The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans: Evolutionary aspects, epidemiology and etiological role in aggressive periodontitis

APMIS

Volumn 118, Issue SUPPL. 130, 2010, Pages 1-53

  Haubek, Dorte ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOTOXIN; VIRULENCE FACTOR; BACTERIAL ANTIGEN; EXOTOXIN;

AGGREGATIBACTER ACTINOMYCETEMCOMITANS; BACTERIAL COLONIZATION; BACTERIAL TRANSMISSION; BACTERIUM DETECTION; CLONE; GENETIC VARIABILITY; GEOGRAPHIC DISTRIBUTION; HUMAN; MOLECULAR EPIDEMIOLOGY; MOLECULAR EVOLUTION; NONHUMAN; OPERON; PERIODONTITIS; PHYLOGENY; POPULATION GENETICS; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; SEROTYPING; ACTINOBACILLUS INFECTION; ADOLESCENT; AFRICA; ARTICLE; DISEASE TRANSMISSION; GENETICS; GENOTYPE; ISOLATION AND PURIFICATION; MICROBIOLOGY; MUTATION; NEGRO; OPPORTUNISTIC INFECTION; PATHOGENICITY; PATHOLOGY;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ACTINOBACILLUS INFECTIONS; ADOLESCENT; AFRICA, NORTHERN; AFRICA, WESTERN; AFRICAN CONTINENTAL ANCESTRY GROUP; ANTIGENS, BACTERIAL; EVOLUTION, MOLECULAR; EXOTOXINS; GENOTYPE; HUMANS; MUTATION; OPPORTUNISTIC INFECTIONS; PERIODONTITIS;

EID: 77957325757     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2010.02665.x     Document Type: Review

References (463)

1. Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 2005 43 : 5721 32.
2. Achtman M. Microevolution and epidemic spread of serogroup A Neisseria meningitidis - a review. Gene 1997 192 : 135 40.
3. Adams SM, Bosch E, Balaresque PL, Ballereau SJ, Lee AC, Arroyo E, et al. The genetic legacy of religious diversity and intolerance: paternal lineages of Christians, Jews, and Muslims in the Iberian Peninsula. Am J Hum Genet 2008 83 : 725 36.
4. Alaluusua S, Asikainen S. Detection and distribution of Actinobacillus actinomycetemcomitans in the primary dentition. J Periodontol 1988 59 : 504 7.
5. Alaluusua S, Asikainen S, Lai CH. Intrafamilial transmission of Actinobacillus actinomycetemcomitans. J Periodontol 1991 62 : 207 10.
6. Alaluusua S, Jousimies-Somer H, Asikainen S. Ribotyping shows intrafamilial similarity in Actinobacillus actinomycetemcomitans isolates. Oral Microbiol Immunol 1993 8 : 225 9.
7. Albandar JM, Lyngstadaas SP, Forbord B. PCR primers for the amplification of the 16S rRNA gene of oral bacteria and for the specific identification of Actinobacillus actinomycetemcomitans. Eur J Oral Sci 1996 104 : 144 7.
8. Albandar JM, Tinoco EMB. Global epidemiology of periodontal diseases in children and young persons. Periodontol 2000 2002 29 : 153 76.
9. Alves-Silva J, da Silva Santos M, Guimaraes PEM, Ferreira ACS, Bandelt H-J, Pena SDJ, et al. The ancestry of Brazilian mtDNA lineages. Am J Hum Genet 2000 67 : 444 61.
10. Amano K, Nishihara T, Shibuya N, Noguchi T, Koga T. Immunochemical and structural characterization of a serotype-specific polysaccharide antigen from Actinobacillus actinomycetemcomitans Y4 (serotype b). Infect Immun 1989 57 : 2942 6.
11. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999 4 : 1 6.
12. Armitage GC. Classifying periodontal diseases - a long-standing dilemma. Periodontol 2000 2002 30 : 9 23.
13. Armitage GC. Periodontal diagnoses and classification of periodontal diseases. Periodontol 2000 2004 34 : 9 21.
14. Arnaiz-Villena A, Gomez-Casado E, Martinez-Laso J. Population genetic relationship between Mediterranean populations determined by HLA allele distribution and a historic perspective. Tissue Antigens 2002 60 : 111 21.
15. Asakawa R, Komatsuzawa H, Kawai T, Yamada S, Goncalves RB, Izumi S, et al. Outer membrane protein 100, a versatile virulence factor of Actinobacillus actinomycetemcomitans. Mol Microbiol 2003 50 : 1125 39.
16. Ashimoto A, Chen C, Bakker I, Slots J. Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions. Oral Microbiol Immunol 1996 11 : 266 73.
17. Ashley FP, Gallagher J, Wilson RF. The occurrence of Actinobacillus actinomycetemcomitans, Bacteroides gingivalis, Bacteroides intermedius and spirochaetes in the subgingival microflora of adolescents and their relationship with the amount of supragingival plaque and gingivitis. Oral Microbiol Immunol 1988 3 : 77 82.
18. Asikainen S, Alaluusua S, Kari K, Kleemola-Kujala E. Subgingival microflora and periodontal conditions in healthy teenagers. J Periodontol 1986 57 : 505 9.
19. Asikainen S, Alaluusua S, Saxén L. Recovery of Actinobacillus actinomycetemcomitans from teeth, tongue, and saliva. J Clin Periodontol 1991B 62 : 203 6.
20. Asikainen S, Lai CH, Alaluusua S, Slots J. Distribution of Actinobacillus actinomycetemcomitans serotypes in periodontal health and disease. Oral Microbiol Immunol 1991A 6 : 115 8.
21. Asikainen S, Chen C, Slots J. Actinobacillus actinomycetemcomitans genotypes in relation to serotypes and periodontal status. Oral Microbiol Immunol 1995 10 : 65 8.
22. Asikainen S, Chen C, Slots J. Likelihood of transmitting Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in families with periodontitis. Oral Microbiol Immunol 1996 11 : 387 94.
23. Asikainen S, Chen C, Alaluusua S, Slots J. Can one acquire periodontal bacteria and periodontitis from a family member? J Am Dent Assoc 1997 128 : 1263 71.
24. Asikainen S, Chen C. Oral ecology and person-to-person transmission of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Periodontol 2000 1999 20 : 65 81.
25. Assuma R, Oates T, Cochran D, Amar S, Graves DT. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J Immunol 1998 160 : 403 9.
26. Avila-Campos MJ. Haemolytic activity of Actinobacillus actinomycetemcomitans strains on different blood types. Microb Pathog 1995 37 : 215 7.
27. Baehni P, Tsai CC, McArthur WP, Hammond BF, Taichman NS. Interaction of inflammatory cells and oral microorganisms. VIII. Detection of leukotoxic activity of a plaque-derived gram-negative microorganism. Infect Immun 1979 24 : 233 43.
28. Baehni PC, Tsai C-C, McArthur WP, Hammond BF, Shenker BJ, Taichman NS. Leukotoxic activity in different strains of the bacterium Actinobacillus actinomycetemcomitans isolated from juvenile periodontitis in man. Arch Oral Biol 1981 26 : 671 6.
29. Baelum V. The epidemiology of destructive periodontal disease. Causes, paradigms, problems, methods, and empirical evidence. Thesis. Aarhus Royal Dental College, University of Aarhus, 1998.
30. Baelum V, Scheutz F. Periodontal disease in Africa. Periodontol 2000 2002 29 : 79 103.
31. Baker PJ, Butler R, Wikesjö UME. Bacterial sampling by absorbant paper points. An in vitro study. J Periodontol 1991 62 : 142 6.
32. Balashova NV, Diaz R, Balashov SV, Crosby JA, Kachlany SC. Regulation of Aggregatibacter (Actinobacillus) actinomycetemcomitans leukotoxin secretion by iron. J Bacteriol 2006B 188 : 8658 61.
33. Balashova NV, Crosby JA, Al Ghofaily L, Kachlany SC. Leukotoxin confers beta-hemolytic activity to Actinobacillus actinomycetemcomitans. Infect Immun 2006A 74 : 2015 21.
34. Beikler T, Schnitzer S, Abdeen G, Ehmke B, Eisenacher M, Flemmig TF. Sampling strategy for intraoral detection of periodontal pathogens before and following periodontal therapy. J Periodontol 2006 77 : 1323 32.
35. Berezow AB, Jin L, Darveau RP. The molecular basis of host defence mechanisms in oral disease. In : Rogers AH, editor. Molecular Oral Microbiology. Caister Academic Press, 2008 : 237 55.
36. Bergey DH. Bergey's Manual of Systematic Bacteriology, 2nd edn.
37. Berthold P, Forti D, Kieba IR, Rosenbloom J, Taichman NS, Lally ET. Electron immunocytochemical localization of Actinobacillus actinomycetemcomitans leukotoxin. Oral Microbiol Immunol 1992 7 : 24 7.
38. Bhattacharjee MK, Kachlany SC, Fine DH, Figurski DH. Nonspecific adherence and fibril biogenesis by Actinobacillus actinomycetemcomitans: TadA protein is an ATPase. J Bacteriol 2001 183 : 5927 36.
39. Birkedal-Hansen H. Role of cytokines and inflammatory mediators in tissue destruction. J Periodontal Res 1993 28 : 500 10.
40. Boch JA, Wara-Aswapati N, Auron PE. Interleukin 1 signal transduction - current concepts and relevance to periodontitis. J Dent Res 2001 80 : 400 7.
41. Borén T, Falk P, Roth KA, Larson G, Normark S. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 1993 262 : 1892 5.
42. Bosch E, Calafell F, Pérez-Lezaun A, Clarimón J, Comas D, Mateu E, et al. Genetic structure of north-west Africa revealed by STR analysis. Eur J Hum Genet 2000 8 : 360 6.
43. Boutaga K, Savelkoul PHM, Winkel EG, van Winkelhoff AJ. Comparison of subgingival bacterial sampling with oral lavage for detection and quantification of periodontal pathogens by real-time polymerase chain reaction. J Periodontol 2007 78 : 79 86.
44. Brogan JM, Lally ET, Poulsen K, Kilian M, Demuth DR. Regulation of Actinobacillus actinomycetemcomitans leukotoxin expression: analysis of the promoter regions of leukotoxic and minimally leukotoxic strains. Infect Immun 1994 62 : 501 8.
45. Brown LJ, Löe H. Prevalence, extent, severity and progression of periodontal disease. Periodontol 2000 1993 2 : 57 71.
46. Bueno LC, Mayer MPA, DiRienzo J.M. Relationship between conversion of localized juvenile periodontitis-susceptible children from health to disease and Actinobacillus actinomycetemcomitans leukotoxin promoter structure. J Periodontol 1998 69 : 998 1007.
47. Caglar EKB, Tanboga I. Bacteriotherapy and probiotics' role on oral health. Oral Dis 2005 11 : 131 7.
48. Califano JV, Schenkein HA, Tew JG. Immunodominant antigens of Actinobacillus actinomycetemcomitans serotype b in early-onset periodontitis patients. Oral Microbiol Immunol 1992 7 : 65 70.
49. Califano JV, Pace BE, Gunsolley JC, Schenkein HA, Lally ET, Tew JG. Antibody reactive with Actinobacillus actinomycetemcomitans leukotoxin in early-onset periodontitis. Oral Microbiol Immunol 1997 12 : 20 6.
50. Campbell S, Fraser A, Holliss B, Schmid J, O'Toole PW. Evidence for ethnic tropism of Helicobacter pylori. Infect Immun 1997 65 : 3708 12.
51. Carlsson G, Wahlin YB, Johansson A, Olsson A, Eriksson T, Claesson R, et al. Periodontal disease in patients from the original Kostmann family with severe congenital neutropenia. J Periodontol 2006 77 : 744 51.
52. Caufield PW, Ratanapridakul K, Allen DN, Cutter GR. Plasmid-containing strains of Streptococcus mutans cluster within family and racial cohorts: implications for natural transmission. Infect Immun 1988 56 : 3216 20.
53. Caufield PW, Saxena D, Fitch D, Li Y. Population structure of plasmid-containing strains of Streptococcus mutans, a member of the human indigenous microbiota. J Bacteriol 2007 189 : 1238 43.
54. Chen C, Slots J. Microbiological tests for Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Periodontol 2000 1999 20 : 53 64.
