Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells

Biochemical Pharmacology

Volumn 80, Issue 10, 2010, Pages 1553-1562

  Chua, Angeline Wei Ling ^a   Hay, Hui Sin ^a,b   Rajendran, Peramaiyan ^a   Shanmugam, Muthu K ^a   Li, Feng ^a   Bist, Pradeep ^a   Koay, Evelyn S C ^a   Lim, Lina H K ^a   Kumar, Alan Prem ^a,b   Sethi, Gautam ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Butein; CXCR4; HER2; Invasion; Metastasis; NF B

Indexed keywords

BUTEIN; CHEMOKINE RECEPTOR CXCR4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE; CXCR4 PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN; LUCIFERASE;

ARTICLE; BREAST CANCER; CANCER CELL; DOWN REGULATION; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BREAST TUMOR; CELL MOTION; CHEMICAL STRUCTURE; DOSE RESPONSE; DRUG EFFECTS; FEMALE; GENETIC TRANSFECTION; GENETICS; IMMUNOPRECIPITATION; ISOLATION AND PURIFICATION; MALE; METABOLISM; PATHOLOGY; PLASMID; PROSTATE TUMOR; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; TUMOR INVASION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CHALCONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FEMALE; HUMANS; IMMUNOPRECIPITATION; LUCIFERASES; MALE; MOLECULAR STRUCTURE; NEOPLASM INVASIVENESS; NF-KAPPA B; PLASMIDS; PROSTATIC NEOPLASMS; RECEPTOR, ERBB-2; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 77957017047     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.07.045     Document Type: Article

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