The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry

Biochemistry

Volumn 45, Issue 28, 2006, Pages 8488-8498

  Horn, James R ^a   Kraybill, Brian ^c   Petro, Elizabeth J ^a   Coales, Stephen J ^c   Morrow, Jeffrey A ^d   Hamuro, Yoshitomo ^c   Kossiakoff, Anthony A ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c ExSAR Corporation   (United States)

^d Sierra Analytics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; FREE ENERGY; HYDROGEN; MASS SPECTROMETRY; MUTAGENESIS; THERMODYNAMIC PROPERTIES; X RAY ANALYSIS;

BINDING KINETICS; BOUND COMPLEX; PROTEIN-PROTEIN BINDING; SOLVATION DYNAMICS;

PROTEINS;

GROWTH HORMONE; HUMAN GROWTH HORMONE;

ARTICLE; BETA SHEET; BINDING AFFINITY; COMPLEX FORMATION; DEUTERIUM HYDROGEN EXCHANGE; ENERGY; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; SOLVATION; TEMPERATURE; THERMODYNAMICS; X RAY ANALYSIS;

BINDING SITES; CIRCULAR DICHROISM; DEUTERIUM; HUMAN GROWTH HORMONE; HUMANS; HYDROGEN; KINETICS; MASS SPECTROMETRY; MEMBRANE PROTEINS; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 33746034950     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0604328     Document Type: Article

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