Triptolide inhibits extracellular matrix protein synthesis by suppressing the Smad2 but not the MAPK pathway in TGF-β1-stimulated NRK-49F cells

Nephrology Dialysis Transplantation

Volumn 25, Issue 10, 2010, Pages 3180-3191

  Zhu, Bin ^a   Wang, Yong Jun ^a   Zhu, Cai Feng ^a   Lin, Yi ^a   Zhu, Xiao Ling ^a   Wei, Sheng ^a   Lu, Ying ^a   Cheng, Xiao Xia ^a  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

extracellular matrix protein; MAPK; renal fibrosis; Smad; triptolide

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COLLAGEN TYPE 3; FIBRONECTIN; MITOGEN ACTIVATED PROTEIN KINASE; SCLEROPROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; SYNAPTOPHYSIN; TRANSFORMING GROWTH FACTOR BETA1; TRIPTOLIDE;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; KIDNEY FIBROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; DITERPENES; EPOXY COMPOUNDS; EXTRACELLULAR MATRIX PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; KIDNEY; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENANTHRENES; PHOSPHORYLATION; RATS; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77957233772     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfq239     Document Type: Article

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