메뉴 건너뛰기




Volumn 3, Issue 1, 2010, Pages 111-127

The future role of personalized medicine in the treatment of glioblastoma multiforme

Author keywords

GBM; Genetics; Oncogenomics; Pharmacogenomics; Signaling cascades

Indexed keywords

AFLIBERCEPT; AMG 102; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CEDIRANIB; CILENGITIDE; DOXORUBICIN; IMATINIB; IMMUNOTOXIN; IRINOTECAN; LB 12; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MICRORNA; PANITUMUMAB; TEMOZOLOMIDE; TP 38; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 77957315367     PISSN: None     EISSN: 11787066     Source Type: Book Series    
DOI: 10.2147/PGPM.S6852     Document Type: Article
Times cited : (27)

References (156)
  • 1
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987-996.
    • (2005) N Engl J Med , vol.352 , Issue.10 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3
  • 2
    • 33750627509 scopus 로고    scopus 로고
    • Adjuvant treatment for gliomas
    • Sehati N, Liau L. Adjuvant treatment for gliomas. Contemp Neurosurg. 2003;25(15):1-10.
    • (2003) Contemp Neurosurg , vol.25 , Issue.15 , pp. 1-10
    • Sehati, N.1    Liau, L.2
  • 3
    • 33745262087 scopus 로고    scopus 로고
    • Central Brain Tumor Registry of the United States, Chicago: Central Brain Tumor Registry of the United States, 2002-2004
    • Central Brain Tumor Registry of the United States. Statistical report: primary brain tumors in the United States, 2000-2004. Chicago: Central Brain Tumor Registry of the United States; 2008.
    • (2008) Statistical Report: Primary Brain Tumors In the United States
  • 4
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360(8):765-773.
    • (2009) N Engl J Med , vol.360 , Issue.8 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 5
    • 4944255253 scopus 로고    scopus 로고
    • Genetic pathways to glioblastoma: A population-based study
    • Ohgaki H, Dessen P, Jourde B, et al. Genetic pathways to glioblastoma: a population-based study. Cancer Res. 2004;64(19):6892-6899.
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 6892-6899
    • Ohgaki, H.1    Dessen, P.2    Jourde, B.3
  • 6
    • 16444368462 scopus 로고    scopus 로고
    • Genetic pathways to glioblastomas
    • Ohgaki H. Genetic pathways to glioblastomas. Neuropathology. 2005; 25(1):1-7.
    • (2005) Neuropathology , vol.25 , Issue.1 , pp. 1-7
    • Ohgaki, H.1
  • 7
    • 65649121938 scopus 로고    scopus 로고
    • Glioblastoma multiforme oncogenomics and signaling pathways
    • Kanu OO, Hughes B, Di C, et al. Glioblastoma multiforme oncogenomics and signaling pathways. Clin Med Oncol. 2009;3:39-52.
    • (2009) Clin Med Oncol , vol.3 , pp. 39-52
    • Kanu, O.O.1    Hughes, B.2    Di, C.3
  • 8
    • 7644224186 scopus 로고    scopus 로고
    • Adult glioma incidence trends in the United States, 1977-2000
    • Hess KR, Broglio KR, Bondy ML. Adult glioma incidence trends in the United States, 1977-2000. Cancer. 2004;101(10):2293-2299.
    • (2004) Cancer , vol.101 , Issue.10 , pp. 2293-2299
    • Hess, K.R.1    Broglio, K.R.2    Bondy, M.L.3
  • 9
    • 0037603470 scopus 로고    scopus 로고
    • Incidences of gliomas and meningiomas in Denmark, 1943 to 1997
    • discussion 1333-1324
    • Christensen HC, Kosteljanetz M, Johansen C. Incidences of gliomas and meningiomas in Denmark, 1943 to 1997. Neurosurgery. 2003; 52(6):1327-1333; discussion 1333-1324.
    • (2003) Neurosurgery , vol.52 , Issue.6 , pp. 1327-1333
    • Christensen, H.C.1    Kosteljanetz, M.2    Johansen, C.3
  • 10
    • 0030989519 scopus 로고    scopus 로고
    • Familial and personal medical history of cancer and nervous system conditions among adults with glioma and controls
    • Wrensch M, Lee M, Miike R, et al. Familial and personal medical history of cancer and nervous system conditions among adults with glioma and controls. Am J Epidemiol. 1997;145(7):581-593.
    • (1997) Am J Epidemiol , vol.145 , Issue.7 , pp. 581-593
    • Wrensch, M.1    Lee, M.2    Miike, R.3
  • 11
    • 0036787611 scopus 로고    scopus 로고
    • Epidemiology of primary brain tumors: Current concepts and review of the literature
    • Wrensch M, Minn Y, Chew T, Bondy M, Berger MS. Epidemiology of primary brain tumors: current concepts and review of the literature. Neuro Oncol. 2002;4(4):278-299.
    • (2002) Neuro Oncol , vol.4 , Issue.4 , pp. 278-299
    • Wrensch, M.1    Minn, Y.2    Chew, T.3    Bondy, M.4    Berger, M.S.5
  • 12
    • 0026846382 scopus 로고
    • Prevalence of glioblastoma multiforme in subjects with prior therapeutic radiation
    • Hodges LC, Smith JL, Garrett A, Tate S. Prevalence of glioblastoma multiforme in subjects with prior therapeutic radiation. J Neurosci Nurs. 1992;24(2):79-83.
    • (1992) J Neurosci Nurs , vol.24 , Issue.2 , pp. 79-83
    • Hodges, L.C.1    Smith, J.L.2    Garrett, A.3    Tate, S.4
  • 15
    • 0025992220 scopus 로고
    • Occupation, socioeconomic status, and brain tumor mortality: A death certificate-based case-control study
    • Demers PA, Vaughan TL, Schommer RR. Occupation, socioeconomic status, and brain tumor mortality: a death certificate-based case-control study. J Occup Med. 1991;33(9):1001-1006.
    • (1991) J Occup Med , vol.33 , Issue.9 , pp. 1001-1006
    • Demers, P.A.1    Vaughan, T.L.2    Schommer, R.R.3
  • 16
    • 0142188691 scopus 로고    scopus 로고
    • Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme
    • Shinojima N, Tada K, Shiraishi S, et al. Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme. Cancer Res. 2003;63(20):6962-6970.
    • (2003) Cancer Res , vol.63 , Issue.20 , pp. 6962-6970
    • Shinojima, N.1    Tada, K.2    Shiraishi, S.3
  • 18
    • 0027018453 scopus 로고
    • Cancer incidence in five continents. Comparability and quality of data
    • Parkin DM, Muir CS. Cancer incidence in five continents. Comparability and quality of data. IARC Sci Publ. 1992;(120):45-173.
    • (1992) IARC Sci Publ , vol.120 , pp. 45-173
    • Parkin, D.M.1    Muir, C.S.2
  • 19
    • 34848824363 scopus 로고    scopus 로고
    • Long-term survival with glioblastoma multiforme
    • Krex D, Klink B, Hartmann C, et al. Long-term survival with glioblastoma multiforme. Brain. 2007;130(Pt 10):2596-2606.
    • (2007) Brain , vol.130 , Issue.PART 10 , pp. 2596-2606
    • Krex, D.1    Klink, B.2    Hartmann, C.3
  • 20
    • 0027294649 scopus 로고
    • Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials
    • Curran WJ Jr, Scott CB, Horton J, et al. Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst. 1993;85(9):704-710.
    • (1993) J Natl Cancer Inst , vol.85 , Issue.9 , pp. 704-710
    • Curran Jr., W.J.1    Scott, C.B.2    Horton, J.3
  • 21
    • 33745010017 scopus 로고    scopus 로고
    • Radiotherapy and temozolomide for newly diagnosed glioblastoma: Recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial
    • Mirimanoff RO, Gorlia T, Mason W, et al. Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial. J Clin Oncol. 2006;24(16):2563-2569.
