Reduced exercise endurance in interleukin-6-deficient mice

Endocrinology

Volumn 145, Issue 6, 2004, Pages 2680-2686

  Fäldt, Jenny ^a,c   Wernstedt, Ingrid ^a   Fitzgerald, Sharyn M ^b   Wallenius, Kristina ^a   Bergström, Göran ^b   Jansson, John Olov ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; FAT; INTERLEUKIN 6;

ANIMAL EXPERIMENT; ARTICLE; CALORIMETRY; CONTROLLED STUDY; ENDURANCE; ENERGY CONSUMPTION; ENERGY EXPENDITURE; EXERCISE; LUNG GAS EXCHANGE; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; REST; TREADMILL EXERCISE;

ANIMALS; BODY COMPOSITION; ENERGY METABOLISM; GLYCOGEN; INTERLEUKIN-6; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; OBESITY; PHYSICAL ENDURANCE; PULMONARY GAS EXCHANGE;

EID: 2542444491     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-1319     Document Type: Article

References (45)

1. Van Snick J 1990 Interleukin-6: an overview. Annu Rev Immunol 8:253-278
2. Fried SK, Bunkin DA, Greenberg AS 1998 Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 83:847-850
3. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S, Coppack SW 1997 Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-α, in vivo. J Clin Endocrinol Metab 82:4196-4200
4. Vgontzas AN, Papanicolaou DA, Bixler EO, Kales A, Tyson K, Chrousos GP 1997 Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J Clin Endocrinol Metab 82:1313-1316
5. Orban Z, Remaley AT, Sampson M, Trajanoski Z, Chrousos GP 1999 The differential effect of food intake and β-adrenergic stimulation on adipose-derived hormones and cytokines in man. J Clin Endocrinol Metab 84:2126-2133
6. Bastard JP, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, Vidal H, Hainque B 2000 Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 85:3338-3342
7. Pedersen BK, Hoffman-Goetz L 2000 Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 80:1055-1081
8. Pedersen BK, Steensberg A, Schjerling P 2001 Muscle-derived interleukin-6: possible biological effects. J Physiol 536:329-337
9. Papanicolaou DA, Petrides JS, Tsigos C, Bina S, Kalogeras KT, Wilder R, Gold PW, Deuster PA, Chrousos GP 1996 Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. Am J Physiol 271:E601-E605
10. Ostrowski K, Rohde T, Zacho M, Asp S, Pedersen BK 1998 Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. J Physiol 508:949-953
11. Febbraio MA, Pedersen BK 2002 Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J 16:1335-1347
12. Colbert LH, Davis JM, Essig DA, Ghaffar A, Mayer EP 2001 Tissue expression and plasma concentrations of TNFα, IL-1β, and IL-6 following treadmill exercise in mice. Int J Sports Med 22:261-267
13. Jonsdottir IH, Schjerling P, Ostrowski K, Asp S, Richter EA, Pedersen BK 2000 Muscle contractions induce interleukin-6 mRNA production in rat skeletal muscles. J Physiol 528:157-163
14. Lyngso D, Simonsen L, Bulow J 2002 Metabolic effects of interleukin-6 in human splanchnic and adipose tissue. J Physiol 543:379-386
15. Stouthard JM, Romijn JA, Van der Poll T, Endert E, Klein S, Bakker PJ, Veenhof CH, Sauerwein HP 1995 Endocrinologic and metabolic effects of interleukin-6 in humans. Am J Physiol 268:E813-E819
16. van Hall G, Steensberg A, Sacchetti M, Fischer C, Keller C, Schjerling P, Hiscock N, Moller K, Saltin B, Febbraio MA, Pedersen BK 2003 Interleukin-6 stimulates lipolysis and fat oxidation in humans. J Clin Endocrinol Metab 88:3005-3010
17. Wallenius V, Wallenius K, Ahren B, Rudling M, Carlsten H, Dickson SL, Ohlsson C, Jansson JO 2002 Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 8:75-79
18. Wallenius K, Wallenius V, Sunter D, Dickson SL, Jansson JO 2002 Intracerebroventricular interleukin-6 treatment decreases body fat in rats. Biochem Biophys Res Commun 293:560-565
19. Stenlof K, Wernstedt I, Fjallman T, Wallenius V, Wallenius K, Jansson JO 2003 Interleukin-6 levels in the central nervous system are negatively correlated with fat mass in overweight/obese subjects. J Clin Endocrinol Metab 88:4379-4383
20. Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B, Klarlund Pedersen B 2000 Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 529:237-242
