Positive and negative cis-acting regulatory sequences control expression of leukotoxin in Actinobacillus actinomycetemcomitans 652

Infection and Immunity

Volumn 71, Issue 10, 2003, Pages 5640-5649

  Mitchell, Christine ^a   Gao, Ling ^a   Demuth, Donald R ^a,b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL RNA; BETA GALACTOSIDASE; CIS ACTING ELEMENT; LEUKOTOXIN;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ARTICLE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; INVERTED REPEAT; NONHUMAN; OPERON; PERIODONTAL DISEASE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ACTINOBACILLUS INFECTIONS; BACTERIAL PROTEINS; BASE SEQUENCE; DNA TRANSPOSABLE ELEMENTS; DNA, BACTERIAL; EXOTOXINS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENES, REGULATOR; GENES, REPORTER; HUMANS; LAC OPERON; MOLECULAR SEQUENCE DATA; OPERON; PROMOTER REGIONS (GENETICS); VIRULENCE;

EID: 0141780973     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.10.5640-5649.2003     Document Type: Article

References (57)

1. Bartlett, D. H., and M. Silverman. 1989. Nucleotide sequence of IS492, a novel insertion sequence causing variation in extracellular polysaccharide production in the marine bacterium Pseudomonas atlantica. J. Bacteriol. 171:1763-1766.
2. Block, P. J., A. C. Fox, C. Yoran, and A. J. Kaltman. 1973. Actinobacillus actinomycetemcomitans endocarditis: report of a case and review of the literature. Am. J. Med. Sci. 276:387-392.
3. Brogan, J. M., E. T. Lally, and D. R. Demuth. 1996. Construction of pYGK, an Actinobacillus actinomycetemcomitans/Escherichia coli shuttle vector. Gene 169:141-142.
4. Brogan, J. M., E. T. Lally, K. Poulsen, M. Kilian, and D. R. Demuth. 1994. Regulation of Actinobacillus actinomycetemcomitans expression: analysis of the promoter regions of leukotoxic and minimally leukotoxic strains. Infect. Immun. 62:501-508.
5. Bueno, L. C., M. P. Mayer, and J. M. DiRienzo. 1998. Relationship between conversion of localized juvenile periodontitis-susceptible children from health to disease and Actinobacillus actinomycetemcomitans leukotoxin promoter structure. J. Periodontol. 69:998-1007.
6. DeShazer, D., G. E. Wood, and R. L. Friedman. 1994. Molecular characterization of catalase from Bordetella pertussis: identification of the katA promoter in an upstream insertion sequence. Mol. Microbiol. 14:123-130.
7. Estrem, S. T., W. Ross, T. Gaal, Z. W. S. Chen, W. Niu, R. H. Ebright, and R. L. Gourse. 1999. Bacterial promoter architecture: subsite structure of UP elements and interactions with the carboxy-terminal domain of the RNA polymerase β-subunit. Genes Dev. 13:2134-2147.
8. Gouhlen, F., A. Hafezi, V.-J. Uitto, D. Hinode, R. Nakamura, D. Grenier, and D. Mayrand. 1998. Subcellular localization and cytotoxic activity of the GroEL-like protein isolated from Actinobacillus actinomycetemcomitans. Infect. Immun. 66:5307-5313.
9. Gourse, R. L., W. Ross, and T. Gaal. 2000. UPs and downs in bacterial transcription initiation: the role of the alpha subunit of RNA polymerase in promoter recognition. Mol. Microbiol. 37:687-695.
10. Guthmiller, J. M., E. T. Lally, and J. Korostoff. 2001. Beyond the specific plaque hypothesis: are highly leukotoxic strains of Actinobacillus actinomycetemcomitans a paradigm for periodontal pathogenesis? Crit. Rev. Oral Biol. Med. 12:116-124.
11. Hammerschmidt, S., R. Hilse, J. P. M. van Putten, R. Gerardy-Schahn, A. Unkmeir, and M. Frosch. 1996. Modulation of cell surface sialic acid expression in Neisseria meningitidis via a transposable genetic element. EMBO J. 15:192-198.
