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Volumn 36, Issue 8, 2010, Pages 469-483

The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease

Author keywords

COPD; interleukin 6; pulmonary inflammation; systemic inflammation

Indexed keywords

CIGARETTE SMOKE; INTERLEUKIN 6; LEPTIN; MESSENGER RNA;

EID: 77958008431     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.3109/01902141003739723     Document Type: Article
Times cited : (15)

References (49)
  • 1
    • 4143051640 scopus 로고    scopus 로고
    • Burden and clinical features of chronic obstructive pulmonary disease (COPD)
    • Pauwels RA, Rabe KF: Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet. 2004;364: 613-620.
    • (2004) Lancet. , vol.364 , pp. 613-620
    • Pauwels, R.A.1    Rabe, K.F.2
  • 2
    • 34548660457 scopus 로고    scopus 로고
    • Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
    • Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al.: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2007;176: 532-555.
    • (2007) Am J Respir Crit Care Med. , vol.176 , pp. 532-555
    • Rabe, K.F.1    Hurd, S.2    Anzueto, A.3    Barnes, P.J.4    Buist, S.A.5    Calverley, P.6
  • 3
    • 2942720573 scopus 로고    scopus 로고
    • The nature of small-airway obstruction in chronic obstructive pulmonary disease
    • Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, et al.: The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med. 2004;350: 2645-2653.
    • (2004) N Engl J Med. , vol.350 , pp. 2645-2653
    • Hogg, J.C.1    Chu, F.2    Utokaparch, S.3    Woods, R.4    Elliott, W.M.5    Buzatu, L.6
  • 4
    • 28244460791 scopus 로고    scopus 로고
    • Systemic effects of chronic obstructive pulmonary disease
    • Agusti AG: Systemic effects of chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2005;2: 367-370.
    • (2005) Proc Am Thorac Soc. , vol.2 , pp. 367-370
    • Agusti, A.G.1
  • 6
    • 0032518415 scopus 로고    scopus 로고
    • IL-6 is an antiinfammatory cytokine required for controlling local or systemic acute infammatory responses
    • Xing Z, Gauldie J, Cox G, Baumann H, Jordana M, Lei XF, et al.: IL-6 is an antiinfammatory cytokine required for controlling local or systemic acute infammatory responses. J Clin Invest. 1998;101: 311-320.
    • (1998) J Clin Invest. , vol.101 , pp. 311-320
    • Xing, Z.1    Gauldie, J.2    Cox, G.3    Baumann, H.4    Jordana, M.5    Lei, X.F.6
  • 7
    • 0022499547 scopus 로고
    • Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce im-munoglobulin
    • Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, et al.: Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce im-munoglobulin. Nature. 1986;324: 73-76.
    • (1986) Nature. , vol.324 , pp. 73-76
    • Hirano, T.1    Yasukawa, K.2    Harada, H.3    Taga, T.4    Watanabe, Y.5    Matsuda, T.6
  • 9
    • 33748121115 scopus 로고    scopus 로고
    • Interleukin-6 and chronic infammation
    • Gabay C: Interleukin-6 and chronic infammation. Arthritis Res Ther. 2006;8(Suppl 2):S3.
    • (2006) Arthritis Res Ther. , vol.8 , Issue.SUPPL. 2
    • Gabay, C.1
  • 12
    • 24744435772 scopus 로고    scopus 로고
    • Directing transition from innate to acquired immunity: Defning a role for IL-6
    • Jones SA: Directing transition from innate to acquired immunity: defning a role for IL-6. J Immunol. 2005;175: 3463-3468.
    • (2005) J Immunol. , vol.175 , pp. 3463-3468
    • Jones, S.A.1
  • 14
    • 0034018102 scopus 로고    scopus 로고
    • Relation of sputum infammatory markers to symptoms and lung function changes in COPD exacerbations
    • Bhowmik A, Seemungal TA, Sapsford RJ, Wedzicha JA: Relation of sputum infammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax. 2000;55: 114-120.
    • (2000) Thorax. , vol.55 , pp. 114-120
    • Bhowmik, A.1    Seemungal, T.A.2    Sapsford, R.J.3    Wedzicha, J.A.4
  • 15
    • 0035178676 scopus 로고    scopus 로고
    • Interleukin-6 in bronchoalveolar lavage fuid from patients with COPD
