Mechanism of transforming growth factor-β1 signaling: Role of the mitogen-activated protein kinase

Kidney International, Supplement

Volumn 58, Issue 77, 2000, Pages

  Choi, M E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ERK1 ERK2; Mitogen activated protein kinase; p38; Signaling; Transforming growth factor 1

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; TRANSFORMING GROWTH FACTOR BETA;

DIABETIC NEPHROPATHY; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FIBROGENESIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; HUMAN; PHYSIOLOGY;

ANIMALS; DIABETIC NEPHROPATHIES; ENZYME ACTIVATION; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033867789     PISSN: 00986577     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2000.07709.x     Document Type: Review

References (60)

1. Expression of TGF-βs and their receptors during implantation and organogenesis of the mouse embryo
2. Differential expression of transforming growth factor-β receptors in rat kidney development
3. Signal transduction by members of the transforming growth factor-β superfamily
4. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
5. Transforming growth factor β in tissue fibrosis
6. Expression of transforming growth factor β is elevated in human and experimental diabetic nephropathy
7. mRNA expression of growth factors in glomeruli from diabetic rats
8. Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in streptozotocin-induced diabetic mice
9. Renal hypertrophy is associated with upregulation of TGF-β1 gene expression in diabetic BB rat and NOD mouse
10. TGF-β receptor expression and binding in rat mesangial cells by glucose and cyclic mechanical strain
11. Elevated expression of transforming growth factor-β and proteoglycan production in experimental glomerulonephritis
12. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor-β1
13. Glomerulosclerosis induced by in vivo transfection of transforming growth factor-β or platelet-derived growth factor gene into the rat kidney
14. Transgenic mice with increased plasma levels of TGF-β1 develop progressive renal disease
15. TGF-beta receptors and TGF-beta binding proteoglycans: Recent progress in identifying their functional properties
16. Rat mesangial cell hypertrophy in response to transforming growth factor-β1
17. Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-β receptors
18. Mechanism of activation of the TGF-β receptor
19. Signaling activity of homologous and heterologous transforming growth factor-β receptor kinase complexes
20. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase
21. The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans larva development
22. Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors
23. Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor
24. Identification of human activin and TGF-β type I receptors that form heteromeric kinase complexes with type II receptors
25. Cloning of a type I TGF-β receptor and its effect on TGF-β binding to the type II receptor
26. Characterization of type I receptors for transforming growth factor-beta and activin
27. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4
28. Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-β
29. Complementation between kinase-defective and activation-defective TGF-β receptors reveals a novel form of receptor cooperativity essential for signaling
30. Cloning and characterization of a naturally-occurring soluble form of TGF-β type I receptor
31. TGFβ signaling receptors, transducers, and Mad proteins
32. Transforming growth factor-β1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages
33. Altered transforming growth factor β signaling in epithelial cells when ras activation is blocked
34. Evidence for a role of rho-like GTPases and stress-activated protein kinase/ c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor β-mediated signaling
35. Role of the protein kinase p38 in transforming growth factor-beta 1-induced collagen expression in mesangial cells
36. Rho family members: Activators of MAP kinase cascades
37. The MAPK signaling cascade
38. The MAP kinase cascade is essential for diverse signal transduction pathways
39. Mapks: New JNK expands the group
40. The stress-activated protein kinase subfamily of c-Jun kinases
41. Transforming growth factor β activation of p44 MAPK in proliferating cultures of epithelial cells
42. Transforming growth factor-β1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells
43. Transforming growth factor-β1-induced activation of the Raf-MEK-MAPK signaling pathway in rat lung fibroblasts via a PKC-dependent mechanism
44. Cloning and expression of a rat smad 1: Regulation by TGFβ and modulation by the Ras/MEK pathway
45. Blockade of TGFβ up-regulation of p27Kip1 and p21 Cip1 by expression of RasN17 in epithelial cells
46. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
47. p38 mitogen-activated protein kinase kinase activation is required for human neutrophil function triggered by TNF-α or FMLP stimulation
48. p38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level
49. Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: A role in cardiac myocyte hypertrophy?
50. The p38 signal transduction pathway: Activation and function
51. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction
52. A novel kinase cascade mediated by mitogen-activated protein kinase 6 and MKK3
53. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-β-induced gene expression
54. Transforming growth factor-β induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase
55. The role of p38 MAP kinase in TGF-β1-induced signal transduction in human neutrophils
56. A role for p38 MAPK/HSP27 pathway in smooth muscle cell migration
57. Activation of the hematopoietic progenitor kinase-1 (HPK1) -dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta) -activated kinase (TAK1), a kinase mediator of TGF beta signal transduction
58. Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-β activities
59. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways
60. Small heat shock protein alteration provides a mechanism to reduce mesangial cell contractility in diabetes and oxidative stress