12. Haraszthy, V. I., G. Hariharan, E. M. Tinoco, J. R. Cortelli, E. T. Lally, E. Davis, and J. J. Zambon. 2000. Evidence for the role of highly leukotoyic Actinobacillus actinomycetemcomitans in the pathogenesis of localized juvenile and other forms of early-onset periodontitis. J. Periodontol. 71:912-922.
13. Haubek, D., J. M. DiRienzo, E. M. B. Tinoco, and M. Kilian. 1997. Racial tropism of a highly toxic clone of Actinobacillus actinomycetemcomitans associated with juvenile periodontitis. J. Clin. Microbiol. 35:3037-3042.
14. Haubek, D., O. K. Ennibi, K. Poulsen, S. Poulesen, N. Benzarti, and M. Kilian. 2001. Early-onset periodontitis in Morocco is associated with the highly leukotoxic clone of Actinobacillus actinomycetemcomitans. J. Dent. Res. 80:1580-1583.
15. He, T., T. Nishihara, D. R. Demuth, and I. Ishikawa. 1999. A novel insertion sequence increases the expression of leukotoxicity in Accinobacillus actinomycetemcomitans clinical isolates. J. Periodontol. 70:1261-1268.
16. Hilse, R., S. Hammerschmidt, W. Bautsch, and M. Frosch. 1996. Site-specific insertion of IS1301 and distribution in Neisseda meningitidis strains. J. Bacteriol. 178:2527-2532.
17. Hubner, A., and W. Hendrickson. 1997. A fusion promoter created by a new insertion sequence, IS1490, activates transcription of 2,4,5-trichlorophenoxy-acetic acid catabolic genes in Burkholderia cepacia AC100. J. Bacteriol. 179:2717-2723.
18. Inouye, T., H. Ohta, S. Kokeguchi, K. Fukui, and K. Kato. 1990. Colonial variation and fimbriation of Actinobacillus actinomycetemcomitans. FEMS Microbiol. Lett. 69:13-17.
19. Issartel, J. P., V. Koronokis, and C. Hughes. 1991. Activation of Escherichia coli prohemolysin to the mature toxin by acyl carrier protein dependent fatty acylation. Nature (London) 351:759-761.
20. Iwase, M., E. T. Laly, P. Berthold, H. M. Korchak, and N. S. Talchman. 1990. Effects of cations and osmotic protectants on cytolytic activity of Actinobacillus actinomycetemcomitans leukotoxin. Infect. Immun. 58:1782-1788.
21. Kachlany, S. C., P. J. Planet, R. DeSalle, D. H. Fine, and D. H. Figurski. 2001. Genes for tight adherence of Actinobacillus actinomycetemcomitans: from plaque to plague to pond scum. Trends Microbiol. 9:429-437.
22. Karakelian, D., J. D. Lear, E. T. Lally, and J. C. Tanaka. 1998. Characterization of Actinobacillus actinomycetemcomitans leukotoxin pore formation in HL60 cells. Biochim. Biophys. Acta 1406:175-187.
23. Kato, T., K. Honma, A. Yamanaka, T. Miura, and K. Okuda. 2000. Heterogeneity in the immune response to serotype b LPS of Actinobacillus actinomycetemcomitans in inbred strains of mice. FEMS Immunol. Med. Microbiol. 28:67-70.
24. Kolodrubetz, D., L. H. Phillips, P. J. Ezzo, and E. Kraig. 1995. Directed genomic integration in Actinobacillus actinomycetemcomitans: generation of defined leukotoxin-negative mutans. Infect. Immun. 63:2780-2784.
25. Kolodrubetz, D., J. Spitznagel, Jr., B. Wang, L. H. Phillips, C. Jacobs, and E. Kraig. 1996. cis elements and trans factors are both important in strain-specific regulation of the leukotoxin gene in Actinobacillus actinomycetemcomitans. Infect. Immun. 64:3451-3460.
