Decreased expression of angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progression

Tohoku Journal of Experimental Medicine

Volumn 217, Issue 2, 2009, Pages 123-131

  Zhou, Lin ^a   Zhang, Ruifeng ^a   Yao, Weiyan ^a   Wang, Jiancheng ^a   Qian, Aihua ^a   Qiao, Minmin ^a   Zhang, Yongping ^a   Yuan, Yaozong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Angiotensin II; Angiotensin converting enzyme 2; Angiotension converting enzyme; Pancreatic ductal adenocarcinoma; Proliferation

Indexed keywords

ALDOSTERONE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE; RENIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PANCREAS ADENOCARCINOMA; PANCREAS RESECTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RNA INTERFERENCE; TISSUE HOMOGENATE; TUMOR GROWTH; WESTERN BLOTTING; DISEASE COURSE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; PROTEIN TRANSPORT; TUMOR CELL LINE;

ADULT; AGED; ANGIOTENSIN II; BLOTTING, WESTERN; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; PEPTIDYL-DIPEPTIDASE A; PROTEIN TRANSPORT; RNA INTERFERENCE;

EID: 66949178060     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.217.123     Document Type: Article

References (30)

1. Agata, J., Ura, N., Yoshida, H., Shinshi, Y., Sasaki, H., Hyakkoku, M., Taniguchi, S. & Shimamo, K. (2006) Olmesartan is an angiotensin II receptor blocker with an inhibitory effect on angiotensin-converting enzyme. Hypertens. Res., 29, 865-874.
2. Arafat, H.A., Gong, Q., Chipitsyna, G., Rizvi, A., Saa, C.T. & Yeo, C.J. (2007) Antihypertensives as novel antineoplastics: Angiotensin-i-converting enzyme inhibitors and angiotensin II type 1 receptor blockers in pancreatic ductal adenocarcinoma. J. Am. Coll. Surg., 204, 996-1005.
3. Arrieta, O., Guevara, P. & Escobar, E. (2005) Blockage of angiotensin II type I receptor decreases the synthesis of growth factors and induces apoptosis in C6 cultured cells and C6 rat glioma. Br. J. Cancer, 92, 1247-1252.
4. Brosnihan, K.B., Neves, L.A. & Chappell, M.C. (2005) Does the angiotensin-converting enzyme (ACE)/ACE2 balance contribute to the fate of angiotensin peptides in programmed hypertension? Hypertension, 46, 1097-1099.
5. Campbell, D.J., Kladis, A. & Duncan, A.M. (1993) Nephrectomy, converting enzyme inhibition, and angiotensin peptides. Hypertension, 22, 513-522.
6. Crackower, M.A., Sarao, R., Oudit, G.Y., Yagil, C., Kozieradzki, I., Scanga, S.E., Oliveira-dos-Santos, A.J., da Costa, J., Zhang, L., Pei, Y., Scholey, J., Ferrario, C.M., Manoukian, A.S., Chappell, M.C., Backx, P.H., Yagil, Y. & Penninger, J.M. (2002) Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature, 417, 822-828.
7. Deshayes, F. & Nahmias, C. (2005) Angiotensin receptors: A new role in cancer? Trend. Endocrinol. Metab., 16, 293-299.
8. Egami, K., Murohara, T., Shimada, T., Sasaki, K., Shintani, S., Sugaya, T., Ishii, M., Akagi, T., Ikeda, H., Matsuishi, T. & Imaizumi, T. (2003) Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth. J. Clin. Invest., 112, 67-75.
9. Epelman, S., Tang, W.H., Chen, S.Y., Van, Lente F., Francis, G.S. & Sen, S. (2008) Detection of soluble angiotensin-converting enzyme 2 in heart failure: Insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system. J. Am. Coll. Cardiol., 52, 750-754.
10. Greco, S., Muscella, A., Elia, M.G., Salvatore, P., Storelli, C., Mazzotta, A., Manca, C. & Marsigliante, S. (2003) Angiotensin II activates extracellular signal regulated kinases via protein kinase c and epidermal growth factor receptor in breast cancer cells. J. Cell. Physiol., 196, 370-377.
11. Igase, M., Kohara, K., Nagai, T., Miki, T. & Ferrario, C.M. (2008) Increased expression of angiotensin converting enzyme 2 in conjunction with reduction of neointima by angiotensin II type 1 receptor blockade. Hypertens. Res., 31, 553-559.
12. Jemal, A., Murray, T., Ward, E., Samuels, A., Tiwari, R.C., Ghafoor, A., Feuer, E.J. & Thun, M.J. (2005) Cancer statistics, 2005. CA Cancer J. Clin., 55, 10-30.
13. Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J. & Thun, M.J. (2007) Cancer statistics, 2007. CA Cancer J. Clin., 57, 43-66.
14. Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., Murray, T. & Thun, M.J. (2008) Cancer statistics, 2008. CA Cancer J. Clin., 58, 71-96.
15. Katovich, M.J., Grobe, J.L., Huentelman, M. & Raizada, M.K. (2005) Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension. Exp. Physiol., 90, 299-305.
16. Koka, V., Huang, X.R., Chung, A.C., Wang, W., Truong, L.D. & Lan, H.Y. (2008) Angiotensin ii up-regulates angiotensin i-converting enzyme (ACE), but down-regulates ACE2 via the at1-erk/p38 map kinase pathway. Am. J. Pathol., 172, 1174-1183.
17. Lever, A.F., Hole, D.J., Gillis, C.R., McCallum, I.R.M.G.T., MacKinnon, P.L., Meredith, P.A., Murray, L.S., Reid, J.L. & Robertson, M.J. (1998) Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer? Lancet, 352, 179-184.
18. Lindberg, H., Nielsen, D., Jensen, B.V., Eriksen, J. & Skovsgaard, T. (2004) Angiotensin converting enzyme inhibitors for cancer treatment? Acta Oncol., 43, 142-152.
19. Mizuiri, S., Hemmi, H., Arita, M., Ohashi, Y., Tanaka, Y., Miyagi, M., Sakai, K., Ishikawa, Y., Shibuya, K., Hase, H. & Aikawa, A. (2008) Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls. Am. J. Kidney Dis., 51, 613-623.
20. Moon, J.Y., Jeong, K.H., Lee, S.H., Lee, T.W., Ihm, C.G. & Lim S.J. (2008) Renal ACE and ACE2 expression in early diabetic rats. Nephron Exp. Nephrol., 110, 8-16.
21. Neo, J.H., Malcontenti-Wilson, C., Muralidharan, V. & Christophi C. (2007) Effect of ACE inhibitors and angiotensin II receptor antagonists in a mouse model of colorectal cancer liver metastases. J. Gastroenterol. Hepatol., 22, 577-584.
22. Ocaranza, M.P., Godoy, I., Jalil, J.E., Varas, M., Collantes, P., Pinto, M., Roman, M., Ramirez, C., Copaja, M., Diaz-Araya, G., Castro, P. & Lavandero, S. (2006) Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat. Hypertension, 48, 572-578.
23. Raizada, M.K. & Ferreira, A.J. (2007) ACE2: A new target for cardiovascular disease therapeutics. J. Cardiovasc. Pharmacol., 50, 112-119.
24. Sohn, T.A., Yeo, C.J., Cameron, J.L., Koniaris, L., Kaushal, S., Abrams, R.A., Sauter, P.K., Coleman, J., Hruban, R.H. & Lillemoe, K.D. (2000) Resected adenocarcinoma of the pancreas-616 patients: Results, outcomes, and prognostic indicators. J. Gastrointest. Surg., 4, 567-579.
25. Soler, M.J., Lloveras, J. & Batlle, D. (2008) Angiotensin converting enzyme 2 and its emerging role in the regulation of the renin angiotensin system. Med. Clin., 131, 230-236.
26. Sugimoto, M., Furuta, T., Shirai, N., Ikuma, M., Sugimura, H. & Hishida, A. (2006) Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in japan. Cancer Epidemiol. Biomarkers Prev., 15, 1929-1934.
27. Uemura, H., Ishiguro, H., Nakaigawa, N., Nagashima, Y., Miyoshi, Y., Fujinami, K., Sakaguchi, A. & Kubota, Y. (2003) Angiotensin II receptor blocker shows antiproliferative activity in prostate cancer cells: A possibility of tyrosine kinase inhibitor of growth factor. Mol. Cancer Therapeu., 2, 1139-1147.
28. Wakahara, S., Konoshita, T., Mizuno, S., Motomura, M., Aoyama, C., Makino, Y., Kato, N., Koni, I. & Miyamori, I. (2007) Synergistic expression of angiotensin-converting enzyme (ACE) and ACE2 in human renal tissue and confounding effects of hypertension on the ace to ace2 ratio. Endocrinology, 148, 2453-2457.
29. Wang, G., Lai, F.M., Lai, K.B., Chow, K.M., Kwan, C.H., Li, K.T. & Szeto, C.C. (2008) Urinary mrna expression of ACE and ACE2 in human type 2 diabetic nephropathy. Diabetologia, 51, 1062-1067.
30. Yamamoto, K., Ohishi, M., Katsuya, T., Ito, N., Ikushima, M., Kaibe, M., Tatara, Y., Shiota, A., Sugano, S., Takeda, S., Rakugi, H. & Ogihara, T. (2006) Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II. Hypertension, 47, 718-726.