55. Chen W, Wang Y, Chen C. Identification of a genomic island of Actinobacillus actinomycetemcomitans. J Periodontol 2005 76 : 2052 60.
56. Christersson LA, Slots J, Zambon JJ, Genco R.J. Transmission and colonization of Actinobacillus actinomycetemcomitans in localized juvenile periodontitis patients. J Periodontol 1985 56 : 127 31.
57. Christersson LA, Zambon JJ. Suppression of subgingival Actinobacillus actinomycetemcomitans in localized juvenile periodontitis by systemic tetracycline. J Clin Periodontol 1993 20 : 395 401.
58. Chung H-J, Chung C-P, Son S-H, Nisengaard R J. Actinobacillus actinomycetemcomitans serotypes and leukotoxicity in Korean localized juvenile periodontitis. J Periodontol 1989 60 : 506 11.
59. Claesson R, Johansson A, Belibasakis G, Hänström L, Kalfas S. Release and activation of matrix metalloproteinase 8 from human neutrophils triggered by the leukotoxin of Actinobacillus actinomycetemcomitans. J Periodontal Res 2002 37 : 353 9.
60. Cochran DL. Inflammation and bone loss in periodontal disease. J Periodontol 2008 79 : 1569 76.
61. Contreras A, Rusitanonta T, Chen C, Wagner WG, Michalowicz BS, Slots J. Frequency of 530-bp deletion in Actinobacillus actinomycetemcomitans leukotoxin promoter region. Oral Microbiol Immunol 2000 15 : 338 40.
62. Cortelli JR, Cortelli SC, Jordan S, Haraszthy VI, Zambon JJ. Prevalence of periodontal pathogens in Brazilians with aggressive or chronic periodontitis. J Clin Periodontol 2005 32 : 860 6.
63. Cortelli SC, Jorge AOC, Cortelli JR, Jordan SF, Haraszthy VI. Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal disease. Pesqui Odontol Bras 2003 17 : 183 8.
64. Cox DP, Weathers DR. Leukocyte adhesion deficiency type 1: an important consideration in the clinical differential diagnosis of prepubertal periodontitis. A case report and review of the literature. Oral Surg, Oral Med, Oral Pathol, Oral Radiol, Endod 2008 105 : 86 90.
65. Crosby JA, Kachlany SC. TdeA, a TolC-like protein required for toxin and drug export in Aggregatibacter (Actinobacillus) actinomycetemcomitans. Gene 2007 388 : 83 92.
66. Czuprynski CJ, Welch RA. Biological effects of RTX toxins: the possible role of lipopolysaccharide. Trends Microbiol 1995 3 : 480 3.
67. Dahlén G. Role of suspected periodontopathogens in microbiological monitoring of periodontitis. Adv Dent Res 1993 7 : 163 74.
68. Dahlén G, Widar F, Teanpaisan R, Papapanou PN, Baelum V, Fejerskov O. Actinobacillus actinomycetemcomitans in a rural adult population in southern Thailand. Oral Microbiol Immunol 2002 17 : 137 42.
69. Dahlén G, Björkander J, Gahnberg L, Slots J, Hanson L-Å. Periodontal disease and dental caries in relation to primary IgG subclass and other humoral immunodeficiencies. J Clin Periodontol 1993 20 : 7 13.
70. Darby I, Curtis M. Microbiology of periodontal disease in children and young adults. Periodontol 2000 2001 26 : 33 53.
71. Das MD, Badley MD, Cockerill MD, Steckelberg MD, Wilson MD. Infective endocarditis caused by HACEK microorganisms. Annu Rev Med 1997 48 : 25 33.
72. de Haar SF, Hiemstra PS, van Steenbergen MTJM, Everts V, Beertsen W. Role of polymorphonuclear leukocyte-derived serine proteinases in defense against Actinobacillus actinomycetemcomitans. Infect Immun 2006 74 : 5284 91.
73. de Vrese M, Schrezenmeir J. Probiotics, Prebiotics, and Synbiotics. Adv Biochem Eng Biotechnol 2008 111 : 1 66.
74. Deas DE, Mackey SA, McDonnell HT. Systemic disease and periodontitis: manifestations of neutrophil dysfunction. Periodontol 2000 2003 32 : 82 104.
75. Delima AJ, Oates T, Assuma R, Schwartz Z, Cochran D, Amar S, et al. Soluble antagonists to interleukin-1 (IL-1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental periodontitis. J Clin Periodontol 2001 28 : 233 40.
76. Delima AJ, Karatzas S, Amar S, Graves DT. Inflammation and tissue loss caused by periodontal pathogens is reduced by interleukin-1 antagonists. J Infect Dis 2002 186 : 511 6.
77. Diaz R, Ghofaily LA, Patel J, Balashova NV, Freitas AC, Labib I, et al. Characterization of leukotoxin from a clinical strain of Actinobacillus actinomycetemcomitans. Microb Pathog 2006 40 : 48 55. (Pubitemid 43221898)
78. Dileepan T, Kachlany SC, Balashova NV, Patel J, Maheswaran SK. Human CD18 is the functional receptor for Aggregatibacter actinomycetemcomitans leukotoxin. Infect Immun 2007 75 : 4851 6.
79. DiRienzo JM, Slots J, Sixou M, Sol MA, Harmon R, McKay TL. Specific genetic variants of Actinobacillus actinomycetemcomitans correlate with disease and health in a regional population of families with localized juvenile periodontitis. Infect Immun 1994 62 : 3058 65.
80. DiRienzo JM, Cornell S, Kazoroski L, Slots J. Probe-specific DNA fingerprinting applied to the epidemiology of localized juvenile periodontitis. Oral Microbiol Immunol 1990 5 : 49 56.
81. DiRienzo JM, McKay TL. Identification and characterization of genetic cluster groups of Actinobacillus actinomycetemcomitans isolated from the human oral cavity. J Clin Microbiol 1994 32 : 75 81.
82. Dogan B, Saarela MH, Jousimies-Somer H, Alaluusua S, Asikainen S. Actinobacillus actinomycetemcomitans serotypes e - biotypes, genetic diversity and distribution in relation to periodontal status. Oral Microbiol Immunol 1999B 14 : 98 103.
83. Dogan B, Saarela M, Asikainen S. Genotyping of Actinobacillus actinomycetemcomitans serotype d isolates based on polymerase chain reaction. Oral Microbiol Immunol 1999A 14 : 387 90.
84. Dogan B, Kipalev AS, Ökte E, Sultan N, Asikainen SE. Consistent intrafamilial transmission of Actinobacillus actinomycetemcomitans despite clonal diversity. J Periodontol 2008 79 : 307 15.
85. Dzink JL, Tanner ACR, Haffajee AD, Socransky SS. Gram negative species associated with active destructive periodontal lesions. J Clin Periodontol 1985 12 : 648 59.
86. Dzink JL, Socransky SS, Haffajee AD. The predominant cultivable microbiota of active and inactive lesions of destructive periodontal diseases. J Clin Periodontol 1988 15 : 316 23.
87. Eriksen KT, Haubek D, Poulsen K. Intragenomic recombination in the highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans. Microbiology 2005 151 : 3371 9.
88. Falush D, Wirth T, Linz B, Pritchard JK, Stephens M, Kidd M, et al. Traces of human migrations in Helicobacter pylori populations. Science 2003 299 : 1582 9.
89. Farjo RS, Foxman B, Patel MJ, Zhang L, Pettigrew MM, McCoy SI, et al. Diversity and sharing of Haemophilus influenzae strains colonizing healthy children attending day-care centers. Pediatr Infect Dis J 2004 23 : 41 6.
90. Faveri M, Mayer MPA, Feres M, de Figueiredo LC, Dewhirst FE, Paster BJ. Microbiological diversity of generalized aggressive periodontitis by 16S rRNA clonal analysis. Oral Microbiol Immunol 2008 23 : 112 8.
91. Fiehn NE, Larsen T, Christiansen N, Holmstrup P, Schroeder TV. Identification of periodontal pathogens in atherosclerotic vessels. J Periodontol 2005 76 : 731 6.
92. Fine DH, Furgang D, Schreiner HC, Goncharoff P, Charlesworth J, Ghazwan G, et al. Phenotypic variation in Actinobacillus actinomycetemcomitans during laboratory growth: implications for virulence. Microbiology 1999 145 : 1335 47.
93. Fine DH, Figurski D, Kachlany SC, Kaplan J. Molecular windows into the pathogenic properties of Aggregatibacter actinomycetemcomitans: a status report with a view to the future. In : Anthony H. Rogers editor. Molecular Oral Microbiology.
94. Fine DH, Furgang D, Kaplan J, Charlesworth J, Figurski DH. Tenacious adhesion of Actinobacillus actinomycetemcomitans strain CU1000 to salivary-coated hydroxyapatite. Arch Oral Biol 1999A 44 : 1063 76.
95. Fine DH, Velliyagounder K, Furgang D, Kaplan JB. The Actinobacillus actinomycetemcomitans autotransporter adhesin Aae exhibits specificity for buccal epithelial cells from humans and old world primates. Infect Immun 2005 73 : 1947 53.
96. Fine DH, Kaplan JB, Kachlany SC, Schreiner HC. How we got attached to Actinobacillus actinomycetemcomitans: a model for infectious diseases. Periodontol 2000 2006 42 : 114 57.
97. Fine DH, Markowitz K, Furgang D, Fairlie K, Ferrandiz J, Nasri C, et al. Aggregatibacter actinomycetemcomitans and its relationship to initiation of localized aggressive periodontitis: Longitudinal cohort study of initially healthy adolescents. J Clin Microbiol 2007 45 : 3859 69.
98. Finlay BB, Falkow S. Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev 1997 61 : 136 69.
99. Fives-Taylor P, Meyer D, Mintz K. Characteristics of Actinobacillus actinomycetemcomitans invasion of and adhesion to cultured epithelial cells. Adv Dent Res 1995 9 : 55 62.
100. Fives-Taylor PM, Meyer DH, Mintz KP, Brissette C. Virulence factors of Actinobacillus actinomycetemcomitans. Periodontol 2000 1999 20 : 136 67.
101. Flemmig TF, Rüdiger S, Hofmann U, Schmidt H, Plaschke B, Strätz A, et al. Identification of Actinobacillus actinomycetemcomitans in subgingival plaque by PCR. J Clin Microbiol 1995 33 : 3102 5.
102. Fong KP, Pacheco CMF, Otis LL, Baranwal S, Kieba IR, Harrison G, et al. Actinobacillus actinomycetemcomitans leukotoxin requires lipid microdomains for target cell cytotoxicity. Cell Microbiol 2006 8 : 1753 67.
103. Frandsen EVG, Poulsen K, Curtis MA, Kilian M. Evidence of recombination in Porphyromonas gingivalis and random distribution of putative virulence markers. Infect Immun 2001 69 : 4479 85.
104. Frey J, Kuhnert P. RTX toxins in Pasteurellaceae. Int J Med Microbiol 2002 292 : 149 58.
105. Friedl P, Weigelin B. Interstitial leukocyte migration and immune function. Nat Immunol 2008 9 : 960 9.
106. Frisken KW, Higgins T, Palmer JM. The incidence of periodontopathic microorganisms in young children. Oral Microbiol Immunol 1990 5 : 43 5.
107. Gafan GP, Lucas VS, Roberts GJ, Petrie A, Wilson M, Spratt DA. Prevalence of periodontal pathogens in dental plaque of children. J Clin Microbiol 2004 42 : 4141 6.
108. Gallant CV, Sedic M, Chicoine EA, Ruiz T, Mintz KP. Membrane morphology and leukotoxin secretion are associated with a novel membrane protein of Aggregatibacter actinomycetemcomitans. J Bacteriol 2008 190 : 5972 80.
109. Garlet GP, Cardoso CR, Silva TA, Ferreira BR, Ávila-Campos MJ, Cunha FQ, et al. Cytokine pattern determines the progression of experimental periodontal disease induced by Actinobacillus actinomycetemcomitans through the modulation of MMPs, RANKL, and their physiological inhibitors. Oral Microbiol Immunol 2006 21 : 12 20.
110. Genco R.J., Zambon JJ, Murray PA. Serum and gingival fluid antibodies as adjuncts in the diagnosis of Actinobacillus actinomycetemcomitans-associated periodontal disease. J Periodontol 1985 56 : S41 S50.
