Psammomys obesus, a model for environment-gene interactions in type 2 diabetes

Diabetes

Volumn 54, Issue SUPPL. 2, 2005, Pages

  Kaiser, Nurit ^a   Nesher, Rafael ^a   Donath, Marc Y ^b   Fraenkel, Merav ^a   Behar, Vered ^c   Magnan, Christophe ^d   Ktorza, Alain ^e   Cerasi, Erol ^a   Leibowitz, Gil ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c QuantomiX Ltd   (Israel)

^d CNRS   (France)

^e INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PREPROINSULIN;

ANIMAL FOOD; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CALORIC INTAKE; CELL DEATH; CELL SURVIVAL; CORRELATION ANALYSIS; DEPLETION; DIETARY INTAKE; DISEASE COURSE; DISEASE PREDISPOSITION; ENVIRONMENT; GENE FUNCTION; GENE INTERACTION; GENETIC ANALYSIS; GENOTYPE ENVIRONMENT INTERACTION; GERBIL; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN SYNTHESIS; LOW CALORY DIET; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRITION; OBESITY; PANCREAS; PANCREAS ISLET BETA CELL; POSTPRANDIAL STATE; PRIORITY JOURNAL; PSAMMOMYS OBESUS;

ANIMAL FEED; ANIMALS; DIABETES MELLITUS, TYPE 2; DIET; DISEASE MODELS, ANIMAL; ENVIRONMENT; GERBILLINAE; INSULIN; ISLETS OF LANGERHANS;

EID: 33644774603     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/diabetes.54.suppl_2.S137     Document Type: Article

References (43)

