Transfer of alopecia areata in the human scalp graft/Prkdcscid (SCID) mouse system is characterized by a TH1 response

Clinical Immunology

Volumn 106, Issue 3, 2003, Pages 181-187

  Gilhar, Amos ^a   Landau, Marina ^b   Assy, Bedia ^a   Ullmann, Yehuda ^d   Shalaginov, Raya ^a   Serafimovich, Sima ^a   Kalish, Richard S ^c  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^c STONY BROOK UNIVERSITY   (United States)

^d Technion Faculty of Medicine ^*

Author keywords

Alopecia areata; Hair; Human; Interferon ; SCID mouse; TH1

Indexed keywords

GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10;

ALLOGRAFT; ALOPECIA AREATA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; EPITHELIUM; HAIR FOLLICLE; HAIR GROWTH; HAIR LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCALP; SCID MOUSE; T LYMPHOCYTE;

EID: 0345700834     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-6616(02)00042-6     Document Type: Article

References (27)

1. Todes-Taylor N., Turner R., Wood G.S., Stratte P.T., Morhenn V.B. T cell subpopulations in alopecia areata. J. Am. Acad. Dermatol. 11:1984;216-223.
2. Milgraum S.S., Mitchell A.J., Bacon G.E., Rasmussen J.E. Alopecia areata, endocrine function, and autoantibodies in patients 16 years of age or younger. J. Am. Acad. Dermatol. 17:1987;57-61.
3. Colon E.A., Popkin M.K., Callies A.L., Dessert N.J., Hordinsky M.K. Lifetime prevalence of psychiatric disorders in patients with alopecia areata. Compr. Psychiatry. 32:1991;245-251.
4. Koo J.Y., Shellow W.V., Hallman C.P., Edwards J.E. Alopecia areata and increased prevalence of psychiatric disorders. Int. J. Dermatol. 33:1994;849-850.
5. Safavi K.H., Muller S.A., Suman V.J., Moshell A.N., Melton L.J. 3rd. Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clinic Proc. 70:1995;628-633.
6. Gilhar A., Ullmann Y., Berkutzki T., Assy B., Kalish R.S. Alopecia areata transferred to human scalp explants on SCID mice with T-lymphocyte injections. J. Clin. Invest. 101:1998;62-67.
7. Gilhar A., Shalaginov R., Assy B., Serafimovich S., Kalish R.S. Alopecia areata is a T-lymphocyte mediated autoimmune disease lesional human T-lymphocytes transfer alopecia areata to human skin grafts on SCID mice . J. Invest. Dermatol. Symp. Proc. 4:1999;207-210.
8. scid mice . Arch. Dermatol. 138:2002;916-922.
9. McElwee K.J., Spiers E.M., Oliver R.F. In vivo depletion of CD8+ T-cells restores hair growth in the DEBR model for alopecia areata. Br. J. Dermatol. 135:1996;211-217.
10. McElwee K.J., Spiers E.M., Oliver R.F. Partial restoration of hair growth in the DEBR model for alopecia areata after in vivo depletion of CD4+ T cells. Br. J. Dermatol. 140:1999;432-437.
11. Bodemer C., Peuchmaur M., Fraitaig S., Chatenoud L., Brousse N., de Prost Y. Role of cytotoxic T cells in chronic alopecia areata. J. Invest. Dermatol. 114:2000;112-116.
12. scid mice. J. Invest. Dermatol. 117:2001;1357-1362.
13. Olsen E., Hordinsky M., McDonald-Hull S., Price V., Roberts J., Shapiro J., Stenn K. Alopecia areata investigational assessment guidelines. J. Am. Acad. Dermatol. 40:1999;242-246.
14. Sauvaigo S., Fretts R.E., Riopelle R.J., Lagarde A.E. Autonomous proliferation of MeWo human melanoma cell lines in serum-free medium secretion of growth-stimulating activities . Int. J. Cancer. 37:1986;123-132.
15. Nelville L.F., Mathiak G., Bagasra O. The immunobiology of interferon-gamma inducible protein 10kD (IP-10) a novel, pleiotropic member of the C-X-C chemokine superfamily . Cytokine Growth Factor Rev. 8:1997;207-219.
16. Gottlieb A.B. Immunologic mechanisms in psoriasis. J. Invest. Dermatol. 95:1990;18S-19S.
17. Daliani D., Ulmer R.A., Jackow C., Pugh W., Gansbacher B., Cabanillas F., Duvic M., Sarris A.H. Tumor necrosis factor-alpha and interferon-gamma, but not HTLV-I tax, are likely factors in the epidermotropism of cutaneous T-cell lymphoma via induction of interferon-inducible protein-10. Leuk. Lymphoma. 29:1998;315-328.
18. Groux H., Bigler M., de Vries J.E., Roncarolo M.G. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J. Exp. Med. 184:1996;19-29.
19. Meng X., Sawamura D., Tamai K., Hanada K., Ishida H., Hashimoto I. Keratinocyte gene therapy for systemic diseases. Circulating interleukin 10 released from gene-transferred keratinocytes inhibits contact hypersensitivity at distant areas of the skin. J. Clin. Invest. 101:1998;1462-1467.
20. Messenger A.G., Bleehen S.S. Expression of HLA-DR by anagen hair follicles in alopecia areata. J. Invest. Dermatol. 85:1985;569-572.
21. Khoury E.L., Price V.H., Greenspan J.S. HLA-DR expression by hair follicle keratinocytes in alopecia areata evidence that it is secondary to the lymphoid infiltration . J. Invest. Dermatol. 90:1988;193-200.
22. Brocker E.B., Echternach-Happle K., Hamm H., Happel R. Abnormal expression of class I and class II major histocompatibility antigens in alopecia areata modulation by topical immunotherapy . J. Invest. Dermatol. 88:1987;564-568.
23. Konig A., Happle R., Hoffmann R. IFN-gamma-induced HLA-DR but not ICAM-1 expression on cultured dermal papilla cells is downregulated by TNF-alpha. Arch. Dermatol. Res. 289:1997;466-470.
24. Mcdonagh A.J., Snowden J.A., Stierle C., Elliott K., Messenger A.G. HLA and ICAM-1 expression in alopecia areata in vivo and in vitro the role of cytokines . Br. J. Dermatol. 129:1993;250-256.
25. Gilhar A., Etzioni A., Assy B., Eidelman S. Response of grafts from patients with alopecia areata transplanted onto nude mice, to administration of interferon-gamma. Clin. Immunol. Immunopathol. 66:1993;120-126.
26. Thein C., Strange P., Hansen E.R., Baadsgaard O. Lesional alopecia areata T lymphocytes downregulate epithelial cell proliferation. Arch. Dermatol. Res. 289:1997;384-388.
27. Paus R., Slominski A., Czarnetzki B.M. Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb? Yale J. Biol. Med. 66:1994;541-554.