메뉴 건너뛰기




Volumn 18, Issue 2, 2007, Pages 472-484

A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

CC 401; COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE 9; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 33846689276     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2006060604     Document Type: Article
Times cited : (151)

References (54)
  • 1
    • 0038004740 scopus 로고    scopus 로고
    • Targeting JNK for therapeutic benefit: From junk to gold?
    • Manning AM, Davis RJ: Targeting JNK for therapeutic benefit: From junk to gold? Nat Rev Drug Discov 2: 554-565, 2003
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 554-565
    • Manning, A.M.1    Davis, R.J.2
  • 4
    • 0027938445 scopus 로고
    • c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases
    • Minden A, Lin A, Smeal T, Derijard B, Cobb M, Davis R, Karin M: c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol Cell Biol 14: 6683-6688, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 6683-6688
    • Minden, A.1    Lin, A.2    Smeal, T.3    Derijard, B.4    Cobb, M.5    Davis, R.6    Karin, M.7
  • 5
    • 1542364421 scopus 로고    scopus 로고
    • Differential phosphorylation of c-Jun and JunD in response to the epidermal growth factor is determined by the structure of MAPK targeting sequences
    • Vinciguerra M, Vivacqua A, Fasanella G, Gallo A, Cuozzo C, Morano A, Maggiolini M, Musti AM: Differential phosphorylation of c-Jun and JunD in response to the epidermal growth factor is determined by the structure of MAPK targeting sequences. J Biol Chem 279: 9634-9641, 2004
    • (2004) J Biol Chem , vol.279 , pp. 9634-9641
    • Vinciguerra, M.1    Vivacqua, A.2    Fasanella, G.3    Gallo, A.4    Cuozzo, C.5    Morano, A.6    Maggiolini, M.7    Musti, A.M.8
  • 6
    • 30044444532 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinase signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment in keratin 16 gene expression
    • Wang YN, Chen YJ, Chang WC: Activation of extracellular signal-regulated kinase signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment in keratin 16 gene expression. Mol Pharmacol 69: 85-98, 2006
    • (2006) Mol Pharmacol , vol.69 , pp. 85-98
    • Wang, Y.N.1    Chen, Y.J.2    Chang, W.C.3
  • 7
    • 0141953270 scopus 로고    scopus 로고
    • A JNK-dependent pathway is required for TNFalpha-induced apoptosis
    • Deng Y, Ren X, Yang L, Lin Y, Wu X: A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell 115: 61-70, 2003
    • (2003) Cell , vol.115 , pp. 61-70
    • Deng, Y.1    Ren, X.2    Yang, L.3    Lin, Y.4    Wu, X.5
  • 8
    • 1242316958 scopus 로고    scopus 로고
    • JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
    • Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN, Xiang J, Lin A: JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 13: 329-340, 2004
    • (2004) Mol Cell , vol.13 , pp. 329-340
    • Yu, C.1    Minemoto, Y.2    Zhang, J.3    Liu, J.4    Tang, F.5    Bui, T.N.6    Xiang, J.7    Lin, A.8
  • 9
    • 16844387124 scopus 로고    scopus 로고
    • Role of JNK activation in apoptosis: A double-edged sword
    • Liu J, Lin A: Role of JNK activation in apoptosis: A double-edged sword. Cell Res 15: 36-42, 2005
    • (2005) Cell Res , vol.15 , pp. 36-42
    • Liu, J.1    Lin, A.2
  • 13
    • 0035019373 scopus 로고    scopus 로고
    • IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line
