Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis

Journal of Neuroscience Research

Volumn 86, Issue 11, 2008, Pages 2441-2449

  Wang, Ying ^a   Mei, Yunhua ^a   Feng, Dechun ^a   Xu, Lingyun ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Experimental autoimmune encephalomyelitis; Multiple sclerosis; NF B; Triptolide

Indexed keywords

DNA; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3; TRIPTOLIDE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; C57BL 6 MOUSE; CELLULAR IMMUNITY; CONTROLLED STUDY; DEMYELINATING DISEASE; DISEASE SEVERITY; DNA BINDING; DRUG DOSE COMPARISON; GENE EXPRESSION REGULATION; IMMUNOMODULATION; IMMUNOREGULATION; INFLAMMATION; INFLAMMATORY INFILTRATE; INHIBITION KINETICS; MALE; MONONUCLEAR CELL; MOUSE; MULTIPLE SCLEROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; SPLEEN CELL; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; CYTOKINES; DEMYELINATING DISEASES; DITERPENES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPOXY COMPOUNDS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PHENANTHRENES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD; T-LYMPHOCYTES;

EID: 49349089380     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21683     Document Type: Article

References (43)

1. Becher B, Durell BG, Noelle RJ. 2002. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J Clin Invest 110:493-497.
2. Bernard CC, Leydon J, Mackay IR. 1976. T cell necessity in the pathogenesis of experimental autoimmune encephalomyelitis in mice. Eur J Immunol 6:655-660.
3. Bettelli E, Dastrange M, Oukka M. 2005. Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A 102:5138-5143.
4. Bonetti B, Stegagno C, Cannella B, Rizzuto N, Moretto G, Raine CS. 1999. Activation of NF-kappaB and c-jun transcription factors in multiple sclerosis lesions. Implications for oligodendrocyte pathology. Am J Pathol 155:1433-1438.
5. Bright JJ, Du C, Coon M, Sriram S, Klaus SJ. 1998. Prevention of experimental allergic encephalomyelitis via inhibition of IL-12 signaling and IL-12-mediated Th1 differentiation: an effect of the novel anti-inflammatory drug lisofylline. J Immunol 161:7015-7022.
6. Bynoe MS, Evans JT, Viret C, Janeway CA Jr. 2003. Epicutaneous immunization with autoantigenic peptides induces T suppressor cells that prevent experimental allergic encephalomyelitis. Immunity 19:317-328.
7. Chan MA, Kohlmeier JE, Branden M, Jung M, Benedict SH. 1999. Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506. Phytother Res 13:464-467.
8. Chen BJ. 2001. Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook f. Leuk Lymphoma 42:253-265.
9. Chen Y, Langrish CL, McKenzie B, Joyce-Shaikh B, Stumhofer JS, McClanahan T, Blumenschein W, Churakovsa T, Low J, Presta L, Hunter CA, Kastelein RA, Cua DJ. 2006. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest 116:1317-1326.
10. Chitnis T, Khoury SJ. 2003. Cytokine shifts and tolerance in experimental autoimmune encephalomyelitis. Immunol Res 28:223-239.
11. De Rosa V, Procaccini C, La Cava A, Chieffi P, Nicoletti GF, Fontana S, Zappacosta S, Matarese G. 2006. Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. J Clin Invest 116:447-455.
12. Dong C. 2006. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol 6:329-333.
13. Ferber IA, Brocke S, Taylor-Edwards C, Ridgway W, Dinisco C, Steinman L, Dalton D, Fathman CG. 1996. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 156:5-7.
14. Fernandez-Martin A, Gonzalez-Rey E, Chomy A, Ganea D, Delgado M. 2006. Vasoactive intestinal peptide induces regulatory T cells during experimental autoimmune encephalomyelitis. Eur J Immunol 36:318-326.
15. + regulatory T cells. Nat Immunol 4:330-336.
16. Fu YF, Zhu YN, Ni J, Zhong XG, Tang W, Zhou R, Zhou Y, Dong JR, He PL, Wan H, Li YC, Yang YF, Zuo JP. 2006. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation. J Neuroimmunol 175:142-151.
