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Volumn 5, Issue 10, 2010, Pages 1760-1769

Structure-activity relationships and molecular docking of novel dihydropyrimidine-based mitotic Eg5 inhibitors

(8) Prokopcová, Hana a Dallinger, Doris a Uray, Georg a Kaan, Hung Yi Kristal b Ulaganathan, Venkatasubramanian b Kozielski, Frank b Laggner, Christian c Kappe, C Oliver a

a UNIVERSITY OF GRAZ (Austria)

b BEATSON INSTITUTE FOR CANCER RESEARCH (United Kingdom)

c UNIVERSITY OF INNSBRUCK (Austria)

Author keywords

Cancer; Dihydropyrimidines; Kinesin inhibitors; Molecular docking; Multicomponent reactions

Indexed keywords

DIHYDROPYRIMIDINE DERIVATIVE; DIMETHYLENASTRON; ENASTRON; ENZYME INHIBITOR; FLUORASTROL; KINESIN 5; MON 97; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; IC 50; MOLECULAR DOCKING; PRIORITY JOURNAL; RACEMIZATION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; KINESIN; MITOSIS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77957671949 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201000252 Document Type: Article

Times cited : (49)

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