    • Chan ED, Riches DW: IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line. Am J Physiol Cell Physiol 280: C441-C450, 2001
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Chan, E.D.1    Riches, D.W.2
  • 14
    • 0034931503 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
    • Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, Manning AM, Firestein GS: c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 108: 73-81, 2001
    • (2001) J Clin Invest , vol.108 , pp. 73-81
    • Han, Z.1    Boyle, D.L.2    Chang, L.3    Bennett, B.4    Karin, M.5    Yang, L.6    Manning, A.M.7    Firestein, G.S.8
  • 18
    • 0033104505 scopus 로고    scopus 로고
    • TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway
    • Hocevar BA, Brown TL, Howe PH: TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J 18: 1345-1356, 1999
    • (1999) EMBO J , vol.18 , pp. 1345-1356
    • Hocevar, B.A.1    Brown, T.L.2    Howe, P.H.3
  • 19
    • 0037636775 scopus 로고    scopus 로고
    • C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts
    • Utsugi M, Dobashi K, Ishizuka T, Masubuchi K, Shimizu Y, Nakazawa T, Mori M: C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts. Am J Respir Cell Mol Biol 28: 754-761, 2003
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 754-761
    • Utsugi, M.1    Dobashi, K.2    Ishizuka, T.3    Masubuchi, K.4    Shimizu, Y.5    Nakazawa, T.6    Mori, M.7
  • 20
    • 0036721605 scopus 로고    scopus 로고
    • Complement activates the c-Jun N-terminal kinase/stress-activated protein kinase in glomerular epithelial cells
    • Peng H, Takano T, Papillon J, Bijian K, Khadir A, Cybulsky AV: Complement activates the c-Jun N-terminal kinase/stress-activated protein kinase in glomerular epithelial cells. J Immunol 169: 2594-2601, 2002
    • (2002) J Immunol , vol.169 , pp. 2594-2601
    • Peng, H.1    Takano, T.2    Papillon, J.3    Bijian, K.4    Khadir, A.5    Cybulsky, A.V.6
  • 21
    • 0037439652 scopus 로고    scopus 로고
    • Preconditioning with cyclosporine A or FK506 differentially regulates mitogen-activated protein kinase expression in rat kidneys with ischemia/reperfusion injury
    • Yang CW, Ahn HJ, Jung JY, Kim WY, Li C, Choi BS, Kim HW, Kim YS, Moon IS, Kim J, Bang BK: Preconditioning with cyclosporine A or FK506 differentially regulates mitogen-activated protein kinase expression in rat kidneys with ischemia/reperfusion injury. Transplantation 75: 20-24, 2003
    • (2003) Transplantation , vol.75 , pp. 20-24
    • Yang, C.W.1    Ahn, H.J.2    Jung, J.Y.3    Kim, W.Y.4    Li, C.5    Choi, B.S.6    Kim, H.W.7    Kim, Y.S.8    Moon, I.S.9    Kim, J.10    Bang, B.K.11
  • 22
    • 0347360288 scopus 로고    scopus 로고
    • ERK and p38 mediate high-glucose-induced hypertrophy and TGF-beta expression in renal tubular cells
    • Fujita H, Omori S, Ishikura K, Hida M, Awazu M: ERK and p38 mediate high-glucose-induced hypertrophy and TGF-beta expression in renal tubular cells. Am J Physiol Renal Physiol 286: F120-F126, 2004
    • (2004) Am J Physiol Renal Physiol , vol.286
    • Fujita, H.1    Omori, S.2    Ishikura, K.3    Hida, M.4    Awazu, M.5
  • 25
    • 0033736396 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction
    • Isaka Y, Tsujie M, Ando Y, Nakamura H, Kaneda Y, Imai E, Hori M: Transforming growth factor-beta 1 antisense oligodeoxynucleotides block interstitial fibrosis in unilateral ureteral obstruction. Kidney Int 58: 1885-1892, 2000
