Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity

Diabetes Care

Volumn 23, Issue 3, 2000, Pages 295-301

  Stumvoll, Michael ^a,g   Mitrakou, Asimina ^b   Pimenta, Walkyria ^c   Jenssen, Trond ^d   Yki Järvinen, Hannele ^e   Van Haeften, Timon ^f   Renn, Walter ^a   Gerich, John ^c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Second Dept Int Med Propaedeutics   (Greece)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e UNIVERSITY OF HELSINKI   (Finland)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^g UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ACCURACY; ADULT; AGED; ANALYTIC METHOD; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; METABOLIC CLEARANCE RATE; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; PREDICTION;

EID: 0034049630     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.23.3.295     Document Type: Article

References (29)

1. World Health Organization: WHO Expert Committee on Diabetes Mellitus. Second Report. Geneva, World Health Org. (Tech. Rep. Ser., no. 646-1)
2. Reaven GM, Brand RJ, Chen YD, Mathur AK, Goldfine I: Insulin resistance and insulin secretion are determinants of oral glucose tolerance in normal individuals. Diabetes 42:1324-1332, 1993
3. Huang XH, Ramalaiho V, Wirta O, Pasternack A, Koivula T, Hiltunen T, Nikkari T, Lehtimaki T: Relationship of the angiotensin-converting enzyme gene polymorphism to glucose intolerance, insulin resistance, and hypertension in MDDM. Hum Genet 102:372-378, 1998
4. Matsui H, Hashimoto H, Fukushima A, Kanayama H, Mitani S, Toki Y, Okumura K, Ito T: MB fraction of cumulative creatine kinase correlates with insulin secretion in patients with acute myocardial infarction: insulin as a possible determinant of myocardial MB creatine kinase. Am Heart J 131:24-31, 1996
5. Giorda C, Appendino M: Effects of doxazosin, a selective alpha 1-inhibitor, on plasma insulin and blood glucose response to a glucose tolerance test in essential hypertension. Metabolism 42:1440-1442, 1993
6. Haffner SM, Kennedy K, Gonzalez C, Stern MP, Miettinen H: A prospective analysis of the HOMA model: the Mexico City Diabetes Study. Diabetes Care 19:1138-1141, 1996
7. Haffner SM, Miettinen H, Stern MP: The homeostasis model in the San Antonio Heart Study. Diabetes Care 20:1087-1092, 1997
8. Polonsky KS, Given BD, Hirsch L, Shapiro ET, Tillil H, Beebe C, Galloway JA, Frank BH, Karrison T, Van-Cauter E: Quantitative study of insulin secretion and clearance in normal and obese subjects. J Clin Invest 81: 435-441, 1988
9. DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223, 1979
10. Pimenta W, Mitrakou A, Jensen T, Yki-Järvinen H, Daily G, Gerich J: Insulin secretion and insulin sensitivity in people with impaired glucose tolerance. Diabet Med 13 (Suppl.):S33-S36, 1996
11. Pimenta W, Kortytkowski M, Mitrakou A, Jenssen T, Yki-Järvinen H, Evron W, Dailey G, Gerich J: Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. JAMA 273:1851-1861, 1995
12. Mitrakou A, Vuorinen-Markkola H, Raptis G, Toft I, Mokan M, Strumph P, Pimenta W, Veneman T, Jenssen T, Bolli G, Korytkowski M, Yki-Järvinen H, Gerich J: Simultaneous assessment of insulin secretion and insulin sensitivity using a hyperglycemic clamp. J Clin Endocrinol Metab 75: 379-382, 1992
13. Cornbleet PJ, Shea MC: Comparison of product moment and rank correlation coeflicients in the assessment of laboratory method-comparison data. Clin Chem 24: 857-861, 1978
14. Cederholm J, Wibell L: Insulin release and peripheral sensitivity at the oral glucose tolerance test. Diabetes Res Clin Pract 10: 167-175, 1990
15. Matsuda A, DeFronzo R: Insulin sensitivity indices obtained from oral glucose tolerance testing. Diabetes Care 22:1462-1470, 1999
16. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419, 1985
17. Diaconis P, Efron B: Computer-intensive methods in statistics. Scientific American 248:116-132, 1981
18. Haffner SM, Mieettinen H, Gaskill SP, Stern MP: Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes 44:1186-1191, 1995
19. Henriksen JE, Alford F, Ward GM, Beck-Nielsen H: Risk and mechanism of dexamethasone-incluced deterioration of glucose tolerance in non-diabetic first-degree relatives of NIDDM patients Diabetologia 40: 1439-1448, 1997
20. Mitrakou A, Kelley D, Mokan M, Veneman T, Pangburn T, Reilly T, Gerich J: Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 326:22-29, 1992
21. DeFronzo RA: Glucose intolerance and aging. Diabetes Care 4:493-501, 1981
22. Rowe JW, Minaker KL, Pallotta JA, Flier JS: Characterization of the insulin resistance of aging. J Clin Invest 71:1581-1587, 1983
23. Elahi D, Muller DC, McAloon-Dyke M, Tobin JD, Andres R: The effect of age on insulin response and glucose utilization during lour hyperglycemic plateaus. Exp Gerontol 28:393-409, 1993
24. Pacini G, Valerio A, Beccaro F, Nosadini R, Cobelli C, Crepaldi G: Insulin sensitivity and beta-cell responsivity are not decreased in elderly subjects with normal OGTT. J Am Geriatr Soc 36:317-323, 1988
25. Chen M, Bergman RN, Pacini G, Porte D Jr: Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased beta-cell function. J Clin Endocrinol Metab 60:13-20, 1985
26. Muller DG, Elahi D, Tobin JD, Andres R: The effect of age on insulin resistance and secretion: a review. Semin Nephrol 16:289-298, 1996
27. Broughton DL, James OW, Alberti KG, Taylor R: Peripheral and hepatic insulin sensitivity in healthy elderly human subjects. Eur J Clin Invest 21 13-21, 1991
28. Ferrannini E, Vichi S, Beck-Nielsen H, Laakso M, Paolisso G, Smith U: Insulin action and age: European Group for the Study of Insulin Resistance (EGIR). Diabetes 45:947-953, 1996
29. Smith SR: The endocrinology of obesity. Endocrinol Metab Clin North Am 25:921-942, 1996