26. Korostoff, J., J. F. Wang, I. Kieba, M. Miller, B. J. Shenker, and E. T. Lally. 1998. Actinobacillus actinomycetemcomitans leukotoxin induces apoptosis in HL-60 cells. Infect. Immun. 66:4474-4483.
27. Korostoff, J., N. Yamaguchi, M. Miller, I. Kieba, and E. T. Lally. 2000. Perturbation of mitochondrial structure and function plays a central role in Actinobacillus actinomycetemcomitans leukotoxin-induced apoptosis. Microb. Pathog. 29:267-278.
28. Kraig, E., T. Dailey, and D. Kolodrubetz. 1990. Nucleotide sequence of the leukotoxin gene from Actinobacillus actinomycetemcomitans: homology to the alpha-hemolysin/leukotoxin gene family. Infect. Immun. 58:920-929.
29. Lally, E. T., E. E. Golub, I. R. Kieba, N. S. Taichman, S. Decker, P. Berthold, C. W. Gibson, D. R. Demuth, and J. C. Rosenbloom. 1990. Structure and function of the B and D genes of the Actinobacillus aetinomycetemcomitans leukotoxin complex. Microb. Pathog. 11:111-121.
30. Lally, E. T., E. E. Golub, I. R. Kieba, N. S. Taichman, J. Rosenbloom, J. C. Rosenbloom, C. W. Gibson, and D. R. Demuth. 1989. Analysis of the Actinobacillus actinomycetemcomitans leukotoxin gene: delineation of unique features and comparison to homologous toxins. J. Biol. Chem. 274:15451-15456.
31. Lally, E. T., R. B. Hill, I. R. Kieba, and J. Korostoff. 1999. The interaction between RTX toxins and target cells. Trends Microbiol. 7:356-361.
32. Lally, E. T., I. R. Kieba, A. Sato, C. L. Green, J. Rosenbloom, J. Korostoff, J. F. Wang, B. S. Shenker, S. Ortlepp, M. K. Robinson, and P. C. Billings. 1997. RTX toxins recognize a β2 integrin on the surface of human target cells. J. Biol. Chem. 272:30463-30469.
33. Lear, J. D., D. Karakelian, U. Furblur, E. T. Lally, and J. C. Tanaka. 2000. Conformational studies of Actinobacillus actinomycetemcomitans leukotoxin: partial denaturation enhances toxicity. Biochim. Biophys. Acta 1476:350-362.
34. Lopez, P., F. L. de Felipe, and C. Magni. 1996. Transcriptional activation of the citrase permease P gene of Lactococcus lactis by an insertion sequence-like element in plasmid pCIT264. Mol. Gen. Genet. 250:428-436.
35. Meyer, D. H., J. E. Lippman, and P. M. Fives-Taylor. 1994. Invasion of epithelial cells by Actinobacillus actinomycetemcomitans: a dynamic multistep process. Infect. Immun. 64:2988-2997.
36. Meyer, D. H., and P. M. Fives-Taylor. 1994. Characteristics of adherence of Actinobacillus actinomycetemcomitans to epithelial cells. Infect. Immun. 62:928-935.
37. Miller, J. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
38. Page, M. I., and E. O. King. 1966. Infection due to Actinobacillus actinomycetemeomitans and Haemophilus aphrophilus. N. Engl. J. Med. 275:181-188.
39. Perez-Martin, J., F. Rojo, and V. de Lorenzo. 1994. Promoters responsive to DNA bending: a common theme in prokaryotic gene expression. Microbiol. Rev. 58:268-290.
40. Podglagen, I., J. Breuil, and E. Collatz. 1994. Insertion of a novel DNA sequence, IS1186, upstream of the silent carbapenemase gene cfi4 promotes expression of carbapenem resistance in clinical isolates of Bacteroides fragilis. Mol. Microbiol. 12:105-114.