1. Adler JH, Kalman R, Lazarovici G, Bar-On H, Ziv E: Achieving predictable model of type 2 diabetes in the sand rat. In Frontiers in Diabetes Research: Lessons from Animal Diabetes III. Shafrir E, Ed. London, Smith-Gordon, 1991, p. 212-214
2. Shafrir E, Gutman A: Psammomys obesus of the Jerusalem colony: a model for nutritionally induced non-insulin-dependent diabetes. J Basic Clin Physiol Pharmacol 4:83-89, 1993
3. Kalman R, Ziv E, Adler JH, Lazarovici G, Bar-On H: The efficiency of the sand rat metabolism is responsible for the development of obesity and diabetes. J Basic Clin Physiol Pharmacol 4:57-68, 1993
4. Kalman R, Lazarovici G, Bar-On H, Ziv E: The sand rat (Psammomys obesus): morphologic, physiologic and biochemical characteristics of a model for type II diabetes mellitus. Contemp Topics Lab Anim Sci 35:67-70, 1996
5. Kalderon B, Gutman A, Levy E, Shafrir E, Adler JH: Characterization of stages in development of obesity-diabetes syndrome in the sand rat (Psammomys obesus). Diabetes 35:717-723, 1986
6. Kaiser N, Yuli M, Uckaya G, Oprescu AI, Berthault MF, Kargar C, Donath MY, Cerasi E, Ktorza A: Dynamic changes in β-cell mass and pancreatic insulin during evolution of nutrition-dependent diabetes in Psammomys obesus. Diabetes 54:138-145, 2005
7. Jorns A, Tiedge M, Ziv E, Shafrir E, Lenzen S: Gradual loss of pancreatic beta-cell insulin, glucokinase and GLUT2 glucose transporter immunoreactivities during the time course of nutritionally induced type-2 diabetes in Psammomys obesus (sand rat). Virchows Arch 440:63-69, 2002
8. Ziv E, Kalman R, Hershkop K, Barash V, Shafrir E, Bar-On H: Insulin resistance in the NIDDM model Psammomys obesus in the normoglycaemic, normoinsulinaemic state. Diabetologia 39:1269-1275, 1996
9. Shafrir E, Ziv E, Saha AK, Ruderman NB: Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus. Diabetes Metab Res Rev 18:217-223, 2002
10. Nesher R, Gross DJ, Donath MY, Cerasi E, Kaiser N: Interaction between genetic and dietary factors determines β-cell function in Psammomys obesus, an animal model of type 2 diabetes. Diabetes 48:731-737, 1999
11. Donath MY, Gross DJ, Cerasi E, Kaiser N: Hyperglycemia-induced β cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes 48:738-744, 1999
12. Ward WK, LaCava EC, Paquette TL, Beard JC, Wallum BJ, Porte DJ: Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance. Diabetologia 30:698-702, 1987
13. Gadot M, Leibowitz G, Shafrir E, Cerasi E, Gross D, Kaiser N: Hyperproinsulinemia and insulin deficiency in the diabetic Psammomys obesus. Endocrinology 135:610-616, 1994
14. Gadot M, Ariav Y, Cerasi E, Kaiser N, Gross D: Hyperproinsulinemia in the diabetic Psammomys obesus is a result of increased secretory demand on the B-cell. Endocrinology 136:4218-4223, 1995
15. Walder K, Oakes N, Fahey RP, Cooney G, Zimmet OZ, Collier GR: Profile of dyslipidemia in Psammomys obesus, an animal model of the metabolic syndrome. Endocrine Reg 36:1-8, 2002
16. Shafrir E, Spielman S, Nachliel I, Khamaisi M, Bar-On H, Ziv E: Treatment of diabetes with vanadium salts: general overview and amelioration of nutritionally induced diabetes in the Psammomys obesus gerbil. Diabetes Metab Res Rev 17:55-66, 2001
17. Kanety H, Moshe S, Shafrir E, Lunenfeld B, Karasik A: Hyperinsulinemia induces a reversible impairment in insulin receptor function leading to diabetes in the sand rat model of NIDDM. Proc Natl Acad Sci U S A 91:1853-1857, 1994
18. Thiberge S, Nechushtan A, Sprinzak D, Gileadi O, Behar V, Zik O, Chowers Y, Michaeli S, Schlessinger J, Moses E: Scanning electron microscopy of cells and tissues under fully hydrated conditions. Proc Natl Acad Sci U S A 101:3346-3351, 2004
19. Jacob S, Machann J, Rett K, Brechtel K, Volk A, Renn W, Maerker E, Matthaei S, Schick F, Claussen CD, Haring HU: Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48:1113-1119, 1999
20. Van Loon LJC, Koopman R, Manders R, van der Weegen W, van Kranenburg GP, Keizer HA: Intramyocellular lipid content in type 2 diabetic patients compared with overweight sedentary men and highly trained endurance athlets. Am J Physiol Endocrinol Metab 287:E558-E565, 2004
