cGMP-independent anti-apoptotic effect of nitric oxide on thapsigargin-induced apoptosis in the pancreatic β-cell line INS-1

Life Sciences

Volumn 83, Issue 25-26, 2008, Pages 865-870

  Noguchi, Akiko ^a   Takada, Masahiro ^a   Nakayama, Koichi ^b   Ishikawa, Tomohisa ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; cGMP; INS 1; Nitric oxide; Thapsigargin

Indexed keywords

CYCLIC GMP; GUANYLATE CYCLASE INHIBITOR; NITRIC OXIDE; THAPSIGARGIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; NONHUMAN; PANCREAS ISLET BETA CELL; RAT;

ANIMALS; APOPTOSIS; CELL CULTURE TECHNIQUES; CELL LINE; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; INSULIN-SECRETING CELLS; NITRIC OXIDE; NITRIC OXIDE DONORS; OXADIAZOLES; QUINOXALINES; RATS; THAPSIGARGIN; TRIAZENES;

EID: 56949106182     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2008.10.002     Document Type: Article

References (29)

1. Asfari M., Janjic D., Meda P., Li G., Halban P.A., and Wollheim C.B. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130 (1992) 167-178
2. Butler A.E., Janson J., Bonner-Weir S., Ritzel R., Rizza R.A., and Butler P.C. β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52 (2003) 102-110
3. Cardozo A.K., Kruhøffer M., Leeman R., Ørntoft T., and Eizirik D.L. Identification of novel cytokine-induced genes in pancreatic β-cells by high-density oligonucleotide arrays. Diabetes 50 (2001) 909-920
4. Ceneviva G.D., Tzeng E., Hoyt D.G., Yee E., Gallagher A., Engelhardt J.F., Kim Y.M., Billiar T.R., Watkins S.A., and Pitt B.R. Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells. American Journal of Physiology 275 (1998) L717-728
5. Choi B.M., Pae H.O., Jang S.I., Kim Y.M., and Chung H.T. Nitric oxide as a pro-apoptotic as well as anti-apoptotic modulator. Journal of Biochemistry and Molecular Biology 35 (2002) 116-126
6. Ciani E., Virgili M., and Contestabile A. Akt pathway mediates a cGMP-dependent survival role of nitric oxide in cerebellar granule neurones. Journal of Neurochemistry 81 (2002) 218-228
7. Cnop M., Welsh N., Jonas J.C., Jörns A., Lenzen S., and Eizirik D.L. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54 (2005) S97-107
8. Darville M.I., and Eizirik D.L. Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Diabetologia 41 (1998) 1101-1108
9. Donath M.Y., Størling J., Maedler K., and Mandrup-Poulsen T. Inflammatory mediators and islet β-cell failure: a link between type 1 and type 2 diabetes. Journal of Molecular Medecine 81 (2003) 455-470
10. Eizirik D.L., and Mandrup-Poulsen T. A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44 (2001) 2115-2213
11. Genaro A.M., Hortelano S., Alvarez A., Martínez C., and Boscá L. Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels. Journal of Clinical Investigation 95 (1995) 1884-1890
12. 2+ concentration of rat pancreatic β-cells. Journal of Pharmacological Sciences 91 (2003) 41-46
13. 2+ concentration and insulin secretion in rat pancreatic beta-cells. American Journal of Physiology. Cell Physiology 284 (2003) C1215-1222
14. Kaneto H., Fujii J., Seo H.G., Suzuki K., Matsuoka T., Nakamura M., Tatsumi H., Yamasaki Y., Kamada T., and Taniguchi N. Apoptotic cell death triggered by nitric oxide in pancreatic β-cells. Diabetes 44 (1995) 733-738
15. Kim Y.M., Talanian R.V., and Billiar T.R. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. Journal of Biological Chemistry 272 (1997) 31138-31148
16. Kim Y.M., Chung H.T., Kim S.S., Han J.A., Yoo Y.M., Kim K.M., Lee G.H., Yun H.Y., Green A., Li J., Simmons R.L., and Billiar T.R. Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signaling. Journal of Neuroscience 19 (1999) 6740-6747
17. Kitiphongspattana K., Khan T.A., Ishii-Schrade K., Roe M.W., Philipson L.H., and Gaskins H.R. Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic β-cells. American Journal of Physiology. Endocrinology and Metabolism 292 (2007) E1543-E1554
18. Kutlu B., Cardozo A.K., Darville M.I., Kruhøffer M., Magnusson N., Øntoft T., and Eizirik D.L. Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes 52 (2003) 2701-2719
19. Loweth A.C., Williams G.T., Scarpello J.H., and Morgan N.G. Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15. FEBS Letters 400 (1997) 285-288
20. Mooradian D.L., Hutsell T.C., and Keefer L.K. Nitric oxide (NO) donor molecules: effect of NO release rate on vascular smooth muscle cell proliferation in vitro. Journal of Cardiovascular Pharmacology 25 (1995) 674-678
21. Nakada S., Ishikawa T., Yamamoto Y., Kaneko Y., and Nakayama K. Constitutive nitric oxide synthases in rat pancreatic islets: direct imaging of glucose-induced nitric oxide production in beta-cells. Pflügers Archiv 447 (2003) 305-311
22. Oyadomari S., Takeda K., Takiguchi M., Gotoh T., Matsumoto M., Wada I., Akira S., Araki E., and Mori M. Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway. Proceedings of the National Academy of Sciences of the United States of America 98 (2001) 10845-10850
23. Sakuraba H., Mizukami H., Yagihashi N., Wada R., Hanyu C., and Yagihashi S. Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia 45 (2002) 85-96
24. Sata M., Kakoki M., Nagata D., Nishimatsu H., Suzuki E., Aoyagi T., Sugiura S., Kojima H., Nagano T., Kangawa K., Matsuo H., Omata M., Nagai R., and Hirata Y. Adrenomedullin and nitric oxide inhibit human endothelial cell apoptosis via a cyclic GMP-independent mechanism. Hypertension 36 (2000) 83-88
25. Sjhölm Å., Berggren P.O., and Cooney R.V. γ-tocopherol partially protects insulin-secreting cells against functional inhibition by nitric oxide. Biochemical and Biophysical Research Communications 277 (2000) 334-340
26. Størling J., Binzer J., Andersson A.K., Züllig R.A., Tonnesen M., Lehmann R., Spinas G.A., Sandler S., Billestrup N., and Mandrup-Poulsen T. Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt. Diabetologia 48 (2005) 2039-2050
27. Tejedo J., Bernabé J.C., Ramírez R., Sobrino F., and Bedoya F.J. NO induces a cGMP-independent release of cytochrome c from mitochondria which precedes caspase 3 activation in insulin producing RINm5F cells. FEBS Letters 459 (1999) 238-243
28. Tejedo J.R., Ramírez R., Cahuana G.M., Rincón P., Sobrino F., and Bedoya F.J. Evidence for involvement of c-Src in the anti-apoptotic action of nitric oxide in serum-deprived RINm5F cells. Cellular Signalling 13 (2001) 809-817
29. Tejedo J.R., Cahuana G.M., Ramírez R., Esbert M., Jiménez J., Sobrino F., and Bedoya F.J. Nitric oxide triggers the phosphatidylinositol 3-kinase/Akt survival pathway in insulin-producing RINm5F cells by arousing Src to activate insulin receptor substrate-1. Endocrinology 145 (2004) 2319-2327