    Powell, M.A.4    Mallon, M.A.5
  • 34
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, et al. (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321: 1801-1806.
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3    Lin, J.C.4    Leary, R.J.5
  • 35
    • 33744725273 scopus 로고    scopus 로고
    • Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: Lack of mutations in the BRAF and EGFR genes
    • Immervoll H, Hoem D, Kugarajh K, Steine SJ, Molven A (2006) Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes. Virchows Arch 448: 788-796.
    • (2006) Virchows Arch , vol.448 , pp. 788-796
    • Immervoll, H.1    Hoem, D.2    Kugarajh, K.3    Steine, S.J.4    Molven, A.5
  • 37
    • 0036303033 scopus 로고    scopus 로고
    • Mechanisms and functions of Eph and ephrin signalling
    • Kullander K, Klein R (2002) Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol 3: 475-486.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 475-486
    • Kullander, K.1    Klein, R.2
  • 38
    • 28544450494 scopus 로고    scopus 로고
    • Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors
    • Alazzouzi H, Davalos V, Kokko A, Domingo E, Woerner SM, et al. (2005) Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors. Cancer Res 65: 10170-10173.
    • (2005) Cancer Res , vol.65 , pp. 10170-10173
    • Alazzouzi, H.1    Davalos, V.2    Kokko, A.3    Domingo, E.4    Woerner, S.M.5
  • 39
    • 4444326581 scopus 로고    scopus 로고
    • Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer
    • Huusko P, Ponciano-Jackson D, Wolf M, Kiefer JA, Azorsa DO, et al. (2004) Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Nat Genet 36: 979-983.
    • (2004) Nat Genet , vol.36 , pp. 979-983
    • Huusko, P.1    Ponciano-Jackson, D.2    Wolf, M.3    Kiefer, J.A.4    Azorsa, D.O.5
  • 40
    • 20344396123 scopus 로고    scopus 로고
    • Eph receptor signalling casts a wide net on cell behaviour
    • Pasquale EB (2005) Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol 6: 462-475.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 462-475
    • Pasquale, E.B.1
  • 41
    • 44449118933 scopus 로고    scopus 로고
    • The Eph receptor/ephrin system: An emerging player in the invasion game
    • Campbell TN, Robbins SM (2008) The Eph receptor/ephrin system: an emerging player in the invasion game. Curr Issues Mol Biol 10: 61-66.
    • (2008) Curr Issues Mol Biol , vol.10 , pp. 61-66
    • Campbell, T.N.1    Robbins, S.M.2
  • 42
    • 34247149803 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma
    • Lee J, Jang KT, Ki CS, Lim T, Park YS, et al. (2007) Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma. Cancer 109: 1561-1569.
    • (2007) Cancer , vol.109 , pp. 1561-1569
    • Lee, J.1    Jang, K.T.2    Ki, C.S.3    Lim, T.4    Park, Y.S.5
  • 43
    • 33947322389 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) is highly conserved in pancreatic cancer
    • Tzeng CW, Frolov A, Frolova N, Jhala NC, Howard JH, et al. (2007) Epidermal growth factor receptor (EGFR) is highly conserved in pancreatic cancer. Surgery 141: 464-469.
    • (2007) Surgery , vol.141 , pp. 464-469
    • Tzeng, C.W.1    Frolov, A.2    Frolova, N.3    Jhala, N.C.4    Howard, J.H.5
  • 44
    • 15644363454 scopus 로고    scopus 로고
    • Gainof-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, et al. (1998) Gainof-function mutations of c-kit in human gastrointestinal stromal tumors. Science 279: 577-580.
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3    Hashimoto, K.4    Nishida, T.5
  • 45
    • 34247895747 scopus 로고    scopus 로고
    • Microfluidic deletion/insertion analysis for rapid screening of KIT and PDGFRA mutations in CD117-positive gastrointestinal stromal tumors: Diagnostic applications and report of a new KIT mutation
    • Zamo A, Bertolaso A, Franceschetti I, Weirich G, Capelli P, et al. (2007) Microfluidic deletion/insertion analysis for rapid screening of KIT and PDGFRA mutations in CD117-positive gastrointestinal stromal tumors: diagnostic applications and report of a new KIT mutation. J Mol Diagn 9: 151-157.
    • (2007) J Mol Diagn , vol.9 , pp. 151-157
    • Zamo, A.1    Bertolaso, A.2    Franceschetti, I.3    Weirich, G.4    Capelli, P.5
  • 48
    • 33750977259 scopus 로고    scopus 로고
    • The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells
    • Yasuda A, Sawai H, Takahashi H, Ochi N, Matsuo Y, et al. (2006) The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells. Mol Cancer 5: 46.
    • (2006) Mol Cancer , vol.5 , pp. 46
    • Yasuda, A.1    Sawai, H.2    Takahashi, H.3    Ochi, N.4    Matsuo, Y.5
  • 49
    • 2942534623 scopus 로고    scopus 로고
    • Effects of STI571 (gleevec) on pancreatic cancer cell growth
    • Li J, Kleeff J, Guo J, Fischer L, Giese N, et al. (2003) Effects of STI571 (gleevec) on pancreatic cancer cell growth. Mol Cancer 2: 32.
    • (2003) Mol Cancer , vol.2 , pp. 32
    • Li, J.1    Kleeff, J.2    Guo, J.3    Fischer, L.4    Giese, N.5
  • 50
    • 31544449750 scopus 로고    scopus 로고
    • Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas
    • Lee JW, Soung YH, Seo SH, Kim SY, Park CH, et al. (2006) Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas. Clin Cancer Res 12: 57-61.
    • (2006) Clin Cancer Res , vol.12 , pp. 57-61
    • Lee, J.W.1    Soung, Y.H.2    Seo, S.H.3    Kim, S.Y.4    Park, C.H.5
  • 51
    • 33750627353 scopus 로고    scopus 로고
    • Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: Mutations are mainly present in adenocarcinomas with bronchioloalveolar features
    • Buttitta F, Barassi F, Fresu G, Felicioni L, Chella A, et al. (2006) Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features. Int J Cancer 119: 2586-2591.
    • (2006) Int J Cancer , vol.119 , pp. 2586-2591
    • Buttitta, F.1    Barassi, F.2    Fresu, G.3    Felicioni, L.4    Chella, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.