Comprehensive allelotype and genetic analysis of 466 human nervous system tumors

Journal of Neuropathology and Experimental Neurology

Volumn 59, Issue 6, 2000, Pages 544-558

  Von Deimling, Andreas ^a   Fimmers, Rolf ^b   Schmidt, Matthias C ^b   Bender, Bernhard ^b   Fassbender, Frank ^b   Nagel, Judith ^b   Jahnke, Rolf ^b   Kaskel, Peter ^b   Duerr, Eva Maria ^b   Koopmann, Jens ^b   Maintz, David ^b   Steinbeck, Stephanie ^b   Wick, Wolfgang ^b   Platten, Michael ^b   Müller, Daniel J ^b   Przkora, René ^b   Waha, Andreas ^b   Blümcke, Britta ^b   Wellenreuther, Ruth ^b   Meyer Puttlitz, Birgit ^b   Schmidt, Ortrud ^b   Mollenhauer, Jan ^c   Poustka, Annemarie ^c   Stangl, Armin P ^b   Lenartz, Doris ^d   Von Ammon, Klaus ^e   Henson, John W ^f   Schramm, Johannes ^b   Louis, David N ^f   Wiestler, Otmar D ^b   more..

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

^e UNIVERSITY OF ZURICH   (Switzerland)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Allelotype; Brain; Molecular genetics; Mutation; Tumor

Indexed keywords

ALLELE; ARTICLE; CANCER GENETICS; GENE AMPLIFICATION; GENE MUTATION; GENETIC ANALYSIS; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MOLECULAR GENETICS; NERVOUS SYSTEM TUMOR; PRIORITY JOURNAL;

EID: 0034129892     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/59.6.544     Document Type: Article

References (49)