111. Genco RJ, Loos BG. The use of genomic DNA fingerprinting in studies of the epidemiology of bacteria in periodontitis. J Clin Periodontol 1991 18 : 396 405.
112. Gmür R, McNabb H, van Steenbergen MTJM, Baehni P, Mombelli A, van Winkelhoff AJ, et al. Seroclassification of hitherto nontypable Actinobacillus actinomycetemcomitans strains: evidence for a new serotype e. Oral Microbiol Immunol 1993 8 : 116 20.
113. Goncharoff P, Figurski DH, Stevens RH, Fine DH. Identification of Actinobacillus actinomycetemcomitans: polymerase chain reaction amplification of lktA-specific sequences. Oral Microbiol Immunol 1993 8 : 105 10.
114. Graves DT, Liu R, Oates TW. Diabetes-enhanced inflammation and apoptosis - impact on periodontal pathosis. Periodontol 2000 2007 45 : 128 37.
115. Gray-Owen SD, Schyvers AB. Bacterial transferrin and lactoferrin receptors. Trends Microbiol 1996 4 : 185 91.
116. Griffen AL, Leys EJ, Fuerst PA. Strain identification of Actinobacillus actinomycetemcomitans using the polymerase chain reaction. Oral Microbiol Immunol 1992 7 : 240 3.
117. Gu K, Bainbridge B, Darveau RP, Pagel RC. Antigenic components of Actinobacillus actinomycetemcomitans lipopolysaccharide recognized by sera from patients with localized juvenile periodontitis. Oral Microbiol Immunol 1998 13 : 150 7.
118. Guerrero A, Griffiths GS, Nibali L, Suvan J, Moles DR, Laurell L, et al. Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. J Clin Periodontol 2005 32 : 1096 107.
119. Gunsolley JC, Tew JG, Gooss CM, Burmeister JA, Scheinkein HA. Effects of race and periodontal status on antibody reactive with Actinobacillus actinomycetemcomitans strain Y4. J Periodontal Res 1988 23 : 303 7.
120. Gunsolley JC, Tew JG, Connor T, Burmeister JA, Schenkein HA. Relationship between race and antibody reactive with periodontitis-associated bacteria. J Periodontal Res 1991 26 : 59 63.
121. Guthmiller JM, Kolodrubetz D, Kraig E. A panel of probes detects DNA polymorhisms in human and non-human primate isolates of a periodontal pathogen, Actinobacillus actinomycetemcomitans. Microb Pathog 1993 14 : 103 15.
122. Guthmiller JM, Lally ET, Korostoff J. Beyond the specific plaque hypothesis: Are highly leukotoxic strains of Actinobacillus actinomycetemcomitans a paradigm for periodontal pathogenesis? Crit Rev Oral Biol Med 2001 12 : 116 24.
123. Guthmiller JM, Kraig E, Cagle MP, Kolodrubetz D. Sequence of the lktD gene from Actinobacillus actinomycetemcomitans. Nucl Acids Res 1990B 18 : 5292. (Pubitemid 20270091)
124. Guthmiller JM, Kolodrubetz D, Cagle MP, Kraig E. Sequence of the lktB gene from Actinobacillus actinomycetemcomitans. Nucl Acids Res 1990A 18 : 5291. (Pubitemid 20270090)
125. Haase EM, Zmuda JL, Scannapieco FA. Identification and molecular analysis of rough-colony-specific outer membrane proteins of Actinobacillus actinomycetemcomitans. Infect Immun 1999 67 : 2901 8.
126. Haase EM, Stream JO, Scannapieco FA. Transcriptional analysis of the 5' terminus of the flp fimbrial gene cluster from Actinobacillus actinomycetemcomitans. Microbiology 2003 149 : 205 15.
127. Haase EM, Bonstein T, Palmer J, Scannapieco FA. Environmental influences on Actinobacillus actinomycetemcomitans biofilm formation. Arch Oral Biol 2006 51 : 299 314.
128. Haffajee AD, Socransky SS, Ebersole JL, Smith DJ. Clinical, microbiological and immunological features associated with the treatment of active periodontosis lesions. J Clin Periodontol 1984 11 : 600 18.
129. Haffajee AD, Socransky SS. Effect of sampling strategy on the false-negative rate for detection of selected subgingival species. Oral Microbiol Immunol 1992 7 : 57 9.
130. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 1994 5 : 78 111.
131. Haffajee AD, Socransky SS, Gunsolley JC. Systemic anti-infective periodontal therapy. A systematic review. Ann Periodontol 2003 8 : 115 81.
132. Haffajee AD. Systemic antibiotics: to use or not to use in the treatment of periodontal infections. That is the question. J Clin Periodontol 2006 33 : 359 61.
133. Hafner MS, Nadler SA. Phylogenetic trees support the coevolution of parasites and their hosts. Nature 1988 332 : 258 9.
134. Hamada S, Amano A, Kimura S, Nakagawa I, Kawabata S, Morisaki I. The importance of fimbriae in the virulence and ecology of some oral bacteria. Oral Microbiol Immunol 1998 13 : 129 38.
135. Han N, Hoover CI, Winkler JR, Ng CYAGC. Identification of genomic clonal types of Actinobacillus actinomycetemcomitans by restriction endonuclease analysis. J Clin Microbiol 1991 29 : 1574 8.
136. Han X, Kawai T, Taubman MA. Interference with immune-cell-mediated bone resorption in periodontal disease. Periodontol 2000 2007 45 : 76 94.
137. Haraszthy VI, Hariharan G, Tinoco EMB, Cortelli JR, Lally ET, Davis E, et al. Evidence for the role of highly leukotoxic Actinobacillus actinomycetemcomitans in the pathogenesis of localized juvenile and other forms of early-onset periodontitis. J Periodontol 2000A 71 : 912 22.
138. Haraszthy VI, Zambon JJ, Trevisan M, Zeid M, Genco RJ. Identification of periodontal pathogens in atheromatous plaques. J Periodontol 2000B 71 : 1554 60.
139. Hart TC, Shapira L, Van Dyke TE. Neutrophil defects as risk factors for periodontal diseases. J Periodontol 1994 65 : 521 9.
140. Hartroth B, Seyfahrt I, Conrads G. Sampling of periodontal pathogens by paper points: evaluation of basic parameters. Oral Microbiol Immunol 1999 14 : 326 30.
141. Haubek D, Poulsen K, Asikainen S, Kilian M. Evidence for absence in Northern Europe of especially virulent clonal types of Actinobacillus actinomycetemcomitans. J Clin Microbiol 1995 33 : 395 401.
142. Haubek D, Poulsen K, Westergaard J, Dahlen G, Kilian M. Highly toxic clone of Actinobacillus actinomycetemcomitans in geographically widespread cases of juvenile periodontitis in adolescents of African origin. J Clin Microbiol 1996 34 : 1576 8.
143. Haubek D, Tinoco EM, Westergaard J, Lopez NJ, Chung CP, Poulsen K, et al. Racial tropism of a highly toxic clone of Actinobacillus actinomycetemcomitans associated with juvenile periodontitis. J Clin Microbiol 1997A 35 : 3037 42.
144. Haubek D, Willi K, Poulsen K, Meyer J, Kilian M. Presence of bacteriophage Aa phi 23 correlates with the population genetic structure of Actinobacillus actinomycetemcomitans. Eur J Oral Sci 1997B 105 : 2 8.
145. Haubek D, Ennibi O-K, Poulsen K, Poulsen S, Benzarti N, Kilian M. Early-onset periodontitis in Morocco is associated with the highly leukotoxic clone of Actinobacillus actinomycetemcomitans. J Dent Res 2001 80 : 1580 3.
146. Haubek D, Ennibi O-K, Abdellaoui L, Benzarti N, Poulsen S. Attachment loss in Moroccan early onset periodontitis patients and infection with the JP2-type of Actinobacillus actinomycetemcomitans. J Clin Periodontol 2002 29 : 657 60.
147. Haubek D, Westergaard J. Detection of a highly toxic clone of Actinobacillus actinomycetemcomitans (JP2) in a Moroccan immigrant family with multiple cases of localized aggressive periodontitis. Int J Paediatr Dent 2004 14 : 41 8.
148. Haubek D, Ennibi OK, Poulsen K, Benzarti N, Baelum V. The highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans and progression of periodontal attachment loss. J Dent Res 2004 83 : 767 70.
149. Haubek D, Ismaili Z, Poulsen S, Ennibi O-K, Benzarti N, Baelum V. Association between sharing of toothbrushes, eating and drinking habits and the presence of Actinobacillus actinomycetemcomitans in Moroccan adolescents. Oral Microbiol Immunol 2005 20 : 195 8.
150. Haubek D, Havemose-Poulsen A, Westergaard J. Aggressive periodontitis in a 16-year-old Ghanaian adolescent, the original source of Actinobacillus actinomycetemcomitans strain HK1651 - a 10-year follow up. Int J Paediatr Dent 2006 16 : 370 5.
151. Haubek D, Ennibi O-K, Væth M, Poulsen S, Poulsen K Stability of the JP2 clone of Aggregatibacter actinomycetemcomitans. J Dent Res 2009 88 : 856 60.
152. Haubek D, Poulsen K, Kilian M. Microevolution and patterns of dissemination of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans. Infect Immun 2007 75 : 3080 8.
153. Haubek D, Ennibi O-K, Poulsen K, Vaeth M, Poulsen S, Kilian M. Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort study. Lancet 2008 317 : 237 42.
154. Hayashida H, Poulsen K, Kilian M. Differences in iron acquisition from human haemoglobin among strains of Actinobacillus actinomycetemcomitans. Microbiology 2002 148 : 3993 4001. (Pubitemid 36097461)
155. Hayashida H, Poulsen K, Takagi O, Kilian M. Phylogenetic associations of ISAa1 and IS150-like insertion sequences in Actinobacillus actinomycetemcomitans. Microbiology 2000 146 : 1977 85.
156. He T, Hayashi J, Yamamoto M, Ishikawa I. Genotypic characterization of Actinobacillus actinomycetemcomitans isolated from periodontitis patients by arbitrarily primed polymerase chain reaction. J Periodontol 1998 69 : 69 75.
157. He T, Nishihara T, Demuth DR, Ishikawa I. A novel insertion sequence increases the expression of leukotoxicity in Actinobacillus actinomycetemcomitans clinical isolates. J Periodontol 1999 70 : 1261 8.
158. Heinrich S, Pulverer G. Zur ätiologie und mikrobiologie der aktinomykose. III. Die pathogene bedeutung des Actinobacillus actinomycetem-comitans unter den "begleitbakterien" des Actinomyces israeli. Zentralbl Bakteriol 1959 176 : 91 101.
159. Henderson B, Wilson M, Sharp L, Ward JM. Actinobacillus actinomycetemcomitans. J Med Microbiol 2002 51 : 1013 20.
160. Henderson B, Nair SP, Ward JM, Wilson M. Molecular pathogenicity of the oral opportunistic pathogen Actinobacillus actinomycetemcomitans. Annu Rev Microbiol 2003 57 : 29.
161. Herrera D, Sanz M, Jepsen S, Needleman I, Roldán S. A systematic review on the effect of systematic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. J Clin Periodontol 2002 29 : 136 59.
162. Hirsh AE, Tsolaki AG, DeRiemer K, Feldman MW, Small PM. Stable association between strains of Mycobacterium tuberculosis and their human host populations. Proc Natl Acad Sci U S A 2004 101 : 4871 6.
163. Hogg N, Herderson R, Leitinger B, McDowall A, Porter J, Stanley P. Mechanisms contributing to the activity of integrins on leukocytes. Immunol Rev 2002 186 : 164 71.
164. Holm P. Studies on the aetiology of human actinomycosis. I. The "other microbes" of actinomycosis and their importance. Acta Pathol Microbiol Scand 1950 27 : 736 51.
165. Holmstrup P, Havemose Poulsen A, Andersen L, Skuldbøl T, Fiehn N-E. Oral infections and systemic diseases. Dent Clin N Am 2003 47 : 575 98.
166. Holt SC, Tanner AC, Socransky SS. Morphology and ultrastructure of oral strains of Actinobacillus actinomycetemcomitans and Haemophilus aphrophilus. Infect Immun 1980 30 : 588 600.
167. Hölttä P, Alaluusua S, Saarela M, Asikainen S. Isolation frequency and serotype distribution of mutans streptococci and Actinobacillus actinomycetemcomitans, and clinical periodontal status in Finnish and Vietnamese children. Scand J Dent Res 1994 102 : 113 9.
