Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-κB and JNK in LPS-treated microglia

Journal of Neurochemistry

Volumn 107, Issue 3, 2008, Pages 779-788

  Gong, Yuntao ^a   Xue, Bing ^a   Jiao, Jian ^a   Jing, Liming ^a   Wang, Xiaomin ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Cyclooxygenase 2; Microglia; Mitogen activated protein kinases; Neuroinflammation; Nuclear factor B; Triptolide

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; TRIPTOLIDE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MICROGLIA; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT; TRANSCRIPTION INITIATION;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; DITERPENES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EPOXY COMPOUNDS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; LIPOPOLYSACCHARIDES; MAP KINASE KINASE 4; MICROGLIA; NF-KAPPA B; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSFECTION;

TRIPTERYGIUM WILFORDII;

EID: 53749093009     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05653.x     Document Type: Article

References (40)

1. Aisen P. S., Schafer K. A., Grundman M. et al. (2003) Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA 289, 2819 2826.
2. Brinker A. M., Ma J., Lipsky P. E. et al. (2007) Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). Phytochemistry 68, 732 766.
3. Chen B. J. (2001) Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F. Leuk. Lymphoma 42, 253 265.
4. Dai Y. Q., Jin D. Z., Zhu X. Z. et al. (2006) Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes. Neurosci. Res. 55, 154 160.
5. Dean J. L., Brook M., Clark A. R. et al. (1999) p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. J. Biol. Chem. 274, 264 269.
6. Dubois R. N., Abramson S. B., Crofford L. et al. (1998) Cyclooxygenase in biology and disease. FASEB J. 12, 1063 1073.
7. FitzGerald G. A. (2003) COX-2 and beyond: approaches to prostaglandin inhibition in human disease. Nat. Rev. Drug Discov. 2, 879 890.
8. Gao H. M., Liu B., Zhang W. et al. (2003) Novel anti-inflammatory therapy for Parkinson's disease. Trends Pharmacol. Sci. 24, 395 401.
9. Geng Y., Valbracht J. Lotz M. (1996) Selective activation of the mitogen-activated protein kinase subgroups c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes. J. Clin. Invest. 98, 2425 2430.
10. Gonzalez-Scarano F. Baltuch G. (1999) Microglia as mediators of inflammatory and degenerative diseases. Annu. Rev. Neurosci. 22, 219 240.
11. Grilli M., Pizzi M., Memo M. et al. (1996) Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation. Science 274, 1383 1385.
12. Guan Z., Buckman S. Y., Pentland A. P. et al. (1998) Induction of cyclooxygenase-2 by the activated MEKK1 → SEK1/MKK4 → p38 mitogen-activated protein kinase pathway. J. Biol. Chem. 273, 12901 12908.
13. Hambleton J., Weinstein S. L., Lem L. et al. (1996) Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc. Natl Acad. Sci. USA 93, 2774 2778.
14. Han Z., Boyle D. L., Chang L. et al. (2001) c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J. Clin. Invest. 108, 73 81.
15. Hwang D., Jang B. C., Yu G. et al. (1997) Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide: mediation through both mitogen-activated protein kinase and NF-kappaB signaling pathways in macrophages. Biochem. Pharmacol. 54, 87 96.
16. Kaltschmidt B., Linker R. A., Deng J. et al. (2002) Cyclooxygenase-2 is a neuronal target gene of NF-kappaB. BMC Mol. Biol. 3, 16.
17. Kim Y. H., Lee S. H., Lee J. Y. et al. (2004) Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-kappa B and c-Jun NH2-terminal kinase. Eur. J. Pharmacol. 494, 1 9.
18. Kumar A., Takada Y., Boriek A. M. et al. (2004) Nuclear factor-kappaB: its role in health and disease. J. Mol. Med. 82, 434 448.
19. Lee K. Y., Chang W., Qiu D. et al. (1999) PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells. J. Biol. Chem. 274, 13451 13455.
20. Liu B. Hong J. S. (2003a) Primary rat mesencephalic neuron-glia, neuron-enriched, microglia-enriched, and astroglia-enriched cultures. Methods Mol. Med. 79, 387 395.
21. Liu B. Hong J. S. (2003b) Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 304, 1 7.
22. Meyer C. F., Wang X., Chang C. et al. (1996) Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation. J. Biol. Chem. 271, 8971 8976.
23. Moon Y. Pestka J. J. (2002) Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases. Toxicol. Sci. 69, 373 382.
24. Nakano H. (2004) Signaling crosstalk between NF-kappaB and JNK. Trends Immunol. 25, 402 405.
25. Park L. C., Zhang H., Sheu K. F. et al. (1999) Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia. J. Neurochem. 72, 1948 1958.
26. Qiu D. Kao P. N. (2003) Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f. Drugs R D 4, 1 18.
27. Righi M., Mori L., De L. G. et al. (1989) Monokine production by microglial cell clones. Eur. J. Immunol. 19, 1443 1448.
28. Roux P. P. Blenis J. (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68, 320 344.
29. Sanchez-Pernaute R., Ferree A., Cooper O. et al. (2004) Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. J. Neuroinflammation 1, 6.
30. Scherle P. A., Jones E. A. Favata M. F. (1998) Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide- stimulated monocytes. J. Immunol. 161, 5681 5686.
31. Stancovski I. Baltimore D. (1997) NF-kappaB activation: the I kappaB kinase revealed? Cell 91, 299 302.
32. Subbaramaiah K., Chung W. J. Dannenberg A. J. (1998) Ceramide regulates the transcription of cyclooxygenase-2. Evidence for involvement of extracellular signal-regulated kinase/c-Jun N-terminal kinase and p38 mitogen-activated protein kinase pathways. J. Biol. Chem. 273, 32943 32949.
33. Subbaramaiah K., Hart J. C., Norton L. et al. (2000) Microtubule- interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 AND p38 mitogen-activated protein kinase pathways. J. Biol. Chem. 275, 14838 14845.
34. Tak P. P. Firestein G. S. (2001) NF-kappaB: a key role in inflammatory diseases. J. Clin. Invest. 107, 7 11.
35. Teismann P., Tieu K., Choi D. K. et al. (2003) Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. Proc. Natl Acad. Sci. USA 100, 5473 5478.
36. Yamamoto K., Arakawa T., Ueda N. et al. (1995) Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J. Biol. Chem. 270, 31315 31320.
37. Yin M. J., Yamamoto Y. Gaynor R. B. (1998) The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 396, 77 80.
38. You H. J., Woo C. H., Choi E. Y. et al. (2005) Roles of Rac and p38 kinase in the activation of cytosolic phospholipase A2 in response to PMA. Biochem. J. 388, 527 535.
39. Zhou H. F., Niu D. B., Xue B. et al. (2003) Triptolide inhibits TNF-alpha, IL-1 beta and NO production in primary microglial cultures. Neuroreport 14, 1091 1095.
40. Zhou H. F., Liu X. Y., Niu D. B. et al. (2005) Triptolide protects dopaminergic neurons from inflammation-mediated damage induced by lipopolysaccharide intranigral injection. Neurobiol. Dis. 18, 441 449.