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Volumn 8, Issue 10, 1997, Pages 903-910

Modulation of chemosensitivity through altered expression of cell cycle regulatory genes in cancer

Author keywords

Cell cycle; Chemosensitivity; Regulatory genes

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; CYCLIN D1; METHOTREXATE; PROTEIN P16; PROTEIN P53;

EID: 0031455518     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199711000-00001     Document Type: Review
Times cited : (26)

References (80)
  • 1
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • Gottesman MM, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 1993; 62: 385-427.
    • (1993) Annu Rev Biochem , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 2
    • 0027253603 scopus 로고
    • The role of topoisomerase IIα and β in drug resistance
    • Hochhauser D, Harris AL. The role of topoisomerase IIα and β in drug resistance. Cancer Treat Rev 1993; 19: 181-94.
    • (1993) Cancer Treat Rev , vol.19 , pp. 181-194
    • Hochhauser, D.1    Harris, A.L.2
  • 3
    • 0028009789 scopus 로고
    • Cellular responses to cisplatin. the roles of DNA-binding proteins and DNA repair
    • Chu G. Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair. J Biol Chem 1994; 269: 787-90.
    • (1994) J Biol Chem , vol.269 , pp. 787-790
    • Chu, G.1
  • 4
    • 0027351189 scopus 로고
    • Ode to methotrexate
    • Bertino JR. Ode to methotrexate. J Clin Oncol 1993; 11: 5-14.
    • (1993) J Clin Oncol , vol.11 , pp. 5-14
    • Bertino, J.R.1
  • 5
    • 9044225527 scopus 로고    scopus 로고
    • BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy
    • Reed JC, Miyashita T, Takayama S, et al. BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J Cell Biochem 1996; 60: 23-32.
    • (1996) J Cell Biochem , vol.60 , pp. 23-32
    • Reed, J.C.1    Miyashita, T.2    Takayama, S.3
  • 6
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anti-cancer agents
    • Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anti-cancer agents. Cell 1993; 74: 957-67.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 7
    • 0027944206 scopus 로고
    • p53 status and the efficacy of cancer therapy in vivo
    • Lowe SW, Bodis S, McClatchley A, et al. p53 status and the efficacy of cancer therapy in vivo. Science 1994; 266: 807-10.
    • (1994) Science , vol.266 , pp. 807-810
    • Lowe, S.W.1    Bodis, S.2    McClatchley, A.3
  • 8
    • 0028171454 scopus 로고
    • p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents
    • Fan S, El-Deiry WS, Bae I, et al. p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res. 1994; 54: 5824-30.
    • (1994) Cancer Res. , vol.54 , pp. 5824-5830
    • Fan, S.1    El-Deiry, W.S.2    Bae, I.3
  • 9
    • 0028204160 scopus 로고
    • DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways
    • Nelson WG, Kastan MB. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol Cell Biol 1994; 14: 1815-23.
    • (1994) Mol Cell Biol , vol.14 , pp. 1815-1823
    • Nelson, W.G.1    Kastan, M.B.2
  • 10
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • el-Deiry WS, Tokino T, Velculescu VE, et al. WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75: 817-25.
    • (1993) Cell , vol.75 , pp. 817-825
    • El-Deiry, W.S.1    Tokino, T.2    Velculescu, V.E.3
  • 11
    • 0028880855 scopus 로고
    • Cyclins, cyclin-dependent kinases and cdk inhibitors: Implications in cell cycle control and cancer
    • MacLachlan TK, Sang N, Giordano A. Cyclins, cyclin-dependent kinases and cdk inhibitors: implications in cell cycle control and cancer. Crit Rev Eukaryot Gene Expr 1995; 5: 127-56.
    • (1995) Crit Rev Eukaryot Gene Expr , vol.5 , pp. 127-156
    • MacLachlan, T.K.1    Sang, N.2    Giordano, A.3
  • 12
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber TG, Osmanian C, Jacks T, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996; 379: 88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3
  • 13
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993; 362: 847-9.
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 14
    • 0026316735 scopus 로고
    • Guanine nucleotide biosynthesis is regulated by the cellular p53 concentration
    • Sherley JL. Guanine nucleotide biosynthesis is regulated by the cellular p53 concentration. J Biol Chem 1991; 266: 24815-28.
