-
1
-
-
34249888775
-
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
-
DOI 10.1126/science.1142358
-
Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, Novartis Institutes for Biomedical Research, et al. 2007 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 316 1331 1336 10.1126/science.1142358 This paper is among the first genome-wide association studies for type 2 diabetes that collaborated with other studies to perform the first meta-analysis (Pubitemid 46871653)
-
(2007)
Science
, vol.316
, Issue.5829
, pp. 1331-1336
-
-
Saxena, R.1
Voight, B.F.2
Lyssenko, V.3
Burtt, N.P.4
De Bakker, P.I.W.5
Chen, H.6
Roix, J.J.7
Kathiresan, S.8
Hirschhorn, J.N.9
Daly, M.J.10
Hughes, T.E.11
Groop, L.12
Altshuler, D.13
-
2
-
-
34249885875
-
A genome-wide association study of type 2 diabetes in finns detects multiple susceptibility variants
-
DOI 10.1126/science.1142382
-
LJ Scott KL Mohlke LL Bonnycastle, et al. 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science 316 1341 1345 1:CAS:528:DC%2BD2sXmtVyitrY%3D 10.1126/science.1142382 17463248 This paper is among the first genome-wide association studies for type 2 diabetes that collaborated with other studies to perform the first meta-analysis (Pubitemid 46871655)
-
(2007)
Science
, vol.316
, Issue.5829
, pp. 1341-1345
-
-
Scott, L.J.1
Mohlke, K.L.2
Bonnycastle, L.L.3
Willer, C.J.4
Li, Y.5
Duren, W.L.6
Erdos, M.R.7
Stringham, H.M.8
Chines, P.S.9
Jackson, A.U.10
Prokunina-Olsson, L.11
Ding, C.-J.12
Swift, A.J.13
Hu, T.14
Pruim, R.15
Xiao, R.16
Li, X.-Y.17
Conneely, K.N.18
Riebow, N.L.19
Sprau, A.G.20
Tong, M.21
White, P.P.22
Hetrick, K.N.23
Barnhart, M.W.24
Bark, C.W.25
Goldstein, J.L.26
Watkins, L.27
Xiang, F.28
Saramies, J.29
Buchanan, T.A.30
Watanabe, R.M.31
Valle, T.T.32
Kinnunen, L.33
Abecasis, G.R.34
Pugh, E.W.35
Doheny, K.F.36
Bergman, R.N.37
Tuomilehto, J.38
Collins, F.S.39
Boehnke, M.40
more..
-
3
-
-
34249895023
-
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
-
DOI 10.1126/science.1142364
-
E Zeggini MN Weedon CM Lindgren, et al. 2007 Replication of genome-wide association signals in U.K. samples reveals risk loci for type 2 diabetes Science 316 1336 1341 1:CAS:528:DC%2BD2sXmtVymtb0%3D 10.1126/science.1142364 17463249 This paper is among the first genome-wide association studies for type 2 diabetes that collaborated with other studies to perform the first meta-analysis (Pubitemid 46871654)
-
(2007)
Science
, vol.316
, Issue.5829
, pp. 1336-1341
-
-
Zeggini, E.1
Weedon, M.N.2
Lindgren, C.M.3
Frayling, T.M.4
Elliott, K.S.5
Lango, H.6
Timpson, N.J.7
Perry, J.R.B.8
Rayner, N.W.9
Freathy, R.M.10
Barrett, J.C.11
Shields, B.12
Morris, A.P.13
Ellard, S.14
Groves, C.J.15
Harries, L.W.16
Marchini, J.L.17
Owen, K.R.18
Knight, B.19
Cardon, L.R.20
Walker, M.21
Hitman, G.A.22
Morris, A.D.23
Doney, A.S.F.24
McCarthy, M.I.25
Hattersley, A.T.26
Bruce, I.N.27
Donovan, H.28
Eyre, S.29
Gilbert, P.D.30
Hider, S.L.31
Hinks, A.M.32
John, S.L.33
Potter, C.34
Silman, A.J.35
Symmons, D.P.M.36
Thomson, W.37
Worthington, J.38
more..
