Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-β1 in rat proximal tubular cells and mouse fibroblasts

Journal of the American Society of Nephrology

Volumn 16, Issue 4, 2005, Pages 899-904

  Nakagawa, Takahiko ^a   Lan, Hui Y ^b   Glushakova, Olena ^a   Zhu, Hong J ^b   Kang, Duk Hee ^c   Schreiner, George F ^c   Böttinger, Erwin P ^d   Johnson, Richard J ^a   Sautin, Yuri Y ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Ewha Womans University   (South Korea)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD2 PROTEIN; SMAD7 PROTEIN; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA1; DNA BINDING PROTEIN; MADH2 PROTEIN, RAT; SMAD2 PROTEIN, MOUSE; TGFB1 PROTEIN, MOUSE; TGFB1 PROTEIN, RAT; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE CONTROL; KIDNEY PROXIMAL TUBULE; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; ENZYME ACTIVATION; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; CELLS, CULTURED; DNA-BINDING PROTEINS; ENZYME ACTIVATION; FIBROBLASTS; KIDNEY TUBULES, PROXIMAL; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; SMAD2 PROTEIN; THROMBOSPONDIN 1; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 24344491188     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2004080689     Document Type: Article

References (30)

1. Bornstein P: Thrombospondins as matricellular modulators of cell function. J Clin Invest 107: 929-934, 2001
2. Kang DH, Anderson S, Kim YG, Mazzalli M, Suga S, Jefferson JA, Gordon KL, Oyama TT, Hughes J, Hugo C, Kerjaschki D, Schreiner GF, Johnson RJ: Impaired angiogenesis in the aging kidney: Vascular endothelial growth factor and thrombospondin-1 in renal disease. Am J Kidney Dis 37: 601-611, 2001
3. Hugo C, Kang DH, Johnson RJ: Sustained expression of thrombospondin-1 is associated with the development of glomerular and tubulointerstitial fibrosis in the remnant kidney model. Nephron 90: 460-470, 2002
4. Hugo C, Shankland SJ, Pichler RH, Couser WG, Johnson RJ: Thrombospondin 1 precedes and predicts the development of tubulointerstitial fibrosis in glomerular disease in the rat. Kidney Int 53: 302-311, 1998
5. Daniel C, Takabatake Y, Mizui M, Isaka Y, Kawashi H, Rupprecht H, Imai E, Hugo C: Antisense oligonucleotides against thrombospondin-1 inhibit activation of TGF-beta in fibrotic renal disease in the rat in vivo. Am J Pathol 163: 1185-1192, 2003
6. Yevdokimova N, Wahab NA, Mason RM: Thrombospondin-1 is the key activator of TGF-β1 in human mesangial cells exposed to high glucose. J Am Soc Nephrol 12: 703-712, 2001
7. Poczatek MH, Hugo C, Darley-Usmar V, Murphy-Ullrich JE: Glucose stimulation of transforming growth factor-beta bioactivity in mesangial cells is mediated by thrombospondin-1. Am J Pathol 157: 1353-1363, 2000
8. Hugo C, Pichler R, Meek R, Gordon K, Kyriakides T, Floege J, Bornstein P, Couser WG, Johnson RJ: Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo. Kidney Int 48: 1846-1856, 1995
9. Bottinger EP, Bitzer M: TGF-β signaling in renal disease. J Am Soc Nephrol 13: 2600-2610, 2002
10. Nakagawa T, Li JH, Garcia G, Mu W, Piek E, Bottinger EP, Chen Y, Zhu HJ, Kang DH, Schreiner GF, Lan HY, Johnson RJ: TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways. Kidney Int 66: 605-613, 2004
11. Mulder KM: Role of Ras and Mapks in TGFβ signaling. Cytokine Growth Factor Rev 11: 23-35, 2000
12. Kutz SM, Hordines J, McKeown-Longo PJ, Higgins PJ: TGF-β1-induced PAI-1 gene expression requires MEK activity and cell-to-substrate adhesion. J Cell Sci 114: 3905-3914, 2001
13. Yu L, Hebert MC, Zhang YE: TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. EMBO J 21: 3749-3759, 2002
14. Watanabe H, de Caestecker MP, Yamada Y: Transcriptional cross-talk between Smad, ERKl/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells. J Biol Chem 276: 14466-14473, 2001
15. Massague J: How cells read TGF-beta signals. Nat Rev Mol Cell Biol 1: 169-178, 2000
16. Deiynck R, Zhang YE: Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425: 577-584, 2003
17. Ohashi R, Nakagawa T, Watanabe S, Kanellis J, Almirez RG, Schreiner GF, Johnson RJ: Inhibition of p38 mitogen-activated protein kinase augments progression of remnant kidney model by activating the ERK pathway. Am J Pathol 164: 477-485, 2004
18. de Larco JE, Todaro GJ: Growth factors from murine sarcoma virus-transformed cells. Proc Natl Acad Sci U S A 75: 4001-4005, 1978
19. Best CJ, Tanzer LR, Phelps PC, Merriman RL, Boder GG, Trump BF, Elliget KA: H-ras-transformed NRK-52E renal epithelial cells have altered growth, morphology, and cytoskeletal structure that correlates with renal cell carcinoma in vivo. In Vitro Cell Dev Biol Anim 35: 205-214, 1999
20. Zhu HJ, Iaria J, Sizeland AM: Smad7 differentially regulates transforming growth factor beta-mediated signaling pathways. J Biol Chem 274: 32258-32264, 1999
21. Piek E, Ju WJ, Heyer J, Escalante-Alcalde D, Stewart CL, Weinstein M, Deng C, Kucherlapati R, Bottinger EP, Roberts AB: Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem 276: 19945-19953, 2001
22. Yue J, Mulder KM: Requirement of Ras/MAPK pathway activation by transforming growth factor beta for transforming growth factor beta 1 production in a Smad-dependent pathway. J Biol Chem 275: 30765-30773, 2000
23. Sowa H, Kaji H, Yamaguchi T, Sugimoto T, Chihara K: Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells. J Biol Chem 277: 36024-36031, 2002
24. Kretzschmar M, Doody J, Massague J: Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 389: 618-622, 1997
25. Dai C, Yang J, Liu Y: Transforming growth factor-betal potentiates renal tubular epithelial cell death by a mechanism independent of Smad signaling. J Biol Chem 278: 12537-12545, 2003
26. Wang L, Ma R, Flavell RA, Choi ME: Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangjal cells. J Biol Chem 277: 47257-47262, 2002
27. Bhowmick NA, Zent R, Ghiassi M, McDonnell M, Moses HL: Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J Biol Chem 276: 46707-46713, 2001
28. Li Y, Yang J, Dai C, Wu C, Liu Y: Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J Clin Invest 112: 503-516, 2003
29. Hayashida T, DeCaestecker M, Schnaper HW: Cross-talk between ERK MAP kinase and Smad-signaling pathways enhances TGF-beta dependent responses in human mesangial cells. FASEB J 11: 1567-1568, 2003
30. Hartsough MT, Frey RS, Zipfel PA, Buard A, Cook SJ, McCormick F, Mulder KM: Altered transforming growth factor signaling in epithelial cells when ras activation is blocked. J Biol Chem 271: 22368-22375, 1996