    • Song W, Zhao J, Li Z: Interleukin-6 in bronchoalveolar lavage fuid from patients with COPD. Chin Med J (Engl ). 2001;114: 1140-1142.
    • (2001) Chin Med J (Engl ) , vol.114 , pp. 1140-1142
    • Song, W.1    Zhao, J.2    Li, Z.3
  • 16
    • 0346901131 scopus 로고    scopus 로고
    • High levels of interleukin-6 in the exhaled breath condensate of patients with COPD
    • Bucchioni E, Kharitonov SA, Allegra L, Barnes PJ: High levels of interleukin-6 in the exhaled breath condensate of patients with COPD. Respir Med. 2003;97: 1299-1302.
    • (2003) Respir Med , vol.97 , pp. 1299-1302
    • Bucchioni, E.1    Kharitonov, S.A.2    Allegra, L.3    Barnes, P.J.4
  • 19
    • 3142517968 scopus 로고    scopus 로고
    • Association between chronic obstructive pulmonary disease and systemic infammation: A systematic review and a meta-analysis
    • Gan WQ, Man SF, Senthilselvan A, Sin DD: Association between chronic obstructive pulmonary disease and systemic infammation: a systematic review and a meta-analysis. Thorax. 2004;59: 574-580.
    • (2004) Thorax , vol.59 , pp. 574-580
    • Gan, W.Q.1    Man, S.F.2    Senthilselvan, A.3    Sin, D.D.4
  • 20
    • 40449118020 scopus 로고    scopus 로고
    • Cigarette smoke-induced pulmonary infammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent
    • Doz E, Noulin N, Boichot E, Guenon I, Fick L, Le BM, et al.: Cigarette smoke-induced pulmonary infammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent. J Immunol. 2008;180: 1169-1178.
    • (2008) J Immunol , vol.180 , pp. 1169-1178
    • Doz, E.1    Noulin, N.2    Boichot, E.3    Guenon, I.4    Fick Le L, B.M.5
  • 21
    • 0028328436 scopus 로고
    • Impaired immune and acute-phase responses in interleukin-6-defcient mice
    • Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, et al.: Impaired immune and acute-phase responses in interleukin-6-defcient mice. Nature. 1994;368: 339-342.
    • (1994) Nature , vol.368 , pp. 339-342
    • Kopf, M.1    Baumann, H.2    Freer, G.3    Freudenberg, M.4    Lamers, M.5    Kishimoto, T.6
  • 22
    • 23144466310 scopus 로고    scopus 로고
    • D'hulst AI, Vermaelen KY, Brusselle GG, Joos GF, Pauwels RA: Time course of cigarette smoke-induced pulmonary infammation in mice
    • D'hulst AI, Vermaelen KY, Brusselle GG, Joos GF, Pauwels RA: Time course of cigarette smoke-induced pulmonary infammation in mice. Eur Respir J. 2005;26: 204-213.
    • (2005) Eur Respir J , vol.26 , pp. 204-213
  • 23
    • 34648823020 scopus 로고    scopus 로고
    • Cigarette smoke-induced pulmonary infammation, but not airway remodeling, is attenuated in chemokine receptor 5-defcient mice
    • Bracke KR, D hulst AI, Maes T, Demedts IK, Moer-loose KB, Kuziel WA, et al.: Cigarette smoke-induced pulmonary infammation, but not airway remodeling, is attenuated in chemokine receptor 5-defcient mice. Clin Exp Allergy. 2007;37: 1467-1479.
    • (2007) Clin Exp Allergy , vol.37 , pp. 1467-1479
    • Bracke, K.R.1    Dhulst, A.I.2    Maes, T.3    Demedts, I.K.4    Moer-Loose, K.B.5    Kuziel, W.A.6
  • 24
    • 0035177431 scopus 로고    scopus 로고
    • Specifc migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes
    • Vermaelen KY, Carro-Muino I, Lambrecht BN, Pauwels RA: Specifc migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J Exp Med. 2001;193: 51-60.
    • (2001) J Exp Med , vol.193 , pp. 51-60
    • Vermaelen, K.Y.1    Carro-Muino, I.2    Lambrecht, B.N.3    Pauwels, R.A.4
  • 25
    • 5444269747 scopus 로고    scopus 로고
    • Accurate and simple discrimination of mouse pulmonary dendritic cell and macrophage populations by fow cytometry: Methodology and new insights
    • Vermaelen K, Pauwels R: Accurate and simple discrimination of mouse pulmonary dendritic cell and macrophage populations by fow cytometry: methodology and new insights. Cytometry A. 2004;61: 170-177.
    • (2004) Cytometry A , vol.61 , pp. 170-177
    • Vermaelen, K.1    Pauwels, R.2
  • 26
