The biological effects of C/EBPα in K562 cells depend on the potency of the N-terminal regulatory region, not on specificity of the DNA binding domain

Journal of Biological Chemistry

Volumn 285, Issue 40, 2010, Pages 30837-30850

  Ferrari Amorotti, Giovanna ^a   Mariani, Samanta Antonella ^a,f   Novi, Chiara ^a   Cattelani, Sara ^a   Pecorari, Luisa ^a   Corradini, Francesca ^a   Soliera, Angela Rachele ^b   Manzotti, Gloria ^a   Fragliasso, Valentina ^a   Zhang, Ying ^c   Martinez, Robert V ^c   Lam, Eric W F ^d   Guerzoni, Clara ^e   Calabretta, Bruno ^a,b  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c PFIZER INC   (United States)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^f SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; BIOLOGICAL EFFECTS; CELL CYCLE; CHIMERIC PROTEINS; DNA BINDING DOMAIN; DOMAIN SWAPPING; GENE EXPRESSION PROFILES; GRANULOCYTE-COLONY STIMULATING FACTOR; IMATINIB; INDUCED APOPTOSIS; INDUCED TRANSCRIPTION; K562 CELLS; N-TERMINALS; PROLIFERATION INHIBITION; REGULATED GENES; REGULATED PROMOTERS; REGULATORY REGIONS; WILD TYPES;

CELL DEATH; GENES; TRANSCRIPTION FACTORS;

TRANSCRIPTION;

4 HYDROXYTAMOXIFEN; BCR ABL PROTEIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; IMATINIB; TRANSCRIPTION FACTOR FKHRL1; CCAAT ENHANCER BINDING PROTEIN; CEBPA PROTEIN, HUMAN; CEBPB PROTEIN, HUMAN; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; GRANULOCYTE COLONY STIMULATING FACTOR; HYBRID PROTEIN;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BINDING AFFINITY; BLAST CELL CRISIS; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRAIN K 562; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; PRIORITY JOURNAL; PROMOTER REGION; TRANSACTIVATION; BIOSYNTHESIS; CELL CYCLE; GENETIC TRANSCRIPTION; GENETICS; HUMAN; K562 CELL LINE; METABOLISM; PROTEIN TERTIARY STRUCTURE;

APOPTOSIS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CCAAT-ENHANCER-BINDING PROTEINS; CELL CYCLE; CELL DIFFERENTIATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; K562 CELLS; PROMOTER REGIONS, GENETIC; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION, GENETIC;

EID: 77957263184     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.128272     Document Type: Article

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