168. Hørmand J, Frandsen A. Juvenile periodontitis. Localization of bone loss in relation to age, sex, and teeth. J Clin Periodontol 1979 6 : 407 16.
169. Hritz M, Fisher E, Demuth DR. Differential regulation of the leukotoxin operon in highly leukotoxic and minimally leukotoxic strains of Actinobacillus actinomycetemcomitans. Infect Immun 1996 64 : 2724 9.
170. Hujoel PP, Drangsholt M, Spiekerman C, DeRouen TA. Periodontal disease and coronary heart disease risk. JAMA 2000 284 : 1406 10.
171. Hutter G, Schlagenhauf U, Valenza G, Horn M, Burgemeister S, Claus H, et al. Molecular analysis of bacteria in periodontitis: evaluation of clone libraries, novel phylotypes and putative pathogens. Microbiology 2003 149 : 67 75.
172. Inoue T, Tanimoto I, Ohta H, Kato K, Murayama Y, Fukui K. Molecular characterization of low-molecular-weight component protein, Flp, in Actinobacillus actinomycetemcomitans fimbriae. Microbiol Immunol 1998 42 : 253 8.
173. Inoue T, Ohta H, Tanimoto I, Shingaki R, Fukui K. Heterogeneous post-translational modification of Actinobacillus actinomycetemcomitans fimbrillin. Microbiol Immunol 2000 44 : 715 8.
174. Inoue T, Tanimoto I, Tada T, Ohashi T, Fukui K, Ohta H. Fermentable-sugar-level-dependent regulation of leukotoxin synthesis in a variably toxic strain of Actinobacillus actinomycetemcomitans. Microbiology 2001 147 : 2749 56.
175. Inouye T, Ohta H, Kokeguchi S, Fukui K, Kato K. Colonial variation and fimbriation of Actinobacillus actinomycetemcomitans. FEMS Microbiol Lett 1990 69 : 13 7.
176. Jenkins WM, Papapanou PN. Epidemiology of periodontal disease in children and adolescents. Periodontol 2000 2001 26 : 16 32.
177. Johansson A, Claesson R, Hänström L, Sandström G, Kalfas S. Polymorphonuclear leukocyte degranulation induced by leukotoxin from Actinobacillus actinomycetemcomitans. J Periodontal Res 2000A 35 : 85 92.
178. Johansson A, Sandström G, Claesson R, Hänström L, Kalfas S. Anaerobic neutrophil-dependent killing of Actinobacillus actinomycetemcomitans in relation to the bacterial leukotoxicity. Eur J Oral Sci 2000B 108 : 136 46.
179. Johansson A, Claesson R, Hänström L, Kalfas S. Serum-mediated release of leukotoxin from the cell surface of the periodontal pathogen Actinobacillus actinomycetemcomitans. Eur J Oral Sci 2003 111 : 209 15.
180. Johnson GK, Guthmiller JM. The impact of cigarette smoking on periodontal disease and treatment. Periodontol 2000 2007 44 : 178 94.
181. Jones N, Bohnsack JF, Takahashi S, Oliver KA, Chan MS, Kunst F, et al. Multilocus sequence typing system for group B Streptococcus. J Clin Microbiol 2003 41 : 2530 6.
182. Junior WR, de Andrade AFB, Colombo APV. Prevalence of leukotoxic genotypes of Actinobacillus actinomycetemcomitans in Brazilians with chronic periodontitis. Braz J Microbiol 2006 37 : 590 6.
183. Kachlany SC, Fine DH, Figurski DH. Secretion of RTX leukotoxin by Actinobacillus actinomycetemcomitans. Infect Immun 2000B 68 : 6094 100.
184. Kachlany SC, Planet PJ, Bhattacharjee MK, Kollia E, DeSalle R, Fine DH, et al. Nonspecific adherence by Actinobacillus actinomycetemcomitans requires genes widespread in bacteria and archaea. J Bacteriol 2000A 182 : 6169 76.
185. Kachlany SC, Planet PJ, DeSalle R, Fine DH, Figurski DH, Kaplan JB. flp-1, the first representative of a new pilin gene subfamily, is required for non-specific adherence of Actinobacillus actinomycetemcomitans. Mol Microbiol 2001A 40 : 542 54.
186. Kachlany SC, Planet PJ, DeSalle R, Fine DH, Figurski DH. Genes for tight adherence of Actinobacillus actinomycetemcomitans: from plaque to plague to pond scum. Trends Microbiol 2001B 9 : 429 37.
187. Kachlany SC, Fine DH, Figurski DH. Purification of secreted leukotoxin (LtxA) from Actinobacillus actinomycetemcomitans. Protein Expr Purif 2002 25 : 465 71.
188. Kagermeier AS, London J. Actinobacillus actinomycetemcomitans strains Y4 and N27 adhere to hydroxyapatite by distinctive mechanisms. Infect Immun 1985 47 : 654 8.
189. Kamma JJ, Diamanti-Kipioti A, Nakou M, Mitsis FJ. Profile of subgingival microbiota in children with primary dentition. J Periodontal Res 2000 35 : 33 41.
190. Kaplan JB, Perry MB, MacLean LL, Furgang D, Wilson ME, Fine DH. Structural and genetic analyses of O polysaccharide from Actinobacillus actinomycetemcomitans serotypes f. Infect Immun 2001 69 : 5375 84.
191. Kaplan JB, Schreiner HC, Furgang D, Fine DH. Population structure and genetic diversity of Actinobacillus actinomycetemcomitans strains isolated from localized juvenile periodontitis patients. J Clin Microbiol 2002 40 : 1181 7.
192. Kato S, Kowashi Y, Demuth DR. Outer membrane-like vesicles secreted by Actinobacillus actinomycetemcomitans are enriched in leukotoxin. Microb Pathog 2002 32 : 1 13.
193. Kato T, Kimizuka R, Okuda K. Isolation and characterization of hemolytic genes from Actinobacillus actinomycetemcomitans. FEMS Microbiol Lett 1996 143 : 217 21.
194. Källestl C, Matsson L, Persson S. Proximal attachment loss in Swedish adolescents. J Clin Periodontol 1991 18 : 760 5.
195. Kelk P, Johansson A, Claesson R, Hanstrom L, Kalfas S. Caspase 1 involvement in human monocyte lysis induced by Actinobacillus actinomycetemcomitans leukotoxin. Infect Immun 2003 71 : 4448 55.
196. Kelk P, Claesson R, Hanstrom L, Lerner UH, Kalfas S, Johansson A. Abundant secretion of bioactive interleukin-1beta by human macrophages induced by Actinobacillus actinomycetemcomitans leukotoxin. Infect Immun 2005 73 : 453 8.
197. Kelk P, Claesson R, Chen C, Sjöstedt A, Johansson A. IL-1beta secretion induced by Aggregatibacter (Actinobacillus) actinomycetemcomitans is mainly caused by the leukotoxin. Int J Med Microbiol 2008 298 : 529 41.
198. Kieba IR, Fong KP, Tang HY, Hoffman KE, Speicher DW, Klickstein LB, et al. Aggregatibacter actinomycetemcomitans leukotoxin requires beta-sheets 1 and 2 of the human CD11a beta-propeller for cytotoxicity. Cell Microbiol 2007 9 : 2689 99.
199. Kilian M, Schiøtt CR. Haemophili and related bacteria in the human oral cavity. Arch Oral Biol 1975 20 : 791 6.
200. Kilian M, Frandsen E, Haubek D, Poulsen K. The etiology of periodontal disease revisited by population genetic analysis. Periodontol 2000, 2006 42 : 158 179.
201. Kimizuka R, Miura T, Okada K. Characterization of Actinobacillus actinomycetemcomitans hemolysin. Microbiol Immunol 1996 40 : 717 23.
202. Kimura S, Ooshima T, Takiguchi M, Sasaki Y, Amano A, Morisaki I, et al. Periodontopathic bacterial infection in childhood. J Periodontol 2002 73 : 20 6.
203. Kinane DF, Podmore M, Ebersole J. Etiopathogenesis of periodontitis in children and adolescents. Periodontol 2000 2001 26 : 54 91.
204. Kinane DF, Mooney J, Ebersole JL. Humoral immune response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in periodontal disease. Periodontol 2000 1999 20 : 289 340.
205. Kinane DF, Shiba H, Hart TC. The genetic basis of periodontitis. Periodontol 2000 2005 39 : 91 117.
206. Kinane DF, Peterson M, Stathopoulou PG. Environmental and other modifying factors of the periodontal diseases. Periodontol 2000 2006 40 : 107 19.
207. Kinane DF, Demuth DR, Gorr SU, Hajishengallis GN, Martin MH. Human variability in innate immunity. Periodontol 2000 2007 45 : 14 34.
208. King EO, Tatum HW. Actinobacillus actinomycetemcomitans and Hemophilus aphrophilus. J Infect Dis 1962 111 : 85 94.
209. Klinger R. Untersuchungenüber menschliche Aktinomykose. Zentralbl Bakteriol 1912 62 : 191 200.
210. Kolodrubetz D, Dailey T, Ebersole J, Kraig E. Cloning and expression of the leukotoxin gene from Actinobacillus actinomycetemcomitans. Infect Immun 1989 57 : 1465 9.
211. Kolodrubetz D, Spitznagel J, Wang B, Phillips LH, Jacobs C, Kraig E. cis elements and trans factors are both important in strain-specific regulation of the leukotoxin gene in Actinobacillus actinomycetemcomitans. Infect Immun 1996 64 : 3451 60.
212. Kolodrubetz D. Molecular genetics and the analysis of leukotoxin in A. actinomycetemcomitans. J Periodontol 1996 67 : 309 16.
213. Kolodrubetz D, Phillips L, Jacobs C, Burgum A, Kraig E. Anaerobic regulation of Actinobacillus actinomycetemcomitans leukotoxin transcription is ArcAFnrA-independent and requires a novel promoter element. Res Microbiol 2003 154 : 645 53.
214. Koronakis V, Hughes C. Synthesis, maturation and export of the E.coli hemolysin. Med Microbiol Immunol 1996 185 : 65 71.
215. Koronakis V, Stanley P, Koronakis E, Hughes C. The HlyBHlyD-dependent secretion of toxins by Gram-negative bacteria. FEMS Microbiol Immunol 1992 105 : 45 54.
216. Korostoff J, Wang JF, Kieba I, Miller M, Shenker BJ, Lally ET. Actinobacillus actinomycetemcomitans leukotoxin induces apoptosis in HL-60 cells. Infect Immun 1998 66 : 4474 83.
217. Korostoff J, Yamaguchi N, Miller M, Kieba I, Lally ET. Perturbation of mitochondrial structure and function plays a central role in Actinobacillus actinomycetemcomitans leukotoxin-induced apoptosis. Microb Pathog 2000 29 : 267 78.
218. Kozarov EV, Dorn BR, Shelburne CE, Dunn WA, Progulske-Fox A. Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Arterioscler Thromb Vasc Biol 2005 25 : e17 e18.
219. Könönen E, Asikainen S, Jousimies-Somer H. The early colonization of gram-negative anaerobic bacteria in edentulous infants. Oral Microbiol Immunol 1992 7 : 28 31.
220. Kraig E, Dailey T, Kolodrubetz D. Nucleotide sequence of the leukotoxin gene from Actinobacillus actinomycetemcomitans: homology to the alphahemolysinleukotoxin gene family. Infect Immun 1990 58 : 920 9.
221. Kroes I, Lepp PW, Relman DA. Bacterial diversity within the human subgingival crevice. Proc Natl Acad Sci U S A 1999 96 : 14547 52.
222. Kulekci G, Leblebicioglu B, Keskin F, Ciftci S, Badur S. Salivary detection of periodontopathic bacteria in periodontally healthy children. Anaerobe 2008 14 : 49 54.
223. Kumar PS, Griffen AL, Barton JA, Paster BJ, Moeschberger ML, Leys EJ. New bacterial species associated with chronic periodontitis. J Dent Res 2003 82 : 338 344.
224. Lai CH, Listgarten MA, Hammond BF. Comparative ultrastructure of leukotoxic and non-leukotoxic strains of Actinobacillus actinomycetemcomitans. J Periodontal Res 1981 16 : 379 89.
