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Volumn 10, Issue 11, 2010, Pages 745-759

The renin-angiotensin system and cancer: Old dog, new tricks

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; ANGIOTENSIN 1-7; ANGIOTENSIN RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; CANDESARTAN; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; UNCLASSIFIED DRUG;

EID: 77958502224     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2945     Document Type: Review
Times cited : (424)

References (202)
  • 1
    • 0038053724 scopus 로고    scopus 로고
    • A novel angiotensin-convertingenzyme-related carboxypeptidase (ACE2) convertsangiotensin i to angiotensin 1-9
    • Donoghue, M. et al. A novel angiotensin-convertingenzyme-related carboxypeptidase (ACE2) convertsangiotensin I to angiotensin 1-9. Circ. Res. 87, e1(2000).
    • (2000) Circ. Res. , vol.87
    • Donoghue, M.1
  • 2
    • 0034721906 scopus 로고    scopus 로고
    • A human homolog of angiotensinconvertingenzyme. Cloning and functional expressionas a captopril-insensitive carboxypeptidase
    • Tipnis, S. R. et al. A human homolog of angiotensinconvertingenzyme. Cloning and functional expressionas a captopril-insensitive carboxypeptidase. J. Biol. Chem. 275, 33238-33243 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 33238-33243
    • Tipnis, S.R.1
  • 3
    • 73749086318 scopus 로고    scopus 로고
    • Not justangiotensinases: New roles for the angiotensinconvertingenzymes
    • Lambert, D. W., Clarke, N. E. & Turner, A. J. Not justangiotensinases: new roles for the angiotensinconvertingenzymes. Cell. Mol. Life Sci. 67, 89-98(2010).
    • (2010) Cell. Mol. Life Sci. , vol.67 , pp. 89-98
    • Lambert, D.W.1    Clarke, N.E.2    Turner, A.J.3
  • 4
    • 36148987224 scopus 로고    scopus 로고
    • Therapeutic targeting of insulinregulatedaminopeptidase: Heads and tails?
    • Albiston, A. L. et al. Therapeutic targeting of insulinregulatedaminopeptidase: heads and tails?Pharmacol. Ther. 116, 417-427 (2007).
    • (2007) Pharmacol Ther. , vol.116 , pp. 417-427
    • Albiston, A.L.1
  • 5
    • 75149152420 scopus 로고    scopus 로고
    • The biology of the (pro)renin receptor
    • Nguyen, G. & Muller, D. N. The biology of the (pro)renin receptor. J. Am. Soc. Nephrol 21, 18-23 (2010).
    • (2010) J. Am. Soc. Nephrol , vol.21 , pp. 18-23
    • Nguyen, G.1    Muller, D.N.2
  • 6
    • 33645831776 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme(ACE) dimerization is the initial step in the ACEinhibitor-induced ACE signaling cascade in endothelialcells
    • Kohlstedt, K. et al. Angiotensin-converting enzyme(ACE) dimerization is the initial step in the ACEinhibitor-induced ACE signaling cascade in endothelialcells. Mol. Pharmacol. 69, 1725-1732 (2006).
    • (2006) Mol. Pharmacol. , vol.69 , pp. 1725-1732
    • Kohlstedt, K.1
  • 7
    • 43449087893 scopus 로고    scopus 로고
    • Genetics of the human renin angiotensinsystem
    • Jeunemaitre, X. Genetics of the human renin angiotensinsystem. J. Mol. Med. 86, 637-641 (2008).
    • (2008) J. Mol. Med. , vol.86 , pp. 637-641
    • Jeunemaitre, X.1
  • 8
    • 33845693028 scopus 로고    scopus 로고
    • Type 1 angiotensinreceptor pharmacology: Signaling beyond G proteins
    • Oro, C., Qian, H. & Thomas, W. G. Type 1 angiotensinreceptor pharmacology: signaling beyond G proteins. Pharmacol. Ther. 113, 210-226 (2007).
    • (2007) Pharmacol. Ther. , vol.113 , pp. 210-226
    • Oro, C.1    Qian, H.2    Thomas, W.G.3
  • 9
    • 65649108517 scopus 로고    scopus 로고
    • Significance of geneticpolymorphisms of the renin-angiotensin- aldosteronesystem in cardiovascular and renal disease
    • Rudnicki, M. & Mayer, G. Significance of geneticpolymorphisms of the renin-angiotensin-aldosteronesystem in cardiovascular and renal disease. Pharmacogenomics 10, 463-476 (2009).
    • (2009) Pharmacogenomics , vol.10 , pp. 463-476
    • Rudnicki, M.1    Mayer, G.2
  • 10
    • 77949536656 scopus 로고    scopus 로고
    • Tissue renin-angiotensin-aldosteronesystems: Targets for pharmacological therapy
    • Bader, M. Tissue renin-angiotensin-aldosteronesystems: targets for pharmacological therapy. Annu. Rev. Pharmacol. Toxicol. 50, 439-465 (2010).
    • (2010) Annu. Rev. Pharmacol. Toxicol. , vol.50 , pp. 439-465
    • Bader, M.1
  • 11
    • 57249089047 scopus 로고    scopus 로고
    • Moleculardeterminants of angiotensin II type 1 receptor functionalselectivity
    • Aplin, M., Bonde, M. M. & Hansen, J. L. Moleculardeterminants of angiotensin II type 1 receptor functionalselectivity. J. Mol. Cell. Cardiol. 46, 15-24 (2009).
    • (2009) J. Mol. Cell. Cardiol. , vol.46 , pp. 15-24
    • Aplin, M.1    Bonde, M.M.2    Hansen, J.L.3
  • 12
    • 0033824138 scopus 로고    scopus 로고
    • International union of pharmacology. XXIII. The angiotensin II receptors
    • De Gasparo, M., Catt, K. J., Inagami, T., Wright, J. W.& Unger, T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol. Rev. 52,415-472 (2000).
    • (2000) Pharmacol. Rev. , vol.52 , pp. 415-472
    • De Gasparo, M.1    Catt, K.J.2    Inagami, T.3    Wright, J.W.4    Unger, T.5
  • 13
    • 29344452247 scopus 로고    scopus 로고
    • Pleiotropic AT1 receptorsignaling pathways mediating physiological andpathogenic actions of angiotensin II
    • Hunyady, L. & Catt, K. J. Pleiotropic AT1 receptorsignaling pathways mediating physiological andpathogenic actions of angiotensin II. Mol. Endocrinol.20, 953-970 (2006).
    • (2006) Mol. Endocrinol. , vol.20 , pp. 953-970
    • Hunyady, L.1    Catt, K.J.2
  • 14
    • 33846362954 scopus 로고    scopus 로고
    • Angiotensin II cellsignaling: Physiological and pathological effects in thecardiovascular system
    • Mehta, P. K. & Griendling, K. K. Angiotensin II cellsignaling: physiological and pathological effects in thecardiovascular system. Am. J. Physiol. Cell Physiol.292, C82-C97 (2007).
    • (2007) Am. J. Physiol. Cell Physiol. , vol.292
    • Mehta, P.K.1    Griendling, K.K.2
  • 15
    • 0037409235 scopus 로고    scopus 로고
    • Angiotensin II signalingpathways mediated by tyrosine kinases
    • Yin, G., Yan, C. & Berk, B. C. Angiotensin II signalingpathways mediated by tyrosine kinases. Int. J. Biochem. Cell Biol. 35, 780-783 (2003).
    • (2003) Int. J. Biochem. Cell Biol. , vol.35 , pp. 780-783
    • Yin, G.1    Yan, C.2    Berk, B.C.3
  • 16
    • 33750602514 scopus 로고    scopus 로고
    • Angiotensin II signal transductionthrough small GTP-binding proteins: Mechanism andsignificance in vascular smooth muscle cells
    • Ohtsu, H. et al. Angiotensin II signal transductionthrough small GTP-binding proteins: mechanism andsignificance in vascular smooth muscle cells. Hypertension 48, 534-540 (2006).
    • (2006) Hypertension , vol.48 , pp. 534-540
    • Ohtsu, H.1
  • 17
    • 2942618584 scopus 로고    scopus 로고
    • β-Arrestins: Traffic copsof cell signaling
    • Lefkowitz, R. J. & Whalen, E. J. β-arrestins: traffic copsof cell signaling. Curr. Opin. Cell Biol. 16, 162-168(2004).
    • (2004) Curr. Opin. Cell Biol. , vol.16 , pp. 162-168
    • Lefkowitz, R.J.1    Whalen, E.J.2
  • 18
    • 77951844975 scopus 로고    scopus 로고
    • Teaching old receptors new tricks: Biasing seventransmembranereceptors
    • Rajagopal, S., Rajagopal, K. & Lefkowitz, R. J. Teaching old receptors new tricks: biasing seventransmembranereceptors. Nature Rev. Drug Discov.9, 373-386 (2010).
    • (2010) Nature Rev. Drug Discov. , vol.9 , pp. 373-386
    • Rajagopal, S.1    Rajagopal, K.2    Lefkowitz, R.J.3
  • 19
    • 33646249825 scopus 로고    scopus 로고
    • TACE-dependent EGFreceptor activation in angiotensin-II-induced kidneydisease
    • Shah, B. H. & Catt, K. J. TACE-dependent EGFreceptor activation in angiotensin-II-induced kidneydisease. Trends Pharmacol. Sci. 27, 235-237 (2006).
    • (2006) Trends Pharmacol. Sci. , vol.27 , pp. 235-237
    • Shah, B.H.1    Catt, K.J.2
  • 20
    • 11144271385 scopus 로고    scopus 로고
    • Hijacking epidermal growth factorreceptors by angiotensin II: New possibilities forunderstanding and treating cardiac hypertrophy
    • Smith, N. J., Chan, H. W., Osborne, J. E., Thomas, W. G.& Hannan, R. D. Hijacking epidermal growth factorreceptors by angiotensin II: new possibilities forunderstanding and treating cardiac hypertrophy. Cell. Mol. Life Sci. 61, 2695-2703 (2004).
    • (2004) Cell. Mol. Life Sci. , vol.61 , pp. 2695-2703
    • Smith, N.J.1    Chan, H.W.2    Osborne, J.E.3    Thomas, W.G.4    Hannan, R.D.5
  • 21
    • 33644987832 scopus 로고    scopus 로고
    • Growth factor receptortransactivation in mediating end organ damage byangiotensin II
    • Suzuki, H. & Eguchi, S. Growth factor receptortransactivation in mediating end organ damage byangiotensin II. Hypertension 47, 339-340 (2006).
    • (2006) Hypertension , vol.47 , pp. 339-340
    • Suzuki, H.1    Eguchi, S.2
  • 22
    • 0030044360 scopus 로고    scopus 로고
    • Roleof transactivation of the EGF receptor in signalling byG-protein-coupled receptors
    • Daub, H., Weiss, F. U., Wallasch, C. & Ullrich, A. Roleof transactivation of the EGF receptor in signalling byG-protein-coupled receptors. Nature 379, 557-560(1996).
    • (1996) Nature , vol.379 , pp. 557-560
    • Daub, H.1    Weiss, F.U.2    Wallasch, C.3    Ullrich, A.4
  • 23
    • 0033599039 scopus 로고    scopus 로고
    • EGF receptor transactivation byG-protein-coupled receptors requiresmetalloproteinase cleavage of proHB-EGF
    • Prenzel, N. et al. EGF receptor transactivation byG-protein-coupled receptors requiresmetalloproteinase cleavage of proHB-EGF. Nature402, 884-888 (1999).
    • (1999) Nature , vol.402 , pp. 884-888
    • Prenzel, N.1
  • 24
    • 33745714456 scopus 로고    scopus 로고
    • ADAMs asmediators of EGF receptor transactivation byG protein-coupled receptors
    • Ohtsu, H., Dempsey, P. J. & Eguchi, S. ADAMs asmediators of EGF receptor transactivation byG protein-coupled receptors. Am. J. Physiol. CellPhysiol. 291, C1-C10 (2006).