    • (2006) J Clin Oncol , vol.24 , Issue.16 , pp. 2563-2569
    • Mirimanoff, R.O.1    Gorlia, T.2    Mason, W.3
  • 23
    • 33644869659 scopus 로고    scopus 로고
    • Recent advances in the treatment of malignant astrocytoma
    • Reardon DA, Rich JN, Friedman HS, Bigner DD. Recent advances in the treatment of malignant astrocytoma. J Clin Oncol. 2006;24(8): 1253-1265.
    • (2006) J Clin Oncol , vol.24 , Issue.8 , pp. 1253-1265
    • Reardon, D.A.1    Rich, J.N.2    Friedman, H.S.3    Bigner, D.D.4
  • 24
    • 0021803702 scopus 로고
    • Glioblastoma multiforme and anaplastic astrocytoma. Pathologic criteria and prognostic implications
    • Burger PC, Vogel FS, Green SB, Strike TA. Glioblastoma multiforme and anaplastic astrocytoma. Pathologic criteria and prognostic implications. Cancer. 1985;56(5):1106-1111.
    • (1985) Cancer , vol.56 , Issue.5 , pp. 1106-1111
    • Burger, P.C.1    Vogel, F.S.2    Green, S.B.3    Strike, T.A.4
  • 25
    • 0020517665 scopus 로고
    • Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study
    • Chang CH, Horton J, Schoenfeld D, et al. Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study. Cancer. 1983;52(6):997-1007.
    • (1983) Cancer , vol.52 , Issue.6 , pp. 997-1007
    • Chang, C.H.1    Horton, J.2    Schoenfeld, D.3
  • 26
    • 0027245492 scopus 로고
    • Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: Results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials
    • Simpson JR, Horton J, Scott C, et al. Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials. Int J Radiat Oncol Biol Phys. 1993;26(2): 239-244.
    • (1993) Int J Radiat Oncol Biol Phys , vol.26 , Issue.2 , pp. 239-244
    • Simpson, J.R.1    Horton, J.2    Scott, C.3
  • 27
    • 0023835686 scopus 로고
    • The prognostic importance of tumor size in malignant gliomas: A computed tomographic scan study by the Brain Tumor Cooperative Group
    • Wood JR, Green SB, Shapiro WR. The prognostic importance of tumor size in malignant gliomas: a computed tomographic scan study by the Brain Tumor Cooperative Group. J Clin Oncol. 1988;6(2): 338-343.
    • (1988) J Clin Oncol , vol.6 , Issue.2 , pp. 338-343
    • Wood, J.R.1    Green, S.B.2    Shapiro, W.R.3
  • 28
    • 0034871451 scopus 로고    scopus 로고
    • A multivariate analysis of 416 patients with glioblastoma multiforme: Prognosis, extent of resection, and survival
    • Lacroix M, Abi-Said D, Fourney DR, et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg. 2001;95(2):190-198.
    • (2001) J Neurosurg , vol.95 , Issue.2 , pp. 190-198
    • Lacroix, M.1    Abi-Said, D.2    Fourney, D.R.3
  • 29
    • 42449117269 scopus 로고    scopus 로고
    • Extent of resection and survival in glioblastoma multiforme: Identification of and adjustment for bias
    • discussion 564-576
    • Stummer W, Reulen HJ, Meinel T, et al. Extent of resection and survival in glioblastoma multiforme: identification of and adjustment for bias. Neurosurgery. 2008;62(3):564-576; discussion 564-576.
    • (2008) Neurosurgery , vol.62 , Issue.3 , pp. 564-576
    • Stummer, W.1    Reulen, H.J.2    Meinel, T.3
  • 30
    • 0037161024 scopus 로고    scopus 로고
    • Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomised trials
    • Stewart LA. Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet. 2002;359(9311):1011-1018.
    • (2002) Lancet , vol.359 , Issue.9311 , pp. 1011-1018
    • Stewart, L.A.1
  • 31
    • 0344921458 scopus 로고    scopus 로고
    • Outcome and cost of craniotomy performed to treat tumors in regional academic referral centers
    • discussion 1063-1055
    • Long DM, Gordon T, Bowman H, et al. Outcome and cost of craniotomy performed to treat tumors in regional academic referral centers. Neurosurgery. 2003;52(5):1056-1063; discussion 1063-1055.
    • (2003) Neurosurgery , vol.52 , Issue.5 , pp. 1056-1063
    • Long, D.M.1    Gordon, T.2    Bowman, H.3
  • 32
    • 0019516715 scopus 로고
    • Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: A prospective multicenter trial of the Scandinavian Glioblastoma Study Group
    • Kristiansen K, Hagen S, Kollevold T, et al. Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: a prospective multicenter trial of the Scandinavian Glioblastoma Study Group. Cancer. 1981;47(4):649-652.
    • (1981) Cancer , vol.47 , Issue.4 , pp. 649-652
    • Kristiansen, K.1    Hagen, S.2    Kollevold, T.3
  • 33
    • 0018125603 scopus 로고
    • Evaluation of BCNU and/ or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial
    • Walker MD, Alexander E Jr, Hunt WE, et al. Evaluation of BCNU and/ or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J Neurosurg. 1978;49(3):333-343.
    • (1978) J Neurosurg , vol.49 , Issue.3 , pp. 333-343
    • Walker, M.D.1    Alexander Jr., E.2    Hunt, W.E.3
  • 34
    • 0027516695 scopus 로고
    • Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults
    • Fine HA, Dear KB, Loeffler JS, Black PM, Canellos GP. Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer. 1993;71(8):2585-2597.
    • (1993) Cancer , vol.71 , Issue.8 , pp. 2585-2597
    • Fine, H.A.1    Dear, K.B.2    Loeffler, J.S.3    Black, P.M.4    Canellos, G.P.5
  • 35
    • 0028917333 scopus 로고
    • Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-brain Tumor Treatment Group
    • Brem H, Piantadosi S, Burger PC, et al. Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-brain Tumor Treatment Group. Lancet. 1995;345(8956):1008-1012.
    • (1995) Lancet , vol.345 , Issue.8956 , pp. 1008-1012
    • Brem, H.1    Piantadosi, S.2    Burger, P.C.3
  • 36
    • 0037384037 scopus 로고    scopus 로고
    • A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma
    • Westphal M, Hilt DC, Bortey E, et al. A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma. Neuro-oncol. 2003;5(2):79-88.
    • (2003) Neuro-oncol , vol.5 , Issue.2 , pp. 79-88
    • Westphal, M.1    Hilt, D.C.2    Bortey, E.3
  • 37
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005;352: 997-1003.
    • (2005) N Engl J Med , vol.352 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 38
    • 35348962671 scopus 로고    scopus 로고
    • Diagnosis and treatment of high-grade astrocytoma
    • x
    • Sathornsumetee S, Rich JN, Reardon DA. Diagnosis and treatment of high-grade astrocytoma. Neurol Clin. 2007;25(4):1111-1139, x.
    • (2007) Neurol Clin , vol.25 , Issue.4 , pp. 1111-1139
    • Sathornsumetee, S.1    Rich, J.N.2    Reardon, D.A.3
  • 39
    • 35949002429 scopus 로고    scopus 로고
    • Malignant astrocytic glioma:Genetics, biology, and paths to treatment
    • Furnari FB, Fenton T, Bachoo RM, et al. Malignant astrocytic glioma:genetics, biology, and paths to treatment. Genes Dev. 2007; 21(21):2683-2710.
    • (2007) Genes Dev , vol.21 , Issue.21 , pp. 2683-2710
    • Furnari, F.B.1    Fenton, T.2    Bachoo, R.M.3
  • 40
    • 33947646898 scopus 로고    scopus 로고
    • Inhibiting kinases in malignant gliomas
    • Chi AS, Wen PY. Inhibiting kinases in malignant gliomas. Expert Opin Ther Targets. 2007;11(4):473-496.
