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Volumn 30, Issue 8, 2009, Pages 441-447

Interleukin-21 as a new therapeutic target for immune-mediated diseases

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR6; CYTOKINE; CYTOKINE RECEPTOR ANTAGONIST; INTERKEULIN 21 RECEPTOR ANTAGONIST; INTERLEUKIN 12P40; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR; JANUS KINASE 1; JANUS KINASE 3; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; UNCLASSIFIED DRUG;

EID: 67849120058     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2009.05.006     Document Type: Review
Times cited : (67)

References (69)
  • 1
    • 58049209834 scopus 로고    scopus 로고
    • Inflammatory signals in dendritic cell activation and the induction of adaptive immunity
    • Joffre O., et al. Inflammatory signals in dendritic cell activation and the induction of adaptive immunity. Immunol. Rev. 227 (2009) 234-247
    • (2009) Immunol. Rev. , vol.227 , pp. 234-247
    • Joffre, O.1
  • 2
    • 55849089267 scopus 로고    scopus 로고
    • Many cytokines are very useful therapeutic targets in disease
    • Feldmann M. Many cytokines are very useful therapeutic targets in disease. J. Clin. Invest. 118 (2008) 3533-3536
    • (2008) J. Clin. Invest. , vol.118 , pp. 3533-3536
    • Feldmann, M.1
  • 3
    • 34247152507 scopus 로고    scopus 로고
    • Immunobiologics in the treatment of psoriasis
    • Chong B.F., and Wong H.K. Immunobiologics in the treatment of psoriasis. Clin. Immunol. 123 (2007) 129-138
    • (2007) Clin. Immunol. , vol.123 , pp. 129-138
    • Chong, B.F.1    Wong, H.K.2
  • 5
    • 43249100959 scopus 로고    scopus 로고
    • Anti-interleukin-6 receptor antibody treatment in inflammatory autoimmune diseases
    • Ding C., and Jones G. Anti-interleukin-6 receptor antibody treatment in inflammatory autoimmune diseases. Rev. Recent Clin. Trials 1 (2006) 193-200
    • (2006) Rev. Recent Clin. Trials , vol.1 , pp. 193-200
    • Ding, C.1    Jones, G.2
  • 6
    • 37549063078 scopus 로고    scopus 로고
    • Cytokines and anti-cytokines as therapeutics-an update
    • Tayal V., and Kalra B.S. Cytokines and anti-cytokines as therapeutics-an update. Eur. J. Pharmacol. 579 (2008) 1-12
    • (2008) Eur. J. Pharmacol. , vol.579 , pp. 1-12
    • Tayal, V.1    Kalra, B.S.2
  • 7
    • 0036852893 scopus 로고    scopus 로고
    • Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses
    • Parrish-Novak J., et al. Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J. Leukoc. Biol. 72 (2002) 856-863
    • (2002) J. Leukoc. Biol. , vol.72 , pp. 856-863
    • Parrish-Novak, J.1
  • 8
    • 0034633734 scopus 로고    scopus 로고
    • Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain
    • Ozaki K., et al. Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 11439-11444
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 11439-11444
    • Ozaki, K.1
  • 9
    • 0034597789 scopus 로고    scopus 로고
    • Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
    • Parrish-Novak J., et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408 (2000) 57-63
    • (2000) Nature , vol.408 , pp. 57-63
    • Parrish-Novak, J.1
  • 10
    • 45449104408 scopus 로고    scopus 로고
    • The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer
    • Spolski R., and Leonard W.J. The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer. Curr. Opin. Immunol. 20 (2008) 295-301
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 295-301
    • Spolski, R.1    Leonard, W.J.2
  • 11
    • 47749141467 scopus 로고    scopus 로고
    • 10: Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin
    • Intlekofer A.M., et al. 10: Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science 321 (2008) 408-411
    • (2008) Science , vol.321 , pp. 408-411
    • Intlekofer, A.M.1
  • 12
    • 33847367120 scopus 로고    scopus 로고
    • IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production
    • Coquet J.M., et al. IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J. Immunol. 178 (2007) 2827-2834
    • (2007) J. Immunol. , vol.178 , pp. 2827-2834
    • Coquet, J.M.1
  • 13
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang A., et al. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29 (2008) 127-137