    • (1991) J Biol Chem , vol.266 , pp. 24815-24828
    • Sherley, J.L.1
  • 16
    • 0030013337 scopus 로고    scopus 로고
    • Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis
    • Attardi LD, Lowe SW, Brugarolas J, Jacks T. Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. EMBO J 1996; 15: 3693-701.
    • (1996) EMBO J , vol.15 , pp. 3693-3701
    • Attardi, L.D.1    Lowe, S.W.2    Brugarolas, J.3    Jacks, T.4
  • 17
    • 0030031757 scopus 로고    scopus 로고
    • Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cells is mediated by lower p53 levels
    • Ronen D, Schwartz D, Teitz Y, Goldfinger N, Rotter V. Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cells is mediated by lower p53 levels. Cell Growth Different 1996; 7: 21-30.
    • (1996) Cell Growth Different , vol.7 , pp. 21-30
    • Ronen, D.1    Schwartz, D.2    Teitz, Y.3    Goldfinger, N.4    Rotter, V.5
  • 18
    • 0027318202 scopus 로고
    • Wild-type p53 induces apoptosis in a Burkitt lymphoma (BL) line that carries mutant p53
    • Ramqvist T, Magnusson KP, Wang Y, Szekely L, Klein G, Wiman KG. Wild-type p53 induces apoptosis in a Burkitt lymphoma (BL) line that carries mutant p53. Oncogene 1993; 8: 1495-500.
    • (1993) Oncogene , vol.8 , pp. 1495-1500
    • Ramqvist, T.1    Magnusson, K.P.2    Wang, Y.3    Szekely, L.4    Klein, G.5    Wiman, K.G.6
  • 19
    • 0029856928 scopus 로고    scopus 로고
    • Wild-type p53 demonstrates functional dominance in a human colon carcinoma cell line in which it induces reversible growth arrest
    • Yang B, Stambrook PJ, Markowitz SD. Wild-type p53 demonstrates functional dominance in a human colon carcinoma cell line in which it induces reversible growth arrest. Clin Cancer Res 1996; 2: 1639-47.
    • (1996) Clin Cancer Res , vol.2 , pp. 1639-1647
    • Yang, B.1    Stambrook, P.J.2    Markowitz, S.D.3
  • 20
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ. Cancer cell cycles. Science 1996; 274: 1672-8.
    • (1996) Science , vol.274 , pp. 1672-1678
    • Sherr, C.J.1
  • 22
    • 0030991235 scopus 로고    scopus 로고
    • The retinoblastoma protein: A master regulator of cell cycle, differentiation and apoptosis
    • Herwig S, Strauss M. The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis. Eur J Biochem 1997; 246: 581-601.
    • (1997) Eur J Biochem , vol.246 , pp. 581-601
    • Herwig, S.1    Strauss, M.2
  • 23
    • 0028023976 scopus 로고
    • Transcriptional regulation of the dihydrofolate reductase/rep-3 locus
    • Schilling LJ, Farnham PJ. Transcriptional regulation of the dihydrofolate reductase/rep-3 locus. Crit Rev Enkaryot Gene Expr 1994; 4: 19-53.
    • (1994) Crit Rev Enkaryot Gene Expr , vol.4 , pp. 19-53
    • Schilling, L.J.1    Farnham, P.J.2
  • 24
    • 0028991396 scopus 로고
    • Mutation of cell cycle regulators; biological and clinical implications for human neoplasia
    • Cordon-Cardo C. Mutation of cell cycle regulators; biological and clinical implications for human neoplasia. Am J Pathol 1995; 147: 545-60.
    • (1995) Am J Pathol , vol.147 , pp. 545-560
    • Cordon-Cardo, C.1
  • 25
    • 0028970951 scopus 로고
    • Oncogenic aberrations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control
    • Lukas J, Aagaard L, Strauss M, Bartek J. Oncogenic aberrations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control. Cancer Res 1995; 55: 4818-23.