    • (2007) Expert Opin Ther Targets , vol.11 , Issue.4 , pp. 473-496
    • Chi, A.S.1    Wen, P.Y.2
  • 42
    • 0028911133 scopus 로고
    • Chromosomal abnormalities in glioblastoma multiforme tumors and glioma cell lines detected by comparative genomic hybridization
    • Kim DH, Mohapatra G, Bollen A, Waldman FM, Feuerstein BG. Chromosomal abnormalities in glioblastoma multiforme tumors and glioma cell lines detected by comparative genomic hybridization. Int J Cancer. 1995;60(6):812-819.
    • (1995) Int J Cancer , vol.60 , Issue.6 , pp. 812-819
    • Kim, D.H.1    Mohapatra, G.2    Bollen, A.3    Waldman, F.M.4    Feuerstein, B.G.5
  • 43
    • 0031929455 scopus 로고    scopus 로고
    • Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade
    • Mohapatra G, Bollen AW, Kim DH, et al. Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade. Genes Chromosomes Cancer. 1998;21(3):195-206.
    • (1998) Genes Chromosomes Cancer , vol.21 , Issue.3 , pp. 195-206
    • Mohapatra, G.1    Bollen, A.W.2    Kim, D.H.3
  • 44
    • 0031971242 scopus 로고    scopus 로고
    • Investigation of genetic alterations associated with the grade of astrocytic tumor by comparative genomic hybridization
    • Nishizaki T, Ozaki S, Harada K, et al. Investigation of genetic alterations associated with the grade of astrocytic tumor by comparative genomic hybridization. Genes Chromosomes Cancer. 1998; 21(4):340-346.
    • (1998) Genes Chromosomes Cancer , vol.21 , Issue.4 , pp. 340-346
    • Nishizaki, T.1    Ozaki, S.2    Harada, K.3
  • 45
    • 0034129892 scopus 로고    scopus 로고
    • Comprehensive allelotype and genetic anaysis of 466 human nervous system tumors
    • von Deimling A, Fimmers R, Schmidt MC, et al. Comprehensive allelotype and genetic anaysis of 466 human nervous system tumors. J Neuropathol Exp Neurol. 2000;59(6):544-558.
    • (2000) J Neuropathol Exp Neurol , vol.59 , Issue.6 , pp. 544-558
    • von Deimling, A.1    Fimmers, R.2    Schmidt, M.C.3
  • 46
    • 2442642550 scopus 로고    scopus 로고
    • Brain tumours: Classification and genes
    • ii
    • Collins VP. Brain tumours: classification and genes. J Neurol Neurosurg Psychiatry. 2004;75 Suppl 2:2-11 ii.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , Issue.SUPPL. 2 , pp. 2-11
    • Collins, V.P.1
  • 47
    • 33947732246 scopus 로고    scopus 로고
    • Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization
    • Vranova V, Necesalova E, Kuglik P, et al. Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization. Oncol Rep. 2007;17(2):457-464.
    • (2007) Oncol Rep , vol.17 , Issue.2 , pp. 457-464
    • Vranova, V.1    Necesalova, E.2    Kuglik, P.3
  • 48
    • 0034998193 scopus 로고    scopus 로고
    • Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization
    • Hui AB, Lo KW, Yin XL, Poon WS, Ng HK. Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization. Lab Invest. 2001;81(5):717-723.
    • (2001) Lab Invest , vol.81 , Issue.5 , pp. 717-723
    • Hui, A.B.1    Lo, K.W.2    Yin, X.L.3    Poon, W.S.4    Ng, H.K.5
  • 49
    • 33749629724 scopus 로고    scopus 로고
    • Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH microarray profiling
    • Ruano Y, Mollejo M, Ribalta T, et al. Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH microarray profiling. Mol Cancer. 2006;5:39.
    • (2006) Mol Cancer , vol.5 , pp. 39
    • Ruano, Y.1    Mollejo, M.2    Ribalta, T.3
  • 50
    • 0025773554 scopus 로고
    • Mutator phenotype may be required for multistage carcinogenesis
    • Loeb LA. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res. 1991;51(12):3075-3079.
    • (1991) Cancer Res , vol.51 , Issue.12 , pp. 3075-3079
    • Loeb, L.A.1
  • 51
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers JH. Genome maintenance mechanisms for preventing cancer. Nature. 2001;411(6835):366-374.
    • (2001) Nature , vol.411 , Issue.6835 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 52
    • 0032008537 scopus 로고    scopus 로고
    • O6-methylguanine-DNA methyltransferase activity in adult gliomas: Relation to patient and tumor characteristics
    • Silber JR, Bobola MS, Ghatan S, Blank A, Kolstoe DD, Berger MS. O6-methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics. Cancer Res. 1998;58(5): 1068-1073.
    • (1998) Cancer Res , vol.58 , Issue.5 , pp. 1068-1073
    • Silber, J.R.1    Bobola, M.S.2    Ghatan, S.3    Blank, A.4    Kolstoe, D.D.5    Berger, M.S.6
  • 53
    • 13344282752 scopus 로고    scopus 로고
    • Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine
    • Belanich M, Pastor M, Randall T, et al. Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine. Cancer Res. 1996;56(4):783-788.
    • (1996) Cancer Res , vol.56 , Issue.4 , pp. 783-788
    • Belanich, M.1    Pastor, M.2    Randall, T.3
  • 54
    • 0030874380 scopus 로고    scopus 로고
    • Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene
    • Watts GS, Pieper RO, Costello JF, Peng YM, Dalton WS, Futscher BW. Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol Cell Biol. 1997;17(9):5612-5619.
    • (1997) Mol Cell Biol , vol.17 , Issue.9 , pp. 5612-5619
    • Watts, G.S.1    Pieper, R.O.2    Costello, J.F.3    Peng, Y.M.4    Dalton, W.S.5    Futscher, B.W.6
  • 55
    • 0034795045 scopus 로고    scopus 로고
    • Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C →A:T mutations of the TP53 tumor suppressor gene
    • Nakamura M, Watanabe T, Yonekawa Y, Kleihues P, Ohgaki H. Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C →A:T mutations of the TP53 tumor suppressor gene. Carcinogenesis. 2001;22(10):1715-1719.
    • (2001) Carcinogenesis , vol.22 , Issue.10 , pp. 1715-1719
    • Nakamura, M.1    Watanabe, T.2    Yonekawa, Y.3    Kleihues, P.4    Ohgaki, H.5
  • 56
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455(7216):1061-1068.
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1061-1068
  • 57
    • 67649583537 scopus 로고    scopus 로고
    • Glioblastoma multiforme: A review of therapeutic targets
    • Kanu OO, Mehta A, Di C, et al. Glioblastoma multiforme: a review of therapeutic targets. Expert Opin Ther Targets. 2009;13(6):701-718.
    • (2009) Expert Opin Ther Targets , vol.13 , Issue.6 , pp. 701-718
    • Kanu, O.O.1    Mehta, A.2    Di, C.3
  • 58
    • 0031465906 scopus 로고    scopus 로고
    • Proliferation of human malignant astrocytomas is dependent on Ras activation
    • Guha A, Feldkamp MM, Lau N, Boss G, Pawson A. Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene. 1997;15(23):2755-2765.
    • (1997) Oncogene , vol.15 , Issue.23 , pp. 2755-2765
    • Guha, A.1    Feldkamp, M.M.2    Lau, N.3    Boss, G.4    Pawson, A.5
  • 59
    • 0025297599 scopus 로고
    • Type 1 neurofibromatosis gene: Identification of a large transcript disrupted in three NF1 patients
    • Wallace MR, Marchuk DA, Andersen LB, et al. Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. Science. 1990;249(4965):181-186.
    • (1990) Science , vol.249 , Issue.4965 , pp. 181-186
    • Wallace, M.R.1    Marchuk, D.A.2    Andersen, L.B.3
  • 60
    • 0025369709 scopus 로고
    • Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus
    • Viskochil D, Buchberg AM, Xu G, et al. Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell. 1990;62(1):187-192.