    • 0014089071 scopus 로고
    • Measurement of pulmonary emphysema
    • Thurlbeck WM: Measurement of pulmonary emphysema. Am Rev Respir Dis. 1967;95: 752-764.
    • (1967) Am Rev Respir Dis , vol.95 , pp. 752-764
    • Thurlbeck, W.M.1
  • 27
    • 33644977112 scopus 로고    scopus 로고
    • Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?
    • D'hulst AI, Maes T, Bracke KR, Demedts IK, Tournoy KG, Joos GF, et al.: Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required? Respir Res. 2005;6: 147.
    • (2005) Respir Res , vol.6 , pp. 147
    • D'Hulst, A.I.1    Maes, T.2    Bracke, K.R.3    Demedts, I.K.4    Tournoy, K.G.5    Joos, G.F.6
  • 28
    • 0030666932 scopus 로고    scopus 로고
    • Interleukin-8 can mediate acute-phase protein production by isolated human hepatocytes
    • Wigmore SJ, Fearon KC, Maingay JP, Lai PB, Ross JA: Interleukin-8 can mediate acute-phase protein production by isolated human hepatocytes. Am J Physiol. 1997;273: E720-E726.
    • (1997) Am J Physiol , vol.273
    • Wigmore, S.J.1    Fearon, K.C.2    Maingay, J.P.3    Lai, P.B.4    Ross, J.A.5
  • 29
    • 33845496958 scopus 로고    scopus 로고
    • Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary infammation and emphysema
    • D'hulst AI, Bracke KR, Maes T, De Bleecker JL, Pauwels RA, Joos GF, et al.: Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary infammation and emphysema. Eur Respir J. 2006;28: 102-112.
    • (2006) Eur Respir J , vol.28 , pp. 102-112
    • D'Hulst, A.I.1    Bracke, K.R.2    Maes, T.3    De Bleecker, J.L.4    Pauwels, R.A.5    Joos, G.F.6
  • 30
    • 2442618838 scopus 로고    scopus 로고
    • The weight of leptin in immunity
    • La Cava A, Matarese G: The weight of leptin in immunity. Nat Rev Immunol. 2004;4: 371-379.
    • (2004) Nat Rev Immunol , vol.4 , pp. 371-379
    • La Cava, A.1    Matarese, G.2
  • 31
    • 0036667371 scopus 로고    scopus 로고
    • The role of interleukin-6 in pulmonary infammation and injury induced by exposure to environmental air pollutants
    • Yu M, Zheng X, Witschi H, Pinkerton KE: The role of interleukin-6 in pulmonary infammation and injury induced by exposure to environmental air pollutants. Toxicol Sci. 2002;68: 488-497.
    • (2002) Toxicol Sci , vol.68 , pp. 488-497
    • Yu, M.1    Zheng, X.2    Witschi, H.3    Pinkerton, K.E.4
  • 32
    • 69249103855 scopus 로고    scopus 로고
    • Role of lymphotoxin-alpha in cigarette smoke-induced infammation and lymphoid neogenesis
    • Demoor T, Bracke KR, Maes T, Vandooren B, Elewaut D, Pilette C, et al.: Role of lymphotoxin-alpha in cigarette smoke-induced infammation and lymphoid neogenesis. Eur Respir J. 2009;34: 405-416.
    • (2009) Eur Respir J , vol.34 , pp. 405-416
    • Demoor, T.1    Bracke, K.R.2    Maes, T.3    Vandooren, B.4    Elewaut, D.5    Pilette, C.6
  • 33
    • 76249091678 scopus 로고    scopus 로고
    • CCR7 modulates pulmonary and lymph node infammatory responses in cigarette smoke-exposed mice
    • Demoor T, Bracke KR, Vermaelen KY, Dupont L, Joos GF, Brusselle GG: CCR7 modulates pulmonary and lymph node infammatory responses in cigarette smoke-exposed mice. J Immunol. 2009;183: 8186-8194.
    • (2009) J Immunol , vol.183 , pp. 8186-8194
    • Demoor, T.1    Bracke, K.R.2    Vermaelen, K.Y.3    Dupont, L.4    Joos, G.F.5    Brusselle, G.G.6
  • 34
    • 0033367799 scopus 로고    scopus 로고
    • B1 B cell numbers and antibodies against phosphorylcholine and LPS are increased in IL-6 gene knockout mice
    • Bao S, Husband AJ, Beagley KW: B1 B cell numbers and antibodies against phosphorylcholine and LPS are increased in IL-6 gene knockout mice. Cell Immunol. 1999;198: 139-142.
    • (1999) Cell Immunol , vol.198 , pp. 139-142
    • Bao, S.1    Husband, A.J.2    Beagley, K.W.3
  • 35
    • 33748848714 scopus 로고    scopus 로고
    • Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: Role in infammation and cancer
