메뉴 건너뛰기




Volumn 34, Issue 6, 2009, Pages 1743-1748

p15 promoter methylation - A novel prognostic marker in glioblastoma patients

Author keywords

Glioblastoma; Methylation; MGMT; p15; Prognosis

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN P14; PROTEIN P14 ARF; PROTEIN P15; PROTEIN P16; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

EID: 67649442519     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000305     Document Type: Article
Times cited : (32)

References (38)
  • 2
    • 0023201753 scopus 로고
    • Patient age, histologic features, and length of survival in patients with glioblastoma multiforme
    • Burger PC and Green SB: Patient age, histologic features, and length of survival in patients with glioblastoma multiforme. Cancer 59: 1617-1625, 1987.
    • (1987) Cancer , vol.59 , pp. 1617-1625
    • Burger, P.C.1    Green, S.B.2
  • 3
    • 0027415401 scopus 로고
    • Surgical resection and radiation therapy versus biopsy and radiation therapy in the treatment of glioblastoma multiforme
    • Kreth FW, Warnke PC, Scheremet R and Ostertag CB: Surgical resection and radiation therapy versus biopsy and radiation therapy in the treatment of glioblastoma multiforme. J Neurosurg 78: 762-766, 1993.
    • (1993) J Neurosurg , vol.78 , pp. 762-766
    • Kreth, F.W.1    Warnke, P.C.2    Scheremet, R.3    Ostertag, C.B.4
  • 4
    • 0034871451 scopus 로고    scopus 로고
    • A multivariate analysis of 416 patients with glioblastoma multiforme: Prognosis, extent of resection, and survival
    • Lacroix M, Abi-Said D, Fourney DR, et al: A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 95: 190-198, 2001.
    • (2001) J Neurosurg , vol.95 , pp. 190-198
    • Lacroix, M.1    Abi-Said, D.2    Fourney, D.R.3
  • 5
    • 42449117269 scopus 로고    scopus 로고
    • Extent of resection and survival in glioblastoma multiforme: Identification of and adjustment for bias
    • Stummer W, Reulen HJ, Meinel T, et al: Extent of resection and survival in glioblastoma multiforme: Identification of and adjustment for bias. Neurosurgery 62: 564-576, 2008.
    • (2008) Neurosurgery , vol.62 , pp. 564-576
    • Stummer, W.1    Reulen, H.J.2    Meinel, T.3
  • 6
    • 0028618304 scopus 로고
    • Deletion of p16 and p15 genes in brain tumors
    • Jen J, Harper JW, Bigner SH, et al: Deletion of p16 and p15 genes in brain tumors. Cancer Res 54: 6353-6358, 1994.
    • (1994) Cancer Res , vol.54 , pp. 6353-6358
    • Jen, J.1    Harper, J.W.2    Bigner, S.H.3
  • 7
    • 0028652269 scopus 로고
    • CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas
    • Schmidt EE, Ichimura K, Reifenberger G and Collins VP: CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res 54: 6321-6324, 1994.
    • (1994) Cancer Res , vol.54 , pp. 6321-6324
    • Schmidt, E.E.1    Ichimura, K.2    Reifenberger, G.3    Collins, V.P.4
  • 8
    • 0344199413 scopus 로고    scopus 로고
    • Functional evidence for a role of combined CDKN2A[p16/p14(arf))]/CDKN2B (p15) gene inactivation in malignant gliomas
    • Simon M, Köster G, Menon AG and Schramm J: Functional evidence for a role of combined CDKN2A[p16/p14(arf))]/CDKN2B (p15) gene inactivation in malignant gliomas. Acta Neuropathol 98: 444-452, 1999.
    • (1999) Acta Neuropathol , vol.98 , pp. 444-452
    • Simon, M.1    Köster, G.2    Menon, A.G.3    Schramm, J.4
  • 9
    • 0037093971 scopus 로고    scopus 로고
    • Molecular markers of prognosis in astrocytic tumors
    • Rasheed A, Herndon JE, Stenzel TT, et al: Molecular markers of prognosis in astrocytic tumors. Cancer 94: 2688-2697, 2002.
    • (2002) Cancer , vol.94 , pp. 2688-2697
    • Rasheed, A.1    Herndon, J.E.2    Stenzel, T.T.3
  • 10
    • 33747587608 scopus 로고    scopus 로고
    • Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all
    • Gil J and Peters G: Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol 7: 667-677, 2006.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 667-677
    • Gil, J.1    Peters, G.2
  • 11
    • 0028970955 scopus 로고
    • INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines
    • INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines. Cancer Res 55: 4833-4836, 1995.
    • (1995) Cancer Res , vol.55 , pp. 4833-4836