    • (2000) Kidney Int , vol.58 , pp. 1885-1892
    • Isaka, Y.1    Tsujie, M.2    Ando, Y.3    Nakamura, H.4    Kaneda, Y.5    Imai, E.6    Hori, M.7
  • 26
    • 0031776275 scopus 로고    scopus 로고
    • Chronic obstructive uropathy in severe combined immunodeficient (SCID) mice: Lymphocyte infiltration is not required for progressive tubulointerstitial injury
    • Shappell SB, Gurpinar T, Lechago J, Suki WN, Truong LD: Chronic obstructive uropathy in severe combined immunodeficient (SCID) mice: Lymphocyte infiltration is not required for progressive tubulointerstitial injury. J Am Soc Nephrol 9: 1008-1017, 1998
    • (1998) J Am Soc Nephrol , vol.9 , pp. 1008-1017
    • Shappell, S.B.1    Gurpinar, T.2    Lechago, J.3    Suki, W.N.4    Truong, L.D.5
  • 27
  • 29
    • 0033601179 scopus 로고    scopus 로고
    • Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription
    • Engel ME, McDonnell MA, Law BK, Moses HL: Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription. J Biol Chem 274: 37413-37420, 1999
    • (1999) J Biol Chem , vol.274 , pp. 37413-37420
    • Engel, M.E.1    McDonnell, M.A.2    Law, B.K.3    Moses, H.L.4
  • 30
    • 4043084803 scopus 로고    scopus 로고
    • Response of human cells to desiccation: Comparison with hyperosmotic stress response
    • Huang Z, Tunnacliffe A: Response of human cells to desiccation: Comparison with hyperosmotic stress response. J Physiol 558: 181-191, 2004
    • (2004) J Physiol , vol.558 , pp. 181-191
    • Huang, Z.1    Tunnacliffe, A.2
  • 31
    • 0032938758 scopus 로고    scopus 로고
    • Activation of mesangial cell signaling cascades in response to mechanical strain
    • Ingram AJ, Ly H, Thai K, Kang M, Scholey JW: Activation of mesangial cell signaling cascades in response to mechanical strain. Kidney Int 55: 476-485, 1999
    • (1999) Kidney Int , vol.55 , pp. 476-485
    • Ingram, A.J.1    Ly, H.2    Thai, K.3    Kang, M.4    Scholey, J.W.5
  • 32
    • 0034842699 scopus 로고    scopus 로고
    • Osmotic stress induces HB-EGF gene expression via Ca(2+)/Pyk2/JNK signal cascades in rat aortic smooth muscle cells
    • Koh YH, Che W, Higashiyama S, Takahashi M, Miyamoto Y, Suzuki K, Taniguchi N: Osmotic stress induces HB-EGF gene expression via Ca(2+)/Pyk2/JNK signal cascades in rat aortic smooth muscle cells. J Biochem (Tokyo) 130: 351-358, 2001
    • (2001) J Biochem (Tokyo) , vol.130 , pp. 351-358
    • Koh, Y.H.1    Che, W.2    Higashiyama, S.3    Takahashi, M.4    Miyamoto, Y.5    Suzuki, K.6    Taniguchi, N.7
  • 33
    • 0031785280 scopus 로고    scopus 로고
    • Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells
    • Malek AM, Goss GG, Jiang L, Izumo S, Alper SL: Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells. Stroke 29: 2631-2640, 1998
    • (1998) Stroke , vol.29 , pp. 2631-2640
    • Malek, A.M.1    Goss, G.G.2    Jiang, L.3    Izumo, S.4    Alper, S.L.5
  • 34
    • 0034912299 scopus 로고    scopus 로고
    • Insight into skeletal muscle mechanotransduction: MAPK activation is quantitatively related to tension
    • Martineau LC, Gardiner PF: Insight into skeletal muscle mechanotransduction: MAPK activation is quantitatively related to tension. J Appl Physiol 91: 693-702, 2001
    • (2001) J Appl Physiol , vol.91 , pp. 693-702
    • Martineau, L.C.1    Gardiner, P.F.2
  • 36
    • 0027165757 scopus 로고
    • Increased expression of TGF-beta 1 mRNA in the obstructed kidney of rats with unilateral ureteral ligation