    • (1990) Cell , vol.62 , Issue.1 , pp. 187-192
    • Viskochil, D.1    Buchberg, A.M.2    Xu, G.3
  • 61
    • 0025326726 scopus 로고
    • A major segment of the neurofibromatosis type 1 gene: CDNA sequence, genomic structure, and point mutations
    • Cawthon RM, Weiss R, Xu GF, et al. A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations. Cell. 1990;62(1):193-201.
    • (1990) Cell , vol.62 , Issue.1 , pp. 193-201
    • Cawthon, R.M.1    Weiss, R.2    Xu, G.F.3
  • 62
    • 18044399847 scopus 로고    scopus 로고
    • The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling
    • Shaw RJ, Paez JG, Curto M, et al. The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell. 2001;1(1):63-72.
    • (2001) Dev Cell , vol.1 , Issue.1 , pp. 63-72
    • Shaw, R.J.1    Paez, J.G.2    Curto, M.3
  • 63
    • 0034601410 scopus 로고    scopus 로고
    • p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma
    • Fulci G, Labuhn M, Maier D, et al. p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma. Oncogene. 2000;19(33):3816-3822.
    • (2000) Oncogene , vol.19 , Issue.33 , pp. 3816-3822
    • Fulci, G.1    Labuhn, M.2    Maier, D.3
  • 64
    • 0028970955 scopus 로고
    • Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines
    • He J, Olson JJ, James CD. Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines. Cancer Res. 1995;55(21):4833-4836.
    • (1995) Cancer Res , vol.55 , Issue.21 , pp. 4833-4836
    • He, J.1    Olson, J.J.2    James, C.D.3
  • 65
    • 0032977124 scopus 로고    scopus 로고
    • Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines
    • Ishii N, Maier D, Merlo A, et al. Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol. 1999;9(3):469-479.
    • (1999) Brain Pathol , vol.9 , Issue.3 , pp. 469-479
    • Ishii, N.1    Maier, D.2    Merlo, A.3
  • 66
    • 0035280251 scopus 로고    scopus 로고
    • Quantitative real-time PCR does not show selective targeting of p14(ARF) but concomitant inactivation of both p16(INK4A) and p14(ARF) in 105 human primary gliomas
    • Labuhn M, Jones G, Speel EJ, et al. Quantitative real-time PCR does not show selective targeting of p14(ARF) but concomitant inactivation of both p16(INK4A) and p14(ARF) in 105 human primary gliomas. Oncogene. 2001;20(9):1103-1109.
    • (2001) Oncogene , vol.20 , Issue.9 , pp. 1103-1109
    • Labuhn, M.1    Jones, G.2    Speel, E.J.3
  • 67
    • 34250877865 scopus 로고    scopus 로고
    • Genetic pathways to primary and secondary glioblastoma
    • Ohgaki H, Kleihues P. Genetic pathways to primary and secondary glioblastoma. Am J Pathol. 2007;170(5):1445-1453.
    • (2007) Am J Pathol , vol.170 , Issue.5 , pp. 1445-1453
    • Ohgaki, H.1    Kleihues, P.2
  • 68
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999;13(12):1501-1512.
    • (1999) Genes Dev , vol.13 , Issue.12 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 69
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997;275(5308):1943-1947.
    • (1997) Science , vol.275 , Issue.5308 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 70
    • 17144436629 scopus 로고    scopus 로고
    • Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    • Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet. 1997;15(4): 356-362.
    • (1997) Nat Genet , vol.15 , Issue.4 , pp. 356-362
    • Steck, P.A.1    Pershouse, M.A.2    Jasser, S.A.3
  • 71
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem. 1998;273(22):13375-13378.
    • (1998) J Biol Chem , vol.273 , Issue.22 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 72
    • 0032904432 scopus 로고    scopus 로고
    • PTEN: A tumour suppressor that functions as a phospholipid phosphatase
    • Maehama T, Dixon JE. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol. 1999;9(4):125-128.
    • (1999) Trends Cell Biol , vol.9 , Issue.4 , pp. 125-128
    • Maehama, T.1    Dixon, J.E.2
  • 73
    • 0033229893 scopus 로고    scopus 로고
    • The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells
    • Maier D, Jones G, Li X, et al. The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells. Cancer Res. 1999; 59(21):5479-5482.
    • (1999) Cancer Res , vol.59 , Issue.21 , pp. 5479-5482
    • Maier, D.1    Jones, G.2    Li, X.3
  • 74
    • 75749115909 scopus 로고    scopus 로고
    • A multigene predictor of outcome in glioblastoma
    • Colman H, Zhang L, Sulman EP, et al. A multigene predictor of outcome in glioblastoma. Neuro Oncol. 2010;12(1):49-57.
    • (2010) Neuro Oncol , vol.12 , Issue.1 , pp. 49-57
    • Colman, H.1    Zhang, L.2    Sulman, E.P.3
  • 75
    • 62449321780 scopus 로고    scopus 로고
    • Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes
    • Li A, Walling J, Ahn S, et al. Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes. Cancer Res. 2009;69(5):2091-2099.
    • (2009) Cancer Res , vol.69 , Issue.5 , pp. 2091-2099
    • Li, A.1    Walling, J.2    Ahn, S.3
  • 76
    • 71549126830 scopus 로고    scopus 로고
    • Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology
    • Gravendeel L, Kouwenhoven M, Gevaert O, et al. Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology. Cancer Res. 2009;69(23):9065-9072.
    • (2009) Cancer Res , vol.69 , Issue.23 , pp. 9065-9072
    • Gravendeel, L.1    Kouwenhoven, M.2    Gevaert, O.3
  • 77
    • 77957319711 scopus 로고    scopus 로고
    • Joint Meeting of the Society for Neuro-Oncology (SNO) and the American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Section on Tumors
    • Abstracts from the 2009
    • Abstracts from the 2009 Joint Meeting of the Society for Neuro-Oncology (SNO) and the American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Section on Tumors. Neuro Oncol. 2009;11(5):563-699.
    • (2009) Neuro Oncol , vol.11 , Issue.5 , pp. 563-699
  • 78
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RGW, Hoadley KA, Purdom E, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010;17(1):98-110.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 98-110
    • Verhaak, R.G.W.1    Hoadley, K.A.2    Purdom, E.3
  • 79
    • 76649130555 scopus 로고    scopus 로고
    • Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship
    • Kim H, Huang W, Jiang X, Pennicooke B, Park PJ, Johnson MD. Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proc Natl Acad Sci. 2010;107(5): 2183-2188.
    • (2010) Proc Natl Acad Sci , vol.107 , Issue.5 , pp. 2183-2188
    • Kim, H.1    Huang, W.2    Jiang, X.3    Pennicooke, B.4    Park, P.J.5    Johnson, M.D.6
  • 80
    • 67651039919 scopus 로고    scopus 로고
    • A network model of a cooperative genetic landscape in brain tumors
    • Bredel M, Scholtens DM, Harsh GR, et al. A network model of a cooperative genetic landscape in brain tumors. JAMA. 2009;302(3):261-275.
    • (2009) JAMA , vol.302 , Issue.3 , pp. 261-275
    • Bredel, M.1    Scholtens, D.M.2    Harsh, G.R.3
  • 81
    • 73249115321 scopus 로고    scopus 로고
    • Characterization of novel and complex genomic aberrations in glioblastoma using a 32K BAC array
    • Nord H, Hartmann C, Andersson R, et al. Characterization of novel and complex genomic aberrations in glioblastoma using a 32K BAC array. Neuro Oncol. 2009;11(6):803-818.
    • (2009) Neuro Oncol , vol.11 , Issue.6 , pp. 803-818
    • Nord, H.1    Hartmann, C.2    Andersson, R.3
  • 82
    • 77949446630 scopus 로고    scopus 로고
    • Automated network analysis identifies core pathways in glioblastoma
    • Cerami E, Demir E, Schultz N, Taylor BS, Sander C. Automated network analysis identifies core pathways in glioblastoma. PLoS One. 2010;5(2):e8918.
