Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study

Arthritis Research and Therapy

Volumn 11, Issue 2, 2009, Pages

  Teixeira, Vitor Hugo ^a,b   Pierlot, Celine ^a   Migliorini, Paola ^c   Balsa, Alejandro ^d   Westhovens, René ^e   Barrera, Pilar ^f   Alves, Helena ^g   Vaz, Carlos ^g   Fernandes, Manuela ^g   Pascual Salcedo, Dora ^d   Bombardieri, Stefano ^c   Dequeker, Jan ^e   Radstake, Timothy R ^f   Van Riel, Piet ^f   van de Putte, Leo ^f   Lopes Vaz, Antonio ^g   Bardin, Thomas ^h   Prum, Bernard ⁱ   Cornélis, François ^a,h,j   Petit Teixeira, Elisabeth ^a  

^a University of Evry Val d'Essonne   (France)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF PISA   (Italy)

^d HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^g HOSPITAL DE SÃO JOÃO   (Portugal)

^h HÔPITAL LARIBOISIÈRE   (France)

ⁱ University of Paris 5   (France)

^j CENTRE HOSPITALIER SUD FRANCILIEN   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 21; IL2 PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE;

ARTICLE; CONTROLLED STUDY; EUROPE; FAMILY STUDY; FEMALE; GENE FREQUENCY; GENE REPLICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SCREENING; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PROMOTER REGION; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; ADULT; CHROMOSOME 4; FAMILY; GENETIC PREDISPOSITION; GENETICS;

ADULT; ARTHRITIS, RHEUMATOID; CHROMOSOMES, HUMAN, PAIR 4; EUROPE; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-2; INTERLEUKINS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 64549089608     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2654     Document Type: Article

References (31)