    • Kaneto H, Morrissey J, Klahr S: Increased expression of TGF-beta 1 mRNA in the obstructed kidney of rats with unilateral ureteral ligation. Kidney Int 44: 313-321, 1993
    • (1993) Kidney Int , vol.44 , pp. 313-321
    • Kaneto, H.1    Morrissey, J.2    Klahr, S.3
  • 37
    • 0942301311 scopus 로고    scopus 로고
    • Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: A mechanism for activation of latent TGF-beta1
    • Naito T, Masaki T, Nikolic-Paterson DJ, Tanji C, Yorioka N, Kohno N: Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: A mechanism for activation of latent TGF-beta1. Am J Physiol Renal Physiol 286: F278-F287, 2004
    • (2004) Am J Physiol Renal Physiol , vol.286
    • Naito, T.1    Masaki, T.2    Nikolic-Paterson, D.J.3    Tanji, C.4    Yorioka, N.5    Kohno, N.6
  • 38
    • 3142521635 scopus 로고    scopus 로고
    • AP-1 complexes mediate oxidized LDL-induced overproduction of TGF-beta(1) in rat mesangial cells
    • Wu Z, Zhou Q, Lan Y, Wang Y, Xu X, Jin H: AP-1 complexes mediate oxidized LDL-induced overproduction of TGF-beta(1) in rat mesangial cells. Cell Biochem Funct 22: 237-247, 2004
    • (2004) Cell Biochem Funct , vol.22 , pp. 237-247
    • Wu, Z.1    Zhou, Q.2    Lan, Y.3    Wang, Y.4    Xu, X.5    Jin, H.6
  • 41
    • 0036715249 scopus 로고    scopus 로고
    • Peripheral blood fibrocytes from burn patients: Identification and quantification of fibrocytes in adherent cells cultured from peripheral blood mononuclear cells
    • Yang L, Scott PG, Giuffre J, Shankowsky HA, Ghahary A, Tredget EE: Peripheral blood fibrocytes from burn patients: Identification and quantification of fibrocytes in adherent cells cultured from peripheral blood mononuclear cells. Lab Invest 82: 1183-1192, 2002
    • (2002) Lab Invest , vol.82 , pp. 1183-1192
    • Yang, L.1    Scott, P.G.2    Giuffre, J.3    Shankowsky, H.A.4    Ghahary, A.5    Tredget, E.E.6
  • 42
    • 0037437371 scopus 로고    scopus 로고
    • TGF-beta1-mediated fibroblast-myofibroblast terminal, differentiation-the role of Smad proteins
    • Evans RA, Tian YC, Steadman R, Phillips AO: TGF-beta1-mediated fibroblast-myofibroblast terminal, differentiation-the role of Smad proteins. Exp Cell Res 282: 90-100, 2003
    • (2003) Exp Cell Res , vol.282 , pp. 90-100
    • Evans, R.A.1    Tian, Y.C.2    Steadman, R.3    Phillips, A.O.4
  • 43
    • 0032842887 scopus 로고    scopus 로고
    • Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro
    • Fan JM, Ng YY, Hill PA, Nikolic-Paterson DJ, Mu W, Atkins RC, Lan HY: Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro. Kidney Int 56: 1455-1467, 1999
    • (1999) Kidney Int , vol.56 , pp. 1455-1467
    • Fan, J.M.1    Ng, Y.Y.2    Hill, P.A.3    Nikolic-Paterson, D.J.4    Mu, W.5    Atkins, R.C.6    Lan, H.Y.7
  • 45
    • 1642523573 scopus 로고    scopus 로고
    • Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: Evidence that mitotic Bcl-2 phosphorylation is JNK-independent
    • Du L, Lyle CS, Hall-Obey TB, Gaarde WA, Muir JA, Bennett BL, Chambers TC: Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: Evidence that mitotic Bcl-2 phosphorylation is JNK-independent. J Biol Chem 279: 11957-11966, 2004
    • (2004) J Biol Chem , vol.279 , pp. 11957-11966
    • Du, L.1    Lyle, C.S.2    Hall-Obey, T.B.3    Gaarde, W.A.4    Muir, J.A.5    Bennett, B.L.6    Chambers, T.C.7
  • 46