    • (2006) Am. J. Physiol. CellPhysiol. , vol.291
    • Ohtsu, H.1    Dempsey, P.J.2    Eguchi, S.3
  • 25
    • 3843147335 scopus 로고    scopus 로고
    • Matrix metalloproteinasedependentEGF receptor activation in hypertensionand left ventricular hypertrophy
    • Shah, B. H. & Catt, K. J. Matrix metalloproteinasedependentEGF receptor activation in hypertensionand left ventricular hypertrophy. Trends Endocrinol. Metab. 15, 241-243 (2004).
    • (2004) Trends Endocrinol. Metab. , vol.15 , pp. 241-243
    • Shah, B.H.1    Catt, K.J.2
  • 26
    • 3442884527 scopus 로고    scopus 로고
    • Differential pathways of angiotensin IIinducedextracellularly regulated kinase 1/2phosphorylation in specific cell types: Role of heparinbindingepidermal growth factor
    • Shah, B. H. et al. Differential pathways of angiotensin IIinducedextracellularly regulated kinase 1/2phosphorylation in specific cell types: role of heparinbindingepidermal growth factor. Mol. Endocrinol. 18,2035-2048 (2004).
    • (2004) Mol. Endocrinol. , vol.18 , pp. 2035-2048
    • Shah, B.H.1
  • 27
    • 0037040165 scopus 로고    scopus 로고
    • Adenoviral-directed expression ofthe type 1A angiotensin receptor promotescardiomyocyte hypertrophy via transactivation of theepidermal growth factor receptor
    • Thomas, W. G. et al. Adenoviral-directed expression ofthe type 1A angiotensin receptor promotescardiomyocyte hypertrophy via transactivation of theepidermal growth factor receptor. Circ. Res. 90,135-142 (2002).
    • (2002) Circ. Res. , vol.90 , pp. 135-142
    • Thomas, W.G.1
  • 28
    • 0035966085 scopus 로고    scopus 로고
    • Evidence that the angiotensin IV(AT4) receptor is the enzyme insulin-regulatedaminopeptidase
    • Albiston, A. L. et al. Evidence that the angiotensin IV(AT4) receptor is the enzyme insulin-regulatedaminopeptidase. J. Biol. Chem. 276, 48623-48626(2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 48623-48626
    • Albiston, A.L.1
  • 29
    • 63149198804 scopus 로고    scopus 로고
    • Functionalinteractions between 7TM receptors in the renin-angiotensin system-dimerization or crosstalk?
    • Lyngso, C., Erikstrup, N. & Hansen, J. L. Functionalinteractions between 7TM receptors in the renin-angiotensin system-dimerization or crosstalk? Mol. Cell. Endocrinol. 302, 203-212 (2009).
    • (2009) Mol. Cell. Endocrinol. , vol.302 , pp. 203-212
    • Lyngso, C.1    Erikstrup, N.2    Hansen, J.L.3
  • 30
    • 75149122361 scopus 로고    scopus 로고
    • The (pro)renin receptor in health anddisease
    • Nguyen, G. The (pro)renin receptor in health anddisease. Ann. Med. 42, 13-18 (2010).
    • (2010) Ann. Med. , vol.42 , pp. 13-18
    • Nguyen, G.1
  • 31
    • 63849169364 scopus 로고    scopus 로고
    • Theangiotensin II type 2 (AT2) receptor: An enigmaticseven transmembrane receptor
    • Porrello, E. R., Delbridge, L. M. & Thomas, W. G. Theangiotensin II type 2 (AT2) receptor: an enigmaticseven transmembrane receptor. Front. Biosci. 14,958-972 (2009).
    • (2009) Front. Biosci. , vol.14 , pp. 958-972
    • Porrello, E.R.1    Delbridge, L.M.2    Thomas, W.G.3
  • 32
  • 33
    • 67651108610 scopus 로고    scopus 로고
    • The potential role of the angiotensinsubtype 2 receptor in cardiovascular protection
    • Siragy, H. M. The potential role of the angiotensinsubtype 2 receptor in cardiovascular protection. Curr. Hypertens. Rep. 11, 260-262 (2009).
    • (2009) Curr. Hypertens. Rep. , vol.11 , pp. 260-262
    • Siragy, H.M.1
  • 34
    • 22544448655 scopus 로고    scopus 로고
    • The AT2receptor-A matter of love and hate
    • Steckelings, U. M., Kaschina, E. & Unger, T. The AT2receptor-a matter of love and hate. Peptides 26,1401-1409 (2005).
    • (2005) Peptides , vol.26 , pp. 1401-1409
    • Steckelings, U.M.1    Kaschina, E.2    Unger, T.3
  • 35
    • 72449197630 scopus 로고    scopus 로고
    • Recent advances inbioluminescence resonance energy transfertechnologies to study GPCR heteromerization
    • Ayoub, M. A. & Pfleger, K. D. Recent advances inbioluminescence resonance energy transfertechnologies to study GPCR heteromerization. Curr. Opin. Pharmacol. 10, 44-52 (2010).
    • (2010) Curr. Opin. Pharmacol. , vol.10 , pp. 44-52
    • Ayoub, M.A.1    Pfleger, K.D.2
  • 36
    • 60249098735 scopus 로고    scopus 로고
    • Building a new conceptual frameworkfor receptor heteromers
    • Ferre, S. et al. Building a new conceptual frameworkfor receptor heteromers. Nature Chem. Biol. 5,131-134 (2009).
    • (2009) Nature Chem. Biol. , vol.5 , pp. 131-134
    • Ferre, S.1
  • 37
    • 77749273888 scopus 로고    scopus 로고
    • Compound 21, the first orallyactive, selective agonist of the angiotensin type 2receptor (AT2): Implications for AT2 receptor researchand therapeutic potential
    • Unger, T. & Dahlof, B. Compound 21, the first orallyactive, selective agonist of the angiotensin type 2receptor (AT2): implications for AT2 receptor researchand therapeutic potential. J. Renin AngiotensinAldosterone Syst. 11, 75-77 (2010).
    • (2010) J. Renin AngiotensinAldosterone Syst. , vol.11 , pp. 75-77
    • Unger, T.1    Dahlof, B.2
  • 38
    • 8644281991 scopus 로고    scopus 로고
    • Design, synthesis, and biologicalevaluation of the first selective nonpeptide AT2receptor agonist
    • Wan, Y. et al. Design, synthesis, and biologicalevaluation of the first selective nonpeptide AT2receptor agonist. J. Med. Chem. 47, 5995-6008(2004).
    • (2004) J. Med. Chem. , vol.47 , pp. 5995-6008
    • Wan, Y.1
  • 39
    • 68249147664 scopus 로고    scopus 로고
    • Role of renin-angiotensinsystem in adipose tissue dysfunction
    • Iwai, M. & Horiuchi, M. Role of renin-angiotensinsystem in adipose tissue dysfunction. Hypertens. Res.32, 425-427 (2009).
    • (2009) Hypertens. Res. , vol.32 , pp. 425-427
    • Iwai, M.1    Horiuchi, M.2
  • 40
    • 52049104502 scopus 로고    scopus 로고
    • Therole of the renin-angiotensin system in aorticaneurysmal diseases
    • Lu, H., Rateri, D. L., Cassis, L. A. & Daugherty, A. Therole of the renin-angiotensin system in aorticaneurysmal diseases. Curr. Hypertens. Rep. 10,99-106 (2008).
    • (2008) Curr. Hypertens. Rep. , vol.10 , pp. 99-106
    • Lu, H.1    Rateri, D.L.2    Cassis, L.A.3    Daugherty, A.4
  • 42
  • 43
    • 66749124113 scopus 로고    scopus 로고
    • Angiotensin-(1-7)stimulates hematopoietic progenitor cells in vitro andin vivo
    • Heringer-Walther, S. et al. Angiotensin-(1-7)stimulates hematopoietic progenitor cells in vitro andin vivo. Haematologica 94, 857-860 (2009).
    • (2009) Haematologica , vol.94 , pp. 857-860
    • Heringer-Walther, S.1
  • 44
    • 66749168189 scopus 로고    scopus 로고
    • A role for the renin-angiotensin system in hematopoiesis
    • Park, T. S. & Zambidis, E. T. A role for the renin-angiotensin system in hematopoiesis. Haematologica94, 745-747 (2009).
    • (2009) Haematologica , vol.94 , pp. 745-747
    • Park, T.S.1    Zambidis, E.T.2
  • 45
    • 55749104551 scopus 로고    scopus 로고
    • Expression of angiotensinconvertingenzyme (CD143) identifies and regulatesprimitive hemangioblasts derived from humanpluripotent stem cells
    • Zambidis, E. T. et al. Expression of angiotensinconvertingenzyme (CD143) identifies and regulatesprimitive hemangioblasts derived from humanpluripotent stem cells. Blood 112, 3601-3614(2008).
    • (2008) Blood , vol.112 , pp. 3601-3614
    • Zambidis, E.T.1
  • 46
    • 0032543880 scopus 로고    scopus 로고
    • Do inhibitors ofangiotensin-I-converting enzyme protect against riskof cancer?
    • Lever, A. F. et al. Do inhibitors ofangiotensin-I-converting enzyme protect against riskof cancer? Lancet 352, 179-184 (1998).
    • (1998) Lancet , vol.352 , pp. 179-184
    • Lever, A.F.1
  • 47
    • 51749120817 scopus 로고    scopus 로고
    • Association of ACE inhibitors andangiotensin receptor blockers with keratinocyte cancerprevention in the randomized VATTC trial
    • Christian, J. B., Lapane, K. L., Hume, A. L., Eaton, C. B.& Weinstock, M. A. Association of ACE inhibitors andangiotensin receptor blockers with keratinocyte cancerprevention in the randomized VATTC trial. J. NatlCancer Inst. 100, 1223-1232 (2008).
    • (2008) J. NatlCancer Inst. , vol.100 , pp. 1223-1232
    • Christian, J.B.1    Lapane, K.L.2    Hume, A.L.3    Eaton, C.B.4    Weinstock, M.A.5
  • 48
    • 33746573470 scopus 로고    scopus 로고
    • ACE inhibitors may reduce esophagealcancer incidence
    • Lang, L. ACE inhibitors may reduce esophagealcancer incidence. Gastroenterology 131, 343-344(2006).
    • (2006) Gastroenterology , vol.131 , pp. 343-344
    • Lang, L.1
  • 49
    • 0346095288 scopus 로고    scopus 로고
    • Association between captopril,other antihypertensive drugs and risk of prostatecancer
    • Ronquist, G. et al. Association between captopril,other antihypertensive drugs and risk of prostatecancer. Prostate 58, 50-56 (2004).
    • (2004) Prostate , vol.58 , pp. 50-56
    • Ronquist, G.1
  • 50
    • 69049113864 scopus 로고    scopus 로고
    • Impact of angiotensin i convertingenzyme inhibitors and angiotensin II type 1 receptorblockers on survival in patients with advancednon-small-cell lung cancer undergoing first-lineplatinum-based chemotherapy
    • Wilop, S. et al. Impact of angiotensin I convertingenzyme inhibitors and angiotensin II type 1 receptorblockers on survival in patients with advancednon-small-cell lung cancer undergoing first-lineplatinum-based chemotherapy. J. Cancer Res. Clin. Oncol. 135, 1429-1435 (2009).
    • (2009) J. Cancer Res. Clin. Oncol. , vol.135 , pp. 1429-1435
    • Wilop, S.1
  • 51
    • 33745845825 scopus 로고    scopus 로고
    • Physiology oflocal renin-angiotensin systems
    • Paul, M., Poyan Mehr, A. & Kreutz, R. Physiology oflocal renin-angiotensin systems. Physiol. Rev. 86,747-803 (2006).