    • He, J.1    Olson, J.J.2    James, C.D.3
  • 12
    • 0029736653 scopus 로고    scopus 로고
    • INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene
    • INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene. Oncogene 13: 1065-1072, 1996.
    • (1996) Oncogene , vol.13 , pp. 1065-1072
    • Ichimura, K.1    Schmidt, E.E.2    Goike, H.M.3    Collins, V.P.4
  • 13
    • 0034649787 scopus 로고    scopus 로고
    • Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities
    • Ichimura K, Bolin MB, Goike HM, Schmidt EE, Moshref A and Collins VP: Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities. Cancer Res 60: 417-424, 2000.
    • (2000) Cancer Res , vol.60 , pp. 417-424
    • Ichimura, K.1    Bolin, M.B.2    Goike, H.M.3    Schmidt, E.E.4    Moshref, A.5    Collins, V.P.6
  • 14
    • 0034601410 scopus 로고    scopus 로고
    • p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma
    • Fulci G, Labuhn M, Maier D, et al: p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma. Oncogene 19: 3816-3822, 2000.
    • (2000) Oncogene , vol.19 , pp. 3816-3822
    • Fulci, G.1    Labuhn, M.2    Maier, D.3
  • 15
    • 0036239616 scopus 로고    scopus 로고
    • Analysis of homozygous deletion of the p16 gene and correlation with survival in patients with glioblastoma multiforme
    • Kamiryo T, Tada K, Shiraishi S, et al: Analysis of homozygous deletion of the p16 gene and correlation with survival in patients with glioblastoma multiforme. J Neurosurg 96: 815-822, 2002.
    • (2002) J Neurosurg , vol.96 , pp. 815-822
    • Kamiryo, T.1    Tada, K.2    Shiraishi, S.3
  • 16
    • 33644874646 scopus 로고    scopus 로고
    • Patients with high-grade gliomas harboring deletions of chromosomes 9p and 10q benefit from temozolomide treatment
    • Wemmert S, Ketter R, Rahnenführer J, et al: Patients with high-grade gliomas harboring deletions of chromosomes 9p and 10q benefit from temozolomide treatment. Neoplasia 7: 883-893, 2005.
    • (2005) Neoplasia , vol.7 , pp. 883-893
    • Wemmert, S.1    Ketter, R.2    Rahnenführer, J.3
  • 21
    • 0037531563 scopus 로고    scopus 로고
    • Distinct methylation profiles of glioma subtypes
    • Uhlmann K, Rohde K, Zeller C, et al: Distinct methylation profiles of glioma subtypes. Int J Cancer 106: 52-59, 2003.
    • (2003) Int J Cancer , vol.106 , pp. 52-59
    • Uhlmann, K.1    Rohde, K.2    Zeller, C.3
  • 23
    • 0036605081 scopus 로고    scopus 로고
    • Inactivation of p16/CDKN2 and p15/MTS2 is associated with prognosis and response to chemotherapy in ovarian cancer
    • Kudoh K, Ichikawa Y, Yoshida S, et al: Inactivation of p16/CDKN2 and p15/MTS2 is associated with prognosis and response to chemotherapy in ovarian cancer. Int J Cancer 99: 579-582, 2002.
    • (2002) Int J Cancer , vol.99 , pp. 579-582
    • Kudoh, K.1    Ichikawa, Y.2    Yoshida, S.3
  • 25
    • 4143084896 scopus 로고    scopus 로고
    • CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas
    • Paz MF, Yaya-Tur R, Rojas-Marcos I, et al: CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas. Clin Cancer Res 10: 4933-4938, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 4933-4938
    • Paz, M.F.1    Yaya-Tur, R.2    Rojas-Marcos, I.3
  • 26
    • 20044366163 scopus 로고    scopus 로고
    • European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al: European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352: 987-996, 2005.
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3
  • 27
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi ME, Diserens AC, Gorlia T, et al: MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 352: 997-1003, 2005.
    • (2005) N Engl J Med , vol.352 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 28
    • 11144305238 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase methylation and TP53 mutation in malignant astrocytomas and their relationships with clinical course
    • 6-methylguanine-DNA methyltransferase methylation and TP53 mutation in malignant astrocytomas and their relationships with clinical course. Int J Cancer 113: 581-587, 2005.
    • (2005) Int J Cancer , vol.113 , pp. 581-587