17. Galetta SL, Markowitz C. 2005. US FDA-approved disease-modifying treatments for multiple sclerosis: review of adverse effect profiles. CNS Drugs 19:239-252.
18. Gran B, Zhang GX, Yu S, Li J, Chen XH, Ventura ES, Kamoun M, Rostami A. 2002. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J Immunol 169:7104-7110.
19. Gu WZ., Brandwein SR. 1998. Inhibition of type II collagen-induced arthritis in rats by triptolide. Int J Immunopharmacol 20:389-400.
20. Hafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P, Baecher-Allan C. 2005. Multiple sclerosis. Immunol Rev 204:208-231.
21. Hilliard B, Samoilova EB, Liu TS, Rostami A, Chen Y. 1999. Experimental autoimmune encephalomyelitis in NF-kappa B-deficient mice: roles of NF-kappa B in the activation and differentiation of autoreactive T cells. J Immunol 163:2937-2943.
22. Hori S, Nomura T, Sakaguchi S. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057-1061.
23. + T regulatory cells. Nat Immunol 4:337-342.
24. + regulatory T cells Suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol 169: 4712-4716.
25. Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, Sudo K, Iwakura Y. 2006. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 177:566-573.
26. Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, McClanahan T, Kastelein RA, Cua DJ. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201:233-240.
27. Li Q, Verma IM. 2002. NF-kappaB regulation in the immune system. Nat Rev Immunol 2:725-734.
28. Miller A. 1997. Current and investigational therapies used to alter the course of disease in multiple sclerosis. South Med J 90:367-375.
29. Olsson T. 1995. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol Rev 144:245-268.
30. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C. 2005. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6:1133-1141.
31. Powell NO, Mitchell D, Lederman J, Buckmeier J, Zamvil SS, Graham M, Ruddle NH, Steinman L. 1990. Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Int Immunol 2:539-544.
32. Qiu. D, Kao PN. 2003. Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook f. Drugs R D 4:1-18.
33. Qiu D, Zhao G, Aoki Y, Shi L, Uyei A, Nazarian S, Ng JC, Kao PN. 1999. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J Biol Chem 274: 13443-13450.
34. + regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 101:15434-15439.
35. Samoilova EB, Horton JL, Hilliard B, Liu TS, Chen Y. 1998. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol 161:6480-6486.
36. Steinman L. 1999. Assessment of animal models for MS and demyelinating disease in the design of rational therapy. Neuron 24:511-514.
37. Tao X, Cai JJ, Lipsky PE. 1995. The identity of immunosuppressive components of the ethyl acetate extract and chloroform methanol extract (T2) of Tripterygium wilfordii Hook f. J Pharmacol Exp Ther 272:1305-1312.
38. Tao XL, Sun Y, Dong Y, Xiao YL, Hu DW, Shi YP, Zhu QL, Dai H, Zhang NZ. 1989. A prospective, controlled, double-blind, cross-over study of Tripterygium wilfodii Hook f. in treatment of rheumatoid arthritis. Chin. Med. J. (Engl) 102:327-332.
39. Wang BX, Yuan ZZ. 1989. [A tablet of Tripterygium wilfordii in treating lupus erythematosus]. Zhong Xi Yi Jie He Za Zhi 9:389, 407-408.
40. Wu Y, Wang Y, Zhong C, Li Y, Li X, Sun B. 2003. The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response. Int Immunopharmacol 3:1457-1465.
41. Wu Y, Cui J, Bao X, Chan S, Young DO, Liu D, Shen P. 2006. Triptolide, attenuates oxidative stress, NF-kappaB activation and multiple cytokine gene expression in murine peritoneal macrophage. Int J Mol Med 17:141-150.
42. Yang Y, Liu Z, Tolosa E, Yang J, Li L. 1998. Triptolide induces apoptotic death of T lymphocyte. Immunopharmacology 40:139-149.
43. Zhu KJ, Shen QY, Cheng H, Mao XH, Lao LM, Hao GL. 2005. Triptolide affects the differentiation, maturation and function of human dendritic cells. Int Immunopharmacol 5:1415-1426.