Superactive mutants of thromboxane prostanoid receptor: Functional and computational analysis of an active form alternative to constitutively active mutants

Cellular and Molecular Life Sciences

Volumn 67, Issue 17, 2010, Pages 2979-2989

  Ambrosio, Manuela ^a   Fanelli, Francesca ^b   Brocchetti, Silvia ^a   Raimondi, Francesco ^b   Mauri, Mario ^c   Rovati, G Enrico ^a   Capra, Valérie ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Computational modeling; Constitutive activity; E DRY motif; G protein coupled receptor; Thromboxane receptor

Indexed keywords

MUTANT PROTEIN; PROSTANOID RECEPTOR; THROMBOXANE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; OLIGONUCLEOTIDE;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; IN VITRO STUDY; MATHEMATICAL MODEL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; WILD TYPE; ANIMAL; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; GENETICS; METABOLISM; MUTATION; PROCEDURES; PROTEIN MOTIF;

AMINO ACID MOTIFS; ANIMALS; CERCOPITHECUS AETHIOPS; COMPUTATIONAL BIOLOGY; COS CELLS; GTP-BINDING PROTEINS; MODELS, MOLECULAR; MUTATION; OLIGONUCLEOTIDES; PROTEIN CONFORMATION; RECEPTORS, THROMBOXANE;

EID: 77956733745     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0368-9     Document Type: Article

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