1. Firestein GS Evolving concepts of rheumatoid arthritis [review] Nature 2003, 423:356-361 10.1038/nature01661 12748655
2. Helm-van Mil Van der AH Wesoly JZ Huizinga TW Understanding the genetic contribution to rheumatoid arthritis Curr Opin Rheumatol 2005, 17:299-304 10.1097/01.bor.0000160780.13012.be 15838240
3. Huizinga TW Amos CI Helm-van Mil van der AH Chen W van Gaalen FA Jawaheer D Schreuder GM Wener M Breedveld FC Ahmad N Lum RF de Vries RR Gregersen PK Toes RE Criswell LA Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins Arthritis Rheum 2005, 52:3433-3438 10.1002/art.21385 16255021
4. Begovich AB Carlton VE Honigberg LA Schrodi SJ Chokkalingam AP Alexander HC Ardlie KG Huang Q Smith AM Spoerke JM Conn MT Chang M Chang SY Saiki RK Catanese JJ Leong DU Garcia VE McAllister LB Jeffery DA Lee AT Batliwalla F Remmers E Criswell LA Seldin MF Kastner DL Amos CI Sninsky JJ Gregersen PK A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis Am J Hum Genet 2004, 75:330-337 1216068 15208781 10.1086/422827
5. Kurreeman FA Padyukov L Marques RB Schrodi SJ Seddighzadeh M Stoeken-Rijsbergen G Helm-van Mil van der AH Allaart CF Verduyn W Houwing-Duistermaat J Alfredsson L Begovich AB Klareskog L Huizinga TW Toes RE A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis PLoS Med 2007, 4:e278 1976626 17880261 10.1371/journal.pmed.0040278
6. Plenge RM Seielstad M Padyukov L Lee AT Remmers EF Ding B Liew A Khalili H Chandrasekaran A Davies LR Li W Tan AK Bonnard C Ong RT Thalamuthu A Pettersson S Liu C Tian C Chen WV Carulli JP Beckman EM Altshuler D Alfredsson L Criswell LA Amos CI Seldin MF Kastner DL Klareskog L Gregersen PK TRAF1-C5 as a risk locus for rheumatoid arthritis: A genomewide study N Engl J Med 2007, 357:1199-1209 2636867 17804836 10.1056/NEJMoa073491
7. Kurreeman FA Rocha D Houwing-Duistermaat J Vrijmoet S Teixeira VH Migliorini P Balsa A Westhovens R Barrera P Alves H Vaz C Fernandes M Pascual-Salcedo D Michou L Bombardieri S Radstake T van Riel P Putte van de L Lopes-Vaz A Prum B Bardin T Gut I Cornelis F Huizinga TW Petit-Teixeira E Toes RE Replication of the tumor necrosis factor receptor-associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study Arthritis Rheum 2008, 58:2670-2674 10.1002/art.23793 18759306
8. Thomson W Barton A Ke X Eyre S Hinks A Bowes J Donn R Symmons D Hider S Bruce IN Wellcome Trust Case Control Consortium Wilson AG Marinou I Morgan A Emery P YEAR Consortium Carter A Steer S Hocking L Reid DM Wordsworth P Harrison P Strachan D Worthington J Rheumatoid arthritis association at 6q23 Nat Genet 2007, 39:1431-1433 10.1038/ng.2007.32 17982455
9. Plenge RM Cotsapas C Davies L Price AL de Bakker PI Maller J Pe'er I Burtt NP Blumenstiel B DeFelice M Parkin M Barry R Winslow W Healy C Graham RR Neale BM Izmailova E Roubenoff R Parker AN Glass R Karlson EW Maher N Hafler DA Lee DM Seldin MF Remmers EF Lee AT Padyukov L Alfredsson L Coblyn J et al Two independent alleles at 6q23 associated with risk of rheumatoid arthritis Nat Genet 2007, 39:1477-1482 2652744 17982456 10.1038/ng.2007.27
10. Lee HS Remmers EF Le JM Kastner DL Bae SC Gregersen PK Association of STAT4 with rheumatoid arthritis in the Korean population Mol Med 2007, 13:455-460 2014726 17932559
11. Remmers EF Plenge RM Lee AT Graham RR Hom G Behrens TW de Bakker PI Le JM Lee HS Batliwalla F Li W Masters SL Booty MG Carulli JP Padyukov L Alfredsson L Klareskog L Chen WV Amos CI Criswell LA Seldin MF Kastner DL Gregersen PK STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus N Engl J Med 2007 357 977 986 2630215 17804842 10.1056/NEJMoa073003
12. Zhernakova A Alizadeh BZ Bevova M van Leeuwen MA Coenen MJ Franke B Franke L Posthumus MD van Heel DA Steege van der G Radstake TR Barrera P Roep BO Koeleman BP Wijmenga C Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases Am J Hum Genet 2007, 81:1284-1288 2276343 17999365 10.1086/522037
13. Raychaudhuri S Remmers EF Lee AT Hackett R Guiducci C Burtt NP Gianniny L Korman BD Padyukov L Kurreeman FA Chang M Catanese JJ Ding B Wong S Helm-van Mil van der AH Neale BM Coblyn J Cui J Tak PP Wolbink GJ Crusius JB Horst-Bruinsma van der IE Criswell LA Amos CI Seldin MF Kastner DL Ardlie KG Alfredsson L Costenbader KH Altshuler D et al Common variants at CD40 and other loci confer risk of rheumatoid arthritis Nat Genet 2008, 40:1216-1623 10.1038/ng.233 18794853