    • Watanabe, T.1    Katayama, Y.2    Komine, C.3    Yoshino, A.4    Ogino, A.5    Ohta, T.6    Fukushima, T.7
  • 29
    • 3042772549 scopus 로고    scopus 로고
    • Correlation of clinical features and methylation status of MGMT gene promoter in glioblastomas
    • Blanc JL, Wager M, Guilhot J, et al: Correlation of clinical features and methylation status of MGMT gene promoter in glioblastomas. J Neurooncol 68: 275-283, 2004.
    • (2004) J Neurooncol , vol.68 , pp. 275-283
    • Blanc, J.L.1    Wager, M.2    Guilhot, J.3
  • 30
    • 34249053906 scopus 로고    scopus 로고
    • MGMT prognostic impact on glioblastoma is dependent on therapeutic modalities
    • Crinière E, Kaloshi G, Laigle-Donadey F, et al: MGMT prognostic impact on glioblastoma is dependent on therapeutic modalities. J Neurooncol 83: 173-179, 2007.
    • (2007) J Neurooncol , vol.83 , pp. 173-179
    • Crinière, E.1    Kaloshi, G.2    Laigle-Donadey, F.3
  • 31
    • 0036168978 scopus 로고    scopus 로고
    • Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis
    • Sato F, Harpaz N, Shibata D, et al: Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis. Cancer Res 62: 1148-1151, 2002.
    • (2002) Cancer Res , vol.62 , pp. 1148-1151
    • Sato, F.1    Harpaz, N.2    Shibata, D.3
  • 32
    • 51649117107 scopus 로고    scopus 로고
    • 6-methylguanin methyltransferase (MGMT) promotor methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
    • 6-methylguanin methyltransferase (MGMT) promotor methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J Clin Oncol 26: 4189-4199, 2008.
    • (2008) J Clin Oncol , vol.26 , pp. 4189-4199
    • Hegi, M.1    Liu, L.2    Herman, J.G.3
  • 33
    • 0034759748 scopus 로고    scopus 로고
    • Frequent mitotic errors in tumor cells of genetically micro-heterogeneous glioblastomas
    • Loeper S, Romeike BF, Heckmann N, et al: Frequent mitotic errors in tumor cells of genetically micro-heterogeneous glioblastomas. Cytogenet Cell Genet 94: 1-8, 2001.
    • (2001) Cytogenet Cell Genet , vol.94 , pp. 1-8
    • Loeper, S.1    Romeike, B.F.2    Heckmann, N.3
  • 34
    • 0032850203 scopus 로고    scopus 로고
    • Evidence of focal genetic microheterogeneity in glioblastoma multiforme by area-specific CGH on microdissected tumor cells
    • Jung V, Romeike BF, Henn W, Feiden W, Moringlane JR, Zang KD and Urbschat S: Evidence of focal genetic microheterogeneity in glioblastoma multiforme by area-specific CGH on microdissected tumor cells. J Neuropathol Exp Neurol 58: 993-999, 1999.
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 993-999
    • Jung, V.1    Romeike, B.F.2    Henn, W.3    Feiden, W.4    Moringlane, J.R.5    Zang, K.D.6    Urbschat, S.7
  • 35
    • 0037809355 scopus 로고    scopus 로고
    • Antitumor effect of cyclin-dependent kinase inhibitors [p16(INK4A), p18(INK4C), p19(INK4D)]. p21 [WAF1(CIP1) and p27 (KIP1)] on malignant glioma cells
    • Komata T, Kanzawa T, Takeuchi H, Germano IM, Schreiber M, Kondo Y and Kondo S: Antitumor effect of cyclin-dependent kinase inhibitors [p16(INK4A), p18(INK4C), p19(INK4D)]. p21 [WAF1(CIP1) and p27 (KIP1)] on malignant glioma cells. Br J Cancer 88: 1277-1280, 2003.
    • (2003) Br J Cancer , vol.88 , pp. 1277-1280
    • Komata, T.1    Kanzawa, T.2    Takeuchi, H.3    Germano, I.M.4    Schreiber, M.5    Kondo, Y.6    Kondo, S.7
  • 36
    • 4243175966 scopus 로고    scopus 로고
    • Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spiced gene expression and growth suppression in glioma cells
    • Inoue R, Moghaddam KA, Ranasinghe M, Saeki Y, Chiocca EA and Wade-Martins R: Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spiced gene expression and growth suppression in glioma cells. Gene Ther 11: 1195-1204, 2004.
    • (2004) Gene Ther , vol.11 , pp. 1195-1204
    • Inoue, R.1    Moghaddam, K.A.2    Ranasinghe, M.3    Saeki, Y.4    Chiocca, E.A.5    Wade-Martins, R.6
  • 38
    • 33847241269 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase genes in astrocytoma progression
    • 6-methylguanine-DNA methyltransferase genes in astrocytoma progression. Brain Pathol 17: 5-10, 2007.
    • (2007) Brain Pathol , vol.17 , pp. 5-10
    • Watanabe, T.1    Katayama, Y.2    Yoshino, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.