    • (1995) Cancer Res , vol.55 , pp. 4818-4823
    • Lukas, J.1    Aagaard, L.2    Strauss, M.3    Bartek, J.4
  • 26
    • 0030467624 scopus 로고    scopus 로고
    • The p16-cyclin D/ Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis
    • Bartkova J, Lukas J, Guldberg P, et al. The p16-cyclin D/ Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res 1996; 56: 5475-83.
    • (1996) Cancer Res , vol.56 , pp. 5475-5483
    • Bartkova, J.1    Lukas, J.2    Guldberg, P.3
  • 27
    • 0028124330 scopus 로고
    • Cyclin D1 overexpression vs retinoblastoma inactivation: Implications for growth control evasion in non-small cell and small cell lung cancer
    • Schauer IE, Siriwardana S, Langan TA, Sclafani RA. Cyclin D1 overexpression vs retinoblastoma inactivation: implications for growth control evasion in non-small cell and small cell lung cancer. Proc Natl Acad Sci USA 1994; 91: 7827-31.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7827-7831
    • Schauer, I.E.1    Siriwardana, S.2    Langan, T.A.3    Sclafani, R.A.4
  • 28
    • 0028961521 scopus 로고
    • Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines
    • Shapiro GI, Edwards CD, Kobzik L, et al. Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. Cancer Res 1995; 55: 505-9.
    • (1995) Cancer Res , vol.55 , pp. 505-509
    • Shapiro, G.I.1    Edwards, C.D.2    Kobzik, L.3
  • 29
    • 0029845760 scopus 로고    scopus 로고
    • Structure and function of the p53 tumor suppressor gene: Clues for rational cancer therapeutic strategies
    • Harris CC. Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies. J Natl Cancer Inst 1996; 88: 1442-55.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1442-1455
    • Harris, C.C.1
  • 30
    • 0029944241 scopus 로고    scopus 로고
    • A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation
    • Lutzker SG, Levine AJ. A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation. Nat Med 1996; 2: 804-10.
    • (1996) Nat Med , vol.2 , pp. 804-810
    • Lutzker, S.G.1    Levine, A.J.2
  • 31
    • 0028785913 scopus 로고
    • Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress
    • Banerjee D, Lenz H-J, Schnieders B, et al. Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress. Cell Growth Afferent 1995; 6: 1405-13.
    • (1995) Cell Growth Afferent , vol.6 , pp. 1405-1413
    • Banerjee, D.1    Lenz, H.-J.2    Schnieders, B.3
  • 32
    • 0029738119 scopus 로고    scopus 로고
    • p53 nuclear protein overexpression in colorectal cancer: A dominant predictor of survival in patients with advanced hepatic metastases
    • Belluco C, Guillem JG, Kemeny N, et al. p53 nuclear protein overexpression in colorectal cancer: a dominant predictor of survival in patients with advanced hepatic metastases. J Clin Oncol 1996; 14: 2696-701.
    • (1996) J Clin Oncol , vol.14 , pp. 2696-2701
    • Belluco, C.1    Guillem, J.G.2    Kemeny, N.3
  • 33
    • 0028901034 scopus 로고
    • Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline
    • Fan S, Smith ML, Rivet DJ, et al. Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline. Cancer Res 1995; 00: 1649-54.
    • (1995) Cancer Res , vol.0 , pp. 1649-1654
    • Fan, S.1    Smith, M.L.2    Rivet, D.J.3
  • 34
    • 13344249778 scopus 로고    scopus 로고
    • A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma
    • Righetti SC, Della Torre G, Pilotti S, et al. A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma. Cancer Res 1996; 56: 689-93.
    • (1996) Cancer Res , vol.56 , pp. 689-693
    • Righetti, S.C.1    Della Torre, G.2    Pilotti, S.3
  • 35
    • 0028840535 scopus 로고
    • Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer
    • Rusch V, Klimstra D, Venkatraman E, et al. Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer. Cancer Res 1995; 55: 5038-42.
    • (1995) Cancer Res , vol.55 , pp. 5038-5042
    • Rusch, V.1    Klimstra, D.2    Venkatraman, E.3
  • 37
    • 9544220646 scopus 로고    scopus 로고
    • p53 mutations do not predict response to paclitaxel/radiation for nonsmall cell lung carcinoma
    • Safran H, King T, Choy H, et al. p53 mutations do not predict response to paclitaxel/radiation for nonsmall cell lung carcinoma. Cancer 1996; 78: 1203-10.