225. Lakio L, Paju S, Alfthan G, Tiirola T, Asikainen S, Pussinen PJ. Actinobacillus actinomycetemcomitans serotype d-specific antigen contains the O antigen of lipopolysaccharide. Infect Immun 2003 71 : 5005 11.
226. Lally ET, Kieba IR, Demuth DR, Rosenbloom J, Golub EE, Taichman NS, et al. Identification and expression of the Actinobacillus actinomycetemcomitans leukotoxin gene. Biochem Biophys Res Commun 1989 159 : 256 62.
227. Lally ET, Kieba IR. Molecular biology of Actinobacillus actinomycetemcomitans leukotoxin. In : Genco R editor. Molecular pathogenesis of periodontal disease. 1994 : 69 82.
228. Lally ET, Kieba IR, Golub EE, Lear JD, Tanaka JC. Structurefunction aspects of Actinobacillus actinomycetemcomitans leukotoxin. J Periodontol 1996 67 : 17 27.
229. Lally ET, Golub EE, Kieba IR, Taichman NS, Decker S, Berthold P, et al. Structure and function of the B and D genes of the Actinobacillus actinomycetemcomitans leukotoxin complex. Microb Pathog 1991 11 : 111 21.
230. Lally ET, Kieba IR, Sato A, Green CL, Rosenbloom J, Korostoff J, et al. RTX toxins recognize a beta 2 integrin on the surface of human target cells. J Biol Chem 1997 272 : 30463 9.
231. Lally ET, Hill RB, Kieba IR, Korostoff J. The interaction between RTX toxins and target cells. Trends Microbiol 1999 7 : 356 61.
232. Lamell CW, Griffen AL, McClellan DL, Leys EJ. Acquisition and colonization stability of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in children. J Clin Microbiol 2000 38 : 1196 9.
233. Lerner UH. New molecules in the tumor necrosis factor ligand and receoptor superfamilies with importance for phsiological and pathological bone resorption. Crit Rev Oral Biol Med 2004 15 : 64 81.
234. Leung NM, Chen R, Rudney JD. Oral bacteria in plaque and invading buccal cells of young orthodontic patients. Am J Orthod Dentofacial Orthop 2006 130 : 698. e11-8.
235. Leung WK, Ngai VKS, Yau JYY, Cheung BPK, Tsang PWK, Corbet EF. Characterization of Actinobacillus actinomycetemcomitans isolated from young Chinese aggressive periodontitis patients. J Periodontal Res 2005 40 : 258 68.
236. Lewis JP. The molecular basis of host-pathogen interaction in the oral cavity. In : Rogers AH editor. Molecular Oral Microbiology. Caister Academic Press, 2008 : 195 235.
237. Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 2007 7 : 678 89.
238. Li L, Matevski D, Aspiras M, Ellen RP, Lepine G. Two epithelial cell invasion-related loci of the oral pathogen Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol 2004 19 : 16 25.
239. Lindhe J, Hamp S-E, Löe H. Plaque induced periodontal disease in beagle dogs. A 4-year clinical, roentgenographical and histometrical study. J Periodontal Res 1975 10 : 245 55.
240. Little JW. Periodontal disease and heart disease: Are they related? Gen Dent 2008 56 : 733 7.
241. Loomer PM. Microbiological diagnostic testing in the treatment of periodontal diseases. Periodontol 2000 2004 34 : 49 56.
242. Lopez NJ, Mellado JC, Leighton GX. Occurrence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Prevotella intermedia in juvenile periodontitis. J Clin Periodontol 1996 23 : 101 5.
243. Löe H, Anerud A, Boysen H, Morrison E. Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age. J Clin Periodontol 1986 13 : 431 40.
244. Löe H, Theilade E, Börglum Jensen S. Experimental gingivitis in man. J Periodontol 1965 36 : 177 87.
245. Macheleidt A, Müller H-P, Eger T, Putzker M, Zöller L. Clonal diversity of Actinobacillus actinomycetemcomitans isolates from young adults with minimal periodontal disease. J Periodontal Res 1999B 34 : 179 87.
246. Macheleidt A, Müller H-P, Eger T, Putzker M, Fuhrmann A, Zöller L. Absence of an especially toxic clone among isolates of Actinobacillus actinomycetemcomitans recovered from army recruits. Clin Oral Invest 1999A 3 : 161 7.
247. Maiden MCJ, Bygraves JA, Feil E, Morelli G, Russell JE, Urwin R, et al. Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci U S A 1998 95 : 3140 5.
248. Mangan DF, Taichman NS, Lally ET, Wahl SM. Lethal effects of Actinobacillus actinomycetemcomitans leukotoxin on human T lymphocytes. Infect Immun 1991 59 : 3267 72.
249. Marques da Silva R, Caugant DA, Lingaas PS, Geiran O, Tronstad L, Olsen I. Detection of Actinobacillus actinomycetemcomitans but not bacteria of the red complex in aortic aneurysms by multiplex polymerase chain reaction. J Periodontol 2005 76 : 590 4.
250. Marsh P, Martin M. Oral Microbiology, 3rd edn.
251. Marsh PD. Microbial ecology of dental plaque and its significance in health and disease. Adv Dent Res 1994 8 : 263 71.
252. Marsh PD. Host defenses and microbial homeostasis: Role of microbial interactions. J Dent Res 1989 68 : S1567 S75.
253. Matsuda M, Takayama K, Haga S, Kagawa S, Ohta H, Kato K, et al. Molecular genotyping of isolates of Actinobacillus actinomycetemcomitans by pulsed-field gel electrophoresis after separate digestion with Sse8387I and XhoI (p 137-144). J Basic Microbiol 2002 42 : 137 44.
254. Matthews DC. Adjunctive antibiotics in the treatment of generalized aggressive periodontitis. Can an adjunctive course of metronidazole and amoxicillin improve outcomes in people who have generalised aggressive periodontitis? Evid Based Dent 2006 7 : 67.
255. May RM, Anderson RM. Parasite-host coevolution. Parasitol 1990 100 : S89 S101.
256. Mayer MP, Bueno LC, Hansen EJ, DiRienzo JM. Identification of a cytolethal distending toxin gene locus and features of a virulence-associated region in Actinobacillus actinomycetemcomitans. Infect Immun 1999 67 : 1227 37.
257. Maynard-Smith J. Do bacteria have population genetics? In : Baumberg S, Young JPW, Wellington EMH, Saunders JR editors. Population genetics of bacteria, 1st edn. Cambridge university Press, 1995 : 1 12.
258. Maynard-Smith J, Smith NH, O'Rourke M, Spratt BG. How clonal are bacteria? Proc Natl Acad Sci U S A 1993 90 : 4384 8.
259. McGee JM, Tucci MA, Edmundson TP, Serio CL, Johnson RB. The relationship between concentrations of proinflammatory cytokines within gingiva and adjacent sulcular depth. J Periodontol 1998 69 : 865 71.
260. Mealey BL, Ocampo GL. Diabetes mellitus and periodontal disease. Periodontol 2000 2007 44 : 127 53.
261. Meats E, Feil EJ, Stringer S, Cody AJ, Goldstein R, Kroll JS, et al. Characterization of encapsulated and noncapsulated Haemophilus influenzae and determination of phylogenetic relationships by multilocus sequence typing. J Clin Microbiol 2003 41 : 1623 36.
262. Mena J, Chen C. Identification of strain-specific DNA of Actinobacillus actinomycetemcomitans by representational difference analysis. Oral Microbiol Immunol 2007 22 : 429 32.
263. Meng H, Xu L, Li Q, Han J, Zhao Y. Determinants of host susceptibility in aggressive periodontitis. Periodontol 2000 2007 43 : 133 59.
264. Meurman JH, Stamatova I. Probiotics: contributions to oral health. Oral Dis 2007 13 : 443 51.
265. Meyer DH, Sreenivasan PK, Fives-Taylor PM. Evidence for invasion of a human oral cell line by Actinobacillus actinomycetemcomitans. Infect Immun 1991 59 : 2719 26.
266. Meyer DH, Fives-Taylor PM. Evidence that extracellular components function in adherence of Actinobacillus actinomycetemcomitans to epithelial cells. Infect Immun 1993 61 : 4933 6.
267. Meyer DH, Fives-Taylor PM. Characteristics of adherence of Actinobacillus actinomycetemcomitans to epithelial cells. Infect Immun 1994 62 : 928 35.
268. Meyer DH, Lippmann JE, Fives-Taylor PM. Invasion of epithelial cells by Actinobacillus actinomycetemcomitans : a dynamic, multistep process. Infect Immun 1996 64 : 2988 97.
269. Meyer DH, Fives-Taylor PM. The role of Actinobacillus actinomycetemcomitans in the pathogenesis of periodontal disease. Trends Microbiol 1997 5 : 224 8.
270. Michalowicz BS, Diehl SR, Gunsolley JC, Sparks BS, Brooks CN, Koertge TE, et al. Evidence of a substantial genetic basis for risk of adult periodontitis. J Periodontol 2000 71 : 1699 707.
271. Mitchell C, Gao L, Demuth DR. Positive and negative cis-acting regulatory sequences control expression of leukotoxin in Actinobacillus actinomycetemcomitans 652. Infect Immun 2003 71 : 5640 9.
272. Mizoguchi K, Ohta H, Miyagi A, Kurihara H, Takashiba S, Kato K, et al. The regulatory effect of fermentable sugar levels on the production of leukotoxin by Actinobacillus actinomycetemcomitans. FEMS Microbiol Lett 1997 146 : 161 6.
273. Moeintaghavi A., Talebi-ardakani MR, Haerian-ardakani A, Zandi H, Taghipour S, Fallahzadeh H, et al. Adjunctive effects of systemic amoxicillin and metronidazole with scaling and root planing: a randomized, placebo controlled clinical trial. J Contemp Dent Pract 2007 8 : 51 9.
274. Mombelli A, Gmür R, Lang NP, Corbet E, Frey J. Actinobacillus actinomycetemcomitans in Chinese adults. Serotypes distribution and analysis of the leukotoxin gene promoter locus. J Clin Periodontol 1999 26 : 505 10.
275. Monot M, Honoré N, Garnier T, Araoz R, Coppée J-Y, Lacroix C, Sow S, Spencer JS, Truman RW, Williams DL, Gelber R, Virmond M, Flageul B, Cho S-N, Ji B, Paniz-Mondolfi A, Convit J, Young S, Fine PE, Rasolofo V, Brennan PJ, Cole ST. On the origin of leprosy. Science 2005 308 : 1040 1042.
276. Moore WEC, Holdeman LV, Smibert RM, Hash DE, Burmeister JA, Ranney RR. Bacteriology of severe periodontitis in young adult humans. Infect Immun 1982 38 : 1137 48.
277. Moore WEC, Holdeman LV, Cato EP, Smibert RM, Burmeister JA, Ranney RR. Bacteriology of moderate (chronic) periodontitis in mature adult humans. Infect Immun 1983 42 : 510 5.
278. Moore WEC, Holdeman LV, Cato EP, Smibert RM, Burmeister JA, Palcains KG, et al. Comparative bacteriology of juvenile periodontitis. Infect Immun 1985 48 : 507 19.
279. Morinushi T, Lopatin DE, Poperin Neal Van, Ueda Y. The relationship between gingivitis and colonization by Porphoromonas gingivalis and Actinobacillus actinomycetemcomitans in children. J Periodontol 2000 71 : 403 9.
280. Morova J, Osicka R, Masin J, Sebo P. RTX cytotoxins recognize beta 2 integrin receptors through N-linked oligosaccharides. Proc Natl Acad Sci U S A 2008 105 : 5355 60.
281. Muhle I, Rau MD, Ruskin J. Vertebral ostemyelitis due to Actinobacillus actinomycetemcomitans. JAMA 1979 241 : 1824 5.
282. Musser JM, Granoff DM, Pattison PE, Selander RK. A population genetic framework for the study of invasive diseases caused by serotype b strains of Haemophilus influenzae. Proc Natl Acad Sci U S A 1985 82 : 5078 82.
283. Musser JM, Schlievert PM, Chow AW, Ewan P, Kreiswirth BN, Rosdahl VT, et al. A single clone of Staphylococcus aureus causes the majority of cases of toxic shock syndrome. Proc Natl Acad Sci U S A 1990A 87 : 225 9.