-
4
-
-
33847176604
-
A genome-wide association study identified novel risk loci for type 2 diabetes
-
1:CAS:528:DC%2BD2sXhvFGiurw%3D 10.1038/nature05616 17293876 This paper discusses the first genome-wide association analysis for type 2 diabetes to appear in the literature
-
R Sladek G Rocheleau J Rung, et al. 2007 A genome-wide association study identified novel risk loci for type 2 diabetes Nature 445 881 885 1:CAS:528:DC%2BD2sXhvFGiurw%3D 10.1038/nature05616 17293876 This paper discusses the first genome-wide association analysis for type 2 diabetes to appear in the literature
-
(2007)
Nature
, vol.445
, pp. 881-885
-
-
Sladek, R.1
Rocheleau, G.2
Rung, J.3
-
5
-
-
34249828965
-
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
-
DOI 10.1038/ng2043, PII NG2043
-
V Steinthorsdottir G Thorleifsson I Reynisdottir, et al. 2007 A variant in CDKAL1 influences insulin response and risk of type 2 diabetes Nat Genet 39 770 775 1:CAS:528:DC%2BD2sXlvVSgtL4%3D 10.1038/ng2043 17460697 This paper is among the first genome-wide association analysis for type 2 diabetes to appear in the literature (Pubitemid 46848592)
-
(2007)
Nature Genetics
, vol.39
, Issue.6
, pp. 770-775
-
-
Steinthorsdottir, V.1
Thorleifsson, G.2
Reynisdottir, I.3
Benediktsson, R.4
Jonsdottir, T.5
Walters, G.B.6
Styrkarsdottir, U.7
Gretarsdottir, S.8
Emilsson, V.9
Ghosh, S.10
Baker, A.11
Snorradottir, S.12
Bjarnason, H.13
Ng, M.C.Y.14
Hansen, T.15
Bagger, Y.16
Wilensky, R.L.17
Reilly, M.P.18
Adeyemo, A.19
Chen, Y.20
Zhou, J.21
Gudnason, V.22
Chen, G.23
Huang, H.24
Lashley, K.25
Doumatey, A.26
So, W.-Y.27
Ma, R.C.Y.28
Andersen, G.29
Borch-Johnsen, K.30
Jorgensen, T.31
Van Vliet-Ostaptchouk, J.V.32
Hofker, M.H.33
Wijmenga, C.34
Christiansen, C.35
Rader, D.J.36
Rotimi, C.37
Gurney, M.38
Chan, J.C.N.39
Pedersen, O.40
Sigurdsson, G.41
Gulcher, J.R.42
Thorsteinsdottir, U.43
Kong, A.44
Stefansson, K.45
more..
-
6
-
-
42349106044
-
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
-
DOI 10.1038/ng.120, PII NG120
-
E Zeggini LJ Scott R Saxena, et al. 2008 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes Nat Genet 40 638 645 1:CAS:528:DC%2BD1cXltFylurY%3D 10.1038/ng.120 18372903 (Pubitemid 351601209)
-
(2008)
Nature Genetics
, vol.40
, Issue.5
, pp. 638-645
-
-
Zeggini, E.1
Scott, L.J.2
Saxena, R.3
Voight, B.F.4
-
7
-
-
50449085998
-
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
-
1:CAS:528:DC%2BD1cXhtVGgt77M 10.1038/ng.207 18711367
-
K Yasuda K Miyake Y Horikawa, et al. 2008 Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus Nat Genet 40 1092 1097 1:CAS:528:DC%2BD1cXhtVGgt77M 10.1038/ng.207 18711367
-
(2008)
Nat Genet
, vol.40
, pp. 1092-1097
-
-
Yasuda, K.1
Miyake, K.2
Horikawa, Y.3
-
8
-
-
50449085212
-
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
-
1:CAS:528:DC%2BD1cXhtVGgt77E 10.1038/ng.208 18711366
-
H Unoki A Takahashi T Kawaguchi, et al. 2008 SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations Nat Genet 40 1098 1102 1:CAS:528:DC%2BD1cXhtVGgt77E 10.1038/ng.208 18711366
-
(2008)
Nat Genet
, vol.40
, pp. 1098-1102
-
-
Unoki, H.1
Takahashi, A.2
Kawaguchi, T.3
-
9
-
-
58149175143
-
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
-
1:CAS:528:DC%2BD1cXhsVKlt7zP 10.1038/ng.277 19060909
-
N Bouatia-Naji A Bonnefond C Cavalcanti-Proenca, et al. 2009 A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk Nat Genet 41 89 94 1:CAS:528:DC%2BD1cXhsVKlt7zP 10.1038/ng.277 19060909
-
(2009)
Nat Genet
, vol.41
, pp. 89-94
-
-
Bouatia-Naji, N.1
Bonnefond, A.2
Cavalcanti-Proenca, C.3
-
10
-
-
58149156287
-
Variants in MTNR1B influence fasting glucose levels
-
1:CAS:528:DC%2BD1cXhsVKlt7vM 10.1038/ng.290 19060907 This paper is among the first studies to demonstrate that genome-wide association studies for diabetes-related quantitative traits can identify type 2 diabetes susceptibility loci
-
I Prokopenko C Langenberg JC Florez, et al. 2009 Variants in MTNR1B influence fasting glucose levels Nat Genet 41 77 81 1:CAS:528:DC%2BD1cXhsVKlt7vM 10.1038/ng.290 19060907 This paper is among the first studies to demonstrate that genome-wide association studies for diabetes-related quantitative traits can identify type 2 diabetes susceptibility loci
-
(2009)
Nat Genet
, vol.41