1. Seizinger BR, De La Monte S, Atkins L, Gusella JF. Molecular genetic approach to human meningiomas: Loss of genes on chromosome 22. Proc Natl Acad Sci USA 1987;84:5419-23
2. Dumanski JP, Carlbom E, Collins P, Nordenskjöld M. Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proc Natl Acad Sci USA 1987;84: 9275-79
3. James CD, Carlblom E, Dumanski JP, et al. Clonal genomic alterations in glioma malignancy stages. Cancer Res 1988;48:5546-51
4. Fults D, Tippets RH, Thomas GA, Nakamura Y, White R. Loss of heterozygosity for loci on chromosome 17p in human malignant astrocytoma. Cancer Res 1989;49:6572-77
5. Dumanski JP, Rouleau GA, Nordeskjoeld M, Collins VP. Molecular genetic analysis of chromosome 22 in 81 cases of meningioma. Cancer Res 1990;50:5863-67
6. von Deimling A, Louis DN, von Ammon K, Petersen I, Wiestler OD, Seizinger BR. Evidence for a tumor suppressor gene on chromosome 19q associated with human astrocytomas, oligodendrogliomas and mixed gliomas. Cancer Res 1992;52:4277-79
7. von Deimling A, von Ammon K, Schoenfeld D, Wiestler OD, Seizinger BR, Louis DN. Subsets of glioblastoma multiforme defined by molecular genetic analysis. Brain Pathol 1993;3:19-26
8. Ueki K, Rubio M-P, Ramesh V, et al. MTSI gene mutations are rare in primary human astrocytomas with allelic loss of chromosome 9p. Hum Mol Genet 1994;3:1841-45
9. Libermann TA, Nusbaum HR, Razon N, et al. Amplification, enhanced expression and possible rearrangement of EGF receptor in primary human brain tumors of glial origin. Nature 1985;313: 144-47
10. Ekstrand AJ, Sugawa N, James CD, Collins VP. Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Proc Natl Acad Sci USA 1992;89: 4309-13
11. Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275:1943-47
12. Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nature Genet 1997;15:356-62
13. Wellenreuther R, Kraus J, Lenartz D, et al. Analysis of the neurofibromatosis 2 gene reveals molecular variants of meningioma. Am J Pathol 1995;146:827-32
14. Ruttledge MH, Sarrazin J, Rangaratnam S, et al. Evidence for the complete inactivation on the NF2 gene in the majority of sporadic meningiomas. Nature Genet 1994;6:180-84
15. He J, Allen JR, Collins VP, et al. CDK4 amplification is an alternative mechanism to p16 homozygous deletion in glioma cell lines. Cancer Res 1994;54:5804-7
16. Reifenberger G, Reifenberger J, Ichimura K, Meltzer PS, Collins VP. Amplification of multiple genes from chromosomal region 12q13-q14 in human malignant gliomas: Preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS and MDM2. Cancer Res 1994;54:4299-4303
17. Cairncross JG, Ueki K, Zlatescu MC, et al. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst 1998;90: 1473-79
18. Kleihues P, Burger PC, Scheithauer BW, Histological typing of tumours of the central nervous system, 2 edition. New York: Springer-Verlag Berlin, 1993
19. Sambrook J, Fritsch EF, Maniatis T, Molecular Cloning, 2 edition. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 1989.
20. von Deimling A, Bender B, Louis DN, Wiestler OD. A rapid and non-radioactive PCR based assay for the detection of allelic loss in human gliomas. Neuropathol Appl Neurobiol 1993;19: 524-29
21. Louis DN, von Deimling A, Seizinger BR. A (CA)n dinucleotide repeat assay for evaluating loss of allelic heterozygosity in small and archival human brain tumor specimens. Am J Pathol 1992;141: 777-82
22. Waha A, Rollbrocker B, Wiestler OD, von Deimling A. A polymerase chain reaction-bused assay for the rapid detection of gene amplification in human tumors. Diagn Mol Pathol 1996;5: 147-50
23. Rollbrocker B, Waha A, Louis DN, Wiestler OD, von Deimling A. Amplification of the cyclin dependent kinase 4 (CDK4) gene is associated with high cdk4 protein levels in glioblastoma multiforme. Acta Neuropathol (Berl) 1996;92:70-74
24. Hayashi Y, Ueki K, Waha A, Wiestler OD, Louis DN, von Deimling A. Association of EGFR gene amplification and CDKN2 (p16/ MTS1) gene deletion in glioblastoma multiforme. Brain Pathol 1997;7:871-75
25. Mollenhauer J, Wiemann S, Scheurlen W, et al. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Nature Genet 1997;17: 32-39
26. Duerr EM, Rollbrocker B, Hayashi Y, et al. PTEN mutations in gliomas and glioneuronal tumors. Oncogene 1998;16:2259-64
27. Bender B, Wiestler OD, von Deimling A. A device for processing large acrylamide gels. Biotechniques 1994;16:204-6
28. Ohgaki H, Eibl RH, Wiestler OD, Yasargil MG, Newcomb EW, Kleihues P. p53 mutations in nonastrocytic human brain tumors. Cancer Res 1991;51:6202-5
29. Maintz D, Fiedler K, Koopmann J, et al. Molecular genetic evidence for subtypes of oligoastrocytomas. J Neuropathol Exp Neurol 1997;56:1098-1104
30. Peters N, Wellenreuther R, Rollbrocker B, et al. Analysis of the PTEN gene in human meningiomas. Neuropathol Appl Neurobiol 1998;24:3-8
31. Kraus JA, Koopmann J, Kaskel P, et al. Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma. J Neuropathol Exp Neurol 1995;54:91-95
32. Meyer-Puttlitz B, Hayashi Y, Waha A, et al. Molecular genetic analysis of giant cell glioblastomas. Am J Pathol 1997;151:853-57
33. von Deimling A, Louis DN, von Ammon K, et al. Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme. J Neurosurg 1992;77:295-301
34. von Deimling A, Eibl RH, Ohgaki H, et al. p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma. Cancer Res 1992;52:2987-90
35. von Deimling A, Louis DN, Menon AG, et al. Deletions on the long arm of chromosome 17 in pilocytic astrocytoma. Acta Neuropathol (Berl) 1993;86:81-85
36. von Deimling A, Bender B, Jahnke R, et al. Loci associated with malignant progression in astrocytomas: A candidate on chromosome 19q. Cancer Res 1994;54:1397-1401
37. Wick W, Petersen I, Schmutzler R, et al. Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastatic stage in breast cancer. Oncogene 1996;12:973-78
38. Vogelstein B, Fearon ER, Kern SE, et al. Allelotype of colorectal carcinomas. Science 1989;244:207-11
39. Scherer HJ. Cerebral astrocytomas and their derivatives. Am J Cancer 1940;40:159-98
40. Kallioniemi A, Kallioniemi OP, Sudar D, et al. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 1992;258:818-21
41. James CD, Carlbom E, Nordenskjold M, Collins VP, Cavenee WK. Mitotic recombination of chromosome 17 in astrocytomas. Proc Natl Acad Sci USA 1989;86:2858-62
42. Mohapatra G, Bollen AW, Kim DH, et al. Genetic analysis of glioblastoma multiforme provides evidence for subgroups within the grade. Genes Chromosomes Cancer 1998;21:195-206
43. Nishizaki T, Ozaki S, Harada K, et al. Investigation of genetic alterations associated with the grade of astrocytic tumor by comparative genomic hybridization. Genes Chromosomes Cancer 1998;21: 340-46
44. Weber RG, Sabel M, Reifenberger J, et al. Characterization of genomic alterations associated with glioma progression by comparative genomic hybridization. Oncogene 1996;13:983-94
45. Boerman RH, Anderl K, Herath J, et al. The glial and mesenchymal elements of gliosarcomas share similar genetic alterations. J Neuropathol Exp Neurol 1996;55:973-81
46. Kim DH, Mohapatra G, Bollen A, Waldman FM, Feuerstein BG. Chromosomal abnormalities in glioblastoma multiforme tumors and glioma cell lines detected by comparative genomic hybridization. Int J Cancer 1995;60:812-19
47. Patel A, van Meyel DJ, Mohapatra G, et al. Gliomas in families: Chromosomal analysis by comparative genomic hybridization. Cancer Genet Cytogenet 1998;100:77-83
48. Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF. Abnormal centrosome amplification in the absence of p53. Science 1996;271:1744-47
49. Peraud A, Watanabe K, Plate KH, Yonekawa Y, Kleihues P, Ohgaki H. p53 mutations versus EGF receptor expression in giant cell glioblastomas. J Neuropathol Exp Neurol 1997;56:1236-41