    • (1996) Cancer , vol.78 , pp. 1203-1210
    • Safran, H.1    King, T.2    Choy, H.3
  • 38
    • 0026683175 scopus 로고
    • p53 mutations in human lung tumors
    • Miller CW, Simon K, Aslo A, et al. p53 mutations in human lung tumors. Cancer Res 1992; 52: 1695-8.
    • (1992) Cancer Res , vol.52 , pp. 1695-1698
    • Miller, C.W.1    Simon, K.2    Aslo, A.3
  • 39
    • 0029956081 scopus 로고    scopus 로고
    • Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
    • Aas T, Borresen A-L, Geisler S, et al. Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nat Med 1996; 2: 811-4.
    • (1996) Nat Med , vol.2 , pp. 811-814
    • Aas, T.1    Borresen, A.-L.2    Geisler, S.3
  • 40
    • 0029910935 scopus 로고    scopus 로고
    • p53 regulates the minimal promoter of the human topoisomerase II alpha gene
    • Sandri MI, Isaacs RJ, Ongkeko WM, et al. p53 regulates the minimal promoter of the human topoisomerase II alpha gene. Nucleic Acids Res 1996; 24: 4464-70.
    • (1996) Nucleic Acids Res , vol.24 , pp. 4464-4470
    • Sandri, M.I.1    Isaacs, R.J.2    Ongkeko, W.M.3
  • 41
    • 0031014797 scopus 로고    scopus 로고
    • Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor
    • Wang Q, Zambetti GP, Suttle DP. Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Mol Cell Biol 1997; 17: 389-97.
    • (1997) Mol Cell Biol , vol.17 , pp. 389-397
    • Wang, Q.1    Zambetti, G.P.2    Suttle, D.P.3
  • 42
    • 0026348140 scopus 로고
    • Relationship between topoisomerase II level and chemosensitivity in human tumour cell lines
    • Fry AM, Chresta CM, Davies SM, et al. Relationship between topoisomerase II level and chemosensitivity in human tumour cell lines. Cancer Res 1991; 51: 6592-5.
    • (1991) Cancer Res , vol.51 , pp. 6592-6595
    • Fry, A.M.1    Chresta, C.M.2    Davies, S.M.3
  • 43
    • 0026555717 scopus 로고
    • Modulation of the activity of the promoter of the human MDR1 gene by Ras and p53
    • Chin K-V, Ueda K, Pastan I, Gottesman MM. Modulation of the activity of the promoter of the human MDR1 gene by Ras and p53. Science 1992; 255: 459-62.
    • (1992) Science , vol.255 , pp. 459-462
    • Chin, K.-V.1    Ueda, K.2    Pastan, I.3    Gottesman, M.M.4
  • 44
    • 0028939453 scopus 로고
    • Wild type p53 stimulates expression from the human multidrug resistance promoter in a p53-negative cell line
    • Goldsmith ME, Gudas JM, Schneider E, Cowan KH. Wild type p53 stimulates expression from the human multidrug resistance promoter in a p53-negative cell line. J Biol Chem 1995; 270: 1894-8.
    • (1995) J Biol Chem , vol.270 , pp. 1894-1898
    • Goldsmith, M.E.1    Gudas, J.M.2    Schneider, E.3    Cowan, K.H.4
  • 47
    • 0028861428 scopus 로고
    • Inhibition of apoptosis by the retinoblastoma gene product
    • Haas-Kogan DA, Kogan SC, Levi D, et al. Inhibition of apoptosis by the retinoblastoma gene product. EMBO J 1995; 14: 461-72.
    • (1995) EMBO J , vol.14 , pp. 461-472
    • Haas-Kogan, D.A.1    Kogan, S.C.2    Levi, D.3
  • 48
    • 0028871672 scopus 로고
    • Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines
    • Li WW, Fan J, Hochhauser D, et al. Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. Proc Natl Acad Sci USA 1995; 92: 10436-40.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10436-10440
    • Li, W.W.1    Fan, J.2    Hochhauser, D.3
  • 49
    • 0028967830 scopus 로고
    • Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis
    • Bartkova J, Lukas J, Strauss M, Bartek J. Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene 1995; 10: 775-8.