, pp. 77-81
-
-
Prokopenko, I.1
Langenberg, C.2
Florez, J.C.3
-
11
-
-
75749091912
-
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
-
1:CAS:528:DC%2BC3cXntVCksw%3D%3D 10.1038/ng.521 20081857 This paper is among the first studies to demonstrate that genome-wide association studies for diabetes-related quantitative traits can identify type 2 diabetes susceptibility loci
-
R Saxena MF Hivert C Langenberg, et al. 2010 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge Nat Genet 42 142 148 1:CAS:528:DC%2BC3cXntVCksw%3D%3D 10.1038/ng.521 20081857 This paper is among the first studies to demonstrate that genome-wide association studies for diabetes-related quantitative traits can identify type 2 diabetes susceptibility loci
-
(2010)
Nat Genet
, vol.42
, pp. 142-148
-
-
Saxena, R.1
Hivert, M.F.2
Langenberg, C.3
-
12
-
-
75749086085
-
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
-
1:CAS:528:DC%2BC3cXntVCqsw%3D%3D 10.1038/ng.520 20081858 This paper is among the first studies to demonstrate that genome-wide association studies for diabetes-related quantitative traits can identify type 2 diabetes susceptibility loci
-
J Dupuis C Langenberg I Prokopenko, et al. 2010 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Nat Genet 42 105 116 1:CAS:528:DC%2BC3cXntVCqsw%3D%3D 10.1038/ng.520 20081858 This paper is among the first studies to demonstrate that genome-wide association studies for diabetes-related quantitative traits can identify type 2 diabetes susceptibility loci
-
(2010)
Nat Genet
, vol.42
, pp. 105-116
-
-
Dupuis, J.1
Langenberg, C.2
Prokopenko, I.3
-
13
-
-
77954143522
-
Twelve type 2 diabetes susceptiblity loci identified through large-scale association analysis
-
1:CAS:528:DC%2BC3cXnvFykt70%3D 10.1038/ng.609 20581827
-
BF Voight LJ Scott V Steinthorsdottir, et al. 2010 Twelve type 2 diabetes susceptiblity loci identified through large-scale association analysis Nat Genet 42 579 589 1:CAS:528:DC%2BC3cXnvFykt70%3D 10.1038/ng.609 20581827
-
(2010)
Nat Genet
, vol.42
, pp. 579-589
-
-
Voight, B.F.1
Scott, L.J.2
Steinthorsdottir, V.3
-
14
-
-
70349557826
-
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
-
1:CAS:528:DC%2BD1MXhtV2gsb%2FL 10.1038/ng.443 19734900 This paper is among the first studies to demonstrate that genome-wide association studies for diabetes-related quantitative traits can identify type 2 diabetes susceptibility loci
-
J Rung S Cauchi A Albrechtsen, et al. 2009 Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia Nat Genet 41 1110 1115 1:CAS:528:DC%2BD1MXhtV2gsb%2FL 10.1038/ng.443 19734900 This paper is among the first studies to demonstrate that genome-wide association studies for diabetes-related quantitative traits can identify type 2 diabetes susceptibility loci
-
(2009)
Nat Genet
, vol.41
, pp. 1110-1115
-
-
Rung, J.1
Cauchi, S.2
Albrechtsen, A.3
-
15
-
-
77951858557
-
Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans
-
1:CAS:528:DC%2BC3cXmtFegtrk%3D 10.2337/db09-1568 20185807 This is the first study to attempt to unravel the underlying physiology of loci underlying variation in fasting glucose by examining a comprehensive series of diabetes-related quantiative traits. This is the first study to also use large samples phenotyped using direct assessment of insulin resistance
-
E Ingelsson C Langenberg MF Hivert, et al. 2010 Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans Diabetes 59 1266 1275 1:CAS:528:DC%2BC3cXmtFegtrk%3D 10.2337/db09-1568 20185807 This is the first study to attempt to unravel the underlying physiology of loci underlying variation in fasting glucose by examining a comprehensive series of diabetes-related quantiative traits. This is the first study to also use large samples phenotyped using direct assessment of insulin resistance
-
(2010)
Diabetes
, vol.59
, pp. 1266-1275
-
-
Ingelsson, E.1
Langenberg, C.2
Hivert, M.F.3
-
16
-
-
0031595923
-
A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
-
DOI 10.1038/3099
-
SS Deeb L Fajas M Nemoto, et al. 1998 A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity Nat Genet 20 284 287 1:CAS:528: DyaK1cXntFOhsL8%3D 10.1038/3099 9806549 (Pubitemid 28507675)
-
(1998)
Nature Genetics
, vol.20
, Issue.3
, pp. 284-287
-
-
Deeb, S.S.1
Fajas, L.2