284. Musser JM, Hauser AR, Kim MH, Schlievert PM, Nelson K, Selander RK. Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression. Proc Natl Acad Sci U S A 1991 88 : 2668 72.
285. Musser JM, Mattingly SJ, Quentin R, Goudeau A, Selander RK. Identification of a high-virulence clone of type III Streptococcus agalactiae (Group B Streptococcus) causing invasive neonatal disease. Proc Natl Acad Sci U S A 1989 86 : 4731 5.
286. Musser JM, Kroll JS, Granoff DM, Moxon ER, Brodeur BR, Campos J, et al. Global genetic structure and molecular epidemiology of encapsulated Haemophilus influenzae. Rev Infect Dis 1990B 12 : 75 111.
287. Müller HP, Heinecke A, Fuhrmann A, Eger T, Zoller L. Intraoral distribution of Actinobacillus actinomycetemcomitans in young adults with minimal periodontal disease. J Periodontal Res 2001 36 : 114 23.
288. Müller H-P, Zöller L, Eger T, Hoffmann S, Lobinsky D. Natural distribution of oral Actinobacillus actinomycetemcomitans in young men with minimal periodontal disease. J Periodontal Res 1996 31 : 373 80.
289. Nallapareddy SR, Wenxiang H, Weinstock GM, Murray BE. Molecular characterization of a widespread, pathogenic, and antibiotic resistance-receptive Enterococcus faecalis lineage and dissemination of its putative pathogenicity island. J Bacteriol 2005 187 : 5709 18.
290. Narayanan SK, Nagaraja TG, Chengappa MM, Stewart GC. Leukotoxins of gram-negative bacteria. Vet Microbiol 2002 84 : 337 56.
291. Nishida E, Hara Y, Kaneko T, Ikeda Y, Ukai T, Kato I. Bone resorption and local interleukin-1 alfa and interleukin-1 beta synthesis induced by Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis lipopolysaccharide. J Periodontal Res 2001 36 : 1 8.
292. Nishihara T, Koseki T. Microbial etiology of periodontitis. Periodontol 2000 2004 36 : 14 26.
293. Noiri Y, Li L, Ebisu S. The localization of periodontal-disease- associated bacteria in human periodontal pockets. J Dent Res 2001 80 : 1930 4.
294. Nørskov-Lauritsen N, Kilian M. Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factor-independent isolates. Int J Syst Evol Microbiol 2006 56 : 2135 46.
295. Nunn ME. Understanding the etiology of periodontitis: an overview of periodontal risk factor. Periodontol 2000 2003 32 : 11 23.
296. O'Rourke M, Stevens E. Genetic structure of Neisseria gonorrhoeae population: a non-clonal pathogen. J Gen Microbiol 1993 139 : 2603 11.
297. O'Rourke M, Spratt BG. Further evidence for the non-clonal population structure of Neisseria gonorrhoeae: extensive genetic diversity within isolates of the same electrophoretic type. Microbiology 1994 140 : 1285 90.
298. Offenbacher S. Periodontal diseases: Pathogenesis. Ann Periodontol 1996 1 : 821 78.
299. Ohta H, Kato K, Kokeguchi S, Hara H, Fukui K, Murayama Y. Nuclease-sensitive binding of an Actinobacillus actinomycetemcomitans leukotoxin to the bacterial cell surface. Infect Immun 1991 59 : 4599 605.
300. Ohta H, Hara H, Fukui K, Kurihara H, Murayama Y, Kato K. Association of Actinobacillus actinomycetemcomitans leukotoxin with nucleic acids on the bacterial cell surface. Infect Immun 1993 61 : 4878 84.
301. Okada M, Hayashi F, Nagasaka N. Detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in dental plaque samples from children 2 to 12 years of age. J Clin Periodontol 2000 27 : 763 8.
302. Okada M, Hayashi F, Soga Y, Zhong X, Miura K, Kozai K. Intra-familial distribution of nine putative periodontopathogens in dental plaque samples analyzed by PCR. J Oral Sci 2004 46 : 149 56.
303. Olsen I, Shah HN, Gharbia SE. Taxonomy and biochemical characteristics of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. Periodontol 2000 1999 20 : 14 52.
304. Ooshima T, Nishiyama N, Hou B, Tamura K, Kusumoto A, Kimura S. Occurrence of periodontal bacteria in healthy children: a 2-year longitudinal study. Community Dent Oral Epidemiol 2003 31 : 417 25.
305. Orrù G, Marini MF, Cuisa ML, Isola D, Cotti M, Baldoni M, et al. Usefullness of real time PCR for the differentiation and quantification of 652 and JP2 Actinobacillus actinomycetemcomitans genotypes in dental plaque and saliva. BMC Infect Dis 2006 6 : 98.
306. Otto BR, Verweij-van AMJJ, MacLaren DM. Transferrins and heme-compounds as iron sources for pathogenic bacteria. Crit Rev Microbiol 1992 18 : 217 33.
307. Page RC, Sims TJ, Engel LD, Moncla BJ, Bainbridge B, Stray J, et al. The immunodominant outer membrane antigen of Actinobacillus actinomycetemcomitans is located in the serotype-specific high-molecular-mass carbohydrate moiety of lipopolysaccharide. Infect Immun 1991 59 : 3451 62.
308. Paju S, Carlson P, Jousimies-Somer H, Asikainen S. Heterogeneity of Actinobacillus actinomycetemcomitans strains in various human infections and relationships between serotype, genotype, and antimicrobial susceptibility. J Clin Microbiol 2000 38 : 79 84.
309. Paju S, Saarela M, Alaluusua S, Fives-Taylor P, Asikainen S. Characterization of serologically nontypeable Actinobacillus actinomycetemcomitans isolates. J Clin Microbiol 1998 36 : 2019 22.
310. Paolantonio M, di Bonaventura G, di Placido G, Tumini V, Catamo G, di Donato A, et al. Prevalence of Actinobacillus actinomycetemcomitans and clinical conditions in children and adolescents from rural and urban areas of central Italy. J Clin Periodontol 2000 27 : 549 57.
311. Paquette DW, Brodala N, Nichols TC. Cardiovascular disease, inflammation, and periodontal infection. Periodontol 2000 2007 44 : 113 26.
312. Paster BJ, Boches SK, Galvin JL, Ericson RE, Lau CN, Levanos VA, et al. Bacterial diversity in human subgingival plaque. J Bacteriol 2001 183 : 3770 83.
313. Paster BJ, Olsen I, Aas JA, Dewhirst FE. The breadth of bacterial diversity in the human periodontal pocket and other oral sites. Periodontol 2000 2006 42 : 80 7.
314. Paturel L, Casalta JP, Habib G, Nezri D, Raoult D. Actinobacillus actinomycetemcomitans endocarditis. Clin Microbiol Infect 2004 10 : 98 118.
315. Pavicic MJAMP, Van Winkelhoff AJ, Douque NH, Steures RWR, De Graaff J. Microbiological and clinical effects of metronidazole and amoxicillin in Actinobacillus actinomycetemcomitans-associated periodontitis. A 2-year evaluation. J Clin Periodontol 1994 21 : 107 12.
316. Perez BA, Planet PJ, Kachlany SC, Tomich M, Fine DH, Figurski DH. Genetic analysis of the requirement for flp-2, tadV, and rcpB in Actinobacillus actinomycetemcomitans biofilm formation. J Bacteriol 2006 188 : 6361 75.
317. Perry MB, MacLean LL, Gmur R, Wilson ME. Characterization of the O-polysaccharide structure of lipopolysaccharide from Actinobacillus actinomycetemcomitans serotype b. Infect Immun 1996 64 : 1215 9.
318. Petit MDA, van Steenbergen TJM, van der Velden U, De Graaff J. Epidemiology and transmission of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans among children and their family members. J Clin Periodontol 1993B 20 : 641 50.
319. Petit MDA, van Steenbergen TJM, De Graaff J, van der Velden U. Transmission of Actinobacillus actinomycetemcomitans in families of adult periodontitis patients. J Periodontal Res 1993A 28 : 85 100.
320. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet 2005 366 : 1809 20.
321. Planet PJ, Kachlany SC, Fine DH, DeSalle R, Figurski DH. The widespread colonization island of Actinobacillus actinomycetemcomitans. Nat Genet 2003 34 : 193 8.
322. Potts TV, Zambon JJ, Genco RJ. Reassignment of Actinobacillus actinomycetemcomitans to the genus Haemophilus as Haemophilus actinomycetemcomitans comb. nov. Int J Syst Bacteriol 1985 35 : 337 41.
323. Poulsen K, Theilade E, Lally ET, Demuth DR, Kilian M. Population structure of Actinobacillus actinomycetemcomitans: a framework for studies of disease-associated properties. Microbiology 1994 140 : 2049 60.
324. Poulsen K, Ennibi O-K, Haubek D. Improved PCR for detection of the highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans in subgingival plaque samples. J Clin Microbiol 2003 41 : 4829 32.
325. Preshaw PM, Foster N, Taylor JJ. Cross-susceptibility between periodontal disease and type 2 diabetes mellitus: an immunobiological perspective. Periodontol 2000 2007 45 : 138 57.
326. Preus HR, Namork E, Olsen I. Fimbriation of Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol 1988 3 : 93 94.
327. Preus HR, Zambon JJ, Dunford RG, Genco RJ. The distribution and transmission of Actinobacillus actinomycetemcomitans in families with established adult periodontitis. J Periodontol 1994 65 : 2 7.
328. Pucar A, Milasin J, Lekovic V, Vukadinovic M, Ristic M, Putnik S, et al. Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries. J Periodontol 2007 78 : 677 82.
329. Pulverer G, Ko HL. Serological studies on Actinobacillus actinomycetemcomitans. Appl Microbiol 1972 23 : 207 10.
330. Pulverer G, Ko HL. Actinobacillus actinomycetem-comitans: fermentative capabilities of 140 strains. Appl Microbiol 1970 20 : 693 5.
331. Rabie G, Lally ET, Shenker BJ. Immunosuppressive properties of Actinobacillus actinomycetemcomitans leukotoxin. Infect Immun 1988 56 : 122 7.
332. Rasmussen L, Hänström L, Lerner U. Characterization of bone resorbing activity in gingival crevicular fluid from patients with periodontitis. J Clin Periodontol 2000 27 : 41 52.
333. Reddi K, Reddi K, Wilson M, Poole S, Meghji S, Henderson B. Relative cytokine-stimulating activities of surface components of the oral periodontopathogenic bacterium Actinobacillus actinomycetemcomitans. Cytokine 1995 7 : 534 41.
334. Renvert S, Wikstrom M, Helmersson M, Dahlen G, Claffey N. Comparative study of subgingival microbiological sampling techniques. J Periodontol 1992 63 : 797 801.
335. Riggio MP, MacFarlane TW, Mackenzie D, Lennon A, Smith AJ, Kinane D. Comparison of polymerase chain reaction and culture methods for detection of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in subgingival plaque samples. J Periodontal Res 1996 31 : 496 501.
336. Rios M, Bianca C. The role of blood group antigens in infectious diseases. Semin Hematol 2000 37 : 177 85.
337. Roberts FA, McCaffery KA, Michalek SM. Profile of cytokine mRNA expression in chronic adult periodontitis. J Dent Res 1997 76 : 1833 9.
338. Rosan B, Slots J, Lamont RJ, Listgarten MA, Nelson GM. Actinobacillus actinomycetemcomitans fimbriae. Oral Microbiol Immunol 1988 3 : 58 63.
339. Rose JE, Meyer DH, Fives-Taylor PM. Aae, an autotransporter involved in adhesion of Actinobacillus actinomycetemcomitans to epithelial cells. Infect Immun 2003 71 : 2384 93.
340. Rosenberg NA, Pritchard JK, Weber JL, Cann HM, Kidd KK, Zhivotovsky LA, et al. Genetic structure of human populations. Science 2002 298 : 2381 5.
341. Rudney JD, Chen R, Sedgewick GJ. Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythensis are components of a polymicrobial intracellular flora within human buccal cells. J Dent Res 2005 84 : 59 63.
342. Rudney JD, Chen R, Sedgewick GJ. Intracellular Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in buccal epithelial cells collected from human subjects. Infect Immun 2001 69 : 2700 7.
343. Saarela M, Asikainen S, Alaluusua S, Pyhälä L, Lai CH, Jousimies-Somer H. Frequency and stability of mono- or poly-infection by Actinobacillus actinomycetemcomitans serotypes a, b, c, d or e. Oral Microbiol Immunol 1992 7 : 277 9.
