Induction of Aggregatibacter actinomycetemcomitans leukotoxin expression by IS1301 and orfA

Microbiology

Volumn 154, Issue 2, 2008, Pages 528-538

  Schaeffer, Lyndsay M ^a   Schmidt, M Lee ^a   Demuth, Donald R ^a  

^a UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BETA GALACTOSIDASE; LEUKOTOXIN; PROTEIN ORFA; UNCLASSIFIED DRUG;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM CULTURE; BACTERIUM ISOLATION; CONTROLLED STUDY; DOWNSTREAM PROCESSING; ENZYME ACTIVITY; FRAMESHIFT MUTATION; GEL MOBILITY SHIFT ASSAY; GENE INSERTION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ACTINOBACILLUS INFECTIONS; BASE SEQUENCE; BETA-GALACTOSIDASE; DNA TRANSPOSABLE ELEMENTS; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EXOTOXINS; FRAMESHIFT MUTATION; GENE EXPRESSION REGULATION, BACTERIAL; GENES, REGULATOR; GENES, REPORTER; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; MUTAGENESIS, SITE-DIRECTED; OPERON; PERIODONTITIS; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; TRANSCRIPTION, GENETIC;

EID: 39749122720     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.2007/012195-0     Document Type: Article

References (35)

1. Balashova, N. V., Crosby, J. A., Al Ghofaily, L. & Kachlany, S. C. (2006). Leukotoxin confers beta-hemolytic activity to Actinobacillus actinomycetemcomitans. Infect Immun 74, 2015-2021.
2. Block, P. J., Yoran, C., Fox, A. C. & Kaltman, A. J. (1973). Actinobacillus actinomycetemcomitans endocarditis: report of a case and review of the literature. Am J Med Sci 266, 387-392.
3. Brogan, J. M., Lally, E. T., Poulsen, K., Kilian, M. & Demuth, D. R. (1994). Regulation of Actinobacillus actinomycetemcomitans expression: analysis of the promoter regions of leukotoxic and minimally leukotoxic strains. Infect Immun 62, 501-508.
4. Brogan, J. M., Lally, E. T. & Demuth, D. R. (1996). Construction of pYGK, an Actinobacillus actinomycetemcomitans/ Escherichia coli shuttle vector. Gene 169, 141-142.
5. Bueno, L. C., Mayer, M. P. & DiRienzo, J. M. (1998). Relationship between conversion of localized juvenile periodontitis-susceptible children from health to disease and Actinobacillus actinomycetemcomitans leukotoxin promoter structure. J Periodontol 69, 998-1007.
6. Cortelli, J. R., Cortelli, S. C., Jordan, S., Haraszthy, V. I. & Zambon, J. J. (2005). Prevalence of periodontal pathogens in Brazilians with aggressive or chronic periodontitis. J Clin Periodontol 32, 860-866.
7. Estrem, S. T., Ross, W., Gaal, T., Chen, Z. W. S, Niu, W., Ebright, R. H. & Gourse, R. L. (1999). Bacterial promoter architecture: subsite structure of UP elements and interactions with the carboxy-terminal domain the RNA polymerase α subunit. Genes Dev 13, 2134-2147.
8. Gourse, R. L., Ross, W. & Gaal, T. (2000). UPs and downs in bacterial transcription initiation: the role of the alpha subunit of RNA polymerase in promoter recognition. Mol Microbiol 37, 687-695.
9. Haraszthy, V. I., Hariharan, G., Tinoco, E. M., Cortelli, J. R., Lally, E. T., Davis, E. & Zambon, J. J. (2000). Evidence for the role of highly leukotoxic Actinobacillus actinomycetemcomitans in the pathogenesis of localized juvenile and other forms of early-onset periodontitis. J Periodontol 71, 912-922.
10. Haubek, D., DiRienzo, J. M., Tinoco, E. M. B. & Kilian, M. (1997). Racial tropism of a highly toxic done of Actinobacillus actinomycetemcomitans associated with juvenile periodontitis. J Clin Microbiol 35, 3037-3042.
11. Haubek, D., Ennibi, O. K., Poulsen, K., Poulesen, S., Benzarti, N. & Kilian, M. (2001). Early-onset periodontitis in Morocco is associated with the highly leukotoxic clone of Actinobacillus actinomycetemcomitans. J Dent Res 80, 1580-1583.
12. Haubek, D., Ennibi, O. K., Poulsen, K., Benzarti, N. & Baelum, V. (2004). The highly leukotoxic JP2 done of Actinobacillus actinomycetemcomitans and progression of periodontal attachment loss. J Dent Res 83, 767-770.
13. Haubek, D., Poulsen, K. & Kilian, M. (2007). Microevolution and patterns of dissemination of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans. Infect Immun 75, 3080-3088.
14. He, T., Nishihara, T., Demuth, D. R. & Ishikawa, I. (1999). A novel insertion sequence increases the expression of leukotoxicity in Actinobacillus actinomycetemcomitans clinical isolates. J Periodontol 70, 1261-1268.