Nemoto, M.3
Pihlajamaki, J.4
Mykkanen, L.5
Kuusisto, J.6
Laakso, M.7
Fujimoto, W.8
Auwerx, J.9
-
18
-
-
54249088172
-
Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations
-
1:CAS:528:DC%2BD1MXhsleis7Y%3D 10.2337/db08-0516 18678614
-
M Orho-Melander O Melander C Guiducci, et al. 2008 Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations Diabetes 57 3112 3121 1:CAS:528:DC%2BD1MXhsleis7Y%3D 10.2337/db08-0516 18678614
-
(2008)
Diabetes
, vol.57
, pp. 3112-3121
-
-
Orho-Melander, M.1
Melander, O.2
Guiducci, C.3
-
19
-
-
0028338590
-
Short-term control of glucokinase activity: Role of a regulatory protein
-
8168691
-
E Van Schaftingen M Detheux CM da Veiga 1994 Short-term control of glucokinase activity: role of a regulatory protein FASEB J 8 414 419 8168691
-
(1994)
FASEB J
, vol.8
, pp. 414-419
-
-
Van Schaftingen, E.1
Detheux, M.2
Da Veiga, C.M.3
-
20
-
-
0034677787
-
Characterization of glucokinase regulatory protein-deficient mice
-
DOI 10.1074/jbc.275.11.7826
-
J Grimsby JW Coffey MT Dvorozniak, et al. 2000 Characterization of glucokinase regulatory protein-deficient mice J Biol Chem 275 7826 7831 1:CAS:528:DC%2BD3cXitVylsbg%3D 10.1074/jbc.275.11.7826 10713097 (Pubitemid 30159689)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.11
, pp. 7826-7831
-
-
Grimsby, J.1
Coffey, J.W.2
Dvorozniak, M.T.3
Magram, J.4
Li, G.5
Matschinsky, F.M.6
Shiota, C.7
Kaur, S.8
Magnuson, M.A.9
Grippo, J.F.10
-
21
-
-
0033432692
-
Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: A sequestration mechanism in metabolic regulation
-
DOI 10.1073/pnas.96.25.14511
-
D Farrelly KS Brown A Tieman, et al. 1999 Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation Proc Natl Acad Sci U S A 96 14511 14516 1:CAS:528:DyaK1MXnvFKks70%3D 10.1073/pnas.96.25.14511 10588736 (Pubitemid 30000681)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.25
, pp. 14511-14516
-
-
Farrelly, D.1
Brown, K.S.2
Tieman, A.3
Ren, J.4
Lira, S.A.5
Hagan, D.6
Gregg, R.7
Mookhtiar, K.A.8
Hariharan, N.9
-
22
-
-
0035433418
-
Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein
-
1:CAS:528:DC%2BD3MXlslKnu7g%3D 10.2337/diabetes.50.8.1813 11473043
-
ED Slosberg UJ Desai B Fanelli, et al. 2001 Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein Diabetes 50 1813 1820 1:CAS:528:DC%2BD3MXlslKnu7g%3D 10.2337/diabetes.50.8.1813 11473043
-
(2001)
Diabetes
, vol.50
, pp. 1813-1820
-
-
Slosberg, E.D.1
Desai, U.J.2
Fanelli, B.3
-
23
-
-
70349980881
-
The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
-
1:CAS:528:DC%2BD1MXht1CrtrvJ 10.1093/hmg/ddp357 19643913
-
NL Beer ND Tribble LJ McCulloch, et al. 2009 The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver Hum Mol Genet 18 4081 4088 1:CAS:528:DC%2BD1MXht1CrtrvJ 10.1093/hmg/ddp357 19643913
-
(2009)
Hum Mol Genet
, vol.18
, pp. 4081-4088
-
-
Beer, N.L.1
Tribble, N.D.2
McCulloch, L.J.3
-
24
-
-
34447289392
-
Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease
-
DOI 10.1007/s00439-007-0378-3
-
S Rodriguez TR Gaunt IN Day 2007 Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease Hum Genet 122 1 21 1:CAS:528:DC%2BD2sXntlWmtLw%3D 10.1007/s00439-007-0378-3 17534663 (Pubitemid 47040569)
-
(2007)
Human Genetics
, vol.122
, Issue.1
, pp. 1-21
-
-
Rodriguez, S.1
Gaunt, T.R.2
Day, I.N.M.3
-
25
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
DOI 10.1126/science.1141634
-
TM Frayling NJ Timpson MN Weedon, et al. 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity Science 316 889 894 1:CAS:528:DC%2BD2sXltVentL0%3D 10.1126/science. 1141634 17434869 (Pubitemid 46764279)
-
(2007)
Science
, vol.316
, Issue.5826
, pp. 889-894
-
-
Frayling, T.M.1
Timpson, N.J.2
Weedon, M.N.3
Zeggini, E.4
Freathy, R.M.5
Lindgren, C.M.6
Perry, J.R.B.7
Elliott, K.S.8
Lango, H.9
Rayner, N.W.10
Shields, B.11
Harries, L.W.12
Barrett, J.C.13
Ellard, S.14
Groves, C.J.15
Knight, B.16
Patch, A.-M.17
Ness, A.R.18
Ebrahim, S.19
Lawlor, D.A.20
Ring, S.M.21
Ben-Shlomo, Y.22
Jarvelin, M.-R.23
Sovio, U.24
Bennett, A.J.25
Melzer, D.26
Ferrucci, L.27
Loos, R.J.F.28
Barroso, I.29
Wareham, N.J.30
Karpe, F.31
Owen, K.R.32
Cardon, L.R.33
Walker, M.34
Hitman, G.A.35
Palmer, C.N.A.36
Doney, A.S.F.37
Morris, A.D.38
Smith, G.D.39
Hattersley, A.T.40
McCarthy, M.I.41
more..
