Molecular genetics and the analysis of leukotoxin in A. actinomycetemcomitans

Journal of Periodontology

Volumn 67, Issue 3 SUPPL., 1996, Pages 309-316

  Kolodrubetz, David ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Actinobacillus actinomycetemcomitans pathogenesis; Genetic vectors; Leukotoxin; Leukotoxin promoters; Mutagenesis, targeted; Periodontitis, early onset microbiology; Virulence factors

Indexed keywords

EID: 0003180422     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.1996.67.3s.309     Document Type: Article

References (50)

1. Zambon JJ. Actinobacillus actinomycetemcomitans in human periodontal disease. J Clin Periodontol 1985;12:1-20.
2. Slots J, Reynolds HS, Genco RJ. Actinobacillus actinomycetemcomitans in human periodontal disease: A cross-sectional microbiological investigation. Infect Immun 1980;29:1013-1020.
3. Zambon JJ, Haraszthy VI, Hariharan G, Lally ET, Demuth DR: The microbiology of early-onset periodontitis: Association of highly toxic Actinobacillus actinomycetemcomitans strains with localized juvenile periodontitis. J Periodontol 1996;67(Suppl.):282-290.
4. Fives-Taylor P, Meyer D, Mintz K. Virulence factors of the periodontopathogen Actinobacillus actinomycetemcomitans. J Periodontol 1996;67(Suppl.):291-297.
5. Simpson DL, Berthold P, Taichman NS. Killing of human myelomonocytic leukemia and lymphocytic cell lines by Actinobacillus actinomycetemcomitans leukotoxin. Infect Immun 1988;56:1162-1166.
6. Tsai CC, McArthur WP, Baehni PC, Hammond BF, Taichman NS. Extraction and partial characterization of a leukotoxin from a plaque-derived Gram-negative microorganism. Infect Immun 1979;25:427-439.
7. Mangan DE, Taichman NS, Lally ET, Wahl SM. Lethal effects of Actinobacillus actinomycetemcomitans leukotoxin on human T lymphocytes. Infect Immun 1991;59:3267-3272.
8. Lally ET, Kieba IR, Golub EE, Lear JD, Tanaka JC. Structure/function aspects of Actinobacillus actinomycetemcomitans leukotoxin. J Periodontol 1996;67(Suppl.):298-308.
9. Kraig E, Dailey T, Kolodrubetz D. Nucleotide sequence of the leukotoxin gene from Actinobacillus actinomycetemcomitans: Homology to the alpha-hemolysin/leukotoxin gene family. Infect Immun 1990;58:920-929
10. Kolodrubetz D, Dailey T, Ebersole J, Kraig E. Cloning and expression of the leukotoxin gene from Actinobacillus actinomycetemcomitans. Infect Immun 1989;57:1465-1469.
11. Lally ET, Kieba IR, Demuth DR, et al. Identification and expression of the Actinobacillus actinomycetemcomitans leukotoxin gene. Biochem Biophys Res Commun 1989;159:256-262.
12. Felmlee T, Pellett S, Welch RA. Nucleotide sequence of an Escherichia coli chromosomal hemolysin. J Bacteriol 1985;163:94-105.
13. Highlander SK, Chidambaram M, Engler MJ, Weinstock GM. DNA sequence of the Pasteurella haemolytica leukotoxin gene cluster. DNA 1989;8:15-28.
14. Lo RY, Strathdee CA, Shewen PE. Nucleotide sequence of the leukotoxin genes of Pasteurella haemolytica A1. Infect Immun 1987;55:1987-1996.
15. Guthmiller JM, Kolodrubetz D, Cagle MP, Kraig E. Sequence of the lktB gene from Actinobacillus actinomycetemcomitans. Nucleic Acids Res 1990;18:5291.
16. Guthmiller JM, Kraig E, Cagle MP, Kolodrubetz D. Sequence of the lktD gene from Actinobacillus actinomycetemcomitans. Nucleic Acids Res 1990;18:5292.
17. Lally ET, Golub EE, Kieba IR, et al. Structure and function of the B and D genes of the Actinobacillus actinomycetemcomitans leukotoxin complex. Microb Pathog 1991;11:111-121.
18. Spitznagel J, Jr., Kraig E, Kolodrubetz D. Regulation of leukotoxin in leukotoxic and nonleukotoxic strains of Actinobacillus actinomycetemcomitans. Infect Immun 1991;59:1394-1401.
19. LeBlanc DJ, Lee LN, Abu-Al-Jaibat AR, Sreenivasan PK, Fives-Taylor PM. Identification of plasmids in Actinobacillus actinomycetemcomitans and construction of intergeneric shuttle plasmids. Oral Microbiol Immunol 1993;8:94-99.
20. Novak KF, LeBlanc DJ. Characterization of plasmid pVT745 isolated from Actinobacillus actinomycetemcomitans. Plasmid 1994;31: 31-39.
21. Novak KF. Characterization of plasmid pVT745 isolated from Actinobacillus actinomycetemcomitans. [Thesis]. San Antonio, Texas: University of Texas Health Science Center; 1994.
22. Galli DM, LeBlanc DJ. Characterization of pVT736-1, a rolling-circle plasmid from the Gram-negative bacterium Actinobacillus actinomycetemcomitans. Plasmid 1994;31:148-157.
23. Sreenivasan PK, LeBlanc DJ, Lee LN, Fives-Taylor P. Transformation of Actinobacillus actinomycetemcomitans by electroporation, utilizing constructed shuttle plasmids. Infect Immun 1991;59:4621-4627.
24. Sreenivasan PK, Fives-Taylor P Isolation and characterization of deletion derivatives of pDL282, an Actinobacillus actinomycetemcomitans/Escherichia coli shuttle plasmid. Plasmid 1994;31:207-214.
