Synthesis and structure-activity relationship of a novel, non-hydroxamate series of TNF-α converting enzyme inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 16, 2007, Pages 4678-4682

  Gilmore, John L ^a   King, Bryan W ^a   Asakawa, Naoyuki ^a   Harrison, Kimberly ^a   Tebben, Andrew ^a   Sheppeck II, James E ^a   Liu, Rui Qin ^a   Covington, Maryanne ^a   Duan, James J W ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

Inflammation; Rheumatoid arthritus; TACE

Indexed keywords

COLLAGENASE 3; GELATINASE A; HYDROXAMIC ACID DERIVATIVE; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; ZINC;

ARTICLE; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION; SWINE;

ADAM PROTEINS; BINDING SITES; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS; MOLECULAR STRUCTURE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

SUS;

EID: 34447322020     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.100     Document Type: Article

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