344. Saarela M, von Troil-Linden B, Torkko H, Stucki AM, Alaluusua S, Jousimies-Somer H, et al. Transmission of oral bacterial species between spouses. Oral Microbiol Immunol 1993B 8 : 349 54.
345. Saarela M, Saxen L, Slots J. Clonal specificity of Actinobacillus actinomycetemcomitans in destructive periodontal disease. Clin Infect Dis 1997 25 : S227 S229.
346. Saarela M, Asikainen S, Jousimies-Somer H, Asikainen T, Von Troil-Lindén B, Alaluusua S. Hybridization patterns of Actinobacillus actinomycetemcomitans serotypes a-e detected with an rRNA gene probe. Oral Microbiol Immunol 1993A 8 : 111 5.
347. Saarela M, Asikainen S, Chen C, Alaluusua S, Slots J. Comparison of arbitrarily primed polymerase chain reaction and ribotyping for subtyping Actinobacillus actinomycetemcomitans. Anaerobe 1995 1 : 97 102.
348. Saarela MH, Dogan B, Alaluusua S, Asikainen S. Persistence of oral colonization by the same Actinobacillus actinomycetemcomitans strain(s). J Periodontol 1999 70 : 504 9.
349. Saddi-Ortega L, Carvalho MAR, Cisalpino PS, Moreira ESA. Actinobacillus actinomycetemcomitans genetic heterogeneity: amplification of JP2-like ltx promoter pattern correlated with specific arbitrarily primed polymerase chain reaction (AP-PCR) genotypes from human but not marmoset Brazilian isolates. Can J Microbiol 2002 48 : 602 10.
350. Sakai VT, Campos MR, Machado MA, Lauris JR, Greene AS, Santos CF. Prevalence of four putative periodontopathic bacteria in saliva of a group of
351. Saxén L, Asikainen S. Metronidazole in the treatment of localized juvenile periodontitis. J Clin Periodontol 1993 20 : 166 71.
352. Saxén L, Murtomaa H. Age-related expression of juvenile periodontitis. J Clin Periodontol 1985 12 : 21 6.
353. Scannapieco FA, Kornman KS, Coykendall AL. Observation of fimbriae and flagella in dispersed subgingival dental plaque and fresh bacterial isolates from periodontal disease. J Periodontal Res 1983 18 : 620 33.
354. Scannapieco FA, Millar SJ, Reynolds HS, Zambon JJ, Levine MJ. Effect of anaerobiosis on the surface ultrastructure and surface proteins of Actinobacillus actinomycetemcomitans (Haemophilus actinomycetemcomitans). Infect Immun 1987 55 : 2320 3.
355. Scannapieco FA, Bush RB, Paju S. Association between periodontal disease and risk for atherosclerosis, cardiovascular disease, and stroke. A systematic review. Ann Periodontol 2003 8 : 38 53.
356. Schaeffer LM, Schmidt ML, Demuth DR. Induction of Aggregatibacter actinomycetemcomitans leukotoxin expression by IS1301 and orfA. Microbiology 2008 154 : 528 38.
357. Scheie AA, Petersen FC. The biofilm concept: Consequences for future prophylaxis of oral diseases? Crit Rev Oral Biol Med 2004 15 : 4 12.
358. Schenkein HA. Host responses in maintaining periodontal health and determining periodontal disease. Periodontol 2000 2006 40 : 77 93.
359. Schenkein HA, Barbour SE, Tew JG. Cytokines and inflammatory factors regulating immunoglobulin production in aggressive periodontitis. Periodontol 2000 2007 45 : 113 27.
360. Schrei O, Waerhaug J, Lövdal A, Arno A. Alveolar bone loss as related to oral hygiene and age. J Periodontol 1959 30 : 7 16.
361. Schreiner HC, Sinatra K, Kaplan JB, Furgang D, Kachlany SC, Planet PJ, et al. Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model. Proc Natl Acad Sci U S A 2003 100 : 7295 300.
362. Schytte Blix IJ, Helgeland K, Hvattum E, Lyberg T. Lipopolysaccharide from Actinobacillus actinomycetemcomitans stimulates production of interleukin-1 beta, tumor necrosis factor-alfa, interleukin-6 and interleukin-1 receptor antagonist in human whole blood. J Periodontal Res 1999 34 : 34 40.
363. Seki M, Poulsen K, Haubek D, Kilian M. A novel loop-mediated isothermal amplification method for detection of the JP2 clone of Aggregatibacter actinomycetemcomitans in subgingival plaque. J Clin Microbiol 2008 46 : 1113 5.
364. Selander RK, Caugant DA, Ochman H, Musser JM, Gilmour MN, Whittam TS. Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics. Appl Environ Microbiol 1986 51 : 873 84.
365. Sheiham A, Nicolau B. Evaluation of social and psychological factors in periodontal disease. Periodontol 2000 2005 39 : 118 31.
366. Shimauchi H, Mayanagi G, Nakaya S, Minamibuchi M, Ito Y, Yamaki K, et al. Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study. J Clin Periodontol 2008 35 : 897 905.
367. Sjödin B, Arnrup K, Matsson L, Wranne L, Carlsson J, Hänström L. Periodontal and systemic findings in children with marginal bone loss in the primary dentition. J Clin Periodontol 1995 22 : 214 24.
368. Slots J, Rosling BG. Suppression of the periodontopathic microflora in localized juvenile periodontitis by systemic tetracycline. J Clin Periodontol 1983 10 : 465 86.
369. Slots J. The predominant cultivable organisms in juvenile periodontitis. Scand J Dent Res 1976 84 : 1 10.
370. Slots J, Reynolds HS, Genco RJ. Actinobacillus actinomycetemcomitans in human periodontal disease: a cross-sectional microbiological investigation. Infect Immun 1980 29 : 1013 20.
371. Slots J. Selective medium for isolation of Actinobacillus actinomycetemcomitans. J Clin Microbiol 1982B 15 : 606 9.
372. Slots J, Genco RJ. Black-pigmented Bacteroides species, Capnocytophaga species, and Actinobacillus actinomycetemcomitans in human periodontal disease: virulence factors in colonization, survival, and tissue destruction. J Dent Res 1984 63 : 412 21.
373. Slots J, Listgarten MA. Bacteroides gingivalis, and Bacteroides intermedius and Actinobacillus actinomycetemcomitans in human periodontal diseases. J Clin Periodontol 1988 15 : 85 93.
374. Slots J, DiRienzo JM, Chen C. Evaluating two methods for fingerprinting genomes of Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol 1993 8 : 337 43.
375. Slots J, Ting M. Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease: occurrence and treatment. Periodontol 2000 1999 20 : 82 121.
376. Slots J. Salient Biochemical characters of Actinobacillus actinomycetemcomitans. Arch Microbiol 1982A 131 : 60 7.
377. Smola SF, Rettenberger G, Simmet TH, Burysek L. Comparison of sample collection methods for the PCR detection of oral anaerobic pathogens. Lett Appl Microbiol 2003 36 : 101 5.
378. Socransky SS. Microbiology of periodontal disease - present status and future considerations. J Periodontol 1977 48 : 497 504.
379. Socransky SS, Haffajee AD. The bacterial etiology of destructive periodontal disease: current concepts. J Periodontol 1992 63 : S322 S31.
380. Socransky SS, Haffajee AD. Evidence of bacterial etiology: a historical perspective. Periodontol 2000 1994 5 : 7 25.
381. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL. Microbial complexes in subgingival plaque. J Clin Periodontol 1998 25 : 134 44.
382. Socransky SS, Haffajee AD. Periodontal microbial ecology. Periodontol 2000 2005 38 : 135 87.
383. Spinola H, Middleton D, Brehm A. HLA genes in Portugal inferred from sequence-based typing: in the crossroad between Europe and Africa. Tissue Antigens 2005 66 : 26 36.
384. Spitznagel J, Kraig E, Kolodrubetz D. Regulation of leukotoxin and nonleukotoxic strains of Actinobacillus actinomycetemcomitans. Infect Immun 1991 59 : 1394 401.
385. Spitznagel J, Kraig E, Kolodrubetz D. The regulation of leukotoxin production in Actinobacillus actinomycetemcomitans strain JP2. Adv Dent Res 1995 9 : 48 54.
386. Sreenivasan PK, Meyer DH, Fives-Taylor PM. Requirements for invasion of epithelial cells by Actinobacillus actinomycetemcomitans. Infect Immun 1993A 61 : 1239 45.
387. Sreenivasan PK, Meyer DH, Fives-Taylor PM. Factors influencing the growth and viability of Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol 1993B 8 : 361 9.
388. Strathdee CA, Lo RY. Cloning, nucleotide sequence, and characterization of genes encoding the secretion function of the Pasteurella haemolytica leukotoxin determinant. J Bacteriol 1989A 171 : 916 28.
389. Strathdee CA, Lo RY. Regulation of expression of the Pasteurella haemolytica leukotoxin determinant. J Bacteriol 1989B 171 : 5955 62.
390. Suda R, Kurihara C, Kurihara M, Sato T, Lai C-H, Hasegawa K. Determination of eight selected periodontal pathogens in subgingival plaque of maxillary first molars in Japanese school children aged 8-11 years. J Periodontal Res 2003 38 : 28 35.
391. Suzuki N, Nakano Y, Yoshida Y, Ikeda D, Koga T. Identification of Actinobacillus actinomycetemcomitans serotypes by multiplex PCR. J Clin Microbiol 2001 39 : 2002 5.
392. Taichman NS, Dean RT, Sanderson CJ. Biochemical and morphological characterization of the killing of human monocytes by a leukotoxin derived from Actinobacillus actinomycetemcomitans. Infect Immun 1980 28 : 258 68.
393. Taichman NS, Simpson DL, Sakurada S, Cranfield M. Comparative studies on the biology of Actinobacillus actinomycetemcomitans leukotoxin in primates. Oral Microbiol Immunol 1987 2 : 97 104.
394. Tamura K, Nakano K, Hayashibara T, Nomura R, Fujita K, Shintani S, et al. Distribution of 10 periodontal bacteria in saliva samples from Japanese children and their mothers. Arch Oral Biol 2006 51 : 371 7.
395. Tan KS, Woo CH, Ong G, Song KP. Prevalence of Actinobacillus actinomycetemcomitans in an ethnic adult Chinese population. J Clin Periodontol 2001 28 : 886 90.
396. Tani Y, Tani M, Kato I. Extracellular 37-kDa antigenic protein from Actinobacillus actinomycetemcomitans induces TNF-alpha, IL-1 beta, and IL-6 in murine macrophages. J Dent Res 1997 76 : 1538 47.
397. Tanner ACR, Goodson JM. Sampling of microorganisms associated with periodontal disease. Oral Microbiol Immunol 1986 1 : 15 20.
398. Tanner ACR, Milgrom PM, Kent R, Mokeem SA, Page RC, Riedy CA, et al. The microbiota of young children from tooth and tongue samples. J Dent Res 2002 81 : 53 7.
399. Taubman MA, Kawai T. Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption. Crit Rev Oral Biol Med 2001 12 : 125 35.
400. Teitelbaum SL. Bone resorption by osteoclasts. Science 2000 289 : 1504 8.
401. Teixeira RE, Mendes EN, de Carvalho MAR, Nicoli JR, Farias LdM, Magalhaes PP. Actinobacillus actinomycetemcomitans serotype-specific genotypes and periodontal status in Brazilian subjects. Can J Microbiol 2006 52 : 182 8.
402. Teles FR, Haffajee AD, Socransky SS. The reproducibility of curet sampling of subgingival biofilms. J Periodontol 2008 79 : 705 13.
403. The Swedish council on technology assessment in health care, Sweden (SBU rapport). Chronic Periodontitis - prevention, diagnosis and treatment. A systematic review. 2004. Report No.: 169.
404. Theilade E. The non-specific theory in microbial etiology of inflammatory periodontal diseases. J Clin Periodontol 1986 13 : 905 11.
405. Theilade E, Wright WH, Jensen SB, Löe H. Experimental gingivitis in man II. A longitudinal clinical and bacteriological investigation. J Periodontal Res 1966 1 : 1 13.