41. Robertson, P. B., M. Lantz, T. Marchuka, K. S. Kornman, C. I. Trummel, and S. C. Holt. 1982. Collagenolytic activity associated with Bacteroides species and Actinobacillus actinomycetemcomitans. J. Periodontal Res. 17:175-283.
42. Rosan, B., J. Slots, R. J. Lamont, M. A. Listgarten, and G. M. Nelson. 1988. Actinobacillus actinomycetemcomitans fimbriae. Oral Microbiol. Immunol. 3:58-63.
43. Ross, W., K. K. Gosink, J. Salomon, K. Igarashi, C. Zou, A. Ishihama, K. Severinov, and R. L. Gourse. 1993. A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase. Science 262:1407-1413.
44. Samuels, M., A. Fire, and P. A. Sharp. 1982. Separation and characterization of factors mediating accurate transcription by RNA polymerase II. J. Biol. Chem. 257:14419-14427.
45. Shenker, B. J., T. McKay, S. Datar, M. Miller, R. Chowden, and D. R. Demuth. 1999. Actinobacillus actinomycetemcomitans immunosuppressive protein is a member of the family of cytolethal distending toxins capable of causing G2 arrest in human T cells. J. Immunol. 162:4773-4780.
46. Shenker, B. S., R. H. Hoffmaster, T. McKay, and D. R. Demuth. 2000. Expression of cytolethal distending toxin (cdt) operon in Actinobacillus actinomycetemcomitans: evidence that the CdtB protein is responsible for G2 arrest of the cell cycle in human T cells. J. Immunol. 165:2612-2618.
47. Simpson, A. E., R. A. Skurry, and N. Firth. 2000. An IS257-derived promoter directs transcription of a tetA(K) tetracycline resistance gene in the Staphylococcus aureus chromosomal mec region. J. Bacteriol. 182:3345-3352.
48. Slots, J., H. S. Reynolds, and R. J. Genco. 1980. Actinobacillus actinomycetemcomitans in human periodontal disease: a cross sectional microbiological investigation. Infect. Immun. 29:1013-1020.
49. Sokol, P. A., M. Z. Juan, D. G. Storey, and P. Thirukkumaran. 1994. Genetic rearrangement associated with in vivo mucoid conversion of Pseudomonas aeruginosa PAO is due to insertion elements. J. Bacteriol. 176:553-562.
50. Sreenivasan, P. K., D. H. Meyer, and P. M. Fives-Taylor. 1993. Requirements for invasion of epithelial cells by Actinobacillus actinomycetemcomitans. Infect. Immun. 61:1239-1245.
51. Sreenivasan, P. K., D. J. LeBlanc, L. N. Lee, and P. Fives-Taylor. 1991. Transformation of Actinobacillus actinomycetemcomitans by electroporation, utilizing constructed shuttle plasmids. Infect. Immun. 59:4621-4627.
52. Teras, R., R. Horak, and M. Kivisaar. 2000. Transcription from fusion promoters generated during transposition of transposon Tn4652 is positively affected by integration host factor in Pseudomonas putida. J. Bacteriol. 182:589-598.
53. Welch, R. A. 1991. Pore forming cytolysins of Gram negative bacteria. Mol. Microbiol. 5:521-528.
54. Wood, M. S., A. Byrne, and T. G. Lessie. 1991. IS406 and IS407, two gene activating insertion sequences for Pseudomonas cepacia. Gene 105:101-105.
55. Zambon, J. J. 1985. Actinobacillus actinomycetemcomitans in human periodontal disease. J. Clin. Periodontol. 12:1-20.
56. Zambon, J. J., V. Haraszthy, G. Hariharan, E. T. Lally, and D. R. Demuth. 1996. The microbiology of early onset periodontitis: association of highly toxic A: actinomycetemcomitans strains with localized juvenile periodontitis. J. Periodontol. 67:282-290.
57. Zambon, J. J., J. Slots, and R. J. Genco. 1983. Serology of oral Actinobacillus actinomycetemcomitans and serotype distribution in human periodontal disease. Infect. Immun. 41:19-27.