    • (2010) PLoS One , vol.5 , Issue.2
    • Cerami, E.1    Demir, E.2    Schultz, N.3    Taylor, B.S.4    Sander, C.5
  • 83
    • 70349620441 scopus 로고    scopus 로고
    • Genetic epidemiology of glioblastoma multiforme: Confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs
    • Song W, Ruder AM, Hu L, et al. Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs. PLoS One. 2009;4(9):e7157.
    • (2009) PLoS One , vol.4 , Issue.9
    • Song, W.1    Ruder, A.M.2    Hu, L.3
  • 84
    • 66549099464 scopus 로고    scopus 로고
    • Common variation in genes related to innate immunity and risk of adult glioma
    • Rajaraman P, Brenner AV, Butler MA, et al. Common variation in genes related to innate immunity and risk of adult glioma. Cancer Epidemiol Biomarkers Prev. 2009;18(5):1651-1658.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , Issue.5 , pp. 1651-1658
    • Rajaraman, P.1    Brenner, A.V.2    Butler, M.A.3
  • 86
    • 66349133436 scopus 로고    scopus 로고
    • High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray
    • Yin D, Ogawa S, Kawamata N, et al. High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarray. Mol Cancer Res. 2009;7(5):665-676.
    • (2009) Mol Cancer Res , vol.7 , Issue.5 , pp. 665-676
    • Yin, D.1    Ogawa, S.2    Kawamata, N.3
  • 87
    • 69949087520 scopus 로고    scopus 로고
    • A microarray-based DNA methylation study of glioblastoma multiforme
    • Martinez R, Martin-Subero JI, Rohde V, et al. A microarray-based DNA methylation study of glioblastoma multiforme. Epigenetics. 2009;4(4):255-265.
    • (2009) Epigenetics , vol.4 , Issue.4 , pp. 255-265
    • Martinez, R.1    Martin-Subero, J.I.2    Rohde, V.3
  • 88
    • 70449707222 scopus 로고    scopus 로고
    • The PFKFB3 splice variant UBI2K4 is downregulated in high-grade astrocytomas and impedes the growth of U87 glioblastoma cells
    • Zscharnack K, Kessler R, Bleichert F, Warnke JP, Eschrich K. The PFKFB3 splice variant UBI2K4 is downregulated in high-grade astrocytomas and impedes the growth of U87 glioblastoma cells. Neuropathol Appl Neurobiol. 2009;35(6):566-578.
    • (2009) Neuropathol Appl Neurobiol , vol.35 , Issue.6 , pp. 566-578
    • Zscharnack, K.1    Kessler, R.2    Bleichert, F.3    Warnke, J.P.4    Eschrich, K.5
  • 89
    • 70849122697 scopus 로고    scopus 로고
    • Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    • Brennan C, Momota H, Hambardzumyan D, et al. Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations. PLoS One. 2009; 4(11):e7752.
    • (2009) PLoS One , vol.4 , Issue.11
    • Brennan, C.1    Momota, H.2    Hambardzumyan, D.3
  • 90
    • 70349653793 scopus 로고    scopus 로고
    • IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas
    • Nobusawa S, Watanabe T, Kleihues P, Ohgaki H. IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. Clin Cancer Res. 2009;15(19):6002-6007.
    • (2009) Clin Cancer Res , vol.15 , Issue.19 , pp. 6002-6007
    • Nobusawa, S.1    Watanabe, T.2    Kleihues, P.3    Ohgaki, H.4
  • 91
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1{alpha}
    • Zhao S, Lin Y, Xu W, et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1{alpha}. Science. 2009;324(5924):261-265.
    • (2009) Science , vol.324 , Issue.5924 , pp. 261-265
    • Zhao, S.1    Lin, Y.2    Xu, W.3
  • 92
    • 77951239243 scopus 로고    scopus 로고
    • Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas
    • Beckner ME, Fellows-Mayle W, Zhang Z, et al. Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas. Int J Cancer. 2010;126(10):2282-2295.
    • (2010) Int J Cancer , vol.126 , Issue.10 , pp. 2282-2295
    • Beckner, M.E.1    Fellows-Mayle, W.2    Zhang, Z.3
  • 93
    • 77953476649 scopus 로고    scopus 로고
    • Identification and functional characterization of microRNAs involved in the malignant progression of gliomas
    • Aug
    • Malzkorn B, Wolter M, Liesenberg F, et al. Identification and functional characterization of microRNAs involved in the malignant progression of gliomas. Brain Pathol. Epub 2009 Aug 19.
    • (2009) Brain Pathol. Epub , pp. 19
    • Malzkorn, B.1    Wolter, M.2    Liesenberg, F.3
  • 94
    • 35348822482 scopus 로고    scopus 로고
    • Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
    • Stommel JM, Kimmelman AC, Ying H, et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science. 2007;318(5848):287-290.
    • (2007) Science , vol.318 , Issue.5848 , pp. 287-290
    • Stommel, J.M.1    Kimmelman, A.C.2    Ying, H.3
  • 95
    • 67650860453 scopus 로고    scopus 로고
    • Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms
    • Lu J, Kovach JS, Johnson F, et al. Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms. Proc Natl Acad Sci USA. 2009; 106(28):11697-11702.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.28 , pp. 11697-11702
    • Lu, J.1    Kovach, J.S.2    Johnson, F.3
  • 96
    • 65949106827 scopus 로고    scopus 로고
    • The plasticity of oncogene addiction: Implications for targeted therapies directed to receptor tyrosine kinases
    • Pillay V, Allaf L, Wilding AL, et al. The plasticity of oncogene addiction: implications for targeted therapies directed to receptor tyrosine kinases. Neoplasia. 2009;11(5):448-458.
    • (2009) Neoplasia , vol.11 , Issue.5 , pp. 448-458
    • Pillay, V.1    Allaf, L.2    Wilding, A.L.3
  • 97
    • 67650496199 scopus 로고    scopus 로고
    • Differential response of glioma cells to FOXO1-directed therapy
    • Lau CJ, Koty Z, Nalbantoglu J. Differential response of glioma cells to FOXO1-directed therapy. Cancer Res. 2009;69(13):5433-5440.
    • (2009) Cancer Res , vol.69 , Issue.13 , pp. 5433-5440
    • Lau, C.J.1    Koty, Z.2    Nalbantoglu, J.3
  • 98
    • 52949098192 scopus 로고    scopus 로고
    • Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors
    • Sampson JH, Akabani G, Archer GE, et al. Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors. Neuro Oncol. 2008;10(3):320-329.
    • (2008) Neuro Oncol , vol.10 , Issue.3 , pp. 320-329
    • Sampson, J.H.1    Akabani, G.2    Archer, G.E.3
  • 99
    • 33947191055 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
    • Vredenburgh JJ, Desjardins A, Herndon JE II, et al. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res. 2007;13(4):1253-1259.
    • (2007) Clin Cancer Res , vol.13 , Issue.4 , pp. 1253-1259
    • Vredenburgh, J.J.1    Desjardins, A.2    Herndon, J.E.I.I.3
  • 100
    • 68849121642 scopus 로고    scopus 로고
    • Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib
    • Halatsch ME, Löw S, Mursch K, et al. Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib. J Neurosurg. 2009;111(2):211-218.
    • (2009) J Neurosurg , vol.111 , Issue.2 , pp. 211-218
    • Halatsch, M.E.1    Löw, S.2    Mursch, K.3
  • 101
    • 58949089716 scopus 로고    scopus 로고
    • A MDR1 (ABCB1) gene single nucleotide polymorphism predicts outcome of temozolomide treatment in glioblastoma patients
    • Schaich M, Kestel L, Pfirrmann M, et al. A MDR1 (ABCB1) gene single nucleotide polymorphism predicts outcome of temozolomide treatment in glioblastoma patients. Ann Oncol. 2009;20(1): 175-181.
