Evaluation of the humoral immune response to the cytolethal distending toxin of Aggregatibacter actinomycetemcomitans Y4 in subjects with localized aggressive periodontitis

Oral Microbiology and Immunology

Volumn 24, Issue 2, 2009, Pages 116-123

  Xynogala, I ^b   Volgina, A ^a   Dirienzo, J M ^a   Korostoff, J ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Departments of Periodontics   (United States)

Author keywords

Aggregatibacter (Actinobacillus) actinomycetemcomitans; Antibody; Cytolethal distending toxin; Localized aggressive periodontitis

Indexed keywords

CYTOLETHAL DISTENDING TOXIN; IMMUNOGLOBULIN G ANTIBODY; VIRULENCE FACTOR;

ADOLESCENT; ADULT; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BINDING AFFINITY; CHILD; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GRAM NEGATIVE SEPSIS; GROWTH INHIBITION; HUMAN; HUMORAL IMMUNITY; INFECTION SENSITIVITY; MAJOR CLINICAL STUDY; MALE; PERIODONTITIS;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ACTINOBACILLUS INFECTIONS; ADOLESCENT; ADULT; AGGRESSIVE PERIODONTITIS; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGEN-ANTIBODY REACTIONS; BACTERIAL TOXINS; CASE-CONTROL STUDIES; CELL CYCLE; CHILD; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; HUMANS; MALE; MUTAGENS; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; VIRULENCE FACTORS; YOUNG ADULT;

EID: 60349091222     PISSN: 09020055     EISSN: 1399302X     Source Type: Journal    
DOI: 10.1111/j.1399-302X.2008.00483.x     Document Type: Article

References (29)