    • (2008) Immunity , vol.29 , pp. 127-137
    • Vogelzang, A.1
  • 14
    • 44549084734 scopus 로고    scopus 로고
    • Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses
    • Monteleone G., et al. Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses. Trends Immunol. 29 (2008) 290-294
    • (2008) Trends Immunol. , vol.29 , pp. 290-294
    • Monteleone, G.1
  • 15
    • 34347324029 scopus 로고    scopus 로고
    • A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
    • van Heel D.A., et al. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat. Genet. 39 (2007) 827-829
    • (2007) Nat. Genet. , vol.39 , pp. 827-829
    • van Heel, D.A.1
  • 16
    • 64549104048 scopus 로고    scopus 로고
    • Genetic variants in the region harbouring IL2/IL21 associated to ulcerative colitis
    • Festen E.A., et al. Genetic variants in the region harbouring IL2/IL21 associated to ulcerative colitis. Gut 58 (2009) 799-804
    • (2009) Gut , vol.58 , pp. 799-804
    • Festen, E.A.1
  • 17
    • 34247186263 scopus 로고    scopus 로고
    • Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes
    • Asano K., et al. Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes. Hum. Immunol. 68 (2007) 384-391
    • (2007) Hum. Immunol. , vol.68 , pp. 384-391
    • Asano, K.1
  • 18
    • 43249083380 scopus 로고    scopus 로고
    • A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci
    • Liu Y., et al. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet. 4 (2008) e1000041
    • (2008) PLoS Genet. , vol.4
    • Liu, Y.1
  • 19
    • 51849118676 scopus 로고    scopus 로고
    • A common exonic variant of interleukin21 confers susceptibility to atopic asthma
    • Chatterjee R., et al. A common exonic variant of interleukin21 confers susceptibility to atopic asthma. Int. Arch. Allergy Immunol. 148 (2009) 137-146
    • (2009) Int. Arch. Allergy Immunol. , vol.148 , pp. 137-146
    • Chatterjee, R.1
  • 20
    • 41549160141 scopus 로고    scopus 로고
    • Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
    • Sawalha A.H., et al. Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann. Rheum. Dis. 67 (2008) 458-461
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 458-461
    • Sawalha, A.H.1
  • 21
    • 0346116791 scopus 로고    scopus 로고
    • Novel genetic variation of human interleukin-21 receptor is associated with elevated IgE levels in females
    • Hecker M., et al. Novel genetic variation of human interleukin-21 receptor is associated with elevated IgE levels in females. Genes Immun. 4 (2003) 228-233
    • (2003) Genes Immun. , vol.4 , pp. 228-233
    • Hecker, M.1
  • 22
    • 33845447347 scopus 로고    scopus 로고
    • Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21
    • Monteleone G., et al. Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut 55 (2006) 1774-1780
    • (2006) Gut , vol.55 , pp. 1774-1780
    • Monteleone, G.1
  • 23
    • 2342491493 scopus 로고    scopus 로고
    • Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis
    • Jüngel A., et al. Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. Arthritis Rheum. 50 (2004) 1468-1476
    • (2004) Arthritis Rheum. , vol.50 , pp. 1468-1476
    • Jüngel, A.1
  • 24
    • 33846248387 scopus 로고    scopus 로고
    • A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells
    • Caruso R., et al. A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells. Gastroenterology 132 (2007) 166-175
    • (2007) Gastroenterology , vol.132 , pp. 166-175
    • Caruso, R.1
  • 25
    • 20144362420 scopus 로고    scopus 로고
    • Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis
    • Distler J.H., et al. Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis. Arthritis Rheum. 52 (2005) 856-864
    • (2005) Arthritis Rheum. , vol.52 , pp. 856-864
    • Distler, J.H.1
  • 26
    • 0037514399 scopus 로고    scopus 로고
    • IL-21 in synergy with IL-15 or IL-18 enhances IFN-γ production in human NK and T cells
    • Strengell M., et al. IL-21 in synergy with IL-15 or IL-18 enhances IFN-γ production in human NK and T cells. J. Immunol. 170 (2003) 5464-5469
    • (2003) J. Immunol. , vol.170 , pp. 5464-5469