    • (1995) Oncogene , vol.10 , pp. 775-778
    • Bartkova, J.1    Lukas, J.2    Strauss, M.3    Bartek, J.4
  • 53
    • 0030949419 scopus 로고    scopus 로고
    • Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells
    • Arber N, Doki Y, Han EK, et al. Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells. Cancer Res 1997; 57: 1569-74.
    • (1997) Cancer Res , vol.57 , pp. 1569-1574
    • Arber, N.1    Doki, Y.2    Han, E.K.3
  • 54
    • 0028907553 scopus 로고
    • Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth
    • Han EK, Sgambato A, Jiang W, et al. Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth. Oncogene 1995; 10: 953-61.
    • (1995) Oncogene , vol.10 , pp. 953-961
    • Han, E.K.1    Sgambato, A.2    Jiang, W.3
  • 55
    • 0029080861 scopus 로고
    • Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer cells
    • Zhou P, Jiang W, Zhang YJ, et al. Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer cells. Oncogene 1995; 11: 571-80.
    • (1995) Oncogene , vol.11 , pp. 571-580
    • Zhou, P.1    Jiang, W.2    Zhang, Y.J.3
  • 56
    • 0029778442 scopus 로고    scopus 로고
    • Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line
    • Hochhauser D, Schnieders B, Ercikan-Abali E, et al. Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line. J Natl Cancer Inst 1996; 88: 1269-75.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1269-1275
    • Hochhauser, D.1    Schnieders, B.2    Ercikan-Abali, E.3
  • 58
    • 0028953560 scopus 로고
    • Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck
    • Michalides R, van Veelen N, Hart A, Loftus B, Wientjens E, Balm A. Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck. Cancer Res 1995; 55: 975-8.
    • (1995) Cancer Res , vol.55 , pp. 975-978
    • Michalides, R.1    Van Veelen, N.2    Hart, A.3    Loftus, B.4    Wientjens, E.5    Balm, A.6
  • 59
    • 0030464769 scopus 로고    scopus 로고
    • Glucose-regulated stresses cause decreased expression of cyclin D1 and hypophosphorylation of retinoblastoma protein in human cancer cells
    • Tomida A, Suzuki H, Kim HD, Tsuruo T. Glucose-regulated stresses cause decreased expression of cyclin D1 and hypophosphorylation of retinoblastoma protein in human cancer cells. Oncogene 1996; 13: 2699-705.
    • (1996) Oncogene , vol.13 , pp. 2699-2705
    • Tomida, A.1    Suzuki, H.2    Kim, H.D.3    Tsuruo, T.4
  • 61
    • 0029982829 scopus 로고    scopus 로고
    • Reversible, p16-mediated cell cycle arrest as protection from chemotherapy
    • Stone S, Dayananth P, Kamb A. Reversible, p16-mediated cell cycle arrest as protection from chemotherapy. Cancer Res 1996; 56: 199-202.
    • (1996) Cancer Res , vol.56 , pp. 199-202
    • Stone, S.1    Dayananth, P.2    Kamb, A.3
  • 62
    • 0029745148 scopus 로고    scopus 로고
    • Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines
    • Terry LA, Boyd J, Alcorta D, et al. Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines. Mol Carcinog 1996; 16: 221-8.
    • (1996) Mol Carcinog , vol.16 , pp. 221-228
    • Terry, L.A.1    Boyd, J.2    Alcorta, D.3
  • 64
    • 0030011128 scopus 로고    scopus 로고
    • Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
    • Waldman T, Lengauer C, Kinzler KW, Vogelstein H. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 1996; 381: 713-6.
    • (1996) Nature , vol.381 , pp. 713-716
    • Waldman, T.1    Lengauer, C.2    Kinzler, K.W.3    Vogelstein, H.4
  • 66
    • 0030612714 scopus 로고    scopus 로고
    • Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells
    • Sheikh MS, Chen YQ, Smith ML, Fornace AJ Jr. Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells. Oncogene 1997; 14: 1875-82.