    • (2006) Physiol. Rev. , vol.86 , pp. 747-803
    • Paul, M.1    Poyan Mehr, A.2    Kreutz, R.3
  • 52
    • 67649505084 scopus 로고    scopus 로고
    • AGTR1 overexpression defines asubset of breast cancer and confers sensitivity tolosartan, an AGTR1 antagonist
    • Through extensive microarray data mining, theseauthors found AGTR1 to be overexpressed in asubset of breast cancers
    • Rhodes, D. R. et al. AGTR1 overexpression defines asubset of breast cancer and confers sensitivity tolosartan, an AGTR1 antagonist. Proc. Natl Acad. Sci. USA 106, 10284-10289 (2009). Through extensive microarray data mining, theseauthors found AGTR1 to be overexpressed in asubset of breast cancers.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 10284-10289
    • Rhodes, D.R.1
  • 53
    • 67649424204 scopus 로고    scopus 로고
    • Local angiotensin II-generation inhuman gastric cancer: Correlation with tumorprogression through the activation of ERK1/2, NF-κBand survivin
    • Kinoshita, J. et al. Local angiotensin II-generation inhuman gastric cancer: correlation with tumorprogression through the activation of ERK1/2, NF-κBand survivin. Int. J. Oncol. 34, 1573-1582 (2009).
    • (2009) Int. J. Oncol. , vol.34 , pp. 1573-1582
    • Kinoshita, J.1
  • 54
    • 20244364824 scopus 로고    scopus 로고
    • The number of lymph nodemetastases in gastric cancer correlates with theangiotensin I-converting enzyme gene insertion/deletion polymorphism
    • Rocken, C. et al. The number of lymph nodemetastases in gastric cancer correlates with theangiotensin I-converting enzyme gene insertion/deletion polymorphism. Clin. Cancer Res. 11,2526-2530 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 2526-2530
    • Rocken, C.1
  • 55
    • 34250810884 scopus 로고    scopus 로고
    • The angiotensin II/angiotensin IIreceptor system correlates with nodal spread inintestinal type gastric cancer
    • Rocken, C. et al. The angiotensin II/angiotensin IIreceptor system correlates with nodal spread inintestinal type gastric cancer. Cancer Epidemiol. Biomarkers Prev. 16, 1206-1212 (2007).
    • (2007) Cancer Epidemiol. Biomarkers Prev. , vol.16 , pp. 1206-1212
    • Rocken, C.1
  • 56
    • 17644416741 scopus 로고    scopus 로고
    • Functional expression of theangiotensin II type 1 receptor in human ovariancarcinoma cells and its blockade therapy resulting insuppression of tumor invasion, angiogenesis, andperitoneal dissemination
    • Suganuma, T. et al. Functional expression of theangiotensin II type 1 receptor in human ovariancarcinoma cells and its blockade therapy resulting insuppression of tumor invasion, angiogenesis, andperitoneal dissemination. Clin. Cancer Res. 11,2686-2694 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 2686-2694
    • Suganuma, T.1
  • 57
    • 33646721799 scopus 로고    scopus 로고
    • Renin-angiotensin system is animportant factor in hormone refractory prostatecancer
    • Uemura, H. et al. Renin-angiotensin system is animportant factor in hormone refractory prostatecancer. Prostate 66, 822-830 (2006).
    • (2006) Prostate , vol.66 , pp. 822-830
    • Uemura, H.1
  • 58
    • 0034805542 scopus 로고    scopus 로고
    • Growth stimulatoryangiotensin II type-1 receptor is upregulated in breasthyperplasia and in situ carcinoma but not in invasivecarcinoma
    • De Paepe, B., Verstraeten, V. L., De Potter, C. R.,Vakaet, L. A. & Bullock, G. R. Growth stimulatoryangiotensin II type-1 receptor is upregulated in breasthyperplasia and in situ carcinoma but not in invasivecarcinoma. Histochem. Cell Biol. 116, 247-254(2001).
    • (2001) Histochem. Cell Biol. , vol.116 , pp. 247-254
    • De Paepe, B.1    Verstraeten, V.L.2    De Potter, C.R.3    Vakaet, L.A.4    Bullock, G.R.5
  • 59
    • 16644396484 scopus 로고    scopus 로고
    • Angiotensin II activates MAP kinaseand NF-κB through angiotensin II type i receptor inhuman pancreatic cancer cells
    • Amaya, K. et al. Angiotensin II activates MAP kinaseand NF-κB through angiotensin II type I receptor inhuman pancreatic cancer cells. Int. J. Oncol. 25,849-856 (2004).
    • (2004) Int. J. Oncol. , vol.25 , pp. 849-856
    • Amaya, K.1
  • 60
    • 77951217116 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor signalingsignificantly attenuates growth of murine pancreaticcarcinoma grafts in syngeneic mice
    • Doi, C. et al. Angiotensin II type 2 receptor signalingsignificantly attenuates growth of murine pancreaticcarcinoma grafts in syngeneic mice. BMC Cancer 10,67 (2010).
    • (2010) BMC Cancer , vol.10 , Issue.67
    • Doi, C.1
  • 61
    • 85047693609 scopus 로고    scopus 로고
    • Role of host angiotensin II type 1receptor in tumor angiogenesis and growth
    • Egami, K. et al. Role of host angiotensin II type 1receptor in tumor angiogenesis and growth. J. Clin. Invest. 112, 67-75 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 67-75
    • Egami, K.1
  • 62
    • 13844255555 scopus 로고    scopus 로고
    • Angiotensin type 1a receptorsignaling-dependent induction of vascular endothelialgrowth factor in stroma is relevant to tumorassociate dangiogenesis and tumor growth
    • Using a Agtr1a-/-mouse model, this studydemonstrated that host AT1A is required fortumour growth and angiogenesis in vivo
    • Using a Agtr1a-/-mouse model, this studydemonstrated that host AT1A is required fortumour growth and angiogenesis in vivo. Fujita, M. et al. Angiotensin type 1a receptorsignaling-dependent induction of vascular endothelialgrowth factor in stroma is relevant to tumorassociatedangiogenesis and tumor growth. Carcinogenesis 26, 271-279 (2005).
    • (2005) Carcinogenesis , vol.26 , pp. 271-279
    • Fujita, M.1
  • 63
    • 33847326965 scopus 로고    scopus 로고
    • Roles for host and tumor angiotensin IItype 1 receptor in tumor growth and tumor-associatedangiogenesis
    • Imai, N. et al. Roles for host and tumor angiotensin IItype 1 receptor in tumor growth and tumor-associatedangiogenesis. Lab. Invest. 87, 189-198 (2007).
    • (2007) Lab. Invest. , vol.87 , pp. 189-198
    • Imai, N.1
  • 64
    • 0025165779 scopus 로고
    • An insertion/deletion polymorphism inthe angiotensin I-converting enzyme gene accountingfor half the variance of serum enzyme levels
    • Rigat, B. et al. An insertion/deletion polymorphism inthe angiotensin I-converting enzyme gene accountingfor half the variance of serum enzyme levels. J. Clin. Invest. 86, 1343-1346 (1990).
    • (1990) J. Clin. Invest. , vol.86 , pp. 1343-1346
    • Rigat, B.1
  • 65
    • 0026651907 scopus 로고
    • Evidence, from combined segregationand linkage analysis, that a variant of the angiotensinI-converting enzyme (ACE) gene controls plasma ACElevels
    • Tiret, L. et al. Evidence, from combined segregationand linkage analysis, that a variant of the angiotensinI-converting enzyme (ACE) gene controls plasma ACElevels. Am. J. Hum. Genet. 51, 197-205 (1992).
    • (1992) Am. J. Hum. Genet. , vol.51 , pp. 197-205
    • Tiret, L.1
  • 66
    • 30344449782 scopus 로고    scopus 로고
    • The angiotensin I-converting enzymegene insertion/deletion polymorphism is linked toearly gastric cancer
    • Ebert, M. P. et al. The angiotensin I-converting enzymegene insertion/deletion polymorphism is linked toearly gastric cancer. Cancer Epidemiol. BiomarkersPrev. 14, 2987-2989 (2005).
    • (2005) Cancer Epidemiol. BiomarkersPrev. , vol.14 , pp. 2987-2989
    • Ebert, M.P.1
  • 67
    • 34247159209 scopus 로고    scopus 로고
    • Effects of ACE I/D polymorphism onprostate cancer risk, tumor grade and metastatis
    • Yigit, B. et al. Effects of ACE I/D polymorphism onprostate cancer risk, tumor grade and metastatis. Anticancer Res. 27, 933-936 (2007).
    • (2007) Anticancer Res. , vol.27 , pp. 933-936
    • Yigit, B.1
  • 68
    • 1542375102 scopus 로고    scopus 로고
    • Linkage of angiotensin I-convertingenzyme gene insertion/deletion polymorphism to theprogression of human prostate cancer
    • Medeiros, R. et al. Linkage of angiotensin I-convertingenzyme gene insertion/deletion polymorphism to theprogression of human prostate cancer. J. Pathol. 202,330-335 (2004).
    • (2004) J. Pathol. , vol.202 , pp. 330-335
    • Medeiros, R.1
  • 69
    • 39049128548 scopus 로고    scopus 로고
    • Renin-angiotensin systeminhibitors, angiotensin I-converting enzyme geneinsertion/deletion polymorphism, and cancer: TheRotterdam Study
    • Van der Knaap, R. et al. Renin-angiotensin systeminhibitors, angiotensin I-converting enzyme geneinsertion/deletion polymorphism, and cancer: theRotterdam Study. Cancer 112, 748-757 (2008).
    • (2008) Cancer , vol.112 , pp. 748-757
    • Van Der Knaap, R.1
  • 70
    • 37349064891 scopus 로고    scopus 로고
    • No association with risk for colorectalcancer of the insertion/deletion polymorphism whichaffects levels of angiotensin-converting enzyme
    • Nikiteas, N., Tsigris, C., Chatzitheofylaktou, A. & Yannopoulos, A. No association with risk for colorectalcancer of the insertion/deletion polymorphism whichaffects levels of angiotensin-converting enzyme. In Vivo21, 1065-1068 (2007).
    • (2007) In Vivo , vol.21 , pp. 1065-1068
    • Nikiteas, N.1    Tsigris, C.2    Chatzitheofylaktou, A.3    Yannopoulos, A.4
  • 71
    • 33750519835 scopus 로고    scopus 로고
    • Influences of chymase andangiotensin I-converting enzyme gene polymorphismson gastric cancer risks in Japan
    • Sugimoto, M. et al. Influences of chymase andangiotensin I-converting enzyme gene polymorphismson gastric cancer risks in Japan. Cancer Epidemiol. Biomarkers Prev. 15, 1929-1934 (2006).
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , pp. 1929-1934
    • Sugimoto, M.1
  • 72
    • 7444253343 scopus 로고    scopus 로고
    • Angiotensin I-convertingenzyme gene insertion/deletion polymorphism andendometrial human cancer in normotensive andhypertensive women
    • Freitas-Silva, M. et al. Angiotensin I-convertingenzyme gene insertion/deletion polymorphism andendometrial human cancer in normotensive andhypertensive women. Cancer Genet. Cytogenet. 155,42-46 (2004).
    • (2004) Cancer Genet. Cytogenet. , vol.155 , pp. 42-46
    • Freitas-Silva, M.1
  • 73
    • 33846466511 scopus 로고    scopus 로고
    • Differential rolesof angiotensinogen and angiotensin receptor type 1polymorphisms in breast cancer risk
    • Gonzalez-Zuloeta Ladd, A. M. et al. Differential rolesof angiotensinogen and angiotensin receptor type 1polymorphisms in breast cancer risk. Breast CancerRes. Treat. 101, 299-304 (2007).
    • (2007) Breast CancerRes. Treat. , vol.101 , pp. 299-304
    • Gonzalez-Zuloeta Ladd, A.M.1
  • 74
    • 45949107313 scopus 로고    scopus 로고
    • Angiotensinogen polymorphism isassociated with risk for malignancy but not for oralcancer
    • Vairaktaris, E. et al. Angiotensinogen polymorphism isassociated with risk for malignancy but not for oralcancer. Anticancer Res. 28, 1675-1679 (2008).