    • Strengell, M.1
  • 27
    • 52949149758 scopus 로고    scopus 로고
    • Involvement of ERK-1/2 in IL-21-induced cytokine production in leukemia cells and human monocytes
    • Fuqua C.F., et al. Involvement of ERK-1/2 in IL-21-induced cytokine production in leukemia cells and human monocytes. Cytokine 44 (2008) 101-107
    • (2008) Cytokine , vol.44 , pp. 101-107
    • Fuqua, C.F.1
  • 28
    • 36248973130 scopus 로고    scopus 로고
    • IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells
    • Fantini M.C., et al. IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells. Eur. J. Immunol. 37 (2007) 3155-3163
    • (2007) Eur. J. Immunol. , vol.37 , pp. 3155-3163
    • Fantini, M.C.1
  • 29
    • 33846196712 scopus 로고    scopus 로고
    • 14: IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes
    • Peluso I., et al. 14: IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes. J. Immunol. 178 (2007) 732-739
    • (2007) J. Immunol. , vol.178 , pp. 732-739
    • Peluso, I.1
  • 30
    • 15744390341 scopus 로고    scopus 로고
    • Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
    • Monteleone G., et al. Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology 128 (2005) 687-694
    • (2005) Gastroenterology , vol.128 , pp. 687-694
    • Monteleone, G.1
  • 31
    • 58149251898 scopus 로고    scopus 로고
    • Late developmental plasticity in the T helper 17 lineage
    • Lee Y.K., et al. Late developmental plasticity in the T helper 17 lineage. Immunity 30 (2009) 92-107
    • (2009) Immunity , vol.30 , pp. 92-107
    • Lee, Y.K.1
  • 32
    • 64849103287 scopus 로고    scopus 로고
    • Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts
    • Nurieva R., et al. Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts. J. Immunol. 182 (2009) 2565-2568
    • (2009) J. Immunol. , vol.182 , pp. 2565-2568
    • Nurieva, R.1
  • 33
    • 34247588626 scopus 로고    scopus 로고
    • IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis
    • Caruso R., et al. IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J. Immunol. 178 (2007) 5957-5965
    • (2007) J. Immunol. , vol.178 , pp. 5957-5965
    • Caruso, R.1
  • 34
    • 46349089381 scopus 로고    scopus 로고
    • Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease
    • Fina D., et al. Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease. Gut 57 (2008) 887-892
    • (2008) Gut , vol.57 , pp. 887-892
    • Fina, D.1
  • 35
    • 61749085092 scopus 로고    scopus 로고
    • IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice
    • Jin H., et al. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J. Clin. Invest. 119 (2009) 47-60
    • (2009) J. Clin. Invest. , vol.119 , pp. 47-60
    • Jin, H.1
  • 36
    • 44849114296 scopus 로고    scopus 로고
    • Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis
    • Andersson A.K., et al. Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis. Scand. J. Immunol. 68 (2008) 103-111
    • (2008) Scand. J. Immunol. , vol.68 , pp. 103-111
    • Andersson, A.K.1
  • 37
    • 41349121555 scopus 로고    scopus 로고
    • Regulation of gut inflammation and th17 cell response by interleukin-21
    • Fina D., et al. Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology 134 (2008) 1038-1048
    • (2008) Gastroenterology , vol.134 , pp. 1038-1048
    • Fina, D.1
  • 38
    • 52949091915 scopus 로고    scopus 로고
    • IL-21 signaling is critical for the development of type I diabetes in the NOD mouse
    • Spolski R., et al. IL-21 signaling is critical for the development of type I diabetes in the NOD mouse. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 14028-14033
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 14028-14033
    • Spolski, R.1
  • 39
    • 65549165290 scopus 로고    scopus 로고
    • IL-21 is required for the development of type 1 diabetes in NOD mice
    • Sutherland A.P., et al. IL-21 is required for the development of type 1 diabetes in NOD mice. Diabetes 58 (2009) 1144-1155
    • (2009) Diabetes , vol.58 , pp. 1144-1155
    • Sutherland, A.P.1
  • 40
    • 60849107595 scopus 로고    scopus 로고
    • A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice
    • Bubier J.A., et al. A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 1518-1523
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 1518-1523
    • Bubier, J.A.1
  • 41
    • 58149279490 scopus 로고    scopus 로고
    • ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity
    • Odegard J.M., et al. ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity. J. Exp. Med. 205 (2008) 2873-2886
    • (2008) J. Exp. Med. , vol.205 , pp. 2873-2886
    • Odegard, J.M.1
  • 42
    • 21144438325 scopus 로고    scopus 로고
    • A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
    • Vinuesa C.G., et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435 (2005) 452-458
    • (2005) Nature , vol.435 , pp. 452-458
    • Vinuesa, C.G.1
  • 43
    • 34247257447 scopus 로고    scopus 로고
    • Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
    • Young D.A., et al. Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum. 56 (2007) 1152-1163
    • (2007) Arthritis Rheum. , vol.56 , pp. 1152-1163
    • Young, D.A.1
  • 44
    • 35748930247 scopus 로고    scopus 로고
    • Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus
    • Bubier J.A., et al. Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus. Ann. N. Y. Acad. Sci. 1110 (2007) 590-601
    • (2007) Ann. N. Y. Acad. Sci. , vol.1110 , pp. 590-601
    • Bubier, J.A.1
  • 45
    • 33947215987 scopus 로고    scopus 로고
    • IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
    • Herber D., et al. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J. Immunol. 178 (2007) 3822-3830
    • (2007) J. Immunol. , vol.178 , pp. 3822-3830
    • Herber, D.1
  • 46
    • 35848958662 scopus 로고    scopus 로고
    • New players in the cytokine orchestra of inflammatory bowel disease
    • Fantini M.C., et al. New players in the cytokine orchestra of inflammatory bowel disease. Inflamm. Bowel Dis. 13 (2007) 1419-1423
    • (2007) Inflamm. Bowel Dis. , vol.13 , pp. 1419-1423
    • Fantini, M.C.1
  • 47
    • 8344284998 scopus 로고    scopus 로고
    • Anti-interleukin-12 antibody for active Crohn's disease
    • Mannon P.J., et al. Anti-interleukin-12 antibody for active Crohn's disease. N. Engl. J. Med. 351 (2004) 2069-2079
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2069-2079
    • Mannon, P.J.1
  • 48
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann B., et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13 (2000) 715-725
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1
  • 49
    • 29744450121 scopus 로고    scopus 로고
    • Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
    • Fuss I.J., et al. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm. Bowel Dis. 12 (2006) 9-15
    • (2006) Inflamm. Bowel Dis. , vol.12 , pp. 9-15
    • Fuss, I.J.1
  • 50
    • 58849152515 scopus 로고    scopus 로고
    • The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut
    • Wang C., et al. The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol 2 (2009) 173-183
    • (2009) Mucosal Immunol , vol.2 , pp. 173-183
    • Wang, C.1
  • 51
    • 64849083153 scopus 로고    scopus 로고
    • IL-21 mediates suppressive effects via its induction of IL-10
    • Spolski R., et al. IL-21 mediates suppressive effects via its induction of IL-10. J. Immunol. 182 (2009) 2859-2867
    • (2009) J. Immunol. , vol.182 , pp. 2859-2867
    • Spolski, R.1
  • 52
    • 61449255987 scopus 로고    scopus 로고
    • IL-21: an executor of B cell fate
    • Konforte D., et al. IL-21: an executor of B cell fate. J. Immunol. 182 (2009) 1781-1787
    • (2009) J. Immunol. , vol.182 , pp. 1781-1787
    • Konforte, D.1
  • 53
    • 47249097068 scopus 로고    scopus 로고
    • The role of IL-21 in regulating B-cell function in health and disease
    • Ettinger R., et al. The role of IL-21 in regulating B-cell function in health and disease. Immunol. Rev. 223 (2008) 60-86
    • (2008) Immunol. Rev. , vol.223 , pp. 60-86
    • Ettinger, R.1
  • 54
    • 6344269331 scopus 로고    scopus 로고
    • Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
    • Ozaki K., et al. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J. Immunol. 173 (2004) 5361-5371
    • (2004) J. Immunol. , vol.173 , pp. 5361-5371
    • Ozaki, K.1
  • 55