    • Rose-John S, Scheller J, Elson G, Jones SA: Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in infammation and cancer. J Leukoc Biol. 2006;80: 227-236.
    • (2006) J Leukoc Biol , vol.80 , pp. 227-236
    • Rose-John, S.1    Scheller, J.2    Elson, G.3    Jones, S.A.4
  • 37
    • 57149105188 scopus 로고    scopus 로고
    • Infection in the pathogenesis and course of chronic obstructive pulmonary disease
    • Sethi S, Murphy TF: Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med. 2008;359: 2355-2365.
    • (2008) N Engl J Med , vol.359 , pp. 2355-2365
    • Sethi, S.1    Murphy, T.F.2
  • 42
    • 3042739678 scopus 로고    scopus 로고
    • Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: Absence of development of age-related obesity
    • Di Gregorio GB, Hensley L, Lu T, Ranganathan G, Kern PA: Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity. Am J Physiol Endocrinol Metab. 2004;287: E182-E187.
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Di Gregorio, G.B.1    Hensley, L.2    Lu, T.3    Ranganathan, G.4    Kern, P.A.5
  • 43
    • 37249074063 scopus 로고    scopus 로고
    • The role of interleukin-6 in insulin resistance, body fat distribution and energy balance
    • Hoene M, Weigert C: The role of interleukin-6 in insulin resistance, body fat distribution and energy balance. Obes Rev. 2008;9: 20-29.
    • (2008) Obes Rev , vol.9 , pp. 20-29
    • Hoene, M.1    Weigert, C.2
  • 44
    • 4344590199 scopus 로고    scopus 로고
    • Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice
    • Hata H, Sakaguchi N, Yoshitomi H, Iwakura Y, Sekikawa K, Azuma Y, et al.: Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest. 2004;114: 582-588.
    • (2004) J Clin Invest , vol.114 , pp. 582-588
    • Hata, H.1    Sakaguchi, N.2    Yoshitomi, H.3    Iwakura, Y.4    Sekikawa, K.5    Azuma, Y.6
  • 45
    • 0034193039 scopus 로고    scopus 로고
    • IL-6 is required for the development of Th1 cell-mediated murine colitis
    • Yamamoto M, Yoshizaki K, Kishimoto T, Ito H: IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol. 2000;164: 4878-4882.
    • (2000) J Immunol , vol.164 , pp. 4878-4882
    • Yamamoto, M.1    Yoshizaki, K.2    Kishimoto, T.3    Ito, H.4
  • 46
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal infammation: Evidence in crohn disease and experimental colitis in vivo
    • Atreya R, Mudter J, Finotto S, Mullberg J, Jostock T, Wirtz S, et al.: Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal infammation: evidence in crohn disease and experimental colitis in vivo. Nat Med. 2000;6: 583-588.
    • (2000) Nat Med , vol.6 , pp. 583-588
    • Atreya, R.1    Mudter, J.2    Finotto, S.3    Mullberg, J.4    Jostock, T.5    Wirtz, S.6
  • 47
    • 70349402169 scopus 로고    scopus 로고
    • Long-term safety and effcacy of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): Evidence of safety and effcacy in a 5-year extension study
    • Nishimoto N, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Azuma J: Long-term safety and effcacy of tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and effcacy in a 5-year extension study. Ann Rheum Dis. 2008;68: 1580-1584.
    • (2008) Ann Rheum Dis , vol.68 , pp. 1580-1584
    • Nishimoto, N.1    Miyasaka, N.2    Yamamoto, K.3    Kawai, S.4    Takeuchi, T.5    Azuma, J.6
  • 48
    • 11144358366 scopus 로고    scopus 로고
    • A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn s disease
    • Ito H, Takazoe M, Fukuda Y, Hibi T, Kusugami K, Andoh A, et al.: A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn s disease. Gastroenterology. 2004;126: 989-996.
    • (2004) Gastroenterology , vol.126 , pp. 989-996
    • Ito, H.1    Takazoe, M.2    Fukuda, Y.3    Hibi, T.4    Kusugami, K.5    Andoh, A.6
  • 49
    • 57349099228 scopus 로고    scopus 로고
    • Emerging pharmacotherapies for COPD
    • Barnes PJ: Emerging pharmacotherapies for COPD. Chest. 2008;134: 1278-1286.
    • (2008) Chest , vol.134 , pp. 1278-1286
    • Barnes, P.J.1


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