    • (2008) Anticancer Res. , vol.28 , pp. 1675-1679
    • Vairaktaris, E.1
  • 75
    • 13844280904 scopus 로고    scopus 로고
    • Polymorphisms in angiotensin II type 1receptor and angiotensin I-converting enzyme genesand breast cancer risk among Chinese women inSingapore
    • Koh, W. P., Yuan, J. M., Van Den Berg, D., Lee, H. P. & Yu, M. C. Polymorphisms in angiotensin II type 1receptor and angiotensin I-converting enzyme genesand breast cancer risk among Chinese women inSingapore. Carcinogenesis 26, 459-464 (2005).
    • (2005) Carcinogenesis , vol.26 , pp. 459-464
    • Koh, W.P.1    Yuan, J.M.2    Van Den Berg, D.3    Lee, H.P.4    Yu, M.C.5
  • 76
    • 42149140094 scopus 로고    scopus 로고
    • Genomic profiling of 766 cancer-relatedgenes in archived esophageal normal and carcinomatissues
    • Chen, J. et al. Genomic profiling of 766 cancer-relatedgenes in archived esophageal normal and carcinomatissues. Int. J. Cancer 122, 2249-2254 (2008).
    • (2008) Int. J. Cancer , vol.122 , pp. 2249-2254
    • Chen, J.1
  • 77
    • 38049100456 scopus 로고    scopus 로고
    • Assessing the significance ofchromosomal aberrations in cancer: Methodology andapplication to glioma
    • Beroukhim, R. et al. Assessing the significance ofchromosomal aberrations in cancer: methodology andapplication to glioma. Proc. Natl Acad. Sci. USA 104,20007-20012 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 20007-20012
    • Beroukhim, R.1
  • 78
    • 77249119762 scopus 로고    scopus 로고
    • The landscape of somatic copynumberalteration across human cancers
    • Beroukhim, R. et al. The landscape of somatic copynumberalteration across human cancers. Nature 463,899-905 (2010).
    • (2010) Nature , vol.463 , Issue.899-905
    • Beroukhim, R.1
  • 79
    • 4444304652 scopus 로고    scopus 로고
    • Angiotensin converting enzymeindependent,local angiotensin II-generation in humanpancreatic ductal cancer tissues
    • Ohta, T. et al. Angiotensin converting enzymeindependent,local angiotensin II-generation in humanpancreatic ductal cancer tissues. Int. J. Oncol. 23,593-598 (2003).
    • (2003) Int. J. Oncol. , vol.23 , pp. 593-598
    • Ohta, T.1
  • 80
    • 0035957683 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor expression in humanpancreatic cancer and growth inhibition by angiotensinII type 1 receptor antagonist
    • Fujimoto, Y., Sasaki, T., Tsuchida, A. & Chayama, K. Angiotensin II type 1 receptor expression in humanpancreatic cancer and growth inhibition by angiotensinII type 1 receptor antagonist. FEBS Lett. 495,197-200 (2001).
    • (2001) FEBS Lett. , vol.495 , pp. 197-200
    • Fujimoto, Y.1    Sasaki, T.2    Tsuchida, A.3    Chayama, K.4
  • 81
    • 0037192344 scopus 로고    scopus 로고
    • The AT1-typeangiotensin receptor in oxidative stress andatherogenesis: Part II: AT1 receptor regulation
    • Nickenig, G. & Harrison, D. G. The AT1-typeangiotensin receptor in oxidative stress andatherogenesis: part II: AT1 receptor regulation. Circulation 105, 530-536 (2002).
    • (2002) Circulation , vol.105 , pp. 530-536
    • Nickenig, G.1    Harrison, D.G.2
  • 82
    • 42649135572 scopus 로고    scopus 로고
    • Tissue-specific regulationof ACE/ACE2 and AT1/AT2 receptor gene expressionby oestrogen in apolipoprotein E/oestrogenreceptor-α knock-out mice
    • Brosnihan, K. B., Hodgin, J. B., Smithies, O.,Maeda, N. & Gallagher, P. Tissue-specific regulationof ACE/ACE2 and AT1/AT2 receptor gene expressionby oestrogen in apolipoprotein E/oestrogenreceptor-α knock-out mice. Exp. Physiol. 93,658-664 (2008).
    • (2008) Exp. Physiol. , vol.93 , pp. 658-664
    • Brosnihan, K.B.1    Hodgin, J.B.2    Smithies Maeda O, N.3    Gallagher, P.4
  • 84
    • 0033303697 scopus 로고    scopus 로고
    • Estrogen regulatesangiotensin AT1 receptor expression via cytosolicproteins that bind to the 5′ leader sequence of thereceptor mRNA
    • Krishnamurthi, K. et al. Estrogen regulatesangiotensin AT1 receptor expression via cytosolicproteins that bind to the 5′ leader sequence of thereceptor mRNA. Endocrinology 140, 5435-5438(1999).
    • (1999) Endocrinology , vol.140 , pp. 5435-5438
    • Krishnamurthi, K.1
  • 85
    • 0032499527 scopus 로고    scopus 로고
    • Estrogen modulates AT1 receptorgene expression in vitro and in vivo
    • Nickenig, G. et al. Estrogen modulates AT1 receptorgene expression in vitro and in vivo. Circulation 97,2197-2201 (1998).
    • (1998) Circulation , vol.97 , pp. 2197-2201
    • Nickenig, G.1
  • 86
    • 0037634546 scopus 로고    scopus 로고
    • Estrogen regulates adrenal angiotensinAT1 receptors by modulating AT1 receptortranslation
    • Wu, Z. et al. Estrogen regulates adrenal angiotensinAT1 receptors by modulating AT1 receptortranslation. Endocrinology 144, 3251-3261(2003).
    • (2003) Endocrinology , vol.144 , pp. 3251-3261
    • Wu, Z.1
  • 87
    • 44549086277 scopus 로고    scopus 로고
    • Potential role of renin-angiotensinsystem for tumor angiogenesis in receptor negativebreast cancer
    • Herr, D. et al. Potential role of renin-angiotensinsystem for tumor angiogenesis in receptor negativebreast cancer. Gynecol. Oncol. 109, 418-425 (2008).
    • (2008) Gynecol. Oncol. , vol.109 , pp. 418-425
    • Herr, D.1
  • 88
    • 33745637262 scopus 로고    scopus 로고
    • Nongenomic oestrogen signalling in oestrogenreceptor negative breast cancer cells: A role for theangiotensin II receptor AT1
    • Lim, K. T., Cosgrave, N., Hill, A. D. & Young, L. S. Nongenomic oestrogen signalling in oestrogenreceptor negative breast cancer cells: a role for theangiotensin II receptor AT1. Breast Cancer Res. 8,R33 (2006).
    • (2006) Breast Cancer Res. , vol.8
    • Lim, K.T.1    Cosgrave, N.2    Hill, A.D.3    Young, L.S.4
  • 89
    • 70349320158 scopus 로고    scopus 로고
    • Causes and consequences of microRNAdysregulation in cancer
    • Croce, C. M. Causes and consequences of microRNAdysregulation in cancer. Nature Rev. Genet. 10,704-714 (2009).
    • (2009) Nature Rev. Genet. , vol.10 , pp. 704-714
    • Croce, C.M.1
  • 90
    • 33745826614 scopus 로고    scopus 로고
    • MicroRNA-155regulates human angiotensin II type 1 receptorexpression in fibroblasts
    • Martin, M. M., Lee, E. J., Buckenberger, J. A.,Schmittgen, T. D. & Elton, T. S. MicroRNA-155regulates human angiotensin II type 1 receptorexpression in fibroblasts. J. Biol. Chem. 281,18277-18284 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 18277-18284
    • Martin, M.M.1    Lee, E.J.2    Buckenberger, J.A.3    Schmittgen, T.D.4    Elton, T.S.5
  • 91
    • 34547727263 scopus 로고    scopus 로고
    • Human microRNA-155 onchromosome 21 differentially interacts with itspolymorphic target in the AGTR1 3¢ untranslatedregion: A mechanism for functional single-nucleotidepolymorphisms related to phenotypes
    • Sethupathy, P. et al. Human microRNA-155 onchromosome 21 differentially interacts with itspolymorphic target in the AGTR1 3¢ untranslatedregion: a mechanism for functional single-nucleotidepolymorphisms related to phenotypes. Am. J. Hum. Genet. 81, 405-413 (2007).
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 405-413
    • Sethupathy, P.1
  • 92
    • 33646471662 scopus 로고    scopus 로고
    • Pre-B cell proliferation andlymphoblastic leukemia/high-grade lymphoma inEμ-miR155 transgenic mice
    • Costinean, S. et al. Pre-B cell proliferation andlymphoblastic leukemia/high-grade lymphoma inEμ-miR155 transgenic mice. Proc. Natl Acad. Sci. USA103, 7024-7029 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 7024-7029
    • Costinean, S.1
  • 93
    • 67650508043 scopus 로고    scopus 로고
    • Association between theangiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C)polymorphisms and breast cancer among Brazilianwomen
    • Alves Correa, S. A. et al. Association between theangiotensin-converting enzyme (insertion/deletion)and angiotensin II type 1 receptor (A1166C)polymorphisms and breast cancer among Brazilianwomen. J. Renin Angiotensin Aldosterone Syst. 10,1151-1158 (2009).
    • (2009) J. Renin Angiotensin Aldosterone Syst. , vol.10 , pp. 1151-1158
    • Alves Correa, S.A.1
  • 94
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks ofcancer
    • Hanahan, D. & Weinberg, R. A. The hallmarks ofcancer. Cell 100, 57-70 (2000).
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 95
    • 34147104450 scopus 로고    scopus 로고
    • Predictors of distant metastasis andmortality in patients with stage II colorectal cancer
    • A landmark review discussing the various hallmarksof cancer biology
    • A landmark review discussing the various hallmarksof cancer biology. Heinzerling, J. H., Anthony, T., Livingston, E. H. & Huerta, S. Predictors of distant metastasis andmortality in patients with stage II colorectal cancer. Am. Surg. 73, 230-238 (2007).
    • (2007) Am. Surg. , vol.73 , pp. 230-238
    • Heinzerling, J.H.1    Anthony, T.2    Livingston, E.H.3    Huerta, S.4
  • 96
    • 0036290279 scopus 로고    scopus 로고
    • Blockade of angiotensin AT1a receptorsignaling reduces tumor growth, angiogenesis, andmetastasis
    • Fujita, M., Hayashi, I., Yamashina, S., Itoman, M. & Majima, M. Blockade of angiotensin AT1a receptorsignaling reduces tumor growth, angiogenesis, andmetastasis. Biochem. Biophys. Res. Commun. 294,441-447 (2002).
    • (2002) Biochem. Biophys. Res. Commun. , vol.294 , pp. 441-447
    • Fujita, M.1    Hayashi, I.2    Yamashina, S.3    Itoman, M.4    Majima, M.5
  • 97
    • 0036681694 scopus 로고    scopus 로고
    • Angiotensin II type i antagonistprevents pulmonary metastasis of murine renal cancerby inhibiting tumor angiogenesis
    • Miyajima, A. et al. Angiotensin II type I antagonistprevents pulmonary metastasis of murine renal cancerby inhibiting tumor angiogenesis. Cancer Res. 62,4176-4179 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 4176-4179
    • Miyajima, A.1
  • 98
    • 53149097024 scopus 로고    scopus 로고
    • Captopril as a potential inhibitor oflung tumor growth and metastasis
    • Attoub, S. et al. Captopril as a potential inhibitor oflung tumor growth and metastasis. Ann. N. Y. Acad. Sci. 1138, 65-72 (2008).
    • (2008) Ann. N. Y. Acad. Sci. , vol.1138 , pp. 65-72
    • Attoub, S.1
  • 99
    • 33644749687 scopus 로고    scopus 로고
    • Angiotensin II augmentedmigration and invasion of choriocarcinoma cellsinvolves PI3K activation through the AT1 receptor
    • Ishimatsu, S. et al. Angiotensin II augmentedmigration and invasion of choriocarcinoma cellsinvolves PI3K activation through the AT1 receptor. Placenta 27, 587-591 (2006).