21. Tsigos C, Papanicolaou DA, Kyrou I, Defensor R, Mitsiadis CS, Chrousos GP 1997 Dose-dependent effects of recombinant human interleukin-6 on glucose regulation. J Clin Endocrinol Metab 82:4167-4170
22. Spriet LL, Watt MJ 2003 Regulatory mechanisms in the interaction between carbohydrate and lipid oxidation during exercise. Acta Physiol Scand 178:443-452
23. Kang J, Schweitzer JS, Hoffman JR 2003 Effects of order of exercise intensity upon cardiorespiratory, metabolic, and perceptual responses during exercise of mixed intensity. Eur J Appl Physiol 90:569-574
24. Jansson JO, Wallenius K, Wernstedt I, Ohlsson C, Dickson SL, Wallenius V 2003 On the site and mechanism of action of the anti-obesity effects of IL-6. Growth Horm IGF Res 13(Suppl A):S28-S32
25. Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, Zinkernagel R, Bluethmann H, Kohler G 1994 Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368:339-342
26. -/-) mice. J Hepatol 33:967-974
27. Sjogren K, Hellberg N, Bohlooly YM, Savendahl L, Johansson MS, Berglindh T, Bosaeus I, Ohlsson C 2001 Body fat content can be predicted in vivo in mice using a modified dual-energy x-ray absorptiometry technique. J Nutr 131:2963-2966
28. Even PC, Mokhtarian A, Pele A 1994 Practical aspects of indirect calorimetry in laboratory animals. Neurosci Biobehav Rev 18:435-447
29. Kemi OJ, Loennechen JP, Wisloff U, Ellingsen O 2002 Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy. J Appl Physiol 93:1301-1309
30. Perrey S, Candau R, Millet GY, Borrani F, Rouillon JD 2002 Decrease in oxygen uptake at the end of a high-intensity submaximal running in humans. Int J Sports Med 23:298-304
31. 2 max and cardiac hypertrophy. Am J Physiol 280:H1301-H1310
32. Marz P, Cheng JG, Gadient RA, Patterson PH, Stoyan T, Otten U, Rose-John S 1998 Sympathetic neurons can produce and respond to interleukin 6. Proc Natl Acad Sci USA 95:3251-3256
33. Motro B, Itin A, Sachs L, Keshet E 1990 Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. Proc Natl Acad Sci USA 87:3092-3096
34. Wei LH, Kuo ML, Chen CA, Chou CH, Lai KB, Lee CN, Hsieh CY 2003 Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene 22:1517-1527
35. Tsigos C, Papanicolaou DA, Defensor R, Mitsiadis CS, Kyrou I, Chrousos GP 1997 Dose effects of recombinant human interleukin-6 on pituitary hormone secretion and energy expenditure. Neuroendocrinology 66:54-62
36. Rothwell NJ, Busbridge NJ, Lefeuvre RA, Hardwick AJ, Gauldie J, Hopkins SJ 1991 Interleukin-6 is a centrally acting endogenous pyrogen in the rat. Can J Physiol Pharmacol 69:1465-1469
37. Li G, Klein RL, Matheny M, King MA, Meyer EM, Scarpace PJ 2002 Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats. Neuroscience 115:879-889
38. Nybo L, Nielsen B, Pedersen BK, Moller K, Secher NH 2002 Interleukin-6 release from the human brain during prolonged exercise. J Physiol 542:991-995
39. Zurlo F, Lillioja S, Esposito-Del Puente A, Nyomba BL, Raz I, Saad MF, Swinburn BA, Knowler WC, Bogardus C, Ravussin E 1990 Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physiol 259:E650-E657
40. Seidell JC, Muller DC, Sorkin JD, Andres R 1992 Fasting respiratory exchange ratio and resting metabolic rate as predictors of weight gain: the Baltimore Longitudinal Study on Aging. Int J Obes Relat Metab Disord 16:667-674
41. Snitker S, Tataranni PA, Ravussin E 1998 Respiratory quotient is inversely associated with muscle sympathetic nerve activity. J Clin Endocrinol Metab 83:3977-3979
42. Tschop M, Smiley DL, Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407:908-913
43. Leaf DA 1985 Fitness: a new look at an old term (measurements of human aerobic performance). Med Hypotheses 18:33-46
44. Law CM, Barker DJ, Osmond C, Fall CH, Simmonds SJ 1992 Early growth and abdominal fatness in adult life. J Epidemiol Community Health 46:184-186
45. Metzger S, Hassin T, Barash V, Pappo O, Chajek-Shaul T 2001 Reduced body fat and increased hepatic lipid synthesis in mice bearing interleukin-6- secreting tumor. Am J Physiol 281:E957-E9565