Suppression of angiogenesis, tumor growth, and metastasis by adenovirus-mediated gene transfer of human angiotensinogen

Molecular Therapy

Volumn 14, Issue 2, 2006, Pages 175-182

  Bouquet, Céline ^a   Lamandé, Noël ^b   Brand, Marcus ^b   Gasc, Jean Marie ^b   Jullienne, Betsy ^a   Faure, Gabrielle ^a   Griscelli, Franck ^a   Opolon, Paule ^a   Connault, Elisabeth ^a   Perricaudet, Michel ^a   Corvol, Pierre ^b  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b INSERM   (France)

Author keywords

adenovirus; angiotensinogen; antiangiogenesis; antimetastasis

Indexed keywords

ADENOVIRUS VECTOR; ANGIOSTATIN; ANGIOTENSIN II; ANGIOTENSINOGEN;

ADENOVIRUS; ANGIOGENESIS; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CANCER REGRESSION; CARCINOGENICITY; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOMEGALOVIRUS; DATA ANALYSIS; ENDOTHELIUM CELL; FEMALE; GENE TRANSFER; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; METASTASIS; MOUSE; MOUSE STRAIN; NECROSIS; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; NUDE MOUSE; PROMOTER REGION; TRANSGENIC MOUSE; TUMOR GROWTH; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANGIOTENSINOGEN; ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENE THERAPY; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; TRANSPLANTATION, HETEROLOGOUS;

ADENOVIRIDAE; CYTOMEGALOVIRUS; MURINAE; MUS MUSCULUS;

EID: 33745399035     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2006.01.017     Document Type: Article

References (32)

1. Hanahan D., and Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86 (1996) 353-364
2. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1 (1995) 27-31
3. Folkman J. Clinical applications of research on angiogenesis. N. Engl. J. Med. 333 (1995) 1757-1763
4. Webb C.P., and Vande Woude G.F. Genes that regulate metastasis and angiogenesis. J. Neuro-Oncol. 50 (2000) 71-87
5. Hagedorn M., and Bikfalvi A. Target molecules for anti-angiogenic therapy: from basic research to clinical trials. Crit. Rev. Oncol. Hematol. 34 (2000) 89-110
6. O'Reilly M.S., et al. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nat. Med. 2 (1996) 689-692
7. O'Reilly M.S., et al. Antiangiogenic activity of the cleaved conformation of the serpin antithrombin. Science 285 (1999) 1926-1928
8. Dawson D.W., et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 285 (1999) 245-248
9. Zhang M., et al. Maspin is an angiogenesis inhibitor. Nat. Med. 6 2000 (1999) 196-199
10. Miao R., et al. Kallistatin is a new inhibitor of angiogenesis and tumor growth. Blood 100 (2002) 3245-3252
11. Corvol P., and Jeunemaitre X. Molecular genetics of human hypertension: role of angiotensinogen. Endocr. Rev. 18 (1997) 662-677
12. Gaillard I., Clauser E., and Corvol P. Structure of human angiotensinogen gene. DNA 8 (1989) 87-99
13. Stein P., Tewkesbury D., and Carrell R. Ovalbumin and angiotensinogen lack serpin S-R conformational change. Biochem. J. 262 (1989) 103-107
14. Mast A., et al. Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin. Biochemistry 30 (1999) 1723-1730
15. Célérier J., et al. Characterization of a human angiotensinogen cleaved in its reactive center loop by a proteolytic activity from Chinese hamster ovary cells. J. Biol. Chem. 275 (2000) 10648-10654
16. Célérier J., et al. Angiotensinogen and its cleaved derivatives inhibit angiogenesis. Hypertension 39 (2002) 224-228
17. Corvol P., et al. Inhibition of angiogenesis: a new function for angiotensinogen and des(angiotensin I)angiotensinogen. Curr. Hypertens. Rep. 5 (2003) 149-154
18. Griscelli F., et al. Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest. Proc. Natl. Acad. Sci. USA 95 (1998) 6367-6372
19. Yang G., et al. Functional expression of the human angiotensinogen gene in transgenic mice. J. Biol. Chem. 269 (1994) 32497-32502
20. Benihoud K., Yeh P., and Perricaudet M. Adenovirus vectors for gene delivery. Curr. Opin. Biotechnol. 10 (1999) 440-447
21. Bass R., Fernandez A., and Ellis V. Maspin inhibits cell migration in the absence of protease inhibitory activity. J. Biol. Chem. 277 (2002) 46845-46848
22. Blacque O., and Worrall D. Evidence for a direct interaction between the tumor-suppressor serpin, maspin and types I and III collagen. J. Biol. Chem. 277 (2002) 10783-10788
23. Larsson H., et al. Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells. Cancer Res. 60 (2001) 6723-6729
24. Tewksbury D., Pan N., and Kaiser S. Detection of a receptor for angiotensinogen on placental cells. Am. J. Hypertens. 16 (2003) 59-62
25. Kakinuma Y., et al. Impaired blood-brain barrier function in angiotensinogen-deficient mice. Nat. Med. 4 (1998) 1078-1080
26. Yanai K., et al. Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. J. Biol. Chem. 275 (2000) 5-8
27. Mullan B., et al. Towards robust functional gene validation by adenoviral vectors: one step E. coli derived recombinant adenoviral genome construction. Gene Ther. 11 (2004) 1599-1605
28. Trochon V., et al. Evidence of involvement of CD44 in endothelial cell proliferation, migration and angiogenesis in vitro. Int. J. Cancer 66 (1996) 664-668
29. Fallaux F.J., et al. Characterization of 911 a new helper cell line for the titration and propagation of early region-1 deleted adenoviral vectors. Hum. Gene Ther. 7 (1996) 215-222
30. Bouquet C., et al. Systemic administration of a recombinant adenovirus encoding a HAS-angiostatin kringle 1-3 conjugate inhibits MDA-MB-231 tumor growth and metastasization in a transgenic model of spontaneous eye cancer. Mol. Ther. 7 (2003) 174-184
31. Ménard J., and Catt K. Measurement of renin activity, concentration and substrate in rat plasma by radioimmunoassay of angiotensin I. Endocrinology 90 (1972) 422-430
32. Gimenez-Roqueplo A., et al. Role of cysteine residues in human angiotensinogen. J. Biol. Chem. 273 (1998) 34480-34487