    • (2006) Placenta , vol.27 , pp. 587-591
    • Ishimatsu, S.1
  • 100
    • 42549137933 scopus 로고    scopus 로고
    • Expression of the local angiotensin II systemin gastric cancer may facilitate lymphatic invasion andnodal spread
    • Carl-McGrath, S., Ebert, M. P., Lendeckel, U. & Rocken, C. Expression of the local angiotensin II systemin gastric cancer may facilitate lymphatic invasion andnodal spread. Cancer Biol. Ther. 6 1229-1237 (2007).
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 1229-1237
    • Carl-Mcgrath, S.1    Ebert, M.P.2    Lendeckel, U.3    Rocken, C.4
  • 102
    • 33745539230 scopus 로고    scopus 로고
    • The role of angiotensin II in theregulation of breast cancer cell adhesion and invasion
    • Puddefoot, J. R., Udeozo, U. K., Barker, S. & Vinson, G. P. The role of angiotensin II in theregulation of breast cancer cell adhesion and invasion. Endocr. Relat. Cancer 13, 895-903 (2006).
    • (2006) Endocr. Relat. Cancer , vol.13 , pp. 895-903
    • Puddefoot, J.R.1    Udeozo, U.K.2    Barker, S.3    Vinson, G.P.4
  • 103
    • 17644394616 scopus 로고    scopus 로고
    • Smolderingand polarized inflammation in the initiation andpromotion of malignant disease
    • Balkwill, F., Charles, K. A. & Mantovani, A. Smolderingand polarized inflammation in the initiation andpromotion of malignant disease. Cancer Cell 7,211-217 (2005).
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 105
    • 51849135397 scopus 로고    scopus 로고
    • The renin-angiotensin system and malignancy
    • Ager, E. I., Neo, J. & Christophi, C. The renin-angiotensin system and malignancy. Carcinogenesis29, 1675-1684 (2008).
    • (2008) Carcinogenesis , vol.29 , pp. 1675-1684
    • Ager, E.I.1    Neo, J.2    Christophi, C.3
  • 106
    • 23944434473 scopus 로고    scopus 로고
    • Angiotensin receptors: Anew role in cancer?
    • Deshayes, F. & Nahmias, C. Angiotensin receptors: anew role in cancer? Trends Endocrinol. Metab. 16,293-299 (2005).
    • (2005) Trends Endocrinol Metab. , vol.16 , pp. 293-299
    • Deshayes, F.1    Nahmias, C.2
  • 107
    • 15444365932 scopus 로고    scopus 로고
    • Cancer inflammation andthe AT1 and AT2 receptors
    • Smith, G. R. & Missailidis, S. Cancer, inflammation andthe AT1 and AT2 receptors. J. Inflamm. (Lond.) 1, 3(2004).
    • (2004) J. Inflamm. (Lond.) , vol.1 , pp. 3
    • Smith, G.R.1    Missailidis, S.2
  • 109
    • 0030022427 scopus 로고    scopus 로고
    • Comparative studiesof the angiogenic activity of vasoactive intestinalpeptide, endothelins-1 and-3 and angiotensin II in arat sponge model
    • Hu, D. E., Hiley, C. R. & Fan, T. P. Comparative studiesof the angiogenic activity of vasoactive intestinalpeptide, endothelins-1 and-3 and angiotensin II in arat sponge model. Br. J. Pharmacol. 117, 545-551(1996).
    • (1996) Br. J. Pharmacol. , vol.117 , pp. 545-551
    • Hu, D.E.1    Hiley, C.R.2    Fan, T.P.3
  • 111
    • 0027537010 scopus 로고
    • Evidence for a novel angiotensin IIreceptor involved in angiogenesis in chick embryochorioallantoic membrane
    • Le Noble, F. A. et al. Evidence for a novel angiotensin IIreceptor involved in angiogenesis in chick embryochorioallantoic membrane. Am. J. Physiol. 264,R460-R465 (1993).
    • (1993) Am. J. Physiol. , vol.264
    • Le Noble, F.A.1
  • 112
    • 0030997520 scopus 로고    scopus 로고
    • Sequential development ofangiotensin receptors and angiotensin i convertingenzyme during angiogenesis in the rat subcutaneoussponge granuloma
    • Walsh, D. A. et al. Sequential development ofangiotensin receptors and angiotensin I convertingenzyme during angiogenesis in the rat subcutaneoussponge granuloma. Br. J. Pharmacol. 120,1302-1311 (1997).
    • (1997) Br. J. Pharmacol. , vol.120 , pp. 1302-1311
    • Walsh, D.A.1
  • 113
    • 0029019246 scopus 로고
    • Direct stimulation of Jak/STATpathway by the angiotensin II AT1 receptor
    • Marrero, M. B. et al. Direct stimulation of Jak/STATpathway by the angiotensin II AT1 receptor. Nature375, 247-250 (1995).
    • (1995) Nature , vol.375 , pp. 247-250
    • Marrero, M.B.1
  • 114
    • 0037073695 scopus 로고    scopus 로고
    • Induction of hypoxia-inducible factor-1α bytranscriptional and translational mechanisms
    • Page, E. L., Robitaille, G. A., Pouyssegur, J. & Richard,D. E. Induction of hypoxia-inducible factor-1α bytranscriptional and translational mechanisms. J. Biol. Chem. 277, 48403-48409 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 48403-48409
    • Page, E.L.1    Robitaille, G.A.2    Pouyssegur, J.3    Richardd., E.4
  • 115
    • 0034705372 scopus 로고    scopus 로고
    • Angiotensin II activates nucleartranscription factor κb through AT1 and AT2 in vascularsmooth muscle cells: Molecular mechanisms
    • Ruiz-Ortega, M. et al. Angiotensin II activates nucleartranscription factor κB through AT1 and AT2 in vascularsmooth muscle cells: molecular mechanisms. Circ. Res.86, 1266-1272 (2000).
    • (2000) Circ. Res. , vol.86 , pp. 1266-1272
    • Ruiz-Ortega, M.1
  • 116
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxiasignalling in cancer and approaches to enforce tumourregression
    • Pouyssegur, J., Dayan, F. & Mazure, N. M. Hypoxiasignalling in cancer and approaches to enforce tumourregression. Nature 441, 437-443 (2006).
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 117
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-κB in cancer developmentand progression
    • Karin, M. Nuclear factor-κB in cancer developmentand progression. Nature 441, 431-436 (2006).
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 118
    • 21344435775 scopus 로고    scopus 로고
    • Mechanisms ofdisease: Insights into the emerging role of signaltransducers and activators of transcription in cancer
    • Haura, E. B., Turkson, J. & Jove, R. Mechanisms ofdisease: insights into the emerging role of signaltransducers and activators of transcription in cancer. Nature Clin. Pract. Oncol. 2, 315-324 (2005).
    • (2005) Nature Clin. Pract. Oncol. , vol.2 , pp. 315-324
    • Haura, E.B.1    Turkson, J.2    Jove, R.3
  • 119
    • 34247511935 scopus 로고    scopus 로고
    • Antihypertensives as novelantineoplastics: Angiotensin-I-converting enzymeinhibitors and angiotensin II type 1 receptor blockersin pancreatic ductal adenocarcinoma
    • Arafat, H. A. et al. Antihypertensives as novelantineoplastics: angiotensin-I-converting enzymeinhibitors and angiotensin II type 1 receptor blockersin pancreatic ductal adenocarcinoma. J. Am. Coll. Surg. 204, 996-1006 (2007).
    • (2007) J. Am. Coll. Surg. , vol.204 , pp. 996-1006
    • Arafat, H.A.1
  • 120
    • 71149097464 scopus 로고    scopus 로고
    • Angiotensin II regulates the expressionof monocyte chemoattractant protein-1 in pancreaticcancer cells
    • Chehl, N. et al. Angiotensin II regulates the expressionof monocyte chemoattractant protein-1 in pancreaticcancer cells. J. Gastrointest. Surg. 13, 2189-2200(2009).
    • (2009) J. Gastrointest. Surg. , vol.13 , pp. 2189-2200
    • Chehl, N.1
  • 121
    • 73449142487 scopus 로고    scopus 로고
    • Ets-1 and hypoxia inducible factor-1αinhibition by angiotensin II type-1 receptor blockade inhormone-refractory prostate cancer
    • Kosaka, T. et al. Ets-1 and hypoxia inducible factor-1αinhibition by angiotensin II type-1 receptor blockade inhormone-refractory prostate cancer. Prostate 70,162-169 (2010).
    • (2010) Prostate , vol.70 , pp. 162-169
    • Kosaka, T.1
  • 122
    • 33646739082 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor antagonistcandesartan as an angiogenic inhibitor in a xenograftmodel of bladder cancer
    • Kosugi, M., Miyajima, A., Kikuchi, E., Horiguchi, Y. & Murai, M. Angiotensin II type 1 receptor antagonistcandesartan as an angiogenic inhibitor in a xenograftmodel of bladder cancer. Clin. Cancer Res. 12,2888-2893 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , pp. 2888-2893
    • Kosugi, M.1    Miyajima, A.2    Kikuchi, E.3    Horiguchi, Y.4    Murai, M.5
  • 123
    • 0348019097 scopus 로고    scopus 로고
    • Adipocyte-derived leucineaminopeptidase suppresses angiogenesis in humanendometrial carcinoma via renin-angiotensin system
    • Watanabe, Y. et al. Adipocyte-derived leucineaminopeptidase suppresses angiogenesis in humanendometrial carcinoma via renin-angiotensin system. Clin. Cancer Res. 9, 6497-6503 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 6497-6503
    • Watanabe, Y.1
  • 124
    • 1942520986 scopus 로고    scopus 로고
    • Renin andangiotensinogen expression and functions in growthand apoptosis of human glioblastoma
    • Juillerat-Jeanneret, L. et al. Renin andangiotensinogen expression and functions in growthand apoptosis of human glioblastoma. Br. J. Cancer90, 1059-1068 (2004).
    • (2004) Br. J. Cancer , vol.90 , pp. 1059-1068
    • Juillerat-Jeanneret, L.1
  • 125
    • 28044466650 scopus 로고    scopus 로고
    • Antiproliferative activity ofangiotensin II receptor blocker through cross-talkbetween stromal and epithelial prostate cancer cells
    • Uemura, H. et al. Antiproliferative activity ofangiotensin II receptor blocker through cross-talkbetween stromal and epithelial prostate cancer cells. Mol. Cancer Ther. 4, 1699-1709 (2005).
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1699-1709
    • Uemura, H.1
  • 126
    • 33947199851 scopus 로고    scopus 로고
    • Effect of ACE inhibitors andangiotensin II receptor antagonists in a mouse modelof colorectal cancer liver metastases
    • Neo, J. H., Malcontenti-Wilson, C., Muralidharan, V. & Christophi, C. Effect of ACE inhibitors andangiotensin II receptor antagonists in a mouse modelof colorectal cancer liver metastases. J. Gastroenterol. Hepatol. 22, 577-584 (2007).
    • (2007) J. Gastroenterol. Hepatol. , vol.22 , pp. 577-584
    • Neo, J.H.1    Malcontenti-Wilson, C.2    Muralidharan, V.3    Christophi, C.4
  • 127
    • 38349006745 scopus 로고    scopus 로고
    • Angiotensin II inducesvascular endothelial growth factor in pancreatic cancercells through an angiotensin II type 1 receptor andERK1/2 signaling
    • Anandanadesan, R. et al. Angiotensin II inducesvascular endothelial growth factor in pancreatic cancercells through an angiotensin II type 1 receptor andERK1/2 signaling. J. Gastrointest. Surg. 12, 57-66(2008).
    • (2008) J. Gastrointest. Surg. , vol.12 , pp. 57-66
    • Anandanadesan, R.1
  • 128
    • 41949114891 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptorantagonist suppress angiogenesis and growth ofgastric cancer xenografts
    • Huang, W. et al. Angiotensin II type 1 receptorantagonist suppress angiogenesis and growth ofgastric cancer xenografts. Dig. Dis. Sci. 53,1206-1210 (2008).
    • (2008) Dig. Dis. Sci. , vol.53 , pp. 1206-1210
    • Huang, W.1
  • 129
    • 33845777021 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptorantagonist as an angiogenic inhibitor in prostatecancer
    • Kosaka, T. et al. Angiotensin II type 1 receptorantagonist as an angiogenic inhibitor in prostatecancer. Prostate 67, 41-49 (2007).