14. Arnett FC Edworthy SM Bloch DA McShane DJ Fries JF Cooper NS Healey L Kaplan S Liang M Luthra H Medsger T Mitchel D Neustadt D Pinals R Schaller J Sharp J Wilder R Hunder G The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis Arthritis Rheum 1988, 31:315-324 10.1002/art.1780310302 3358796
15. Garnier S Dieudé P Michou L Barbet S Tan A Lasbleiz S Bardin T Prum B Cornélis F IRF5 rs2004640-T allele, the new genetic factor for systemic lupus erythematosus, is not associated with rheumatoid arthritis Ann Rheum Dis 2007, 66:828-831 10.1136/ard.2006.061390 17158136
16. Spielman R McGinnis E Ewens W Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM) Am J Hum Genet 1993, 52:506-526 1682161 8447318
17. Lathrop GM Estimating genotype relative risks Tissue Antigens 1983, 22:160-162 6623452
18. Woolf B On estimating the relation between blood group and disease Ann Hum Genet 1955, 19:251-253 10.1111/j.1469-1809.1955.tb01348.x 14388528
19. Haldane JB The estimation and significance of the logarithm of a ratio of frequencies Ann Hum Genet 1956, 20:309-311 10.1111/ j.1469-1809.1955.tb01285.x 13314400
20. Kruglyak L Daly MJ Reeve-Daly MP Lander ES Parametric and nonparametric linkage analysis: A unified multipoint approach Am J Hum Genet 1996, 58:1347-1363 1915045 8651312
21. Bonferroni CE Teoria statistica delle classi e calcolo delle probabilità Pubblicazioni del R Istituto Superiore di Scienze Economiche e Commerciali di Firenze 1936, 8:3-62
22. Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 2007, 447:661-678 10.1038/nature05911 17554300
23. Todd JA Walker NM Cooper JD Smyth DJ Downes K Plagnol V Bailey R Nejentsev S Field SF Payne F Lowe CE Szeszko JS Hafler JP Zeitels L Yang JH Vella A Nutland S Stevens HE Schuilenburg H Coleman G Maisuria M Meadows W Smink LJ Healy B Burren OS Lam AA Ovington NR Allen J Adlem E Leung HT et al Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes Nat Genet 2007, 39:857-864 2492393 17554260 10.1038/ng2068
24. Cooper JD Smyth DJ Smiles AM Plagnol V Walker NM Allen JE Downes K Barrett JC Healy BC Mychaleckyj JC Warram JH Todd JA Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci Nat Genet 2008, 40:1399-1401 10.1038/ng.249 18978792
25. Festen EA Goyette P Scott R Annese V Zhernakova A Brant SR Cho JH Silverberg MS Taylor KD de Jong DJ Stokkers PC McGovern D Palmieri O Achkar JP Xavier RJ Duerr RH Daly MJ Wijmenga C Weersma RK Rioux JD Genetic variants in the region harbouring IL2/IL21 associated to ulcerative colitis Gut 2009
26. van Heel DA Franke L Hunt KA Gwilliam R Zhernakova A Inouye M Wapenaar MC Barnardo MC Bethel G Holmes GK Feighery C Jewell D Kelleher D Kumar P Travis S Walters JR Sanders DS Howdle P Swift J Playford RJ McLaren WM Mearin ML Mulder CJ McManus R McGinnis R Cardon LR Deloukas P Wijmenga C A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 Nat Genet 2007, 39:827-829 2274985 17558408 10.1038/ng2058
27. Liu Y Helms C Liao W Zaba LC Duan S Gardner J Wise C Miner A Malloy MJ Pullinger CR Kane JP Saccone S Worthington J Bruce I Kwok PY Menter A Krueger J Barton A Saccone NL Bowcock AM A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci PLoS Genet 2008, 4:e1000041 18369459 2274885 10.1371/journal.pgen.1000041
28. Sawalha AH Kaufman KM Kelly JA Adler AJ Aberle T Kilpatrick J Wakeland EK Li QZ Wandstrat AE Karp DR James JA Merrill JT Lipsky P Harley JB Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus Ann Rheum Dis 2008, 67:458-461 10.1136/ard.2007.075424 17720724
29. Julià A Ballina J Cañete JD Balsa A Tornero-Molina J Naranjo A Alperi-López M Erra A Pascual-Salcedo D Barceló P Camps J Marsal S Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility Arthritis Rheum 2008, 58:2275-2286 10.1002/ art.23623 18668548
30. Chistiakov DA Voronova NV Chistiakov PA The crucial role of IL-2/ IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies [review] Immunol Lett 2008, 118:1-5 10.1016/j.imlet.2008.03.002 18417224
31. Spolski R Leonard WJ The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer [review] Curr Opin Immunol 2008, 20:295-301 10.1016/j.coi.2008.02.004 18554883