-
26
-
-
34547625955
-
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
-
DOI 10.1371/journal.pgen.0030115
-
A Scuteri S Sanna WM Chen, et al. 2007 Genome-wide asociation scan shows genetic variants in the FTO gene are associated with obesity-related traits PLoS Genet 3 e115 10.1371/journal.pgen.0030115 17658951 (Pubitemid 47203970)
-
(2007)
PLoS Genetics
, vol.3
, Issue.7
, pp. 1200-1210
-
-
Scuteri, A.1
Sanna, S.2
Chen, W.-M.3
Uda, M.4
Albai, G.5
Strait, J.6
Najjar, S.7
Nagaraja, R.8
Orru, M.9
Usala, G.10
Dei, M.11
Lai, S.12
Maschio, A.13
Busonero, F.14
Mulas, A.15
Ehret, G.B.16
Fink, A.A.17
Weder, A.B.18
Cooper, R.S.19
Galan, P.20
Chakravarti, A.21
Schlessinger, D.22
Cao, A.23
Lakatta, E.24
Abecasis, G.R.25
more..
-
27
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
DOI 10.1038/ng.140, PII NG140
-
RJ Loos CM Lindgren S Li, et al. 2008 Common variants near MC4R are associated with fat mass, weight and risk of obesity Nat Genet 40 768 775 1:CAS:528:DC%2BD1cXmsVejsLo%3D 10.1038/ng.140 18454148 (Pubitemid 351748863)
-
(2008)
Nature Genetics
, vol.40
, Issue.6
, pp. 768-775
-
-
Loos, R.J.F.1
Lindgren, C.M.2
Li, S.3
Wheeler, E.4
Zhao, J.H.5
Prokopenko, I.6
Inouye, M.7
Freathy, R.M.8
Attwood, A.P.9
Beckmann, J.S.10
Berndt, S.I.11
Jacobs, K.B.12
Chanock, S.J.13
Hayes, R.B.14
Bergmann, S.15
Bennett, A.J.16
Bingham, S.A.17
Bochud, M.18
Brown, M.19
Cauchi, S.20
Connell, J.M.21
Cooper, C.22
Smith, G.D.23
Day, I.24
Dina, C.25
Dermitzakis, E.T.26
Doney, A.S.F.27
Elliott, K.S.28
Elliott, P.29
Evans, D.M.30
Sadaf Farooqi, I.31
Froguel, P.32
Ghori, J.33
Groves, C.J.34
Gwilliam, R.35
Hadley, D.36
Hall, A.S.37
Hattersley, A.T.38
Hebebrand, J.39
Heid, I.M.40
Lamina, C.41
Gieger, C.42
Illig, T.43
Meitinger, T.44
Wichmann, H.-E.45
Herrera, B.46
Hinney, A.47
Hunt, S.E.48
Jarvelin, M.-R.49
Johnson, T.50
Jolley, J.D.M.51
Karpe, F.52
Keniry, A.53
Khaw, K.-T.54
Luben, R.N.55
Mangino, M.56
Marchini, J.57
McArdle, W.L.58
McGinnis, R.59
Meyre, D.60
Munroe, P.B.61
Morris, A.D.62
Ness, A.R.63
Neville, M.J.64
Nica, A.C.65
Ong, K.K.66
O'Rahilly, S.67
Owen, K.R.68
Palmer, C.N.A.69
Papadakis, K.70
Potter, S.71
Pouta, A.72
Qi, L.73
Kraft, P.74
Hankinson, S.E.75
Hunter, D.J.76
Hu, F.B.77
Randall, J.C.78
Rayner, N.W.79
Ring, S.M.80
Sandhu, M.S.81
Scherag, A.82
Sims, M.A.83
Song, K.84
Soranzo, N.85
Speliotes, E.K.86
Lyon, H.N.87
Voight, B.F.88
Ridderstrale, M.89
Groop, L.90
Syddall, H.E.91
Teichmann, S.A.92
Timpson, N.J.93
Tobias, J.H.94
Uda, M.95
Scheet, P.96
Sanna, S.97
more..