    • (2007) Prostate , vol.67 , pp. 41-49
    • Kosaka, T.1
  • 130
    • 68349096413 scopus 로고    scopus 로고
    • Synergistic inhibitory effect ofgemcitabine and angiotensin type-1 receptor blocker,losartan, on murine pancreatic tumor growth via antiangiogenicactivities
    • Noguchi, R. et al. Synergistic inhibitory effect ofgemcitabine and angiotensin type-1 receptor blocker,losartan, on murine pancreatic tumor growth via antiangiogenicactivities. Oncol. Rep. 22, 355-360(2009).
    • (2009) Oncol. Rep. , vol.22 , pp. 355-360
    • Noguchi, R.1
  • 131
    • 58149355795 scopus 로고    scopus 로고
    • Effects of angiotensin-convertingenzyme inhibitors and angiotensin II type 1 receptorblockers on lymphangiogenesis of gastric cancer in anude mouse model
    • Wang, L. et al. Effects of angiotensin-convertingenzyme inhibitors and angiotensin II type 1 receptorblockers on lymphangiogenesis of gastric cancer in anude mouse model. Chin. Med. J. 121, 2167-2171(2008).
    • (2008) Chin. Med. J. , vol.121 , pp. 2167-2171
    • Wang, L.1
  • 132
    • 0034907881 scopus 로고    scopus 로고
    • The angiotensin-I-converting enzymeinhibitor perindopril suppresses tumor growth andangiogenesis: Possible role of the vascular endothelialgrowth factor
    • Yoshiji, H. et al. The angiotensin-I-converting enzymeinhibitor perindopril suppresses tumor growth andangiogenesis: possible role of the vascular endothelialgrowth factor. Clin. Cancer Res. 7, 1073-1078(2001).
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1073-1078
    • Yoshiji, H.1
  • 133
    • 77954624561 scopus 로고    scopus 로고
    • Deficiency or blockade of angiotensin IItype 2 receptor delays tumorigenesis by inhibitingmalignant cell proliferation and angiogenesis
    • Clere, N. et al. Deficiency or blockade of angiotensin IItype 2 receptor delays tumorigenesis by inhibitingmalignant cell proliferation and angiogenesis. Int. J. Cancer 127, 2279-2291 (2010).
    • (2010) Int. J. Cancer , vol.127 , Issue.2279-2291
    • Clere, N.1
  • 134
    • 0022536710 scopus 로고
    • Isolation and characterization of a newcellular oncogene encoding a protein with multiplepotential transmembrane domains
    • Young, D., Waitches, G., Birchmeier, C., Fasano, O. & Wigler, M. Isolation and characterization of a newcellular oncogene encoding a protein with multiplepotential transmembrane domains. Cell 45, 711-719(1986).
    • (1986) Cell , vol.45 , pp. 711-719
    • Young, D.1    Waitches, G.2    Birchmeier, C.3    Fasano, O.4    Wigler, M.5
  • 135
    • 8844265279 scopus 로고    scopus 로고
    • Inhibition of humanlung cancer cell growth by angiotensin-(1-7)
    • Gallagher, P. E. & Tallant, E. A. Inhibition of humanlung cancer cell growth by angiotensin-(1-7).Carcinogenesis 25, 2045-2052 (2004).
    • (2004) Carcinogenesis , vol.25 , pp. 2045-2052
    • Gallagher, P.E.1    Tallant, E.A.2
  • 136
    • 67649366366 scopus 로고    scopus 로고
    • Angiotensin-(1-7) inhibits tumorangiogenesis in human lung cancer xenografts with areduction in vascular endothelial growth factor
    • Soto-Pantoja, D. R., Menon, J., Gallagher, P. E. & Tallant, E. A. Angiotensin-(1-7) inhibits tumorangiogenesis in human lung cancer xenografts with areduction in vascular endothelial growth factor. Mol. Cancer Ther. 8, 1676-1683 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 1676-1683
    • Soto-Pantoja, D.R.1    Menon, J.2    Gallagher, P.E.3    Tallant, E.A.4
  • 137
    • 34047256118 scopus 로고    scopus 로고
    • Angiotensin-(1-7) inhibits growth ofhuman lung adenocarcinoma xenografts in nude micethrough a reduction in cyclooxygenase-2
    • Menon, J. et al. Angiotensin-(1-7) inhibits growth ofhuman lung adenocarcinoma xenografts in nude micethrough a reduction in cyclooxygenase-2. Cancer Res.67, 2809-2815 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 2809-2815
    • Menon, J.1
  • 138
    • 0037652234 scopus 로고    scopus 로고
    • Immunohistochemical expression of cyclooxygenaseisoenzymes and downstream enzymes in human lungtumors
    • Ermert, L., Dierkes, C. & Ermert, M. Immunohistochemical expression of cyclooxygenaseisoenzymes and downstream enzymes in human lungtumors. Clin. Cancer Res. 9, 1604-1610 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1604-1610
    • Ermert, L.1    Dierkes, C.2    Ermert, M.3
  • 139
    • 0032521401 scopus 로고    scopus 로고
    • Non-small cell lung cancercyclooxygenase-2-dependent regulation of cytokinebalance in lymphocytes and macrophages:up-regulation of interleukin 10 and down-regulation ofinterleukin 12 production
    • Huang, M. et al. Non-small cell lung cancercyclooxygenase-2-dependent regulation of cytokinebalance in lymphocytes and macrophages:up-regulation of interleukin 10 and down-regulation ofinterleukin 12 production. Cancer Res. 58,1208-1216 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 1208-1216
    • Huang, M.1
  • 140
    • 62949101948 scopus 로고    scopus 로고
    • NADPH oxidasesand angiotensin II receptor signaling
    • Garrido, A. M. & Griendling, K. K. NADPH oxidasesand angiotensin II receptor signaling. Mol. Cell. Endocrinol. 302, 148-158 (2009).
    • (2009) Mol. Cell. Endocrinol. , vol.302 , pp. 148-158
    • Garrido, A.M.1    Griendling, K.K.2
  • 141
    • 2642551439 scopus 로고    scopus 로고
    • Angiotensin II and endothelin-1 regulate MAP kinasesthrough different redox-dependent mechanisms inhuman vascular smooth muscle cells
    • Touyz, R. M., Yao, G., Viel, E., Amiri, F. & Schiffrin, E. L. Angiotensin II and endothelin-1 regulate MAP kinasesthrough different redox-dependent mechanisms inhuman vascular smooth muscle cells. J. Hypertens.22, 1141-1149 (2004).
    • (2004) J. Hypertens , vol.22 , pp. 1141-1149
    • Touyz, R.M.1    Yao, G.2    Viel, E.3    Amiri, F.4    Schiffrin, E.L.5
  • 142
    • 3242677091 scopus 로고    scopus 로고
    • Role of p38 MAPK andMAPKAPK-2 in angiotensin II-induced Akt activationin vascular smooth muscle cells
    • Taniyama, Y. et al. Role of p38 MAPK andMAPKAPK-2 in angiotensin II-induced Akt activationin vascular smooth muscle cells. Am. J. Physiol. CellPhysiol. 287, C494-C499 (2004).
    • (2004) Am. J. Physiol. CellPhysiol. , vol.287
    • Taniyama, Y.1
  • 143
    • 0037306526 scopus 로고    scopus 로고
    • Redox-dependent MAP kinasesignaling by Ang II in vascular smooth muscle cells:role of receptor tyrosine kinase transactivation
    • Touyz, R. M. et al. Redox-dependent MAP kinasesignaling by Ang II in vascular smooth muscle cells:role of receptor tyrosine kinase transactivation. Can. J. Physiol. Pharmacol. 81, 159-167 (2003).
    • (2003) Can. J. Physiol. Pharmacol. , vol.81 , pp. 159-167
    • Touyz, R.M.1
  • 144
    • 0033529675 scopus 로고    scopus 로고
    • Reactive oxygen speciesmediate the activation of Akt/protein kinase B byangiotensin II in vascular smooth muscle cells
    • Ushio-Fukai, M. et al. Reactive oxygen speciesmediate the activation of Akt/protein kinase B byangiotensin II in vascular smooth muscle cells. J. Biol. Chem. 274, 22699-22704 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 22699-22704
    • Ushio-Fukai, M.1
  • 145
    • 33847349283 scopus 로고    scopus 로고
    • Reactive oxygenspecies: A breath of life or death?
    • Fruehauf, J. P. & Meyskens, F. L. Reactive oxygenspecies: a breath of life or death? Clin. Cancer Res.13, 789-794 (2007).
    • (2007) Clin Cancer Res , vol.13 , pp. 789-794
    • Fruehauf, J.P.1    Meyskens, F.L.2
  • 146
    • 0031015288 scopus 로고    scopus 로고
    • P22phox mRNA expression andNADPH oxidase activity are increased in aortas fromhypertensive rats
    • Fukui, T. et al. p22phox mRNA expression andNADPH oxidase activity are increased in aortas fromhypertensive rats. Circ. Res. 80, 45-51 (1997).
    • (1997) Circ. Res. , vol.80 , pp. 45-51
    • Fukui, T.1
  • 147
    • 0036792751 scopus 로고    scopus 로고
    • Role of p47phox in vascularoxidative stress and hypertension caused byangiotensin II
    • Landmesser, U. et al. Role of p47phox in vascularoxidative stress and hypertension caused byangiotensin II. Hypertension 40, 511-515 (2002).
    • (2002) Hypertension , vol.40 , pp. 511-515
    • Landmesser, U.1
  • 148
    • 0030005713 scopus 로고    scopus 로고
    • Angiotensin II-mediatedhypertension in the rat increases vascular superoxideproduction via membrane NADH/NADPH oxidaseactivation. Contribution to alterations of vasomotortone
    • Rajagopalan, S. et al. Angiotensin II-mediatedhypertension in the rat increases vascular superoxideproduction via membrane NADH/NADPH oxidaseactivation. Contribution to alterations of vasomotortone. J. Clin. Invest. 97, 1916-1923 (1996).
    • (1996) J. Clin. Invest. , vol.97 , pp. 1916-1923
    • Rajagopalan, S.1
  • 149
    • 1642276271 scopus 로고    scopus 로고
    • Role of NAD(P)H oxidase on vascularalterations in angiotensin II-infused mice
    • Virdis, A., Neves, M. F., Amiri, F., Touyz, R. M. & Schiffrin, E. L. Role of NAD(P)H oxidase on vascularalterations in angiotensin II-infused mice. J. Hypertens.22, 535-542 (2004).
    • (2004) J. Hypertens , vol.22 , pp. 535-542
    • Virdis, A.1    Neves, M.F.2    Amiri, F.3    Touyz, R.M.4    Schiffrin, E.L.5
  • 150
    • 40349103654 scopus 로고    scopus 로고
    • Angiotensin II induces oxidativestress in prostate cancer
    • Uemura, H. et al. Angiotensin II induces oxidativestress in prostate cancer. Mol. Cancer Res. 6,250-258 (2008).
    • (2008) Mol. Cancer Res. , vol.6 , pp. 250-258
    • Uemura, H.1
  • 151
    • 0036175320 scopus 로고    scopus 로고
    • Angiotensinogen and its cleaved derivativesinhibit angiogenesis
    • Celerier, J., Cruz, A., Lamande, N., Gasc, J. M. & Corvol, P. Angiotensinogen and its cleaved derivativesinhibit angiogenesis. Hypertension 39, 224-228(2002).
    • (2002) Hypertension , vol.39 , pp. 224-228
    • Celerier, J.1    Cruz, A.2    Lamande, N.3    Gasc, J.M.4    Corvol, P.5
  • 152
    • 33745399035 scopus 로고    scopus 로고
    • Suppression of angiogenesis, tumorgrowth, and metastasis by adenovirus-mediated genetransfer of human angiotensinogen
    • Bouquet, C. et al. Suppression of angiogenesis, tumorgrowth, and metastasis by adenovirus-mediated genetransfer of human angiotensinogen. Mol. Ther. 14,175-182 (2006).