    • 25444482606 scopus 로고    scopus 로고
    • Genetic inhibition or activation of JNK1/2 each protect the myocardium from ischemia-reperfusion-induced cell death in vivo
    • Kaiser RA, Liang Q, Bueno OF, Huang Y, Lackey T, Klevitsky R, Hewett TE, Molkentin JD: Genetic inhibition or activation of JNK1/2 each protect the myocardium from ischemia-reperfusion-induced cell death in vivo. J Biol Chem 280: 32602-32608, 2005
    • (2005) J Biol Chem , vol.280 , pp. 32602-32608
    • Kaiser, R.A.1    Liang, Q.2    Bueno, O.F.3    Huang, Y.4    Lackey, T.5    Klevitsky, R.6    Hewett, T.E.7    Molkentin, J.D.8
  • 47
    • 10044247350 scopus 로고    scopus 로고
    • c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis
    • Liu J, Minemoto Y, Lin A: c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis. Mol Cell Biol 24: 10844-10856, 2004
    • (2004) Mol Cell Biol , vol.24 , pp. 10844-10856
    • Liu, J.1    Minemoto, Y.2    Lin, A.3
  • 48
    • 0042664089 scopus 로고    scopus 로고
    • Fibrogenic stresses activate different mitogen-activated protein kinase pathways in renal epithelial, endothelial or fibroblast cell populations
    • Pat BK, Cuttle L, Watters D, Yang T, Johnson DW, Gobe GC: Fibrogenic stresses activate different mitogen-activated protein kinase pathways in renal epithelial, endothelial or fibroblast cell populations. Nephrology (Carlton) 8: 196-204, 2003
    • (2003) Nephrology (Carlton) , vol.8 , pp. 196-204
    • Pat, B.K.1    Cuttle, L.2    Watters, D.3    Yang, T.4    Johnson, D.W.5    Gobe, G.C.6
  • 49
    • 1642504413 scopus 로고    scopus 로고
    • Activation of ERK or inhibition of JNK ameliorates H2O2 cytotoxicity in mouse renal proximal tubule cells
    • Arany I, Megyesi JK, Kaneto H, Tanaka S, Safirstein RL: Activation of ERK or inhibition of JNK ameliorates H2O2 cytotoxicity in mouse renal proximal tubule cells. Kidney Int 65: 1231-1239, 2004
    • (2004) Kidney Int , vol.65 , pp. 1231-1239
    • Arany, I.1    Megyesi, J.K.2    Kaneto, H.3    Tanaka, S.4    Safirstein, R.L.5
  • 50
    • 30644468596 scopus 로고    scopus 로고
    • JNK/SAPK and p38 SAPK-2 mediate mechanical stretch-induced apoptosis via caspase-3 and -9 in NRK-52E renal epithelial cells
    • Nguyen HT, Hsieh MH, Gaborro A, Tinloy B, Phillips C, Adam RM: JNK/SAPK and p38 SAPK-2 mediate mechanical stretch-induced apoptosis via caspase-3 and -9 in NRK-52E renal epithelial cells. Nephron Exp Nephrol 102: e49-e61, 2006
    • (2006) Nephron Exp Nephrol , vol.102
    • Nguyen, H.T.1    Hsieh, M.H.2    Gaborro, A.3    Tinloy, B.4    Phillips, C.5    Adam, R.M.6
  • 52
    • 3042628478 scopus 로고    scopus 로고
    • Macrophage-mediated renal injury is dependent on signaling via the JNK pathway
    • Ikezumi Y, Hurst L, Atkins RC, Nikolic-Paterson DJ: Macrophage-mediated renal injury is dependent on signaling via the JNK pathway. J Am Soc Nephrol 15: 1775-1784, 2004
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1775-1784
    • Ikezumi, Y.1    Hurst, L.2    Atkins, R.C.3    Nikolic-Paterson, D.J.4
  • 54
    • 0041524094 scopus 로고    scopus 로고
    • A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun
    • Morton S, Davis RJ, McLaren A, Cohen P: A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun. EMBO J 22: 3876-3886, 2003
    • (2003) EMBO J , vol.22 , pp. 3876-3886
    • Morton, S.1    Davis, R.J.2    McLaren, A.3    Cohen, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.