    • (2009) Ann Oncol , vol.20 , Issue.1 , pp. 175-181
    • Schaich, M.1    Kestel, L.2    Pfirrmann, M.3
  • 102
    • 70350449411 scopus 로고    scopus 로고
    • Advances in the genetics of glioblastoma: Are we reaching critical mass?
    • Purow B, Schiff D. Advances in the genetics of glioblastoma: are we reaching critical mass? Nat Rev Neurol. 2009;5(8):419-426.
    • (2009) Nat Rev Neurol , vol.5 , Issue.8 , pp. 419-426
    • Purow, B.1    Schiff, D.2
  • 103
    • 61449455726 scopus 로고    scopus 로고
    • New developments in targeted molecular therapies for glioblastoma
    • Wen PY. New developments in targeted molecular therapies for glioblastoma. Expert Rev Anticancer Ther. 2009;9(1):7-10.
    • (2009) Expert Rev Anticancer Ther , vol.9 , Issue.1 , pp. 7-10
    • Wen, P.Y.1
  • 104
    • 65549093775 scopus 로고    scopus 로고
    • Angiogenesis and anti-angiogenic molecularly targeted therapies in malignant gliomas
    • Argyriou AA, Giannopoulou E, Kalofonos HP. Angiogenesis and anti-angiogenic molecularly targeted therapies in malignant gliomas. Oncology. 2009;77(1):1-11.
    • (2009) Oncology , vol.77 , Issue.1 , pp. 1-11
    • Argyriou, A.A.1    Giannopoulou, E.2    Kalofonos, H.P.3
  • 105
    • 67649413407 scopus 로고    scopus 로고
    • Endocan expression and localization in human glioblastomas
    • Maurage CA, Adam E, Mineo JF, et al. Endocan expression and localization in human glioblastomas. J Neuropathol Exp Neurol. 2009;68(6):633-641.
    • (2009) J Neuropathol Exp Neurol , vol.68 , Issue.6 , pp. 633-641
    • Maurage, C.A.1    Adam, E.2    Mineo, J.F.3
  • 106
    • 77957307774 scopus 로고    scopus 로고
    • FDA Approval for Bevacizumad. National Cancer Institute
    • FDA Approval for Bevacizumad. National Cancer Institute.
  • 108
    • 0030956966 scopus 로고    scopus 로고
    • Molecular detection of tumorassociated antigens shared by human cutaneous melanomas and gliomas
    • Chi DD, Merchant RE, Rand R, et al. Molecular detection of tumorassociated antigens shared by human cutaneous melanomas and gliomas. Am J Pathol. 1997;150(6):2143-2152.
    • (1997) Am J Pathol , vol.150 , Issue.6 , pp. 2143-2152
    • Chi, D.D.1    Merchant, R.E.2    Rand, R.3
  • 109
    • 0015461544 scopus 로고
    • Depressed cell-mediated immunity in patients with primary intracranial tumors. Characterization of a humoral immunosuppressive factor
    • Brooks WH, Netsky MG, Normansell DE, Horwitz DA. Depressed cell-mediated immunity in patients with primary intracranial tumors. Characterization of a humoral immunosuppressive factor. J Exp Med. 1972;136(6):1631-1647.
    • (1972) J Exp Med , vol.136 , Issue.6 , pp. 1631-1647
    • Brooks, W.H.1    Netsky, M.G.2    Normansell, D.E.3    Horwitz, D.A.4
  • 110
    • 0016278772 scopus 로고
    • Immune responses in patients with gliomas
    • Brooks WH, Caldwell HD, Mortara RH. Immune responses in patients with gliomas. Surg Neurol. 1974;2(6):419-423.
    • (1974) Surg Neurol , vol.2 , Issue.6 , pp. 419-423
    • Brooks, W.H.1    Caldwell, H.D.2    Mortara, R.H.3
  • 111
    • 0026100939 scopus 로고
    • Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas
    • Brem H, Mahaley MS Jr, Vick NA, et al. Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas. J Neurosurg. 1991;74(3):441-446.
    • (1991) J Neurosurg , vol.74 , Issue.3 , pp. 441-446
    • Brem, H.1    Mahaley Jr., M.S.2    Vick, N.A.3
  • 112
    • 0019139671 scopus 로고
    • Impaired thymusderived lymphocyte function in patients with malignant brain tumour
    • Menzies CB, Gunar M, Thomas DG, Behan PO. Impaired thymusderived lymphocyte function in patients with malignant brain tumour. Clin Neurol Neurosurg. 1980;82(3):157-168.
    • (1980) Clin Neurol Neurosurg , vol.82 , Issue.3 , pp. 157-168
    • Menzies, C.B.1    Gunar, M.2    Thomas, D.G.3    Behan, P.O.4
  • 113
    • 0017654660 scopus 로고
    • Immunobiology of primary intracranial tumours. II. Analysis of lymphocyte subpopulations in patients with primary brain tumours
    • Brooks WH, Roszman TL, Mahaley MS, Woosley RE. Immunobiology of primary intracranial tumours. II. Analysis of lymphocyte subpopulations in patients with primary brain tumours. Clin Exp Immunol. 1977;29(1):61-66.
    • (1977) Clin Exp Immunol , vol.29 , Issue.1 , pp. 61-66
    • Brooks, W.H.1    Roszman, T.L.2    Mahaley, M.S.3    Woosley, R.E.4
  • 114
    • 0017081941 scopus 로고
    • Impairment of rosette-forming T lymphocytes in patients with primary intracranial tumors
    • Brooks WH, Roszman TL, Rogers AS. Impairment of rosette-forming T lymphocytes in patients with primary intracranial tumors. Cancer. 1976;37(4):1869-1873.
    • (1976) Cancer , vol.37 , Issue.4 , pp. 1869-1873
    • Brooks, W.H.1    Roszman, T.L.2    Rogers, A.S.3
  • 115
    • 0020062745 scopus 로고
    • Immunoregulatory cell function in peripheral blood leukocytes of patients with intracranial gliomas
    • Braun DP, Penn RD, Flannery AM, Harris JE. Immunoregulatory cell function in peripheral blood leukocytes of patients with intracranial gliomas. Neurosurgery. 1982;10(2):203-209.
    • (1982) Neurosurgery , vol.10 , Issue.2 , pp. 203-209
    • Braun, D.P.1    Penn, R.D.2    Flannery, A.M.3    Harris, J.E.4
  • 116
    • 0025283530 scopus 로고
    • Inability of mitogen-activated lymphocytes obtained from patients with malignant primary intracranial tumors to express high affinity interleukin 2 receptors
    • Elliott LH, Brooks WH, Roszman TL. Inability of mitogen-activated lymphocytes obtained from patients with malignant primary intracranial tumors to express high affinity interleukin 2 receptors. J Clin Invest. 1990;86(1):80-86.
    • (1990) J Clin Invest , vol.86 , Issue.1 , pp. 80-86
    • Elliott, L.H.1    Brooks, W.H.2    Roszman, T.L.3
  • 117
    • 0022597562 scopus 로고
    • Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: Effects of tumor cells and their supernatants on proliferative responses of lymphocytes
    • Miescher S, Whiteside TL, Carrel S, von Fliedner V. Functional properties of tumor-infiltrating and blood lymphocytes in patients with solid tumors: effects of tumor cells and their supernatants on proliferative responses of lymphocytes. J Immunol. 1986;136(5):1899-1907.
    • (1986) J Immunol , vol.136 , Issue.5 , pp. 1899-1907
    • Miescher, S.1    Whiteside, T.L.2    Carrel, S.3    von Fliedner, V.4
  • 118
    • 0019948809 scopus 로고
    • Immunobiology of primary intracranial tumors. VI. Suppressor cell function and lectin-binding lymphocyte subpopulations in patients with cerebral tumors
    • Roszman TL, Brooks WH, Elliott LH. Immunobiology of primary intracranial tumors. VI. Suppressor cell function and lectin-binding lymphocyte subpopulations in patients with cerebral tumors. Cancer. 1982;50(7):1273-1279.