    • 0037446642 scopus 로고    scopus 로고
    • IL-21 induces the apoptosis of resting and activated primary B cells
    • Mehta D.S., et al. IL-21 induces the apoptosis of resting and activated primary B cells. J. Immunol. 170 (2003) 4111-4118
    • (2003) J. Immunol. , vol.170 , pp. 4111-4118
    • Mehta, D.S.1
  • 56
    • 2942709751 scopus 로고    scopus 로고
    • Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis
    • Jin H., et al. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J. Immunol. 173 (2004) 657-665
    • (2004) J. Immunol. , vol.173 , pp. 657-665
    • Jin, H.1
  • 57
    • 0037159687 scopus 로고    scopus 로고
    • A critical role for IL-21 in regulating immunoglobulin production
    • Ozaki K., et al. A critical role for IL-21 in regulating immunoglobulin production. Science 298 (2002) 1630-1634
    • (2002) Science , vol.298 , pp. 1630-1634
    • Ozaki, K.1
  • 58
    • 18344394955 scopus 로고    scopus 로고
    • IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity
    • Kasaian M.T., et al. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 16 (2002) 559-569
    • (2002) Immunity , vol.16 , pp. 559-569
    • Kasaian, M.T.1
  • 59
    • 48649083489 scopus 로고    scopus 로고
    • Interleukin 21: a cytokine/cytokine receptor system that has come of age
    • Leonard W.J., et al. Interleukin 21: a cytokine/cytokine receptor system that has come of age. J. Leukoc. Biol. 84 (2008) 348-356
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 348-356
    • Leonard, W.J.1
  • 60
    • 33847412873 scopus 로고    scopus 로고
    • IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo
    • Fröhlich A., et al. IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood 109 (2007) 2023-2031
    • (2007) Blood , vol.109 , pp. 2023-2031
    • Fröhlich, A.1
  • 61
    • 33745840137 scopus 로고    scopus 로고
    • The IL-21 receptor augments Th2 effector function and alternative macrophage activation
    • Pesce J., et al. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J. Clin. Invest. 116 (2006) 2044-2055
    • (2006) J. Clin. Invest. , vol.116 , pp. 2044-2055
    • Pesce, J.1
  • 62
    • 47549112840 scopus 로고    scopus 로고
    • H17 cells
    • H17 cells. Nature 454 (2008) 350-352
    • (2008) Nature , vol.454 , pp. 350-352
    • Yang, L.1
  • 63
    • 34547188748 scopus 로고    scopus 로고
    • H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8 (2007) 967-974
    • (2007) Nat. Immunol. , vol.8 , pp. 967-974
    • Zhou, L.1
  • 64
    • 34547232503 scopus 로고    scopus 로고
    • H17 cells
    • H17 cells. Nature 448 (2007) 484-487
    • (2007) Nature , vol.448 , pp. 484-487
    • Korn, T.1
  • 65
    • 45149123617 scopus 로고    scopus 로고
    • Development and characterization of IL-21-producing CD4+ T cells
    • Suto A., et al. Development and characterization of IL-21-producing CD4+ T cells. J. Exp. Med. 205 (2008) 1369-1379
    • (2008) J. Exp. Med. , vol.205 , pp. 1369-1379
    • Suto, A.1
  • 66
    • 19944434230 scopus 로고    scopus 로고
    • Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
    • Zeng R., et al. Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J. Exp. Med. 201 (2005) 139-148
    • (2005) J. Exp. Med. , vol.201 , pp. 139-148
    • Zeng, R.1
  • 67
    • 2542595794 scopus 로고    scopus 로고
    • IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21
    • Moroz A., et al. IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21. J. Immunol. 173 (2004) 900-909
    • (2004) J. Immunol. , vol.173 , pp. 900-909
    • Moroz, A.1
  • 68
    • 33947663871 scopus 로고    scopus 로고
    • Role of interleukin-21 in inflammation and allergy
    • Fina D., et al. Role of interleukin-21 in inflammation and allergy. Inflamm. Allergy Drug Targets 6 (2007) 63-68
    • (2007) Inflamm. Allergy Drug Targets , vol.6 , pp. 63-68
    • Fina, D.1
  • 69
    • 31144479124 scopus 로고    scopus 로고
    • IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells
    • Burgess S.J., et al. IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells. J. Immunol. 176 (2006) 1490-1497
    • (2006) J. Immunol. , vol.176 , pp. 1490-1497
    • Burgess, S.J.1


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