    • (2006) Mol. Ther. , vol.14 , pp. 175-182
    • Bouquet, C.1
  • 153
    • 66149133341 scopus 로고    scopus 로고
    • Angiotensinogen delays angiogenesisand tumor growth of hepatocarcinoma in transgenicmice
    • Vincent, F. et al. Angiotensinogen delays angiogenesisand tumor growth of hepatocarcinoma in transgenicmice. Cancer Res. 69, 2853-2860 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 2853-2860
    • Vincent, F.1
  • 154
    • 0034044261 scopus 로고    scopus 로고
    • Captopril inhibits in vitro and in vivothe proliferation of primitive haematopoietic cellsinduced into cell cycle by cytotoxic drug administrationor irradiation but has no effect on myeloid leukaemiacell proliferation
    • Chisi, J. E. et al. Captopril inhibits in vitro and in vivothe proliferation of primitive haematopoietic cellsinduced into cell cycle by cytotoxic drug administrationor irradiation but has no effect on myeloid leukaemiacell proliferation. Br. J. Haematol. 109, 563-570(2000).
    • (2000) Br. J. Haematol. , vol.109 , pp. 563-570
    • Chisi, J.E.1
  • 155
    • 63349098669 scopus 로고    scopus 로고
    • Induction of apoptosis inleukemic cell lines treated with captopril, trandolapriland losartan: A new role in the treatment of leukaemiafor these agents
    • De la Iglesia Iñigo, S. et al. Induction of apoptosis inleukemic cell lines treated with captopril, trandolapriland losartan: a new role in the treatment of leukaemiafor these agents. Leuk. Res. 33, 810-816 (2009).
    • (2009) Leuk. Res. , vol.33 , pp. 810-816
    • De La Iglesia Iñigo, S.1
  • 156
    • 0031937612 scopus 로고    scopus 로고
    • Captopril inhibits tumour growth in axenograft model of human renal cell carcinoma
    • Hii, S. I. et al. Captopril inhibits tumour growth in axenograft model of human renal cell carcinoma. Br. J. Cancer 77, 880-883 (1998).
    • (1998) Br. J. Cancer , vol.77 , pp. 880-883
    • Hii, S.I.1
  • 157
    • 40349106045 scopus 로고    scopus 로고
    • Dual repressive effect of angiotensinII-type 1 receptor blocker telmisartan on angiotensinII-induced and estradiol-induced uterine leiomyomacell proliferation
    • Isobe, A. et al. Dual repressive effect of angiotensinII-type 1 receptor blocker telmisartan on angiotensinII-induced and estradiol-induced uterine leiomyomacell proliferation. Hum. Reprod. 23, 440-446 (2008).
    • (2008) Hum. Reprod. , vol.23 , pp. 440-446
    • Isobe, A.1
  • 158
    • 0036098932 scopus 로고    scopus 로고
    • Angiotensin II stimulation of Na+/K+ATPase activity and cell growth by calciumindependentpathway in MCF-7 breast cancer cells
    • Muscella, A., Greco, S., Elia, M. G., Storelli, C. & Marsigliante, S. Angiotensin II stimulation of Na+/K+ATPase activity and cell growth by calciumindependentpathway in MCF-7 breast cancer cells. J. Endocrinol. 173, 315-323 (2002).
    • (2002) J. Endocrinol. , vol.173 , pp. 315-323
    • Muscella, A.1    Greco, S.2    Elia, M.G.3    Storelli, C.4    Marsigliante, S.5
  • 159
    • 0141483551 scopus 로고    scopus 로고
    • PKC-zeta is required for angiotensinII-induced activation of ERK and synthesis of C-FOS inMCF-7 cells
    • Muscella, A., Greco, S., Elia, M. G., Storelli, C. & Marsigliante, S. PKC-zeta is required for angiotensinII-induced activation of ERK and synthesis of C-FOS inMCF-7 cells. J. Cell Physiol. 197, 61-68 (2003).
    • (2003) J. Cell Physiol. , vol.197 , pp. 61-68
    • Muscella, A.1    Greco, S.2    Elia, M.G.3    Storelli, C.4    Marsigliante, S.5
  • 160
    • 0037784053 scopus 로고    scopus 로고
    • Angiotensin II activates extracellularsignal regulated kinases via protein kinase C andepidermal growth factor receptor in breast cancercells
    • Greco, S. et al. Angiotensin II activates extracellularsignal regulated kinases via protein kinase C andepidermal growth factor receptor in breast cancercells. J. Cell. Physiol. 196, 370-377 (2003).
    • (2003) J. Cell. Physiol. , vol.196 , pp. 370-377
    • Greco, S.1
  • 161
    • 43049085545 scopus 로고    scopus 로고
    • Angiotensin II and epidermal growthfactor receptor cross-talk mediated by a disintegrinand metalloprotease accelerates tumor cellproliferation of hepatocellular carcinoma cell lines
    • Itabashi, H. et al. Angiotensin II and epidermal growthfactor receptor cross-talk mediated by a disintegrinand metalloprotease accelerates tumor cellproliferation of hepatocellular carcinoma cell lines. Hepatol. Res. 38, 601-613 (2008).
    • (2008) Hepatol. Res. , vol.38 , pp. 601-613
    • Itabashi, H.1
  • 162
    • 55249097976 scopus 로고    scopus 로고
    • Evaluation of role of angiotensin IIIand aminopeptidases in prostate cancer cells
    • Teranishi, J. et al. Evaluation of role of angiotensin IIIand aminopeptidases in prostate cancer cells. Prostate68, 1666-1673 (2008).
    • (2008) Prostate , vol.68 , pp. 1666-1673
    • Teranishi, J.1
  • 163
    • 3242678224 scopus 로고    scopus 로고
    • Angiotensin II receptor blockershows antiproliferative activity in prostate cancer cells: A possibility of tyrosine kinase inhibitor of growthfactor
    • Uemura, H. et al. Angiotensin II receptor blockershows antiproliferative activity in prostate cancer cells:a possibility of tyrosine kinase inhibitor of growthfactor. Mol. Cancer Ther. 2, 1139-1147 (2003).
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 1139-1147
    • Uemura, H.1
  • 164
    • 18044364823 scopus 로고    scopus 로고
    • Blockage of angiotensin II type Ireceptor decreases the synthesis of growth factors andinduces apoptosis in C6 cultured cells and C6 ratglioma
    • Arrieta, O. et al. Blockage of angiotensin II type Ireceptor decreases the synthesis of growth factors andinduces apoptosis in C6 cultured cells and C6 ratglioma. Br. J. Cancer 92, 1247-1252 (2005).
    • (2005) Br. J. Cancer , vol.92 , pp. 1247-1252
    • Arrieta, O.1
  • 165
    • 77956507930 scopus 로고    scopus 로고
    • Angiotensin II / angiotensin II type Ireceptor (AT1R) signaling promotes MCF-7 breastcancer cells survival via PI3-kinase/Akt pathway
    • Zhao, Y. et al. Angiotensin II / angiotensin II type Ireceptor (AT1R) signaling promotes MCF-7 breastcancer cells survival via PI3-kinase/Akt pathway. J. Cell. Physiol. (2010).
    • (2010) J. Cell. Physiol.
    • Zhao, Y.1
  • 166
    • 66949178060 scopus 로고    scopus 로고
    • Decreased expression of angiotensinconvertingenzyme 2 in pancreatic ductaladenocarcinoma is associated with tumor progression
    • Zhou, L. et al. Decreased expression of angiotensinconvertingenzyme 2 in pancreatic ductaladenocarcinoma is associated with tumor progression. Tohoku J. Exp. Med. 217, 123-131 (2009).
    • (2009) Tohoku J. Exp. Med. , vol.217 , pp. 123-131
    • Zhou, L.1
  • 167
    • 42449131721 scopus 로고    scopus 로고
    • Angiotensin II suppresses adriamycininducedapoptosis through activation ofphosphatidylinositol 3-kinase/Akt signaling in humanbreast cancer cells
    • Zhao, Y. et al. Angiotensin II suppresses adriamycininducedapoptosis through activation ofphosphatidylinositol 3-kinase/Akt signaling in humanbreast cancer cells. Acta Biochim. Biophys. Sin.(Shanghai) 40, 304-310 (2008).
    • (2008) Acta Biochim. Biophys. Sin.(Shanghai) , vol.40 , pp. 304-310
    • Zhao, Y.1
  • 169
    • 0036082606 scopus 로고    scopus 로고
    • Angiotensin receptor subtype AT1 mediates alveolarepithelial cell apoptosis in response to ANG II
    • Papp, M., Li, X., Zhuang, J., Wang, R. & Uhal, B. D. Angiotensin receptor subtype AT1 mediates alveolarepithelial cell apoptosis in response to ANG II. Am. J. Physiol. Lung Cell. Mol. Physiol. 282, L713-L718(2002).
    • (2002) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.282
    • Papp, M.1    Li, X.2    Zhuang, J.3    Wang, R.4    Uhal, B.D.5
  • 170
    • 0033795370 scopus 로고    scopus 로고
    • Apoptosis of lung epithelial cells inresponse to TNF-α requires angiotensin II generationde novo
    • Wang, R. et al. Apoptosis of lung epithelial cells inresponse to TNF-α requires angiotensin II generationde novo. J. Cell. Physiol. 185, 253-259 (2000).
    • (2000) J. Cell. Physiol. , vol.185 , pp. 253-259
    • Wang, R.1
  • 171
    • 73149106602 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor-mediatedapoptosis of human prostate cancer cells
    • Li, H. et al. Angiotensin type 2 receptor-mediatedapoptosis of human prostate cancer cells. Mol. CancerTher. 8, 3255-3265 (2009).
    • (2009) Mol. CancerTher. , vol.8 , pp. 3255-3265
    • Li, H.1
  • 172
    • 77953556670 scopus 로고    scopus 로고
    • Overexpression of angiotensin II type 2receptor gene induces cell death in lung adenocarcinomacells
    • Pickel, L. et al. Overexpression of angiotensin II type 2receptor gene induces cell death in lung adenocarcinomacells. Cancer Biol. Ther. 9, 277-285 (2010).
    • (2010) Cancer Biol. Ther. , vol.9 , Issue.277-285
    • Pickel, L.1
  • 173
    • 77950637731 scopus 로고    scopus 로고
    • Changes in the renin angiotensinsystem during the development of colorectal cancerliver metastases
    • Neo, J. H. et al. Changes in the renin angiotensinsystem during the development of colorectal cancerliver metastases. BMC Cancer 10, 134 (2010).
    • (2010) BMC Cancer , vol.10 , Issue.134
    • Neo, J.H.1
  • 174
    • 77951891161 scopus 로고    scopus 로고
    • Inhibition of angiotensin IIreceptor 1 limits tumor-associated angiogenesis andattenuates growth of murine melanoma
    • Otake, A. H. et al. Inhibition of angiotensin IIreceptor 1 limits tumor-associated angiogenesis andattenuates growth of murine melanoma. CancerChemother. Pharmacol. 66, 79-87 (2010).
    • (2010) Cancer Chemother. Pharmacol. , vol.66 , pp. 79-87
    • Otake, A.H.1
  • 175
    • 0035798467 scopus 로고    scopus 로고
    • AT1 receptor is present in glioma cells; Itsblockage reduces the growth of rat glioma
    • Rivera, E., Arrieta, O., Guevara, P., Duarte-Rojo, A. & Sotelo, J. AT1 receptor is present in glioma cells; itsblockage reduces the growth of rat glioma. Br. J. Cancer 85, 1396-1399 (2001).
    • (2001) Br. J. Cancer , vol.85 , pp. 1396-1399
    • Rivera, E.1    Arrieta, O.2    Guevara, P.3    Duarte-Rojo, A.4    Sotelo, J.5
  • 176
    • 0029916051 scopus 로고    scopus 로고
    • Captopril inhibits angiogenesis andslows the growth of experimental tumors in rats
    • Volpert, O. V. et al. Captopril inhibits angiogenesis andslows the growth of experimental tumors in rats. J. Clin. Invest. 98, 671-679 (1996).