-
28
-
-
58149163142
-
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
-
1:CAS:528:DC%2BD1cXhsV2hsrnK 10.1038/ng.287 19079261
-
CJ Willer EK Speliotes RJ Loos, et al. 2009 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation Nat Genet 41 25 34 1:CAS:528:DC%2BD1cXhsV2hsrnK 10.1038/ng.287 19079261
-
(2009)
Nat Genet
, vol.41
, pp. 25-34
-
-
Willer, C.J.1
Speliotes, E.K.2
Loos, R.J.3
-
29
-
-
58149163141
-
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
-
1:CAS:528:DC%2BD1cXhsV2hsrjO 10.1038/ng.274 19079260
-
G Thorleifsson GB Walters DF Gudbjartsson, et al. 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity Nat Genet 41 18 24 1:CAS:528:DC%2BD1cXhsV2hsrjO 10.1038/ng.274 19079260
-
(2009)
Nat Genet
, vol.41
, pp. 18-24
-
-
Thorleifsson, G.1
Walters, G.B.2
Gudbjartsson, D.F.3
-
30
-
-
67651236725
-
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution
-
10.1371/journal.pgen.1000508 19557161
-
CM Lindgren IM Heid JC Randall, et al. 2009 Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution PLoS Genet 5 e1000508 10.1371/journal.pgen.1000508 19557161
-
(2009)
PLoS Genet
, vol.5
, pp. 1000508
-
-
Lindgren, C.M.1
Heid, I.M.2
Randall, J.C.3
-
31
-
-
34249777814
-
Variation in FTO contributes to childhood obesity and severe adult obesity
-
DOI 10.1038/ng2048, PII NG2048
-
C Dina D Meyre S Gallina, et al. 2007 Variation in FTO contributes to childhood obesity and severe adult obesity Nat Genet 39 724 726 1:CAS:528:DC%2BD2sXlvVSgtL0%3D 10.1038/ng2048 17496892 (Pubitemid 46848595)
-
(2007)
Nature Genetics
, vol.39
, Issue.6
, pp. 724-726
-
-
Dina, C.1
Meyre, D.2
Gallina, S.3
Durand, E.4
Korner, A.5
Jacobson, P.6
Carlsson, L.M.S.7
Kiess, W.8
Vatin, V.9
Lecoeur, C.10
Delplanque, J.11
Vaillant, E.12
Pattou, F.13
Ruiz, J.14
Weill, J.15
Levy-Marchal, C.16
Horber, F.17
Potoczna, N.18
Hercberg, S.19
Le Stunff, C.20
Bougneres, P.21
Kovacs, P.22
Marre, M.23
Balkau, B.24
Cauchi, S.25
Chevre, J.-C.26
Froguel, P.27
more..
-
32
-
-
0031016728
-
Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians
-
1:STN:280:DyaK2s7psFGmsQ%3D%3D 9042926
-
H Sakul R Pratley L Cardon, et al. 1997 Familiality of physical and metabolic characteristics that predict the development of non-insulin-dependent diabetes mellitus in Pima Indians Am J Hum Genet 60 651 656 1:STN:280: DyaK2s7psFGmsQ%3D%3D 9042926
-
(1997)
Am J Hum Genet
, vol.60
, pp. 651-656
-
-
Sakul, H.1
Pratley, R.2
Cardon, L.3
-
33
-
-
0033312608
-
Heritability of pancreatic β-cell function among nondiabetic members of Caucasian familial type 2 diabetic kindreds
-
1:CAS:528:DyaK1MXisVyrtLo%3D 10.1210/jc.84.4.1398 10199785
-
SC Elbein SJ Hasstedt K Wegner SE Kahn 1999 Heritability of pancreatic β-cell function among nondiabetic members of Caucasian familial type 2 diabetic kindreds J Clin Endocrinol Metab 84 1398 1403 1:CAS:528: DyaK1MXisVyrtLo%3D 10.1210/jc.84.4.1398 10199785
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 1398-1403
-
-
Elbein, S.C.1
Hasstedt, S.J.2
Wegner, K.3
Kahn, S.E.4
-
34
-
-
0032980306
-
Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus
-
DOI 10.1159/000022865
-
RM Watanabe T Valle ER Hauser, et al. 1999 Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus Hum Hered 49 159 168 1:STN:280:DyaK1M3psVOgtw%3D%3D 10.1159/000022865 10364681 (Pubitemid 29261381)
-
(1999)
Human Heredity
, vol.49
, Issue.3
, pp. 159-168
-
-
Watanabe, R.M.1
Valle, T.2
Hauser, E.R.3
Ghosh, S.4
Eriksson, J.5
Kohtamaki, K.6
Ehnholm, C.7
Tuomilehto, J.8
Collins, F.S.9
Bergman, R.N.10
Boehnke, M.11
-
35
-
-
0343518970
-
Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins
-
1:CAS:528:DC%2BD3cXhsFyltbY%3D 10.1007/s001250050046 10768089
-
M Lehtovirta J Kaprio C Forsblom, et al. 2000 Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins Diabetologia 43 285 293 1:CAS:528:DC%2BD3cXhsFyltbY%3D 10.1007/s001250050046 10768089