    • (1982) Cancer , vol.50 , Issue.7 , pp. 1273-1279
    • Roszman, T.L.1    Brooks, W.H.2    Elliott, L.H.3
  • 119
    • 0026713089 scopus 로고
    • Proliferative potential of T-cell lymphocytes from gliomas
    • Roszman TL, Elliott LH, Brooks WH. Proliferative potential of T-cell lymphocytes from gliomas. J Neurosurg. 1992;77(5):820-821.
    • (1992) J Neurosurg , vol.77 , Issue.5 , pp. 820-821
    • Roszman, T.L.1    Elliott, L.H.2    Brooks, W.H.3
  • 120
    • 0018832524 scopus 로고
    • Immunobiology of primary intracranial tumours. III. Demonstration of a qualitative lymphocyte abnormality in patients with primary brain tumours
    • Roszman TL, Brooks WH. Immunobiology of primary intracranial tumours. III. Demonstration of a qualitative lymphocyte abnormality in patients with primary brain tumours. Clin Exp Immunol. 1980;39(2): 395-402.
    • (1980) Clin Exp Immunol , vol.39 , Issue.2 , pp. 395-402
    • Roszman, T.L.1    Brooks, W.H.2
  • 121
    • 0033561756 scopus 로고    scopus 로고
    • Human glioma-induced immunosuppression involves soluble factor(s) that alters monocyte cytokine profile and surface markers
    • Zou JP, Morford LA, Chougnet C, et al. Human glioma-induced immunosuppression involves soluble factor(s) that alters monocyte cytokine profile and surface markers. J Immunol. 1999;162(8):4882-4892.
    • (1999) J Immunol , vol.162 , Issue.8 , pp. 4882-4892
    • Zou, J.P.1    Morford, L.A.2    Chougnet, C.3
  • 122
    • 0034118217 scopus 로고    scopus 로고
    • Glioma immunology and immunotherapy
    • discussion 791-772
    • Parney IF, Hao C, Petruk KC. Glioma immunology and immunotherapy. Neurosurgery. 2000;46(4):778-791; discussion 791-772.
    • (2000) Neurosurgery , vol.46 , Issue.4 , pp. 778-791
    • Parney, I.F.1    Hao, C.2    Petruk, K.C.3
  • 123
    • 63449086968 scopus 로고    scopus 로고
    • Epigenetic mechanisms in glioblastoma multiforme
    • Nagarajan RP, Costello JF. Epigenetic mechanisms in glioblastoma multiforme. Semin Cancer Biol. 2009;19(3):188-197.
    • (2009) Semin Cancer Biol , vol.19 , Issue.3 , pp. 188-197
    • Nagarajan, R.P.1    Costello, J.F.2
  • 125
    • 67649442519 scopus 로고    scopus 로고
    • p15 promoter methylation - a novel prognostic marker in glioblastoma patients
    • Wemmert S, Bettscheider M, Alt S, et al. p15 promoter methylation - a novel prognostic marker in glioblastoma patients. Int J Oncol. 2009; 34(6):1743-1748.
    • (2009) Int J Oncol , vol.34 , Issue.6 , pp. 1743-1748
    • Wemmert, S.1    Bettscheider, M.2    Alt, S.3
  • 126
    • 70449521966 scopus 로고    scopus 로고
    • Long-term survivors of glioblastoma: Clinical features and molecular analysis
    • Sonoda Y, Kumabe T, Watanabe M, et al. Long-term survivors of glioblastoma: clinical features and molecular analysis. Acta Neurochir (Wien). 2009;151(11):1349-1358.
    • (2009) Acta Neurochir (Wien) , vol.151 , Issue.11 , pp. 1349-1358
    • Sonoda, Y.1    Kumabe, T.2    Watanabe, M.3
  • 127
    • 68049121594 scopus 로고    scopus 로고
    • DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation
    • Sun P, Xia S, Lal B, et al. DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation. Stem Cells. 2009;27(7):1473-1486.
    • (2009) Stem Cells , vol.27 , Issue.7 , pp. 1473-1486
    • Sun, P.1    Xia, S.2    Lal, B.3
  • 128
    • 67349107523 scopus 로고    scopus 로고
    • microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs
    • Xia H, Qi Y, Ng SS, et al. microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs. Brain Res. 2009;1269:158-165.
    • (2009) Brain Res , vol.1269 , pp. 158-165
    • Xia, H.1    Qi, Y.2    Ng, S.S.3
  • 129
    • 67349238629 scopus 로고    scopus 로고
    • Oncogenic role of microRNAs in brain tumors
    • Pang JC, Kwok WK, Chen Z, Ng HK. Oncogenic role of microRNAs in brain tumors. Acta Neuropathol. 2009;117(6):599-611.
    • (2009) Acta Neuropathol , vol.117 , Issue.6 , pp. 599-611
    • Pang, J.C.1    Kwok, W.K.2    Chen, Z.3    Ng, H.K.4
  • 130
    • 65249121446 scopus 로고    scopus 로고
    • Emerging functions of microRNAs in glioblastoma
    • Lawler S, Chiocca EA. Emerging functions of microRNAs in glioblastoma. J Neurooncol. 2009;92(3):297-306.
    • (2009) J Neurooncol , vol.92 , Issue.3 , pp. 297-306
    • Lawler, S.1    Chiocca, E.A.2
  • 133
    • 67849103555 scopus 로고    scopus 로고
    • MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme
    • Li Y, Li W, Yang Y, et al. MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme. Brain Res. 2009;1286:13-18.
    • (2009) Brain Res , vol.1286 , pp. 13-18
    • Li, Y.1    Li, W.2    Yang, Y.3
  • 134
    • 68249139817 scopus 로고    scopus 로고
    • MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC
    • Sasayama T, Nishihara M, Kondoh T, Hosoda K, Kohmura E. MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC. Int J Cancer. 2009;125(6):1407-1413.
    • (2009) Int J Cancer , vol.125 , Issue.6 , pp. 1407-1413
    • Sasayama, T.1    Nishihara, M.2    Kondoh, T.3    Hosoda, K.4    Kohmura, E.5
  • 135
    • 67649814967 scopus 로고    scopus 로고
    • Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1
    • Ueda R, Kohanbash G, Sasaki K, et al. Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1 Proc Natl Acad Sci USA. 2009;106(26):10746-10751.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.26 , pp. 10746-10751
    • Ueda, R.1    Kohanbash, G.2    Sasaki, K.3
  • 136
    • 77950472059 scopus 로고    scopus 로고
    • MIRAGAA - a methodology for finding coordinated effects of microRNA expression changes and genome aberrations in cancer
    • Gaire RK, Bailey J, Bearfoot J, Campbell IG, Stuckey PJ, Haviv I. MIRAGAA - a methodology for finding coordinated effects of microRNA expression changes and genome aberrations in cancer. Bioinformatics. 2010;26(2):161-167.
    • (2010) Bioinformatics , vol.26 , Issue.2 , pp. 161-167
    • Gaire, R.K.1    Bailey, J.2    Bearfoot, J.3    Campbell, I.G.4    Stuckey, P.J.5    Haviv, I.6
  • 137
    • 72449210651 scopus 로고    scopus 로고
    • Cancer stem cells: Cell culture, markers, and targets for new therapies
    • Gilbert CA, Ross AH. Cancer stem cells: cell culture, markers, and targets for new therapies. J Cell Biochemistry. 2009;108(5):1031-1038.
    • (2009) J Cell Biochemistry , vol.108 , Issue.5 , pp. 1031-1038
    • Gilbert, C.A.1    Ross, A.H.2
  • 138
    • 65349115320 scopus 로고    scopus 로고
    • SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma
    • Son MJ, Woolard K, Nam DH, Lee J, Fine HA. SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell. 2009;4(5):440-452.