15. Hritz, M., Fisher, E. & Demuth, D. R. (1996). Differential regulation of the leukotoxin operon in highly leukotoxic and minimally leukotoxic strains of Actinobacillus actinomycetemcomitans. Infect Immun 64, 2724-2729.
16. Iwase, M., Laly, E. T., Berthold, P., Korchak H. M. & Taichman, N. S. (1990). Effects of cations and osmotic protectants on cytolytic activity of Actinobacillus actinomycetemcomitans leukotoxin. Infect Immun 58, 1782-1788.
17. Karakelian, D., Lear, J. D., Lally, E. T. & Tanaka, J. C. (1998). Characterization of Actinobacillus actinomycetemcomitans leukotoxin pore formation in HL60 cells. Biochim Biophys Acta 1406, 175-187.
18. Kolodrubetz, D., Spitznagel, J., Jr, Wang, B,, Phillips, L. H., Jacobs, C. & Kraig, E. (1996). cis elements and trans factors are both important in strain-specific regulation of the leukotoxin gene in Actinobacillus actinomycetemcomitans. Infect Immun 64, 3451-3460.
19. Korostoff, J., Wang, J. F., Kieba, I., Miller, M., Shenker, B. J. & Lally, E. T. (1998). Actinobacillus actinomycetemcomitans leukotoxin induces apoptosis in HL-60 cells. Infect Immun 66, 4474-4483.
20. Korostoff, J., Yamaguchi, N., Miller, M., Kieba, I. & Lally, E. T. (2000). Perturbation of mitochondrial structure and function plays a central role in Actinobacillus actinomycetemcomitans leukotoxin-induced apoptosis. Microb Pathog 29, 267-278.
21. Kraig, E., Dailey, T. & Kolodrubetz, D. (1990). Nucleotide sequence of the leukotoxin gene from Actinobacillus actinomycetemcomitans: homology to the alpha-hemolysin/leukotoxin gene family. Infect Immun 58, 920-929.
22. Lally, E. T., Golub, E. E., Kieba, I. R., Taichman, N. S., Rosenbloom, J., Rosenbloom, J. C., Gibson, C. W. & Demuth, D. R. (1989). Analysis of the Actinobacillus actinomycetemcomitans leukotoxin gene. Delineation of unique features and comparison to homologous toxins. J Biol Chem 264, 15451-15456.
23. Lally, E. T., Kieba, I. R., Sato, A., Green, C. L., Rosenbloom, J., Korostoff, J., Wang, J. F., Shenker, B. S., Ortlepp, S. & other authors (1997). RTX toxins recognize a β2 integrin on the surface of human target cells. J Biol Chem 272, 30463-30469.
24. Lally, E. T., Hill, R. B., Kieba, I. R. & Korostoff, J. (1999). The interaction between RTX toxins and target cells. Trends Microbiol 7, 356-361.
25. Miller, J. (1972). Experiments in Molecular Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
26. Mitchell, C., Gao, L. & Demuth, D. R. (2003). Positive and negative cis-acting regulatory sequences control expression of leukotoxin in Actinobacillus actinomycetemcomitans 652. Infect Immun 71, 5640-5649.
27. Page, M. I. & King, E. O. (1966). Infection due to Actinobacillus actinomycetemcomitans and Haemophilus aphrophilus. N Engl J Med 275, 181-188.
28. Ross, W., Gosink, K. K., Salomon, J., Igarashi, K., Zou, C., Ishihama, A., Severinov, K. & Gourse, R. L. (1993). A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase. Science 262, 1407-1413.
29. Shenker, B. J., McKay, T., Datar, S., Miller, M., Chowden, R. & Demuth, D. R. (1999). Actinobacillus actinomycetemcomitans immunosuppressive protein is a member of the family of cytolethal distending toxins capable of causing G2 arrest in human T cells. J Immunol 162, 4773-4780.
30. Shenker, B. J., Hoffmaster, R. H., McKay, T. L. Demuth, D. R. (2000). Expression of cytolethal distending toxin (Cdt) operon in Actinobacillus actinomycetemcomitans: evidence that the CdtB protein is responsible for G2 arrest of the cell cycle in human T cells. J Immunol 165, 2612-2618.
31. Slots, J., Reynolds, H. S. & Genco, R. J. (1980). Actinobacillus actinomycetemcomitans in human periodontal disease: a cross sectional microbiological investigation. Infect Immun 29, 1013-1020.
32. Welch, R. A. (1991). Pore forming cytolysins of Gram-negative bacteria. Mol Microbiol 5, 521-528.
33. Zambon, J. J. (1985). Actinobacillus actinomycetemcomitans in human periodontal disease. J Clin Periodontol 12, 1-20.
34. Zambon, J. J., Slots, J. & Genco, R. J. (1983). Serology of oral Actinobacillus actinomycetemcomitans and serotype distribution in human periodontal disease. Infect Immun 41, 19-27.
35. Zambon, J. J., Haraszthy, V., Hariharan, G., Lally, E. T. & Demuth, D. R. (1996). The microbiology of early onset periodontitis: association of highly toxic Actinobacillus. actinomycetemcomitans strains with localized juvenile periodontitis. J Periodontol 67, 282-290.