-
(2000)
Diabetologia
, vol.43
, pp. 285-293
-
-
Lehtovirta, M.1
Kaprio, J.2
Forsblom, C.3
-
36
-
-
0034049630
-
Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity
-
1:CAS:528:DC%2BD3cXjt1Ckuro%3D 10.2337/diacare.23.3.295 10868854
-
M Stumvoll A Mitrakou W Pimenta, et al. 2000 Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity Diabetes Care 23 295 301 1:CAS:528:DC%2BD3cXjt1Ckuro%3D 10.2337/diacare.23.3.295 10868854
-
(2000)
Diabetes Care
, vol.23
, pp. 295-301
-
-
Stumvoll, M.1
Mitrakou, A.2
Pimenta, W.3
-
37
-
-
0032821965
-
Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp
-
DOI 10.2337/diacare.22.9.1462
-
M Matsuda RA DeFronzo 1999 Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp Diabetes Care 22 1462 1470 1:STN:280:DyaK1MvgvVertQ%3D%3D 10.2337/diacare.22.9. 1462 10480510 (Pubitemid 29418240)
-
(1999)
Diabetes Care
, vol.22
, Issue.9
, pp. 1462-1470
-
-
Matsuda, M.1
DeFronzo, R.A.2
-
38
-
-
0031711610
-
Insulin sensitivity indices calculated from basal and OGTT-induced insulin, glucose, and FFA levels
-
DOI 10.1006/mgme.1997.2658
-
F Belfiore S Iannello G Volpicelli 1998 Insulin sensitivity indices calculated from basal and OGTT-induced insulin, glucose, and FFA levels Mol Genet Metab 63 134 141 1:CAS:528:DyaK1cXisFSmur0%3D 10.1006/mgme.1997.2658 9562967 (Pubitemid 28453331)
-
(1998)
Molecular Genetics and Metabolism
, vol.63
, Issue.2
, pp. 134-141
-
-
Belfiore, F.1
Iannello, S.2
Volpicelli, G.3
-
39
-
-
0033969799
-
0,120): Comparison with other measures
-
DOI 10.1016/S0168-8227(99)00116-3, PII S0168822799001163
-
M Gutt CL Davis SB Spitzer, et al. 2000 Validation of the insulin sensitivity index (ISI(0, 120)): comparison with other measures Diabetes Res Clin Pract 47 177 184 1:CAS:528:DC%2BD3cXosValuw%3D%3D 10.1016/S0168-8227(99) 00116-3 10741566 (Pubitemid 30068708)
-
(2000)
Diabetes Research and Clinical Practice
, vol.47
, Issue.3
, pp. 177-184
-
-
Gutt, M.1
Davis, C.L.2
Spitzer, S.B.3
Llabre, M.M.4
Kumar, M.5
Czarnecki, E.M.6
Schneiderman, N.7
Skyler, J.S.8
Marks, J.B.9
-
40
-
-
0022361971
-
Assessment of insulin sensitivity in vivo
-
1:CAS:528:DyaL2MXitFGiurs%3D 10.1210/edrv-6-1-45 3884329
-
RN Bergman DT Finegood M Ader 1985 Assessment of insulin sensitivity in vivo Endocr Rev 6 45 86 1:CAS:528:DyaL2MXitFGiurs%3D 10.1210/edrv-6-1-45 3884329
-
(1985)
Endocr Rev
, vol.6
, pp. 45-86
-
-
Bergman, R.N.1
Finegood, D.T.2
Ader, M.3
-
41
-
-
48749112040
-
OGTT-derived measures of insulin sensitivity are confounded by factors other than insulin sensitivity itself
-
10.1038/oby.2008.336 18670420 This is the first study to use mathematical modeling to assess the quality of indirect measures of insulin resistance
-
K Hücking RM Watanabe D Stefanovski RN Bergman 2008 OGTT-derived measures of insulin sensitivity are confounded by factors other than insulin sensitivity itself Obesity 16 1938 1945 10.1038/oby.2008.336 18670420 This is the first study to use mathematical modeling to assess the quality of indirect measures of insulin resistance
-
(2008)
Obesity
, vol.16
, pp. 1938-1945
-
-
Hücking, K.1
Watanabe, R.M.2
Stefanovski, D.3
Bergman, R.N.4
-
42
-
-
0042767042
-
Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin
-
DOI 10.2337/diabetes.52.8.2168
-
RN Bergman DJ Zaccaro RM Watanabe, et al. 2003 Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin Diabetes 52 2168 2174 1:CAS:528:DC%2BD3sXlvFCgtbY%3D 10.2337/diabetes.52.8.2168 12882937 (Pubitemid 36919813)
-
(2003)
Diabetes
, vol.52
, Issue.8
, pp. 2168-2174
-
-
Bergman, R.N.1
Zaccaro, D.J.2
Watanabe, R.M.3
Haffner, S.M.4
Saad, M.F.5
Norris, J.M.6
Wagenknecht, L.E.7
Hokanson, J.E.8
Rotter, J.I.9
Rich, S.S.10
-
43
-
-
37349056377
-
Association between KCNJ11 E23K genotype and cardiovascular and glucose metabolism phenotypes in older men and women