    • (1997) Oncogene , vol.14 , pp. 1875-1882
    • Sheikh, M.S.1    Chen, Y.Q.2    Smith, M.L.3    Fornace Jr., A.J.4
  • 67
    • 0030610390 scopus 로고    scopus 로고
    • waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells
    • waf1 leads to increased inhibition of E2F-1 phosphorylation and sensitivity to anticancer drugs in retinoblastoma-negative human sarcoma cells. Cancer Res 1997; 57: 2193-9.
    • (1997) Cancer Res , vol.57 , pp. 2193-2199
    • Li, W.W.1    Fan, J.2    Hochhauser, D.3    Bertino, J.R.4
  • 68
    • 0031048716 scopus 로고    scopus 로고
    • Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
    • Porter PL, Malone KE, Heagerty PJ, et al. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nat Med 1997; 3: 222-5.
    • (1997) Nat Med , vol.3 , pp. 222-225
    • Porter, P.L.1    Malone, K.E.2    Heagerty, P.J.3
  • 69
    • 0001405430 scopus 로고    scopus 로고
    • Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents
    • St Croix H, Florenes VA, Rak JW, et al. Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents. Nat Med 1996; 2: 1204-10.
    • (1996) Nat Med , vol.2 , pp. 1204-1210
    • St Croix, H.1    Florenes, V.A.2    Rak, J.W.3
  • 70
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Nevins JR. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 1992; 258: 424.
    • (1992) Science , vol.258 , pp. 424
    • Nevins, J.R.1
  • 72
    • 0028360766 scopus 로고
    • Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation
    • Singh P, Wong SH, Hong W. Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation. EMBO J 1994; 13: 3329-38.
    • (1994) EMBO J , vol.13 , pp. 3329-3338
    • Singh, P.1    Wong, S.H.2    Hong, W.3
  • 73
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S phase entry and p53-mediated apoptosis
    • Qin XQ, Livingston DM, Kaelin WG, Adams PD. Deregulated transcription factor E2F-1 expression leads to S phase entry and p53-mediated apoptosis. Proc Natl Acad Sci USA 1994; 91: 10918-22.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10918-10922
    • Qin, X.Q.1    Livingston, D.M.2    Kaelin, W.G.3    Adams, P.D.4
  • 74
    • 0031024991 scopus 로고    scopus 로고
    • E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis
    • Nip J, Strom DK, Fee BE, Zambetti G, Cleveland JL, Hiebert SW. E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis. Mol Cell Biol 1997; 17: 1049-56.
    • (1997) Mol Cell Biol , vol.17 , pp. 1049-1056
    • Nip, J.1    Strom, D.K.2    Fee, B.E.3    Zambetti, G.4    Cleveland, J.L.5    Hiebert, S.W.6
  • 75
    • 0028909272 scopus 로고
    • Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line
    • Saito M, Helin K, Valentine MB, et al. Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line. Genomics 1995; 25: 130-8.
    • (1995) Genomics , vol.25 , pp. 130-138
    • Saito, M.1    Helin, K.2    Valentine, M.B.3
  • 77
    • 0025196215 scopus 로고
    • 2 arrest in Chinese hamster ovary cells
    • 2 arrest in Chinese hamster ovary cells. Cancer Res 1990; 50: 3761-6.
    • (1990) Cancer Res , vol.50 , pp. 3761-3766
    • Lock, R.B.1    Ross, W.E.2
  • 78
    • 0029661932 scopus 로고    scopus 로고
    • 2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells
    • 2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells. Cancer Res 1996; 56: 4430-7.
    • (1996) Cancer Res , vol.56 , pp. 4430-4437
    • Goldwasser, F.1    Shimizu, T.2    Jackman, J.3
  • 79
    • 0029116545 scopus 로고
    • Inactivation of Cdc2 increases the level of apoptosis induced by DNA damage
    • Ongkeko W, Ferguson DJ, Harris AL, Norbury C. Inactivation of Cdc2 increases the level of apoptosis induced by DNA damage. J Cell Sci 1995; 108: 2897-904
    • (1995) J Cell Sci , vol.108 , pp. 2897-2904
    • Ongkeko, W.1    Ferguson, D.J.2    Harris, A.L.3    Norbury, C.4


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