1. AbuOun M, Manning G, Cawthraw SA et al. Cytolethal distending toxin (CDT) -negative Campylobacter jejuni strains and anti-CDT neutralizing antibodies are induced during human infection but not during colonization in chickens. Infect Immun 2005 : 73 : 3053 3062.
2. Avenaud P, Castroviejo M, Claret S, Rosenbaum J, Megraud F, Menard A. Expression and activity of the cytolethal distending toxin of Helicobacter hepaticus. Biochem Biophys Res Comm 2004 : 318 : 739 745.
3. Belibasakis G, Johansson A, Wang Y et al. Inhibited proliferation of human periodontal ligament cells and gingival fibroblasts by Actinobacillus actinomycetemcomitans: involvement of the cytolethal distending toxin. Eur J Oral Sci 2002 : 110 : 366 373.
4. Califano JV, Pace BE, Gunsolley JC, Schenkein HA, Lally ET, Tew JG. Antibody reactive with Actinobacillus actinomycetemcomitans leukotoxin in early-onset periodontitis patients. Oral Microbiol Immunol 1997 : 12 : 20 26.
5. Cope LD, Lumbey S, Latimer JL et al. A diffusible cytotoxin of Haemophilus ducreyi. Proc Natl Acad Sci USA 1997 : 94 : 4056 4061.
6. DiRienzo JM, Slots J, Sixou M et al. Specific genetic variants of Actinobacillus actinomycetemcomitans correlate with disease and health in a regional population of families with localized juvenile periodontitis. Infect Immun 1994 : 62 : 3058 3065.
7. Fives-Taylor PM, Meyer DH, Mintz KP, Brisette C. Virulence factors of Actinobacillus actinomycetemcomitans. Periodontol 2000 1999 : 20 : 136 167.
8. Hassane DC, Lee RB, Picket CL. Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells. Infect Immun 2003 : 71 : 541 545.
9. Johansson A, Buhlin K, Koski R, Gustafsson A. The immunoreactivity of systemic antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in adult periodontitis. J Eur Oral Sci 2005 : 113 : 197 202.
10. Johnson WM, Lior H. Response of Chinese hamster ovary cells to a cytolethal distending toxin (CDT) of Escherichia coli and possible misinterpretation as heat-labile (LT) enterotoxin. FEMS Microb Lett 1987 : 43 : 19 23.
11. Johnson WM, Lior H. Production of Shiga toxin and a cytolethal distending toxin (CLDT) by serogroups of Shigella spp. FEMS Microb Lett 1987 : 48 : 235 238.
12. Kanno F, Volgina A, Korostoff J, DiRienzo JM. Differential response of human oral cells to the cytolethal distending toxin of Actinobacillus actinomycetemcomitans. J Periodontol 2005 : 76 : 1189 1201.
13. Karlsson Hedestam GB, Fouchier RAM, Phogat S, Burton DR, Sodroski J, Wyatt RT. The challenge of eliciting neutralizing antibodies to HIV-1 and to influenza virus. Nat Rev Microbiol 2008 : 6 : 143 155.
14. Kinane DF, Mooney J, Ebersole JL. Humoral immune response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in periodontal disease. Periodontol 2000 1999 : 20 : 289 340.
15. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1972 : 227 : 680 685.
16. Lang N, Bartold PM, Cullinan M et al. Consensus report: aggressive periodontitis. Ann Periodontol 1999 : 4 : 53.
17. Löe H, Brown LJ. Early onset periodontitis in the United States of America. J Periodontol 1991 : 62 : 608 616.
18. Mao X, DiRienzo JM. Functional studies of the recombinant subunits of a cytolethal distending holotoxin. Cell Microbiol 2002 : 4 : 245 255.
19. Mayer MPA, Bueno LC, Hansen EJ, DiRienzo JM. Identification of a cytolethal distending toxin gene locus and features of a virulence-associated region in Actinobacillus actinomycetemcomitans. Infect Immun 1999 : 67 : 1227 1237.
20. Mbwana J, Ahmed HJ, Ahlman K et al. Specificity of antibodies directed against the cytolethal distending toxin of Haemophilus ducreyi in patients with chancroid. Microb Pathog 2003 : 35 : 133 137.
21. Okuda JG, Kato T, Naito Y, Takazoe I. Precipitating antibody against lipopolysaccharide of Haemophilus actinomycetemcomitans in human serum. J Clin Microbiol 1986 : 24 : 846 848.
22. Purven M, Falsen E, Lagergård T. Cytotoxin production in 100 strains of Haemophilus ducreyi from different geographic locations. FEMS Microb Lett 1995 : 129 : 221 224.
23. 2 cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin. Infect Immun 2002 : 70 : 528 534.
24. Shenker BJ, McKay T, Datar S, Miller M, Chowhan R, Demuth D. Actinobacillus actinomycetemcomitans immuno-suppressive protein is a member of the family of cytolethal distending toxins capable of causing a G2-arrest in human T cells. J Immunol 1999 : 162 : 244 251.
25. Sims TJ, Moncla BJ, Darveau RP, Page RC. Antigens of Actinobacillus actinomycetemcomitans recognized by patients with juvenile periodontitis and periodontally-normal subjects. Infect Immun 1991 : 59 : 913 924.
26. Svensson LA, Tarkowski A, Thelestam M, Lagergård T. The impact of Haemophilus ducreyi cytolethal distending toxin on cells involved in the immune response. Microbial Pathog 2001 : 30 : 157 166.
27. Tan KS, Song KP, Ong G. Cytolethal distending toxin of Actinobacillus actinomycetemcomitans. Occurrence and association with periodontal disease. J Periodontal Res 2002 : 37 : 268 272.
28. Wilson M, Henderson B. Virulence factors of Actinobacillus actinomycetemcomitans relevant to the pathogenesis of inflammatory periodontal diseases. FEMS Microbiol Rev 1995 : 17 : 365 379.
29. Yamano R, Ohara M, Nishikubo S et al. Prevalence of a cytolethal distending toxin production in periodontopathogenic bacteria. J Clin Microb 2003 : 41 : 1391 1398.