Interaction of epothilone B (patupilone) with microtubules as detected by two-dimensional solid-state NMR spectroscopy

Angewandte Chemie - International Edition

Volumn 49, Issue 41, 2010, Pages 7504-7507

  Kumar, Ashutosh ^a   Heise, Henrike ^a,d   Blommers, Marcel J J ^c   Krastel, Philipp ^c   Schmitt, Esther ^c   Petersen, Frank ^c   Jeganathan, Siva ^b   Mandelkow, Eva Maria ^b   Carlomagno, Teresa ^a,e   Griesinger, Christian ^a   Baldus, Marc ^a,f  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b MAX PLANCK UNIT FOR STRUCTURAL MOLECULAR BIOLOGY   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^f UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Antitumor agents; Drug binding; Microtubules NMR spectroscopy; Structure elucidation

Indexed keywords

ANTI-TUMOR AGENTS; APOPTOSIS; ATOMIC POSITIONS; CANCER CELLS; CORRELATION SPECTRA; DRUG BINDING; EPOTHILONES; MICROTUBULES; MICROTUBULES NMR SPECTROSCOPY; SHIFT CHANGES; SOLID-STATE NMR SPECTROSCOPY; STRUCTURE ELUCIDATION;

CELL DEATH; CYTOTOXICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERS; SOLID STATE PHYSICS;

ATOMIC SPECTROSCOPY;

ANTINEOPLASTIC AGENT; EPOTHILONE B; EPOTHILONE DERIVATIVE; TUBULIN; TUBULIN MODULATOR;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; MICROTUBULE; MYXOCOCCALES; NEOPLASM; NUCLEAR MAGNETIC RESONANCE; ULTRASTRUCTURE;

ANTINEOPLASTIC AGENTS; EPOTHILONES; HUMANS; MICROTUBULES; MODELS, MOLECULAR; MYXOCOCCALES; NEOPLASMS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; TUBULIN; TUBULIN MODULATORS;

EID: 77957601705     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201001946     Document Type: Article

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