    • (1996) J. Clin. Invest. , vol.98 , pp. 671-679
    • Volpert, O.V.1
  • 177
    • 29244485406 scopus 로고    scopus 로고
    • Pilot study of angiotensin II receptorblocker in advanced hormone-refractory prostatecancer
    • Uemura, H. et al. Pilot study of angiotensin II receptorblocker in advanced hormone-refractory prostatecancer. Int. J. Clin. Oncol. 10, 405-410 (2005).
    • (2005) Int. J. Clin. Oncol. , vol.10 , pp. 405-410
    • Uemura, H.1
  • 178
    • 73149102795 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic studyof angiotensin-(1-7), an endogenous antiangiogenichormone
    • Petty, W. J. et al. Phase I and pharmacokinetic studyof angiotensin-(1-7), an endogenous antiangiogenichormone. Clin. Cancer Res. 15, 7398-7404 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7398-7404
    • Petty, W.J.1
  • 179
    • 0029974215 scopus 로고    scopus 로고
    • Effects of captopril related toincreased levels of prostacyclin and angiotensin-(1-7)in essential hypertension
    • Luque, M. et al. Effects of captopril related toincreased levels of prostacyclin and angiotensin-(1-7)in essential hypertension. J. Hypertens. 14, 799-805(1996).
    • (1996) J. Hypertens. , vol.14 , pp. 799-805
    • Luque, M.1
  • 180
    • 77952659304 scopus 로고    scopus 로고
    • Keratinocyte cancer preventionwith ACE inhibitors, angiotensin receptor blockers ortheir combination in renal transplant recipients
    • Moscarelli, L. et al. Keratinocyte cancer preventionwith ACE inhibitors, angiotensin receptor blockers ortheir combination in renal transplant recipients. Clin. Nephrol. 73, 439-445 (2010).
    • (2010) Clin. Nephrol. , vol.73 , Issue.439-445
    • Moscarelli, L.1
  • 181
    • 33745380780 scopus 로고    scopus 로고
    • A cohort study of antihypertensivemedication use and breast cancer among Danishwomen
    • Fryzek, J. P. et al. A cohort study of antihypertensivemedication use and breast cancer among Danishwomen. Breast Cancer Res. Treat. 97, 231-236(2006).
    • (2006) Breast Cancer Res. Treat. , vol.97 , pp. 231-236
    • Fryzek, J.P.1
  • 182
    • 0141563692 scopus 로고    scopus 로고
    • Relation between use of antihypertensivemedications and risk of breast carcinoma amongwomen ages 65-79 years
    • Li, C. I. et al. Relation between use of antihypertensivemedications and risk of breast carcinoma amongwomen ages 65-79 years. Cancer 98, 1504-1513(2003).
    • (2003) Cancer , vol.98 , pp. 1504-1513
    • Li, C.I.1
  • 183
    • 0034645944 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors, calciumchannel blockers, and breast cancer
    • Meier, C. R., Derby, L. E., Jick, S. S. & Jick, H. Angiotensin-converting enzyme inhibitors, calciumchannel blockers, and breast cancer. Arch. Intern. Med. 160, 349-353 (2000).
    • (2000) Arch. Intern. Med. , vol.160 , pp. 349-353
    • Meier, C.R.1    Derby, L.E.2    Jick, S.S.3    Jick, H.4
  • 185
    • 77954030665 scopus 로고    scopus 로고
    • Angiotensin-receptor blockade and riskof cancer: μ-Analysis of randomised controlled trials
    • Sipahi, I., Debanne, S. M., Rowland, D. Y., Simon, D. I.& Fang, J. C. Angiotensin-receptor blockade and riskof cancer: μ-analysis of randomised controlled trials. Lancet Oncol. 11, 627-636 (2010).
    • (2010) Lancet Oncol. , vol.11 , pp. 627-636
    • Sipahi, I.1    Debanne, S.M.2    Rowland, D.Y.3    Simon, D.I.4    Fang, J.C.5
  • 186
    • 0032788508 scopus 로고    scopus 로고
    • Angiotensin II receptorantagonists: An emerging new class of cardiovasculartherapeutics
    • Timmermans, P. B. Angiotensin II receptorantagonists: an emerging new class of cardiovasculartherapeutics. Hypertens. Res. 22, 147-153 (1999).
    • (1999) Hypertens. Res. , vol.22 , pp. 147-153
    • Timmermans, P.B.1
  • 187
    • 47949089905 scopus 로고    scopus 로고
    • Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotesbreast carcinoma cell invasion
    • Arora, P., Cuevas, B. D., Russo, A., Johnson, G. L. & Trejo, J. Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotesbreast carcinoma cell invasion. Oncogene 27,4434-4445 (2008).
    • (2008) Oncogene , vol.27 , pp. 4434-4445
    • Arora, P.1    Cuevas, B.D.2    Russo, A.3    Johnson, G.L.4    Trejo, J.5
  • 188
    • 0038581051 scopus 로고    scopus 로고
    • TACE cleavage of proamphiregulin regulates GPCRinducedproliferation and motility of cancer cells
    • Gschwind, A., Hart, S., Fischer, O. M. & Ullrich, A. TACE cleavage of proamphiregulin regulates GPCRinducedproliferation and motility of cancer cells. EMBO J. 22, 2411-2421 (2003).
    • (2003) EMBO J. , vol.22 , pp. 2411-2421
    • Gschwind, A.1    Hart, S.2    Fischer, O.M.3    Ullrich, A.4
  • 189
    • 0036828287 scopus 로고    scopus 로고
    • Lysophosphatidic acid-induced squamous cellcarcinoma cell proliferation and motility involvesepidermal growth factor receptor signaltransactivation
    • Gschwind, A., Prenzel, N. & Ullrich, A. Lysophosphatidic acid-induced squamous cellcarcinoma cell proliferation and motility involvesepidermal growth factor receptor signaltransactivation. Cancer Res. 62, 6329-6336 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 6329-6336
    • Gschwind, A.1    Prenzel, N.2    Ullrich, A.3
  • 190
    • 0035177216 scopus 로고    scopus 로고
    • Human breast cancer cellsgenerated by oncogenic transformation of primarymammary epithelial cells
    • Elenbaas, B. et al. Human breast cancer cellsgenerated by oncogenic transformation of primarymammary epithelial cells. Genes Dev. 15, 50-65(2001).
    • (2001) Genes Dev. , vol.15 , pp. 50-65
    • Elenbaas, B.1
  • 191
    • 0037409417 scopus 로고    scopus 로고
    • Inflammation and angiotensin II
    • Suzuki, Y. et al. Inflammation and angiotensin II. Int. J. Biochem. Cell Biol. 35, 881-900 (2003).
    • (2003) Int. J. Biochem. Cell Biol. , vol.35 , pp. 881-900
    • Suzuki, Y.1
  • 192
    • 33344460242 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor expressionin ovarian cancer and its correlation with tumourangiogenesis and patient survival
    • Ino, K. et al. Angiotensin II type 1 receptor expressionin ovarian cancer and its correlation with tumourangiogenesis and patient survival. Br. J. Cancer 94,552-560 (2006).
    • (2006) Br. J. Cancer , vol.94 , pp. 552-560
    • Ino, K.1
  • 193
    • 2542441386 scopus 로고    scopus 로고
    • Activation of invasiveness of cervicalcarcinoma cells by angiotensin II
    • Kikkawa, F. et al. Activation of invasiveness of cervicalcarcinoma cells by angiotensin II. Am. J. Obstet. Gynecol. 190, 1258-1263 (2004).
    • (2004) Am. J. Obstet. Gynecol. , vol.190 , pp. 1258-1263
    • Kikkawa, F.1
  • 194
    • 0030963531 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptorexpression in human breast tissues
    • Inwang, E. R. et al. Angiotensin II type 1 receptorexpression in human breast tissues. Br. J. Cancer 75,1279-1283 (1997).
    • (1997) Br. J. Cancer , vol.75 , pp. 1279-1283
    • Inwang, E.R.1
  • 195
    • 33745552517 scopus 로고    scopus 로고
    • Localisation of renin-angiotensin system(RAS) components in breast
    • Tahmasebi, M., Barker, S., Puddefoot, J. R. & Vinson, G. P. Localisation of renin-angiotensin system(RAS) components in breast. Br. J. Cancer 95, 67-74(2006).
    • (2006) Br. J. Cancer , vol.95 , pp. 67-74
    • Tahmasebi, M.1    Barker, S.2    Puddefoot, J.R.3    Vinson, G.P.4
  • 196
    • 42949158678 scopus 로고    scopus 로고
    • Functional angiotensin II type 2receptors inhibit growth factor signaling in LNCaP andPC3 prostate cancer cell lines
    • Chow, L. et al. Functional angiotensin II type 2receptors inhibit growth factor signaling in LNCaP andPC3 prostate cancer cell lines. Prostate 68, 651-660(2008).
    • (2008) Prostate , vol.68 , pp. 651-660
    • Chow, L.1
  • 197
    • 36448944666 scopus 로고    scopus 로고
    • Appearance of angiotensin IIexpression in non-basal epithelial cells is an earlyfeature of malignant change in human prostate
    • Louis, S. N. et al. Appearance of angiotensin IIexpression in non-basal epithelial cells is an earlyfeature of malignant change in human prostate. Cancer Detect. Prev. 31, 391-395 (2007).
    • (2007) Cancer Detect Prev. , vol.31 , pp. 391-395
    • Louis, S.N.1
  • 198
    • 0030596043 scopus 로고    scopus 로고
    • AT1 angiotensin II receptorsubtype in the human larynx and squamous laryngealcarcinoma
    • Marsigliante, S. et al. AT1 angiotensin II receptorsubtype in the human larynx and squamous laryngealcarcinoma. Cancer Lett. 110, 19-27 (1996).
    • (1996) Cancer Lett. , vol.110 , pp. 19-27
    • Marsigliante, S.1
  • 199
    • 0035008410 scopus 로고    scopus 로고
    • Differences between squamouscell carcinoma and keratoacanthoma in angiotensintype-1 receptor expression
    • Takeda, H. & Kondo, S. Differences between squamouscell carcinoma and keratoacanthoma in angiotensintype-1 receptor expression. Am. J. Pathol. 158,1633-1637 (2001).
    • (2001) Am. J. Pathol. , vol.158 , pp. 1633-1637
    • Takeda, H.1    Kondo, S.2
  • 200
    • 0037308650 scopus 로고    scopus 로고
    • Angiotensin I-converting enzyme(ACE) gene polymorphism and breast cancer riskamong Chinese women in Singapore
    • Koh, W. P. et al. Angiotensin I-converting enzyme(ACE) gene polymorphism and breast cancer riskamong Chinese women in Singapore. Cancer Res. 63,573-578 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 573-578
    • Koh, W.P.1
  • 201
    • 27744524499 scopus 로고    scopus 로고
    • Angiotensinconvertingenzyme gene insertion/deletionpolymorphism and breast cancer risk
    • Gonzalez-Zuloeta Ladd, A. M. et al. Angiotensinconvertingenzyme gene insertion/deletionpolymorphism and breast cancer risk. CancerEpidemiol. Biomarkers Prev. 14, 2143-2146(2005).
    • (2005) Cancer Epidemiol. Biomarkers Prev. , vol.14 , pp. 2143-2146
    • Gonzalez-Zuloeta Ladd, A.M.1
  • 202
    • 0142188689 scopus 로고    scopus 로고
    • Genetic variation inangiotensin I-converting enzyme (ACE) and breastcancer risk: The multiethnic cohort
    • Haiman, C. A., Henderson, S. O., Bretsky, P.,Kolonel, L. N. & Henderson, B. E. Genetic variation inangiotensin I-converting enzyme (ACE) and breastcancer risk: the multiethnic cohort. Cancer Res. 63,6984-6987 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 6984-6987
    • Haiman, C.A.1    Henderson, S.O.2    Bretsky, P.3    Kolonel, L.N.4    Henderson, B.E.5


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