Role of mitogen-activated protein kinase in the regulation of transforming growth factor-β-induced fibronectin accumulation in cultured renal interstitial fibroblasts

Clinical and Experimental Nephrology

Volumn 8, Issue 3, 2004, Pages 188-195

  Suzuki, Hitoe ^a   Uchida, Keiko ^a   Nitta, Kosaku ^a   Nihei, Hiroshi ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Fibroblasts; Fibronectin; Glucose; MAP kinase; Smad

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYTOKINE; FIBRONECTIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD4 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CONCENTRATION (PARAMETERS); CULTURE MEDIUM; DIABETIC NEPHROPATHY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROBLAST; IMMUNOBLOTTING; INTERSTITIAL NEPHRITIS; KIDNEY FIBROSIS; KIDNEY INJURY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CELLS, CULTURED; DNA PRIMERS; DNA-BINDING PROTEINS; ENZYME INHIBITORS; FIBROBLASTS; FIBRONECTINS; GLUCOSE; HUMANS; IMIDAZOLES; IMMUNOBLOTTING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KIDNEY; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SMAD PROTEINS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 7044272697     PISSN: 13421751     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10157-004-0297-8     Document Type: Article

References (25)

1. Ziyadeh FN, Goldfarb S. The renal tubulointerstitium in diabetes mellitus. Kidney Int 1991;39:464-75.
2. Bohle A, Wehrmann M, Bogenschutz O, Muller CA. The pathogenesis of chronic renal failure in diabetic nephropathy: investigation of 488 cases of diabetic glomerulosclerosis. Pathol Res Pract 1991;187:251-9.
3. Boder WA, Noble NA. Transforming growth factor-β in tissue fibrosis. N Engl J Med 1994;331:1286-92.
4. Eddy AA. Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 1996;7:2495-508.
5. Ziyadeh FN, Sharma K, Ericksen M, Wolf G. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor β. J Clin Invest 1994;93:536-42.
6. Hann DC, Isono M, Huffman BB, Ziyadeh FN. High glucose stimulates proliferation collagen type I synthesis in renal cortical fibroblasts: Mediation by autocrine activation of TGF-β. J Am Soc Nephrol 1999;10:1891-9.
7. van Det NF, Verhangen NA, Tamsma JT, Berden JH, Bruijin JA, Daha MR, et al. Regulation of glomerular epithelial cell production of fibronectin and transforming growth factor-β by high glucose, not by angiotensin II. Diabetes 1997;46:834-40.
8. Serger R, Krebs EG. The MAPK signaling cascade. FASEB J 1995;9:726-35.
9. Borkemeyer D, Sorokin A, Dunn MJ. Multiple intracellular MAP kinase signaling cascades. Kidney Int 1996;49:1187-98.
10. Heldin CH, Miyazono K, Ten Duke P. TGF-β signaling from cell membrane to nucleus through SMAD proteins. Nature 1997;390:465-71.
11. Eto Y, Shimosawa T, Nitta K, Nihei H, Maruyama N. Interaction between adrenomedullin and angiotensin II in DNA synthesis and extracellular matrix accumulation in cultured rat kidney interstitial cells. Clin Exp Nephrol 2002;6:7-12.
12. Sekine S, Nitta K, Uchida K, Yumura W, Nihei H. Possible involvement of mitogen-activated protein kinase in the angiotensin II-induced fibronectin synthesis in renal interstitial fibroblasts. Arch Biochem Biophys 2003;415;63-8.
13. Uchida K, Suzuki H, Ohashi T, Nitta K, Yumura W, Nihei H. Involvement of MAP kinase cascades in Smad7 transcriptional regulation. Biochem Biophys Res Commun 2001;289:376-81.
14. Yamamoto T, Nakamura T, Noble NA, Ruoslahti E, Border WA. Expression of Transforming growth factor β is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci USA 1993;90:1814-18.
15. Ziyadeh FN, Hoffman BB, Han DC, Iglesias-de la Cruz MC, Hong SW, Isono M, et al. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. Proc Natl Acad Sci USA 2000;97:8015-20.
16. Isaka Y, Akagi Y, Ando Y, Imai E. Application of gene therapy to diabetic nephropathy. Kidney Int 1997;60:S100-3.
17. Igarashi M, Wakasaki H, Takahara N, Ishii H, Jiang ZY, Yamauchi T, et al. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest 1999;103:185-95.
18. Tsiani E, Lekas P, Fantus G, Dlugosz J, Whiteside C. High glucose-enhanced activation of mesangial cell p38 MAPK by ET-1, angiotensin II, and platelet-derived growth factor. Am J Physiol Endocrinol Metab 2002;282:E161-9.
19. Wilmer WA, Dixon CL, Hebert C. Chronic exposure of human mesangial cells to high glucose environments activates the p38 MAPK pathway. Kidney Int 2001;60:858-71.
20. Bokemeyer D, Lindemann M, Kramer HJ. Regulation of mitogen-activated protein kinase phosphatase-1 in vascular smooth muscle cells. Hypertension 1998;32:661-7.
21. Awazu M, Ishikura K, Hida M, Hoshiya M. Mechanisms of mitogen-activation in experimental diabetes. J Am Soc Nephrol 1999;10:738-45.
22. Kang MJ, Wu X, Ly H, Thai K, Scholey JW. Effect of glucose on stress-activated protein kinase activity in mesangial cells and diabetic glomeruli. Kidney Int 1999;55:2203-14.
23. Hsieh TJ, Zhang SL, Filep JG, Tang SS, Ingelfinger JR, Chan J. High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells. Endocrinology 2002;143:2975-85.
24. Natarajan R, Scott S, Bai W, Yerneni KK, Nadler J. Angiotensin II signaling in vascular smooth muscle cells under high glucose conditions. Hypertension 1999;33:378-84.
25. Polhill TS, Saad S, Poronnik P, Fulcher GR, Pollock CA. Short-term peaks in glucose promote renal fibrogenesis independent of total glucose exposure. Am J Physiol 2004;65:1647-53.