25. Goncharoff P, Yip JK, Wang H, et al. Conjugal transfer of broadhost-range incompatibility group P and Q plasmids from Escherichia coli to Actinobacillus actinomycetemcomitans. Infect Immun 1993;61:3544-3547.
26. Stevens RH, Hammond BF, Lai CH. Characterization of an inducible bacteriophage from a leukotoxic strain of Actinobacillus actinomycetemcomitans. Infect Immun 1982;35:343-349.
27. Preus HR, Olsen I, Namork E. The presence of phage-infected Actinobacillus actinomycetemcomitans in localized juvenile periodontitis patients. J Clin Periodontol 1987;14:605-609.
28. Preus HR, Olsen I, Namork E. Association between bacteriophageinfected Actinobacillus actinomycetemcomitans and rapid periodontal destruction. J Clin Periodontol 1987;14:245-247.
29. Stevens RH, Goncharoff P, Furgang D, Fine DH, Schreiner HC, Figurski DH. Characterization and physical mapping of the genome of bacteriophage phi Aa from Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol 1993;8:100-104.
30. Stevens RH, Preus HR, Dokko B, et al. Prevalence and distribution of bacteriophage phi Aa DNA in strains of Actinobacillus actinomycetemcomitans. FEMS Microbiol Lett 1994;119:329-337.
31. Preus HR, Russell DT, Zambon JJ. Serotype shift in Aa FDC Y4 following lysogenization with phage from Aa ATCC 33384. J Dent Res 1993;72(Spec. Issue):119 (Abstr. 126).
32. LeBlanc DJ, Lee LN, Inamine JM. Cloning and nucleotide base sequence analysis of a spectinomycin adenyltransferase AAD(9) determinant from Enterococcus faecalis. Antimicrob Agents Chemother 1991;35:1804-1810.
33. Guthmiller JM, Kolodrubetz D, Kraig E. Mutational analysis of the putative leukotoxin transport genes in Actinobacillus actinomycetemcomitans. Microb Pathog 1995;18:307-321.
34. Sato S, Takamatsu N, Okahashi N, et al. Construction of mutants of Actinobacillus actinomycetemcomitans defective in serotype b-specific polysaccharide antigen by insertion of transposon Tn916. J Gen Microbiol 1992;138:1203-1209
35. Clewell DB, Gawron-Burke C Conjugative transposons and the dissemination of antibiotic resistance in streptococci. Annu Rev Microbiol 1986;40:635-659.
36. Kolodrubetz D, Kraig E. Transposon Tn5 mutagenesis of Actinobacillus actinomycetemcomitans via conjugation. Oral Microbiol Immunol 1994;9:290-296.
37. Barletta RG, Michalek SM, Curtiss R. Analysis of the virulence of Streptococcus mutans serotype c gtfA mutants in the rat model system. Infect Immun 1988;56:322-330.
38. Shortle D, Haber JE, Botstein D. Lethal disruption of the yeast actin gene by integrative DNA transformation. Science 1982;217:371-373.
39. Niaudet B, Ooze A, Ehrlich SD. Insertional mutagenesis in Bacillus subtilis: Mechanism and use in gene cloning. Gene 1982;19:277-284.
40. Ohta H, Hara H, Fukui K, Kurihara H, Murayama Y, Kato K. Association of Actinobacillus actinomycetemcomitans leukotoxin with nucleic acids on the bacterial cell surface. Infect Immun 1993;61: 4878-4884.
41. Berthold P, Forti D, Kieba IR, Rosenbloom J, Taichman NS, Lally ET. Electron immunocytochemical localization of Actinobacillus actinomycetemcomitans leukotoxin. Oral Microbiol Immunol 1992;7: 24-27.
42. Menestrina G, Moser C, Pellet S, Welch R. Pore-formation by Escherichia cou hemolysin (HlyA) and other members of the RTX toxins family. Toxicology 1994;87:249-267.
43. Koronakis V, Hughes C. Bacterial signal peptide-independent protein export: HlyB-directed secretion of hemolysin. Semin Cell Biol 1993;4:7-15.
44. Lai CH, Listgarten MA, Hammond BE Comparative ultrastructure of leukotoxic and non-leukotoxic strains of Actinobacillus actinomycetemcomitans. J Periodont Res 1981;16:379-389.
45. Ohta H, Kato K. Leukotoxic activity of Actinobacillus actinomycetemcomitans. In. Hamada S, Holt SC, McGhee JR, eds. Periodontal Disease: Pathogens and Host Immune Responses. Tokyo: Quintessence Publishing Company; 1991:143-154.
46. Spitznagel J, Jr., Kraig E, Kolodrubetz D. The regulation of leukotoxin production in Actinobacillus actinomycetemcomitans strain JP2. Adv Dent Res 1995,9.48-54.
47. Winston JL, Chen CK, Neiders ME, Dyer DW. Membrane protein expression by Actinobacillus actinomycetemcomitans in response to iron availability. J Dent Res 1993;72:1366-1373.
48. Strathdee CA, Lo RY. Regulation of expression of the Pasteurella haemolytica leukotoxin determinant. J Bacteriol 1989;171:5955-5962.
49. Grunig HM, Lebek G. Haemolytic activity and characteristics of plasmid and chromosomally borne hly genes isolated from E. coli of different origin. Zentralbl Bakteriol Mikrobiol Hyg 1988;267: 485-494.
50. Brogan JM, Lally ET, Poulsen K, Kilian M, Demuth DR. Regulation of Actinobacillus actinomycetemcomitans leukotoxin expression: Analysis of the promoter regions of leukotoxic and minimally leukotoxic strains. Infect Immun 1994;62:501-508.