    • (2009) Cell Stem Cell , vol.4 , Issue.5 , pp. 440-452
    • Son, M.J.1    Woolard, K.2    Nam, D.H.3    Lee, J.4    Fine, H.A.5
  • 140
    • 33645986455 scopus 로고    scopus 로고
    • Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: A randomised controlled multicentre phase III trial
    • Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol. 2006;7(5):392-401.
    • (2006) Lancet Oncol , vol.7 , Issue.5 , pp. 392-401
    • Stummer, W.1    Pichlmeier, U.2    Meinel, T.3    Wiestler, O.D.4    Zanella, F.5    Reulen, H.J.6
  • 141
    • 70149096641 scopus 로고    scopus 로고
    • Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration
    • Burgoyne AM, Phillips-Mason PJ, Burden-Gulley SM, et al. Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration. Cancer Res. 2009;69(17):6960-6968.
    • (2009) Cancer Res , vol.69 , Issue.17 , pp. 6960-6968
    • Burgoyne, A.M.1    Phillips-Mason, P.J.2    Burden-Gulley, S.M.3
  • 142
    • 74049111863 scopus 로고    scopus 로고
    • The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion
    • Nakada M, Anderson EM, Demuth T, et al. The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion. Int J Cancer. 2010;126(5):1155-1165.
    • (2010) Int J Cancer , vol.126 , Issue.5 , pp. 1155-1165
    • Nakada, M.1    Anderson, E.M.2    Demuth, T.3
  • 143
    • 70349873207 scopus 로고    scopus 로고
    • Matrix gla protein (MGP): An overexpressed and migration-promoting mesenchymal component in glioblastoma
    • Mertsch S, Schurgers L, Weber K, Paulus W, Senner V. Matrix gla protein (MGP): an overexpressed and migration-promoting mesenchymal component in glioblastoma. BMC Cancer. 2009;9(1):302.
    • (2009) BMC Cancer , vol.9 , Issue.1 , pp. 302
    • Mertsch, S.1    Schurgers, L.2    Weber, K.3    Paulus, W.4    Senner, V.5
  • 144
    • 70149107047 scopus 로고    scopus 로고
    • A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion
    • Lo HW, Zhu H, Cao X, Aldrich A, All-Osman F. A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion. Cancer Res. 2009;69(17):6790-6798.
    • (2009) Cancer Res , vol.69 , Issue.17 , pp. 6790-6798
    • Lo, H.W.1    Zhu, H.2    Cao, X.3    Aldrich, A.4    All-Osman, F.5
  • 145
    • 75949130595 scopus 로고    scopus 로고
    • Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9
    • Kenig S, Alonso MB, Mueller MM, Lah TT. Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9. Cancer Lett. 2010;289(1):53-61.
    • (2010) Cancer Lett , vol.289 , Issue.1 , pp. 53-61
    • Kenig, S.1    Alonso, M.B.2    Mueller, M.M.3    Lah, T.T.4
  • 146
    • 70349973901 scopus 로고    scopus 로고
    • Autocrine semaphorin 3A signaling promotes glioblastoma dispersal
    • Bagci T, Wu JK, Pfannl R, Ilag LL, Jay DG. Autocrine semaphorin 3A signaling promotes glioblastoma dispersal. Oncogene. 2009;28(40): 3537-3550.
    • (2009) Oncogene , vol.28 , Issue.40 , pp. 3537-3550
    • Bagci, T.1    Wu, J.K.2    Pfannl, R.3    Ilag, L.L.4    Jay, D.G.5
  • 147
    • 70350567644 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 regulates the NF-[kappa] B signaling pathway and interleukin-8 expression in glioblastoma
    • Atkinson GP, Nozell SE, Harrison DK, Stonecypher MS, Chen D, Benveniste EN. The prolyl isomerase Pin1 regulates the NF-[kappa] B signaling pathway and interleukin-8 expression in glioblastoma. Oncogene. 2009;28(42):3735-3745.
    • (2009) Oncogene , vol.28 , Issue.42 , pp. 3735-3745
    • Atkinson, G.P.1    Nozell, S.E.2    Harrison, D.K.3    Stonecypher, M.S.4    Chen, D.5    Benveniste, E.N.6
  • 148
    • 77949889855 scopus 로고    scopus 로고
    • Selective osteopontin knockdown exerts anti-tumoral activity in a human glioblastoma model
    • Lamour V, Mercier ML, Lefranc F, et al. Selective osteopontin knockdown exerts anti-tumoral activity in a human glioblastoma model. Int J Cancer. 2010;126(8):1797-1805.
    • (2010) Int J Cancer , vol.126 , Issue.8 , pp. 1797-1805
    • Lamour, V.1    Mercier, M.L.2    Lefranc, F.3
  • 149
    • 69249159918 scopus 로고    scopus 로고
    • ADAM19/adamalysin 19 structure, function, and role as a putative target in tumors and inflammatory diseases
    • Qi B, Newcomer RG, Sang QX. ADAM19/adamalysin 19 structure, function, and role as a putative target in tumors and inflammatory diseases. Curr Pharm Des. 2009;15(20):2336-2348.
    • (2009) Curr Pharm Des , vol.15 , Issue.20 , pp. 2336-2348
    • Qi, B.1    Newcomer, R.G.2    Sang, Q.X.3
  • 150
    • 67649985753 scopus 로고    scopus 로고
    • Vesicle amine transport protein-1 (VAT-1) is upregulated in glioblastomas and promotes migration
    • Mertsch S, Becker M, Lichota A, Paulus W, Senner V. Vesicle amine transport protein-1 (VAT-1) is upregulated in glioblastomas and promotes migration. Neuropathol Appl Neurobiol. 2009;35(4): 342-352.
    • (2009) Neuropathol Appl Neurobiol , vol.35 , Issue.4 , pp. 342-352
    • Mertsch, S.1    Becker, M.2    Lichota, A.3    Paulus, W.4    Senner, V.5
  • 151
  • 152
    • 42549116694 scopus 로고    scopus 로고
    • Current issues in ER and HER2 testing by IHC in breast cancer
    • Gown AM. Current issues in ER and HER2 testing by IHC in breast cancer. Mod Pathol. 2008;21 Suppl 2:S8-S15.
    • (2008) Mod Pathol , vol.21 , Issue.SUPPL. 2
    • Gown, A.M.1
  • 153
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatinpaclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatinpaclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361(10): 947-957.
    • (2009) N Engl J Med , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 154
    • 33845893608 scopus 로고    scopus 로고
    • Pharmacogenetics of irinotecan: Clinical perspectives on the utility of genotyping
    • Innocenti F, Ratain MJ. Pharmacogenetics of irinotecan: clinical perspectives on the utility of genotyping. Pharmacogenomics. 2006;7(8): 1211-1221.
    • (2006) Pharmacogenomics , vol.7 , Issue.8 , pp. 1211-1221
    • Innocenti, F.1    Ratain, M.J.2
  • 155
    • 39749164161 scopus 로고    scopus 로고
    • Medical Education: A key partner in realizing personalized medicine in gastroenterology
    • Patel KK, Babyatsky MW. Medical Education: a key partner in realizing personalized medicine in gastroenterology. Gastroenterology. 2008;134(3):656-661.
    • (2008) Gastroenterology , vol.134 , Issue.3 , pp. 656-661
    • Patel, K.K.1    Babyatsky, M.W.2
  • 156
    • 75149166496 scopus 로고    scopus 로고
    • MGMT promoter methylation in malignant gliomas: Ready for personalized medicine?
    • Weller M, Stupp R, Reifenberger G, et al. MGMT promoter methylation in malignant gliomas: ready for personalized medicine? Nat Rev Neurol. 2010;6(1):39-51.
    • (2010) Nat Rev Neurol , vol.6 , Issue.1 , pp. 39-51
    • Weller, M.1    Stupp, R.2    Reifenberger, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.