-
DOI 10.1113/expphysiol.2007.038893
-
Y Yi L Dongmei DA Phares, et al. 2008 Association between KCNJ11 E23K genotype and cardiovascular and glucose metabolism phenotypes in older men and women Exp Physiol 93 95 103 1:CAS:528:DC%2BD1cXivFKlu7o%3D 10.1113/expphysiol. 2007.038893 17720745 (Pubitemid 350293965)
-
(2008)
Experimental Physiology
, vol.93
, Issue.1
, pp. 95-103
-
-
Yi, Y.1
Dongmei, L.2
Phares, D.A.3
Weiss, E.P.4
Brandauer, J.5
Hagberg, J.M.6
-
44
-
-
17844377908
-
ATP channels: Muscular impact on type 2 diabetes
-
DOI 10.2337/diabetes.54.5.1592
-
L Li Y Shi X Wang, et al. 2005 Single nucleotide polymorphisms in K(ATP) channels: muscular impact on type 2 diabetes Diabetes 54 1592 1597 1:CAS:528:DC%2BD2MXktVCktrk%3D 10.2337/diabetes.54.5.1592 15855351 (Pubitemid 40586695)
-
(2005)
Diabetes
, vol.54
, Issue.5
, pp. 1592-1597
-
-
Li, L.1
Shi, Y.2
Wang, X.3
Shi, W.4
Jiang, C.5
-
45
-
-
0029933511
-
A variation at position -30 of the β-cell glucokinase gene promoter is associated with reduced β-cell function in middle-aged Japanese-American men
-
10.2337/diabetes.45.4.422
-
LM Stone SE Kahn WY Fujimoto, et al. 1996 A variation at position -30 of the β-cell glucokinase gene promoter is associated with reduced β-cell function in middle-aged Japanese-American men Diabetes 45 428 10.2337/diabetes.45.4.422
-
(1996)
Diabetes
, vol.45
, pp. 428
-
-
Stone, L.M.1
Kahn, S.E.2
Fujimoto, W.Y.3
-
46
-
-
19944432769
-
Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet promoter of the glucokinase gene
-
1:CAS:528:DC%2BD2MXhsVCrtrY%3D 10.2337/diabetes.54.2.576 15677518
-
MN Weedon TM Frayling B Shields, et al. 2005 Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet promoter of the glucokinase gene Diabetes 54 576 581 1:CAS:528:DC%2BD2MXhsVCrtrY%3D 10.2337/diabetes.54.2.576 15677518
-
(2005)
Diabetes
, vol.54
, pp. 576-581
-
-
Weedon, M.N.1
Frayling, T.M.2
Shields, B.3
-
47
-
-
46749100599
-
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
-
WM Chen MR Erdos AU Jackson, et al. 2008 Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels J Clin Invest 118 2609 2628
-
(2008)
J Clin Invest
, vol.118
, pp. 2609-2628
-
-
Chen, W.M.1
Erdos, M.R.2
Jackson, A.U.3
-
48
-
-
44449091627
-
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels
-
DOI 10.1126/science.1156849
-
N Bouatia-Naji G Rocheleau L Van Lommel, et al. 2008 A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels Science 320 1085 1088 1:CAS:528:DC%2BD1cXmtVKnsLc%3D 10.1126/science.1156849 18451265 (Pubitemid 351929551)
-
(2008)
Science
, vol.320
, Issue.5879
, pp. 1085-1088
-
-
Bouatia-Naji, N.1
Rocheleau, G.2
Van Lommel, L.3
Lemaire, K.4
Schuit, F.5
Cavalcanti-Proenca, C.6
Marchand, M.7
Hartikainen, A.-L.8
Sovio, U.9
De Graeve, F.10
Rung, J.11
Vaxillaire, M.12
Tichet, J.13
Marre, M.14
Balkau, B.15
Weill, J.16
Elliott, P.17
Jarvelin, M.-R.18
Meyre, D.19
Polychronakos, C.20
Dina, C.21
Sladek, R.22
Froguel, P.23
more..
-
49
-
-
73249120208
-
Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose
-
1:CAS:528:DC%2BD1MXhsFKlu77F 10.2337/db09-0228 19741163 This study demonstrates the complex nature of combined gene effects, even under the assumption of additivity. The results suggest that interorgan signaling may play a role in gene variants exerting biologic effects
-
X Li YH Shu AH Xiang, et al. 2009 Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose Diabetes 58 2946 2953 1:CAS:528:DC%2BD1MXhsFKlu77F 10.2337/db09-0228 19741163 This study demonstrates the complex nature of combined gene effects, even under the assumption of additivity. The results suggest that interorgan signaling may play a role in gene variants exerting biologic effects
-
(2009)
Diabetes
, vol.58
, pp. 2946-2953
-
-
Li, X.1
Shu, Y.H.2
Xiang, A.H.3
|