406. Timmerman MF, Van der Weijden GA, Abbas F, Arief EM, Armand S, Winkel EG, et al. Untreated periodontal disease in Indonesian adolescents. Longitudinal clinical data and prospective clinical and microbiological risk assessment. J Clin Periodontol 2000 27 : 932 42.
407. Tinoco EMB, Stevens R, Haubek D, Lai CH, Balachandran S, Preus H. Relationship of serotype, leukotoxin gene type and lysogeny in Actinobacillus actinomycetemcomitans to periodontal disease status. Eur J Oral Sci 1997B 105 : 310 7.
408. Tinoco EMB, Beldi MI, Loureiro CA, Lana M, Campedelli F, Tinoco NMB, et al. Localized juvenile periodontitis and Actinobacillus actinomycetemcomitans in a Brazilian population. Eur J Oral Sci 1997A 105 : 9 14.
409. Tomich M, Planet PJ, Figurski DH. The tad locus: postcards from the widespread colonization island. Nat Rev Micro 2007 5 : 363 75.
410. Tonetti MS. Molecular factors associated with compartmentalization of gingival immune responses and transepithelial neutrophil migration. J Periodontal Res 1997 32 : 104 9.
411. Topley WWC, Wilson GS. The principles of bacteriology and immunity.
412. Tønjum T, Haas R. Identification of Actinobacillus actinomycetemcomitans by leukotoxin gene-specific hybridization and polymerase chain reaction assays. J Clin Microbiol 1993 31 : 1856 9.
413. Tsai C-C, McArthur WP, Baehni PC, Hammond BF, Taichman NS. Extraction and partial characterization of a leukotoxin from a plaque-derived gram-negative microorganism. Infect Immun 1979 25 : 427 39.
414. Tsai C-C, McArthur WP, Baehni PC, Evian C, Genco RJ, Taichman NS. Serum neutralizing activity against Actinobacillus actinomycetemcomitans leukotoxin in juvenile periodontitis. J Clin Periodontol 1981 8 : 338 48.
415. Tsai C-C, Shenker BJ, DiRienzo JM, Malamud D, Taichman NS. Extraction and isolation of a leukotoxin from Actinobacillus actinomycetemcomitans with polymyxin B. Infect Immun 1984 43 : 700 5.
416. Tsai C-C, Taichman S. Dynamics of infection by leukotoxic strains of Actinobacillus actinomycetemcomitans in juvenile periodontitis. J Clin Periodontol 1986 11 : 330 1.
417. Twetman S, Stecksén-Blicks C. Probiotics and oral health effects in children. Int J Paediatr Dent 2008 18 : 3 10.
418. Uchida Y, Shiba H, Komatsuzawa H, Takemoto T, Sakata M, Fujita T, et al. Expression of IL-1beta and IL-8 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans. Cytokine 2001 14 : 152 61.
419. Urwin R, Maiden MCJ. Multi-locus sequence typing: a tool for global epidemiology. Trends Microbiol 2003 11 : 479 87.
420. Valcarcel J, Allardet-Servent A, Bourg G, O'Callaghan D, Michailesco P, Ramuz M. Investigation of the Actinobacillus actinomycetemcomitans genome by pulsed field gel electrophoresis. Oral Microbiol Immunol 1997 12 : 33 9.
421. van der Reijden WA, Bosch-Tijhof CJ, van der Velden U, van Winkelhoff AJ. Java project on periodontal diseases: serotype distribution of Aggregatibacter actinomycetemcomitans and serotype dynamics over an 8-year period. J Clin Periodontol 2008 35 : 487 92.
422. van der Velden U, Abbas F, Armand S, Loos BG, Timmerman MF, van der Weijden GA, et al. Java project on periodontal diseases. The natural development of periodontitis: risk factors, risk predictors and risk determinants. J Clin. Periodontol 2006 33 : 540 8.
423. van der Velden U. Purpose and problems of periodontal disease classification. Periodontol 2000 2005 39 : 13 21.
424. Van Dyke TE, Schweinebraten M, Cianciola LJ, Offenbacher S, Genco RJ. Neutrophil chemotaxis in families with localized juvenile periodontitis. J Periodontal Res 1985 20 : 503 14.
425. Van Dyke TE, Champagne CME. Neutrophils and oral disease. Dtsch Zahnärztl 1995 50 : 278 86.
426. Van Dyke TE. The etiology and pathogenesis of periodontitis revisited. J Appl Oral Science 2009 17 : S1678-77572009000100001.
427. Van Dyke TE. Cellular and molecular susceptibility determinants for periodontitis. Periodontol 2000 2007A 45 : 10 3.
428. Van Dyke TE. Control of inflammation and periodontitis. Periodontol 2000 2007B 45 : 158 66.
429. van Essche M, Quirynen M, Sliepen I, van Eldere J, Teughels W. Bdellovibrio bacteriovorus attacks Aggregatibacter actinomycetemcomitans. J Dent Res 2009 88 : 182 6.
430. van Steenbergen TJ, Bosch-Tijhof CJ, van Winkelhoff AJ, Gmür R, de Graaff J. Comparison of six typing methods for Actinobacillus actinomycetemcomitans. J Clin Microbiol 1994 32 : 2769 74.
431. van Winkelhoff AJ, Rodenburg JP, Goené RJ, Abbas F, Winkel EG, de Graaff J. Metronidazole plus amoxycillin in treatment of Actinobacillus actinomycetemcomitans associated periodontitis. J Clin Periodontol 1989 16 : 128 31.
432. van Winkelhoff AJ, Boutaga K. Transmission of periodontal bacteria and models of infection. J Clin Periodontol 2005 32 : 16 27.
433. van Winkelhoff AJ. Antibiotics in periodontics: are we getting somewhere? J Clin Periodontol 2005 32 : 1094 5.
434. van Winkelhoff AJ, Slots J. Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in nonoral infections. Periodontol 2000 1999 20 : 122 35.
435. van Winkelhoff AJ, Tijhof CJ, de Graaff J. Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis. J Periodontol 1992 63 : 52 7.
436. Venketaraman V, Lin AK, Le A, Kachlany SC, Connell ND, Kaplan JB. Both leukotoxin and poly-N-acetylglucosamine surface polysaccharide protect Aggregatibacter actinomycetemcomitans cells from macrophage killing. Microb Pathog 2008 45 : 173 80.
437. Verner C, Lemaitre P, Daniel A, Giumelli B, Lakhssassi N, Sixou M. Carpegen real-time polymerase chain reaction vs. anaerobic culture for periodontal pathogen identification. Oral Microbiol Immunol 2006 21 : 341 6.
438. Wang Y, Liu A, Chen C. Genetic basis for conversion of rough-to-smooth colony morphology in Actinobacillus actinomycetemcomitans. Infect Immun 2005 73 : 3749 53.
439. Welch RA, Bauer ME, Kent AD, Leeds JA, Moayeri M, Regassa LB, et al. Battling against host phagocytes: The wherefore of the RTX family of toxins? Infect Agents Dis 1995 4 : 254 72.
440. Welch RA, Pellett S. Transcriptional organization of the Escherichia coli hemolysin genes. J Bacteriol 1988 170 : 1622 30.
441. Welch RA. Pore-forming cytolysins of Gram-negative bacteria. Mol Microbiol 1991 5 : 521 8.
442. Whittam TS, Wolfe ML, Wachsmuth IK, Orskov F, Orskov I, Wilson RA. Clonal relationships among Escherichia coli strains that cause hemorrhagic colitis and infantile diarrhea. Infect Immun 1993 61 : 1619 29.
443. Wilson M, Henderson B. Virulence factors of Actinobacillus actinomycetemcomitans relevant to the pathogenesis of inflammatory periodontal diseases. FEMS Microbiol Rev 1995 17 : 365 79.
444. Wilson ME, Schifferle RE. Evidence that the serotype b antigenic determinant of Actinobacillus actinomycetemcomitans Y4 resides in the polysaccharide moiety of lipopolysaccharide. Infect Immun 1991 59 : 1544 51.
445. Wilson ME, Genco RJ. The role of antibody, complement and neutrophils in host defense against Actinobacillus actinomycetemcomitans. Immunol Invest 1989 18 : 187 209.
446. Wirth T, Wang X, Linz B, Lum JK, Blaser M, Morelli G, et al. Distinguishing human ethnic groups by means of sequences from Helicobacter pylori: Lessons from Ladakh. Proc Natl Acad Sci U S A 2004 101 : 4746 51.
447. Xynogala I, Volgina A, DiRienzo JM, Korostoff J. Evaluation of the humoral immune response to the cytolethal distending toxin of Aggregatibacter actinomycetemcomitans Y4 in subjects with localized aggressive periodontitis. Oral Microbiol Immunol 2009 24 : 116 23.
448. Yamaguchi N, Kubo C, Masuhiro Y, Lally ET, Koga T, Hanazawa S. Tumor necrosis factor alpha enhances Actinobacillus actinomycetemcomitans leukotoxin-induced HL-60 cell apoptosis by stimulating lymphocyte function-associated antigen 1 expression. Infect Immun 2004 72 : 269 76.
449. Yamamoto M, Nishihara T, Koseki T, He T, Yamato K, Zhang Y-J, et al. Prevalence of Actinobacillus actinomycetemcomitans serotypes in Japanese patients with periodontitis. J Periodontal Res 1997 32 : 676 81.
450. Yang HW, Asikainen S, Dogan B, Suda R, Lai CH. Relationship of Actinobacillus actinomycetemcomitans serotype b to aggressive periodontitis: Frequency in pure cultured isolates. J Periodontol 2004 75 : 592 9.
451. Yang HW, Huang YF, Chan Y, Chou MY. Relationship of Actinobacillus actinomycetemcomitans serotypes to periodontal condition: prevalence and proportions in subgingival plaque. Eur J Oral Sci 2005 113 : 28 33.
452. Yuan K, Hsu P-C, Tseng C-C, Kiang D, Wang J-R. Detection rate of Actinobacillus actinomycetemcomitans on the permanent 1st molars of primary school children in Taiwan by polymerase chain reaction. J Clin Periodontol 2001 28 : 348 52.
453. Zadeh HH, Nichols FC, Miyasaki KT. The role of the cell-mediated immune response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in periodontitis. Periodontol 2000 1999 20 : 239 88.
454. Zambon JJ. Actinobacillus actinomycetemcomitans in human periodontal disease. J Clin Periodontol 1985 12 : 1 20.
455. Zambon JJ, Christersson LA, Slots J. Actinobacillus actinomycetemcomitans in human periodontal disease. Prevalence in patient groups and distribution of biotypes and serotypes within families. J Periodontol 1983A 54 : 707 711.
456. Zambon JJ, DeLuca C, Slots J, Genco RJ. Studies of leukotoxin from Actinobacillus actinomycetemcomitans using the promyelocytic HL-60 cell line. Infect Immun 1983C 40 : 205 12.
457. Zambon JJ, Haraszthy VI, Hariharan G, Lally ET, Demuth DR. The microbiology of early-onset periodontitis: Association of highly toxic Actinobacillus actinomycetemcomitans strains with localized juvenile periodontitis. J Periodontol 1996 67 : 282 90.
458. Zambon JJ, Slots J, Genco RJ. Serology of oral Actinobacillus actinomycetemcomitans and serotype distribution in human periodontal disease. Infect Immun 1983B 41 : 19 27.
459. Zambon JJ, Slots J, Miyasaki K, Linzer Rosemary, Cohen R, Levine Michael, et al. Purification and characterization of the serotype c antigen from Actinobacillus actinomycetemcomitans. Infect Immun 1984 44 : 22 7.
460. Zambon JJ, Sunday GJ, Smutko JS. Molecular genetic analysis of Actinobacillus actinomycetemcomitans epidemiology. J Periodontol 1990 61 : 75 80.
461. Zambon JJ, Umemoto T, De Nardin E, Nakazawa F, Christersson LA, Genco RJ. Actinobacillus actinomycetemcomitans in the pathogenesis of human periodontal disease. Adv Dent Res 1988 2 : 269 74.
462. Zaremba M, Gorska R, Suwalski P, Kowalski J. Evaluation of the incidence of periodontitis-associated bacteria in the atherosclerotic plaque of coronary blood vessels. J Periodontol 2007 78 : 322 7.
463. Ørskov F, Ørskov I. Summary of a workshop on the clone concept in the epidemiology, taxonomy, and evolution of the Enterobacteriaceae and other bacteria. J Infect Dis 1983 148 : 346 357.