21. Heled Y, Shapiro Y, Shani Y, Moran DS, Langzam L, Braiman L, Sampson SR, Meyerovitch J: Physical exercise enhances protein kinase C δ activity and insulin receptor tyrosine phosphorylation in diabetes-prone Psammomys obesus. Metabolism 52:1028-1033, 2003
22. Heled Y, Shapiro Y, Shani Y, Moran DS, Langzam L, Barash V, Sampson SR, Meyerovitch J: Physical exercise enhances hepatic insulin signaling and inhibits phosphoenolpyruvate carboxykinase activity in diabetes-prone Psammomys obesus. Metabolism 53:836-841, 2004
23. Cerasi E: Insulin deficiency and insulin resistance in the pathogenesis of NIDDM: is a divorce possible? Diabetologia 38:992-997, 1995
24. Weyer C, Bogardus C, Mott DM, Pratley RE: The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787-794, 1999
25. Kaiser N, Leibowitz G, Nesher R: Glucotoxicity and β-cell failure in type 2 diabetes mellitus. J Ped Endocrinol Metab 16:5-22, 2003
26. Nesher R, Warwar N, Khan A, Efendic S, Cerasi E, Kaiser N: Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes. Diabetes 50:308-314, 2001
27. Pertusa JAG, Nesher R, Kaiser N, Cerasi E, Henquin JC, Jonas JC: Increased glucose sensitivity of stimulus-secretion coupling in islets of Psammomys obesus after diet induction of diabetes. Diabetes 51:2552-2560, 2002
28. Leibowitz G, Yuli M, Donath M, Nesher R, Melloul D, Cerasi E, Gross D, Kaiser N: β-Cell glucotoxicity in the Psammomys obesus model of type 2 diabetes. Diabetes 50 (Suppl. 1):S113-S117, 2001
29. Leibowitz G, Uckaya G, Oprescu IA, Cerasi E, Gross DJ, Kaiser N: Defective glucose-regulated insulin gene expression limits insulin production in the Psammomys obesus model of type 2 diabetes (Abstract). Diabetologia 44 (Suppl. 1):A147, 2001
30. Leibowitz G, Khaldi MZ, Shauer A, Parnes M, Oprescu AI, Cerasi E, Jonas JC, Kaiser N: Mitochondrial regulation of insulin production in rat pancreatic islets. Diabetologia 48:1549-1559, 2005
31. Leibowitz G, Oprescu AI, Uckaya G, Gross DJ, Cerasi E, Kaiser N: Insulin does not mediate glucose stimulation of proinsulin biosynthesis. Diabetes 52:998-1003, 2003
32. Wicksteed B, Alarcon C, Briaud I, Lingohr MK, Rhodes CJ: Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin. J Biol Chem 278:42080-42090, 2003
33. Leibowitz G, Uckaya G, Oprescu AI, Cerasi E, Gross DJ, Kaiser N: Glucose-regulated proinsulin gene expression is required for adequate insulin production during chronic glucose exposure. Endocrinology 143:3214-3220, 2002
34. Leibowitz G, Ferber S, Apelquist A, Edlund H, Gross DJ, Cerasi E, Melloul D, Kaiser N: IPF1/PDX1 deficiency and β-cell dysfunction in Psammomys obesus, an animal with type 2 diabetes. Diabetes 50:1799-1806, 2001
35. Tanaka Y, Gleason CE, Tran PO, Harmon JS, Robertson RP: Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci U S A 96:10857-10862, 1999
36. Kaneto H, Kajimoto Y, Miyagawa J-I, Matsuoka T-A, Fujitani Y, Umayahara Y, Hanafusa T, Matsuzawa Y, Yamasaki Y, Hori M: Beneficial effects of antioxidants in diabetes: possible protection of pancreatic β-cells against glucose toxicity. Diabetes 48:2398-2406, 1999
37. Kawamori D, Kajimoto Y, Kaneto H, Umayahara Y, Fujitani Y, Miyatsuka T, Watada H, Leibiger IB, Yamasaki Y, Hori M: Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes 52:2896-2904, 2003
38. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC: Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110, 2003
39. Deng S, Vatamaniuk M, Huang X, Doliba N, Lian M-M, Frank A, Velidedeoglu E, Desai NM, Koeberlein B, Wolf B, Barker CF, Naji A, Matschinsky FM, Markmann JF: Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects. Diabetes 53:624-632, 2004
40. Guiot Y, Sempoux C, Moulin P, Rahier J: No decrease of the beta-cell mass in type 2 diabetic patients. Diabetes 50 (Suppl. 1):S188, 2001
41. Rahier J, Goebbels RM, Henquin JC: Cellular composition of the human diabetic pancreas. Diabetologia 24:366-371, 1983
42. Rahier J, Loozen S, Goebbels RM, Abrahem M: The haemochromatotic human pancreas: a quantitative immunohistochemical and ultrastructural study. Diabetologia 30:5-12, 1987
43. Stefan Y, Orci L, Malaisse-Lagae F, Perrelet A, Patel Y, Unger R: Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans. Diabetes 31:694-700, 1982